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Alisa 愛理沙 @alisaiakupova.bsky.social · 10d

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Alisa 愛理沙 @alisaiakupova.bsky.social · 10d

Elsevier… 😫

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Alisa 愛理沙 @alisaiakupova.bsky.social · 10d

A nice review about mucosal mechanisms in celiac disease and food allergy, loved all #IgA mentions 🥸👇

www.sciencedirect.com/science/arti...

Gut mucosal immune responses – Implications for celiac disease and food allergy

The intestinal mucosa employs a diverse set of defense mechanisms—from mucosal barrier regulation to immunoregulatory pathways—to maintain homeostasis…

www.sciencedirect.com

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Alisa 愛理沙 @alisaiakupova.bsky.social · 11d

Got excited too quickly it is actually about some IgE mechanisms, in fact it is about IgE from the clinical perspective! Worth reading if you are interested in current anti-IgE therapies against atopic diseases onlinelibrary.wiley.com/doi/abs/10.1...

IgE in Allergic Diseases

Immunoglobulin E (IgE) is key in the pathogenesis of allergic diseases, exerting both systemic and local effects through high-affinity binding to FcεRI on mast cells and basophils. Cross-linking of a....

onlinelibrary.wiley.com

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Alisa 愛理沙 @alisaiakupova.bsky.social · 16d

haha 3 preprints in a row about mucosal immunity, what a time to be alive

Reposted by Alisa 愛理沙

Preprint Club - Immunology @preprintclub.bsky.social · 16d

Tomorrow #PreprintHub1 is starting for the 2025-2026 season! Laura Rosenberg from Mount Sinai will present a #preprint by the @BelkaidLab on how endogenous retroelements promote tolerance to dietary antigens.

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Alisa 愛理沙

Preprint Club - Immunology @preprintclub.bsky.social · 17d

Tomorrow in #PreprintHub2,
@alisaiakupova.bsky.social from
‪@mdc-berlin.bsky.social‬ will present a #preprint on tolerance to dietary antigens from the Xiaohuan Guo lab 🧬📷
Preprint: www.researchsquare.com/article/rs-4...

RORγt+ APCs require a distinct cis-regulatory element to instruct tolerance to dietary antigens

Oral tolerance represents a hallmark of intestinal mucosal immunity to prevent inflammatory responses to harmless natural antigens, such as dietary components or commensal organisms. However, the unde...

www.researchsquare.com

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Alisa 愛理沙 @alisaiakupova.bsky.social · 22d

JCI Insight - Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions insight.jci.org/articles/vie...

JCI Insight - Histamine-induced RPS6 phosphorylation in dendritic cells is associated with the severity of peanut allergic reactions

insight.jci.org

Reposted by Alisa 愛理沙

Waggoner Lab @labwaggoner.bsky.social · 27d

@biorxivpreprint.bsky.social There are some cool aspects to this new genetic study, so forgive my poking for fun:
1. HLA is associated control of virus infections (uh, duh?)
2. Is it even significant? (p = 9.1×10-851 )
www.biorxiv.org/content/10.1... @harvardmed.bsky.social

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Alisa 愛理沙 @alisaiakupova.bsky.social · Sep 8

I wish I have met David Baltimore.. it is very very sad.

Igor Brodsky @brodskyigorlab.bsky.social · Sep 8

www.latimes.com/obituaries/s... RIP David Baltimore. A true giant of biomedical research. Made so many fundamental discoveries: Reverse transcriptase; NF-kB; Rag genes (among others) Also shut down his lab for a week in 1970 to protest the US invasion of Cambodia.

David Baltimore, Nobel Prize-winning scientist and former Caltech president, dies at 87

Baltimore played a role in virtually every important national debate over the use and potential misuse of the science of genetic engineering.

www.latimes.com

Alisa 愛理沙 @alisaiakupova.bsky.social · Sep 4

Today we learnt a lot about tuft cells from @jmoltke.bsky.social at the @mdc-berlin.bsky.social afternoon for immunology. Thank you! 😊

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Reposted by Alisa 愛理沙

Max Delbrück Center @mdc-berlin.bsky.social · Aug 28

📢 Interested in #immunology research? Join our “Afternoon for Immunology”! Scientists at all career stages will present their research.

📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin

🔗 www.mdc-berlin.de/Afternoonfor...

Poster for "Afternoon for Immunology" on 4 September 2025 at MDC-Campus Buch, featuring talks, coffee break, and networking.

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Alisa 愛理沙 @alisaiakupova.bsky.social · Jul 22

@mdc-berlin.bsky.social

Alisa 愛理沙 @alisaiakupova.bsky.social · Jul 22

Our new paper is out in Allergy! 🚨

Understanding the Variability of Peanut-Oral Immunotherapy Responses by Multi-Omics Profiling of Immune Cells

I personally like the ILC3 link with OIT :^)

onlinelibrary.wiley.com/doi/10.1111/...

Understanding the Variability of Peanut‐Oral Immunotherapy Responses by Multi‐Omics Profiling of Immune Cells

This study analyzes molecular drivers of OIT responsiveness. Multi-omics profiling of peanut-stimulated PBMCs in a controlled peanut-OIT trial identifies immune, transcriptomic, and epigenetic change...

onlinelibrary.wiley.com

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Alisa 愛理沙 @alisaiakupova.bsky.social · Jul 17

will be there!

Max Delbrück Center @mdc-berlin.bsky.social · Jul 11

🏳️‍🌈 Resilience in Times of Change: Join #mdcBerlin’s LGBTQI+ community for the 4th Pride Symposium on July 18 at #mdcBIMSB.

