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Reposted by Amulya Sreekumar

Ben Schumann @drglycoben.bsky.social · 6d

Check our new venture into drug discovery #glycotime!

Ben Schumann @drglycoben.bsky.social · 6d

Check out our new preprint "Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase" on Chemrxiv led by Will Browne in close collab with GSK @jtbush.bsky.social

chemrxiv.org/engage/chemr...

Convergent Lead Discovery Strategies Yield Covalent and Non-covalent Inhibitors of Human UDP-Galactose-4-Epimerase

O-GalNAc (N-acetylgalactosaminyl) glycosylation is an abundant posttranslational modification in mammalian cells. Dysregulation of O-GalNAc glycosylation is implicated in cancer metastasis and immune ...

chemrxiv.org

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Amulya Sreekumar @amulyasreekumar.bsky.social · Sep 3

Comprehensive experiments in pre-clinical models and clinical data analysis demonstrate that dormancy creates a unique window of opportunity to deplete minimal residual disease and delay recurrence. Congratulations to all the authors on this important body of work!

Targeting dormant tumor cells to prevent recurrent breast cancer: a randomized phase 2 trial - Nature Medicine

A combination of mouse model data and data from a randomized phase 2 trial in patients with breast cancer in remission demonstrates feasibility, safety and a reduction in residual tumor cells followin...

www.nature.com

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Reposted by Amulya Sreekumar

Nature Nanotechnology @natnano.nature.com · Jul 28

New paper online:

Ångström-resolution imaging of cell-surface glycans.

The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.

#Glycotime

www.nature.com/articles/s41...

Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology

By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

www.nature.com

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Reposted by Amulya Sreekumar

Vikas Navratna @vikasnavaratna.bsky.social · Jul 26

World central kitchen has been doing great work consistently. Every meal counts. Donate here.

donate.wck.org/give/525879/...

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Amulya Sreekumar @amulyasreekumar.bsky.social · Jul 3

Congratulations!! 🥂

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Amulya Sreekumar @amulyasreekumar.bsky.social · May 10

As a budding scientist, the idea that form follows function led me to a career studying developmental biology and how these principles are distorted in cancer. Excited to share this preprint reporting a surprising transdifferentiation of breast cancer cells unlocked by dormancy. Link below:

bioRxiv Cancer Bio @biorxiv-cancer.bsky.social · May 10

Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy https://www.biorxiv.org/content/10.1101/2025.05.07.652632v1

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Reposted by Amulya Sreekumar

Ashani Weeraratna @ashi-w.bsky.social · Feb 18

Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...

AACR Legislative Action Center

Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...

nam02.safelinks.protection.outlook.com

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Reposted by Amulya Sreekumar

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 6

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime

www.nature.com/articles/s41...

Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods

Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

www.nature.com

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Amulya Sreekumar @amulyasreekumar.bsky.social · Jan 21

Done!

Reposted by Amulya Sreekumar

Development @dev-journal.bsky.social · Dec 27

Apply for our Pathway to Independence programme, a scheme supporting postdocs going on the job market in 2025 with training, mentorship, profile-raising and networking opportunities. Apply by 31 Jan 2025: https://buff.ly/3VJGgDC

Pathway to independence: a new initiative supporting postdocs on the job market

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Reposted by Amulya Sreekumar

Meera Sundaram @meera-sundaram.bsky.social · Nov 16

#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!

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Amulya Sreekumar @amulyasreekumar.bsky.social · Dec 4

Done!

Amulya Sreekumar @amulyasreekumar.bsky.social · Dec 2

Of course!

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Reposted by Amulya Sreekumar

Jessica Stark @jcstark.bsky.social · Nov 20

The secret is out! 🚀 Thrilled to support Valora's mission to bring our #AbLec technology to patients, alongside co-inventor @carolynbertozzi.bsky.social. More to come, and in the meantime, you can learn more about AbLecs here:
www.biorxiv.org/content/10.1...

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Amulya Sreekumar @amulyasreekumar.bsky.social · Nov 20

Done!

Reposted by Amulya Sreekumar

Anna Obenauf @obenaufa.bsky.social · Nov 20

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025

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Reposted by Amulya Sreekumar

Jacob A Hoffman @jahoffman1.bsky.social · Nov 19

Ever wondered how gene therapies know where to go? Screening AAV vector libraries across different species I uncovered evidence of altered #glycan profiles between mouse, NHP and human liver, with implications for translation of #AAV #genetherapy

pubmed.ncbi.nlm.nih.gov/39001819/

Enjoy!

Modulation of AAV9 Galactose Binding Yields Novel Gene Therapy Vectors and Predicts Cross-Species Differences in Glycan Avidity - PubMed

Effective use of adeno-associated viruses (AAVs) for clinical gene therapy is limited by their propensity to accumulate in and transduce the liver. This natural liver tropism is associated with severe...

pubmed.ncbi.nlm.nih.gov

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Amulya Sreekumar @amulyasreekumar.bsky.social · Nov 19

Done! Nice seeing you here Lance

Amulya Sreekumar @amulyasreekumar.bsky.social · Nov 18

Of course! You're on the list

Amulya Sreekumar @amulyasreekumar.bsky.social · Nov 18

Done!

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Amulya Sreekumar @amulyasreekumar.bsky.social · Nov 18

Done!

Amulya Sreekumar @amulyasreekumar.bsky.social · Nov 18

Thanks, Manuel! You're in the pack.

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Amulya Sreekumar @amulyasreekumar.bsky.social · Nov 17

Done!

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Amulya Sreekumar @amulyasreekumar.bsky.social · Nov 17

Thank you to the organizers of #SFG2024 for hosting a wonderful meeting @sfglycobiology.bsky.social

As a 1st time attendee, it was a privilege to present my work on B3galt6-heparan sulfate biosynthesis as a functional regulator of dormant breast cancer cell survival.

www.cell.com/cancer-cell/...

B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling

Sreekumar et al. identify a previously uncharacterized function for the galactosyltransferase B3galt6 in cancer, specifically enabling dormant residual tumor cell survival following therapy or in a re...

www.cell.com

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Reposted by Amulya Sreekumar

Ben Schumann @drglycoben.bsky.social · Nov 16

#SFG24 was so much fun - amazing #glycotime in a fantastic place. The right mix between talks by legends in the field and early career colleagues. Thank you to the organizers!
I contributed our own story on xylosyltransferase bump-and-hole engineering, check here: www.biorxiv.org/content/10.1...

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