Antoine Madar
@antoinemadar.bsky.social
Neuroscientist at UChicago (Sheffield lab). Hippocampus, memory, computations, neural code. Computational modeling, data analysis, 2P imaging, patch-clamp.
Pinned
Antoine Madar
@antoinemadar.bsky.social
· Mar 25
Behavioral timescale synaptic plasticity (BTSP), not Hebbian spike-timing-dependent plasticity (STDP), explains heterogenous place field shifting in the mouse hippocampus 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synaptic plasticity rules driving representational shifting in the hippocampus - Nature Neuroscience
Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The probability of BTS...
www.nature.com
Want to know what synaptic plasticity rules operate in-vivo to support learning? Read our new paper, combining computational modeling and analysis of place field trajectories during familiarization to novel environments.
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
If you're at SfN and interested in Behavioral Timescale Plasticity, dendritic plateaus or mechanisms for learning and memory, consider coming to our minisymposium on BTSP tomorrow morning: eppro02.ativ.me/appinfo.php?... #SfN25
November 17, 2025 at 7:16 PM
If you're at SfN and interested in Behavioral Timescale Plasticity, dendritic plateaus or mechanisms for learning and memory, consider coming to our minisymposium on BTSP tomorrow morning: eppro02.ativ.me/appinfo.php?... #SfN25
Reposted by Antoine Madar
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Antoine Madar
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
October 15, 2025 at 6:33 AM
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
Reposted by Antoine Madar
*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...
March 10, 2025 at 6:14 PM
*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...
Reposted by Antoine Madar
Delighted that our main #TeamReuniens paper is finally out in @plosbiology.org. Been a long time in the making, congratulations to Lilya and all the team. A thread to follow soon, after I've had some sleep... #NeuroSkyence
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Hippocampal pyramidal cells of the CA1 region are not a major target of the thalamic nucleus reuniens
Excitatory input from the prefrontal cortex to hippocampus pyramidal cells is commonly believed to be mediated through the thalamic nucleus reuniens brain region. This study shows in rodents that this...
journals.plos.org
October 13, 2025 at 8:45 PM
Delighted that our main #TeamReuniens paper is finally out in @plosbiology.org. Been a long time in the making, congratulations to Lilya and all the team. A thread to follow soon, after I've had some sleep... #NeuroSkyence
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Antoine Madar
First author Ramanujan Srinath demonstrated some of the things that make him a great scientist: he thinks deeply & creatively, brings together many forms of evidence & people, and is determined and innovative. He is on the job market this year and will run an incredible lab – don’t miss out! 5/
August 15, 2025 at 3:38 PM
First author Ramanujan Srinath demonstrated some of the things that make him a great scientist: he thinks deeply & creatively, brings together many forms of evidence & people, and is determined and innovative. He is on the job market this year and will run an incredible lab – don’t miss out! 5/
Reposted by Antoine Madar
Not too early to get excited about presenting in San Diego in November! A minisymposium on BTSP organized by @antoinemadar.bsky.social
www.sfn.org/meetings/neu...
www.sfn.org/meetings/neu...
Minisymposia
www.sfn.org
July 16, 2025 at 2:25 AM
Not too early to get excited about presenting in San Diego in November! A minisymposium on BTSP organized by @antoinemadar.bsky.social
www.sfn.org/meetings/neu...
www.sfn.org/meetings/neu...
A broken clock gives the right time twice a day... A call for Universities to stop feeding the publishing industries 40% margins and build a global university consortium taking charge of academic publishing (by R Kaplan, former associate director of NIH)
www.chronicle.com/article/what...
www.chronicle.com/article/what...
Opinion | What RFK Jr. Got Right About Academic Publishing
The system no longer works for anyone except corporate publishers.
www.chronicle.com
June 28, 2025 at 7:37 AM
A broken clock gives the right time twice a day... A call for Universities to stop feeding the publishing industries 40% margins and build a global university consortium taking charge of academic publishing (by R Kaplan, former associate director of NIH)
www.chronicle.com/article/what...
www.chronicle.com/article/what...
Reposted by Antoine Madar
Today NIH staff sent a letter to the NIH Director voicing their concerns over the impact of recent actions on biomedical research, and urging him to reverse the disruptive NIH policy changes and restore NIH grants that have been cut or delayed. Add your signature. actionnetwork.org/forms/add-na...
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
actionnetwork.org
June 10, 2025 at 12:42 AM
Today NIH staff sent a letter to the NIH Director voicing their concerns over the impact of recent actions on biomedical research, and urging him to reverse the disruptive NIH policy changes and restore NIH grants that have been cut or delayed. Add your signature. actionnetwork.org/forms/add-na...