Talks, panel discussion, bake sale, and a Pride After Hour – amplifying queer voices in science.

Info and registration:
👉 www.mdc-berlin.de/news/news/me... 👈

Graphic with photo and text: The top half features a photo of a speaker addressing a seated audience in a modern room, with a rainbow Pride flag on the wall and a screen displaying speaker info. The background is framed with a vibrant rainbow-colored marbled design. Overlaid white sans-serif text appears in dark green and magenta text boxes in the lower half, reading “PRIDE SYMPOSIUM” and “JULI 18, 2025 MDC-BIMSB.”

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Reposted by Alisa 愛理沙

Trends in Genetics @cp-trendsgenetics.bsky.social · Jul 7

Online Now! A new @genomicspc.bsky.social Spotlight:

"Psychiatric disorders: teasing apart genetic similarities and differences"
by Jiayi Xu (徐佳依) (@xujiayi.bsky.social) & Laura M. Huckins (@laurahuckins.bsky.social)

Read for FREE till Aug. 23rd at this link:
authors.elsevier.com/a/1lNROcQbJF...

Figure 1. Five genomic factors shared across 14 psychiatric disorders.

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Reposted by Alisa 愛理沙

Ruth Ann Crystal @drruth.bsky.social · Jul 8

🥜 Food Allergies may start in the Skin, not just the Gut🥜

Damaged skin (as with eczema) can let food proteins in, priming IgE responses that later trigger gut Mast Cells, which drives allergic reactions & anaphylaxis. buff.ly/Nfo06vB

#medsky #pedsky #foodallergy #immunosky 🛟🧪

Complex chart showing a peanut above the skin layer with S. Aureus bacteria. This triggers a chain of reaction in the skin and in the lymph nodes. When the baby eats the peanut, it triggers the tuft cells and SAP and this eventually causes mast cells to degranulate.

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Alisa 愛理沙 @alisaiakupova.bsky.social · Jul 3

yeah but… this doesn’t justify the existence of current (broken) publishing system 💀

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Reposted by Alisa 愛理沙

Trends in Genetics @cp-trendsgenetics.bsky.social · Jun 19

Our first preprint Spotlight is now online!

"Toward Equitable Biomarkers of Aging: Rethinking Methylation Clocks"
by Chen & colleagues (@genomicspc.bsky.social)

It highlights a bioRxiv preprint (@biorxivpreprint.bsky.social) by Cruz-González et al.

Read here:
authors.elsevier.com/a/1lHcdcQbJF...

Figure 1. Epigenetic and multi-omic clocks in aging biomarker development.

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Alisa 愛理沙 @alisaiakupova.bsky.social · Jun 27

My dreams come true 🥺 a preprint club in genomics!!

Genomics Preprint Club @genomicspc.bsky.social · Jun 25

📣 Hello Bluesky! We’re hosting our June Genomics Preprint Club meeting this Friday, June 27 from 3–4pm EST!

📩 Contact us to join!

🗣️ Presenters:
- Krzysiek Gogolewski: www.medrxiv.org/content/10.1...
- Arnav Wadhawan: www.medrxiv.org/content/10.1...

Informational flyer for next GPC meeting on Friday, June 27 from 3-4pm EST.

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Alisa 愛理沙 @alisaiakupova.bsky.social · Jun 10

@bsky.app you have to improve, name tags are awfully long. plus, it would be useful to allow drafts for posts. X is still better, if ignoring all the sex bots attacking my dm and hate speech. 😬

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Alisa 愛理沙 @alisaiakupova.bsky.social · Jun 10

I look like these T cells: 🫩

Preprint Club - Immunology @preprintclub.bsky.social · Jun 10

Today, in #preprinthub2 @cleeterichter.bsky.social will lead a discussion of a #preprint from @santoshvardhana.bsky.social @mskcancercenter.bsky.social on MEK-dependent bioenergetic demand driving terminal CD8+ T cell exhaustion. 🫩🍰💥 #immunosky

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Alisa 愛理沙

natimmunol.nature.com @natimmunol.nature.com · May 13

Iwasaki and colleagues show that mucosal vaccine boosters can induce protective immune responses without any adjuvant by retooling lymph node resident memory B cells with memory T cells acting as a natural adjuvant. Read it here: rdcu.be/elTur
www.nature.com/articles/s41...

Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice

Nature Immunology - Iwasaki and colleagues show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with an mRNA vaccine encoding...

rdcu.be

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Alisa 愛理沙 @alisaiakupova.bsky.social · May 7

congrats to my friend @encent.bsky.social and the team 😊

Iana V. Kim @ianakim.bsky.social · May 7

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

www.nature.com

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Reposted by Alisa 愛理沙

Preprint Club - Immunology @preprintclub.bsky.social · May 6

Today in #preprinthub2 @alisaiakupova.bsky.social will discuss a #preprint from @krishnaroskin.bsky.social @cincyresearch.bsky.social on how B cell repertoire of children with AD exhibits altered #IgE maturation associated with allergic food sensitization. 🥜🐕👶
#medsky
www.biorxiv.org/content/10.1...

B cell repertoire of children with atopic dermatitis exhibit altered IgE maturation associated with allergic food sensitization

IgE B cells produce antibodies responsible for the inappropriate specificity seen in allergic disease. In this study, we sequence antibody gene repertoires from a large, well-characterized early life ...

www.biorxiv.org

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