Learning a motor skill requires exploring multiple possible solutions to find and retain an optimal strategy. The exploration and consolidation of the motor strategy are usually considered to be segre...

Biological fidelity: The engine driving the neuromorphic renaissance

Using two-photon optogenetics, electrical recordings and sparse signal reconstruction, the authors demonstrate in vivo synaptic connectivity mapping in the mouse visual cortex.

Nature - Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in...

Morabito et al. observed that different neocortical interneuron (IN) populations display distinct dendritic properties by varying synaptic receptor composition and input location. These IN-specific de...

Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the human hippocampus is distinct from both rodent counterparts and human neocortical circuits.

GPCR-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain function. While experiments in transfected cells often reveal selectivity for individual neurotransmitt...

Information storage in neuronal circuits is hypothesized to involve nanoscopic structural changes at synapses, but direct evidence for this is lacking. This study uses nanophysiology and functional el...