Arun Sharma
@arunphd.bsky.social
Pinned
Arun Sharma
@arunphd.bsky.social
· Dec 3
Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis
Communications Biology - The ectopic expression of VapC13 and VapC26 results in transcriptional reprogramming of M. tuberculosis. Both, VapBC13 and VapBC26 TA systems are dispensable for infection...
rdcu.be
Happy to share that a part of my PhD work published in Communications Biology rdcu.be/dYA61. In this work we have characterised VapBC13 and VapBC26 TA systems. Thanks to Dr Raman and team for support.
Reposted by Arun Sharma
Many of you in the mycobacterial community attended the awesome inaugural 2025 Biology of Mycobacteria GRC, organized by @heran.bsky.social and myself: www.grc.org/biology-of-m....
I am writing with an update about this conference as the new chair.
I am writing with an update about this conference as the new chair.
2025 Biology of Mycobacteria Conference GRC
The 2025 Gordon Research Conference on Biology of Mycobacteria will be held in Pomona, California. Apply today to reserve your spot.
www.grc.org
January 21, 2026 at 7:19 PM
Many of you in the mycobacterial community attended the awesome inaugural 2025 Biology of Mycobacteria GRC, organized by @heran.bsky.social and myself: www.grc.org/biology-of-m....
I am writing with an update about this conference as the new chair.
I am writing with an update about this conference as the new chair.
Reposted by Arun Sharma
While everyone is hustling for the holidays, hopefully folks will have time to submit abstracts or register for #ASMMicrobe2026 in DC! Please repost!
Abstract portal is open for ASM Microbe 2026. New meeting format, same great science. Hope to see you in DC!
ASM Microbe | Abstracts
ASM Microbe showcases the best microbial sciences in the world and provides a one-of-a-kind forum to explore everything from basic microbiology to translation and application.
asm.org
December 22, 2025 at 2:40 PM
While everyone is hustling for the holidays, hopefully folks will have time to submit abstracts or register for #ASMMicrobe2026 in DC! Please repost!
Reposted by Arun Sharma
🚨 𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐫𝐨𝐦 𝐨𝐮𝐫 𝐥𝐚𝐛, 𝐚𝐧𝐝 𝐚 𝐟𝐢𝐫𝐬𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐓𝐁 𝐟𝐢𝐞𝐥𝐝! 🚨
We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses.
📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9
We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses.
📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9
December 11, 2025 at 6:07 AM
🚨 𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐫𝐨𝐦 𝐨𝐮𝐫 𝐥𝐚𝐛, 𝐚𝐧𝐝 𝐚 𝐟𝐢𝐫𝐬𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐓𝐁 𝐟𝐢𝐞𝐥𝐝! 🚨
We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses.
📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9
We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses.
📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9
Reposted by Arun Sharma
Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
November 17, 2025 at 10:31 AM
Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...
Reposted by Arun Sharma
Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular
Distinct immunity protein families mediate compartment-specificneutralisation of a bacterial toxin https://www.biorxiv.org/content/10.1101/2025.05.31.657152v1
June 1, 2025 at 7:37 AM
Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular
Reposted by Arun Sharma
while we wait for #adaptive #tissue #immunity to take off in August ... join us!!! register by end of May
meetings.embo.org/event/25-bar...
@eurovision.tv
#ArtBasel
youtu.be/xyTEK-jUlZo
www.youtube.com/watch?v=bi2Y...
meetings.embo.org/event/25-bar...
@eurovision.tv
#ArtBasel
youtu.be/xyTEK-jUlZo
www.youtube.com/watch?v=bi2Y...
May 2, 2025 at 10:57 AM
while we wait for #adaptive #tissue #immunity to take off in August ... join us!!! register by end of May
meetings.embo.org/event/25-bar...
@eurovision.tv
#ArtBasel
youtu.be/xyTEK-jUlZo
www.youtube.com/watch?v=bi2Y...
meetings.embo.org/event/25-bar...
@eurovision.tv
#ArtBasel
youtu.be/xyTEK-jUlZo
www.youtube.com/watch?v=bi2Y...
Reposted by Arun Sharma
Looks like some CRISPR evolved form TA systems, exciting!
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins: Cell www-cell-com.insb.bib.cnrs.fr/cell/fulltex...