Reposted by Antoine Madar
In a recent study, @antoinemadar.bsky.social & Mark Sheffield looked at place cells of the mouse hippocampus in vivo to understand what plasticity rules support learning—spoiler alert, it wasn’t Hebbian plasticity! Go check out my story for @thetransmitter.bsky.social
#neuroskyence 🧪
#neuroskyence 🧪
Learning in living mice defies classic synaptic plasticity rule
Donald Hebb’s theory—memorably summarized as “cells that fire together, wire together”—does not explain the shifting hippocampal connections in mice learning to navigate a virtual environment…
www.thetransmitter.org
June 2, 2025 at 3:47 PM
In a recent study, @antoinemadar.bsky.social & Mark Sheffield looked at place cells of the mouse hippocampus in vivo to understand what plasticity rules support learning—spoiler alert, it wasn’t Hebbian plasticity! Go check out my story for @thetransmitter.bsky.social
#neuroskyence 🧪
#neuroskyence 🧪
Reposted by Antoine Madar
"My instinctive reaction was to withhold this case from publication. The patient was my only sister."
An incredible article (still guarded behind a paywall by Oxford University Press, 90 years after publication)
An incredible article (still guarded behind a paywall by Oxford University Press, 90 years after publication)
Amazing drawings and opening to the discussion in this classic article from 1935 by Penfield and Evans:
THE FRONTAL LOBE IN MAN: A CLINICAL STUDY OF MAXIMUM REMOVALS
academic.oup.com/brain/articl...
THE FRONTAL LOBE IN MAN: A CLINICAL STUDY OF MAXIMUM REMOVALS
academic.oup.com/brain/articl...
May 17, 2025 at 6:44 PM
"My instinctive reaction was to withhold this case from publication. The patient was my only sister."
An incredible article (still guarded behind a paywall by Oxford University Press, 90 years after publication)
An incredible article (still guarded behind a paywall by Oxford University Press, 90 years after publication)
Reposted by Antoine Madar
HAPPY 75th, NSF!
We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.
Read on 🧵(1/11):
We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.
Read on 🧵(1/11):
May 10, 2025 at 8:19 PM
HAPPY 75th, NSF!
We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.
Read on 🧵(1/11):
We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.
Read on 🧵(1/11):
Reposted by Antoine Madar
New from me: Everything feels overwhelming. But here is a tangible thing you can do: write a comment to oppose Trump's plan to convert 50,000 career civil servants into political appointees. Deadline is May 23. Please share!
donmoynihan.substack.com/p/here-is-a-...
donmoynihan.substack.com/p/here-is-a-...
Here is a specific thing you can do to fight Trump's politicization of public services
Plus: what I wrote in Science about the revised Schedule F
donmoynihan.substack.com
May 9, 2025 at 12:33 PM
New from me: Everything feels overwhelming. But here is a tangible thing you can do: write a comment to oppose Trump's plan to convert 50,000 career civil servants into political appointees. Deadline is May 23. Please share!
donmoynihan.substack.com/p/here-is-a-...
donmoynihan.substack.com/p/here-is-a-...
Reposted by Antoine Madar
How do cognitive maps fail? And how can this help us understand/treat psychosis? My lab at @oxexppsy.bsky.social is hiring a Postdoc tinyurl.com/2p935hhz and RA tinyurl.com/3myfpb78 to answer these questions in mouse models.
Here's why you might want to join: 🧵
Here's why you might want to join: 🧵
April 8, 2025 at 10:54 AM
How do cognitive maps fail? And how can this help us understand/treat psychosis? My lab at @oxexppsy.bsky.social is hiring a Postdoc tinyurl.com/2p935hhz and RA tinyurl.com/3myfpb78 to answer these questions in mouse models.
Here's why you might want to join: 🧵
Here's why you might want to join: 🧵
Reposted by Antoine Madar
Turns out, saving science costs money.
Please consider supporting our fight with a donation to @standupforscience.bsky.social.
Every. Single. Dollar. Counts. (really!)
Please consider supporting our fight with a donation to @standupforscience.bsky.social.
Every. Single. Dollar. Counts. (really!)
🚨HEY DORKS, WE NEED YOUR HELP🚨
We preparing for a BIG fight against Trump's attack on science and we won't stop until we win!
We are grassroots and run on donations. Whether it's $5 or $500, every little bit counts in the fight to save science.
#standupforscience
actionnetwork.org/fundraising/...
We preparing for a BIG fight against Trump's attack on science and we won't stop until we win!
We are grassroots and run on donations. Whether it's $5 or $500, every little bit counts in the fight to save science.
#standupforscience
actionnetwork.org/fundraising/...
Stand Up For Science Summer Campaign!
Can you help us mobilize the fight for science and democracy? Every contribution matters!
actionnetwork.org
May 3, 2025 at 5:19 PM
Turns out, saving science costs money.