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins: Cell www-cell-com.insb.bib.cnrs.fr/cell/fulltex...
February 21, 2025 at 11:05 AM
Looks like some CRISPR evolved form TA systems, exciting!
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins: Cell www-cell-com.insb.bib.cnrs.fr/cell/fulltex...
Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins: Cell www-cell-com.insb.bib.cnrs.fr/cell/fulltex...
Reposted by Arun Sharma
Excited to share that our paper on locus visualisation tool LoVis4u is out! Entirely driven by fantastic PhD student Artyom Egorov @egorov.bsky.social academic.oup.com/nargab/artic...
LoVis4u: a locus visualization tool for comparative genomics and coverage profiles
Abstract. Comparative genomic analysis often involves visualization of alignments of genomic loci. While several software tools are available for this task
academic.oup.com
February 25, 2025 at 7:27 AM
Excited to share that our paper on locus visualisation tool LoVis4u is out! Entirely driven by fantastic PhD student Artyom Egorov @egorov.bsky.social academic.oup.com/nargab/artic...
Reposted by Arun Sharma
“… rats have detected #Tuberculosis but follow up clinical tests have been negative; in some of these cases, patients later developed TB... Apopo is monitoring these patients to better understand rats’ sensitivity to low levels of bacteria”.
www.theguardian.com/global-devel...
www.theguardian.com/global-devel...
Cheap, smart and efficient: how giant rats are transforming the fight against TB
After success in Tanzania, other African countries may introduce the rodents to help sniff out the disease
www.theguardian.com
December 19, 2024 at 1:04 PM
“… rats have detected #Tuberculosis but follow up clinical tests have been negative; in some of these cases, patients later developed TB... Apopo is monitoring these patients to better understand rats’ sensitivity to low levels of bacteria”.
www.theguardian.com/global-devel...
www.theguardian.com/global-devel...
Reposted by Arun Sharma
Reposted by Arun Sharma
There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...
December 16, 2024 at 9:25 AM
There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...
Reposted by Arun Sharma
Also by @wcm-imp.bsky.social alum @norapyenson.bsky.social ! Congrats!
another hit by Sanchez lab: Diverse phage communities are maintained stably on a clonal bacterial host #microsky
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Diverse phage communities are maintained stably on a clonal bacterial host
Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, w...
www.science.org
December 15, 2024 at 12:10 AM
Also by @wcm-imp.bsky.social alum @norapyenson.bsky.social ! Congrats!
Reposted by Arun Sharma
Speaker line up for #EMBOTissueImmunity to take place in Basel 🇨🇭 26-29 August 2025. Come join @maurogaya.bsky.social and I for some fantastic #immunology along the Rhine! Please share this invitation - we hope you will join us. Registrations will be open soon.
December 10, 2024 at 12:57 PM
Speaker line up for #EMBOTissueImmunity to take place in Basel 🇨🇭 26-29 August 2025. Come join @maurogaya.bsky.social and I for some fantastic #immunology along the Rhine! Please share this invitation - we hope you will join us. Registrations will be open soon.
Reposted by Arun Sharma
Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏
If you're interested in learning about the latest of fundamental mycobacteriology, sign up for #GRCMyco2025! Acceptances will start in September, check out the full program and please RT!
We're live with the program!
www.grc.org/biology-of-m...
www.grc.org/biology-of-m...
November 19, 2024 at 10:46 PM
Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏
Reposted by Arun Sharma
Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH | mBio
Despite the availability of antibiotic treatment, M. tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a major infectious disease
killer worldwide. A better understanding of the en...
journals.asm.org
December 3, 2024 at 3:00 PM
Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Happy to share that a part of my PhD work published in Communications Biology rdcu.be/dYA61. In this work we have characterised VapBC13 and VapBC26 TA systems. Thanks to Dr Raman and team for support.
Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis
Communications Biology - The ectopic expression of VapC13 and VapC26 results in transcriptional reprogramming of M. tuberculosis. Both, VapBC13 and VapBC26 TA systems are dispensable for infection...
rdcu.be
December 3, 2024 at 5:20 PM
Happy to share that a part of my PhD work published in Communications Biology rdcu.be/dYA61. In this work we have characterised VapBC13 and VapBC26 TA systems. Thanks to Dr Raman and team for support.