Please consider supporting our fight with a donation to @standupforscience.bsky.social.
Every. Single. Dollar. Counts. (really!)
Please consider supporting our fight with a donation to @standupforscience.bsky.social.
Every. Single. Dollar. Counts. (really!)
Reposted by Antoine Madar
You can join the Tax Strike at anytime, not just during tax filing season. If you're a W4 employee, retiree, or self-employed, you can change your withholding now and delay your decision to pay federal income taxes. It's time to take back our power. Join us today: Taxstrike.info
Home - National Tax Strike
We’re fighting this constitutional crisis. Say NO to unchecked powers, NO to corrupt leadership, and NO to dismantling the federal government! What is the National Tax Strike? A movement to STOP payin...
Taxstrike.info
April 15, 2025 at 3:32 PM
You can join the Tax Strike at anytime, not just during tax filing season. If you're a W4 employee, retiree, or self-employed, you can change your withholding now and delay your decision to pay federal income taxes. It's time to take back our power. Join us today: Taxstrike.info
Reposted by Antoine Madar
Tax Day is a reminder that there is strength in numbers. This administration is using our money to takeover our government - and WE have the power to stop them. We will not allow our tax dollars to be used to undermine the Constitution, disappear our neighbors, or destroy our institutions.
April 15, 2025 at 3:32 PM
Tax Day is a reminder that there is strength in numbers. This administration is using our money to takeover our government - and WE have the power to stop them. We will not allow our tax dollars to be used to undermine the Constitution, disappear our neighbors, or destroy our institutions.
Tax day today. Or is it? Not paying taxes is a historical and fundamental tool to resist. #taxstrike @nationaltaxstrike.bsky.social taxstrike.info
Home - National Tax Strike
We’re fighting this constitutional crisis. Say NO to unchecked powers, NO to corrupt leadership, and NO to dismantling the federal government! What is the National Tax Strike? A movement to STOP payin...
taxstrike.info
April 15, 2025 at 6:49 PM
Tax day today. Or is it? Not paying taxes is a historical and fundamental tool to resist. #taxstrike @nationaltaxstrike.bsky.social taxstrike.info
Reposted by Antoine Madar
Public protests are important for solidarity & signaling. But the real work having impact right now is in the courts. So if you've attended protests and are thinking 'what's next?' here are some legal funds to donate to:
statedemocracydefenders.org/fund/
democracyforward.org
ldad.org/letters-briefs
statedemocracydefenders.org/fund/
democracyforward.org
ldad.org/letters-briefs
March 7, 2025 at 11:14 PM
Public protests are important for solidarity & signaling. But the real work having impact right now is in the courts. So if you've attended protests and are thinking 'what's next?' here are some legal funds to donate to:
statedemocracydefenders.org/fund/
democracyforward.org
ldad.org/letters-briefs
statedemocracydefenders.org/fund/
democracyforward.org
ldad.org/letters-briefs
Reposted by Antoine Madar
Guys it's a reasonable ask #handsoff2025
April 5, 2025 at 12:41 AM
Guys it's a reasonable ask #handsoff2025
Reposted by Antoine Madar
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
March 28, 2025 at 2:15 AM
Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs.
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
Find out how your community may be impacted.
Explore more at SCIMaP: scienceimpacts.org
a 🧵
Reposted by Antoine Madar
Excited to share our latest story! We found disentangled memory representations in the hippocampus that generalized across time and environments, despite the seemingly random drift and remapping of single cells. This code enabled the transfer of prior knowledge to solve new tasks
March 17, 2025 at 1:35 AM
Excited to share our latest story! We found disentangled memory representations in the hippocampus that generalized across time and environments, despite the seemingly random drift and remapping of single cells. This code enabled the transfer of prior knowledge to solve new tasks
Want to know what synaptic plasticity rules operate in-vivo to support learning? Read our new paper, combining computational modeling and analysis of place field trajectories during familiarization to novel environments.
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
Behavioral timescale synaptic plasticity (BTSP), not Hebbian spike-timing-dependent plasticity (STDP), explains heterogenous place field shifting in the mouse hippocampus 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Synaptic plasticity rules driving representational shifting in the hippocampus - Nature Neuroscience
Madar et al. report that behavioral timescale synaptic plasticity (BTSP), not spike-timing-dependent plasticity, explains heterogeneous place fields shifting in the hippocampus. The probability of BTS...
www.nature.com
March 25, 2025 at 9:04 PM
Want to know what synaptic plasticity rules operate in-vivo to support learning? Read our new paper, combining computational modeling and analysis of place field trajectories during familiarization to novel environments.
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet
#BTSP #STDP #hippocampus #CA1 #CA3
#FirstBlueskyTweet