Carlo Barnaba 🇮🇹🇲🇽
@barnabalab.bsky.social
I lead a young, vibrant research group at the University of Kansas - Pharmaceutical Chemistry. My lab works on metabolic adaptation: how our cells rewire their metabolism when challenged by chemical and nutrient stressors.
I have a strong feeling that science is being killed day by day by this. Oligarchs should keep their hands off science.
Gemini 3 created this figure in under 30 seconds from a couple reference images and a one sentence prompt
So I’m at a loss for words, honestly #MicroscopyMonday
So I’m at a loss for words, honestly #MicroscopyMonday
November 24, 2025 at 8:51 PM
I have a strong feeling that science is being killed day by day by this. Oligarchs should keep their hands off science.
Three years ago I was farming in Southern Italy to replace dad who had a terrible accident. Social media made me remember this picture: a detail in my dad’s workers van. It’s a tough life.
November 15, 2025 at 2:36 PM
Three years ago I was farming in Southern Italy to replace dad who had a terrible accident. Social media made me remember this picture: a detail in my dad’s workers van. It’s a tough life.
😒
NIH grant applicants:
October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD.
grants.nih.gov/grants/guide...
October and November grant application submission *deadlines* will be rescheduled (🤯). Specific dates TBD.
grants.nih.gov/grants/guide...
NOT-OD-26-005: Interim Guidance on Reopening of NIH Extramural Activities
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Interim Guidance on Reopening of NIH Extramural Activities NOT-OD-26-005. NIH
grants.nih.gov
November 14, 2025 at 9:08 PM
😒
Jeff Tweedy warming our hearts yesterday evening.
November 9, 2025 at 7:22 PM
Jeff Tweedy warming our hearts yesterday evening.
You have a dozen active grants, half of them the size of an R01. You have committed 100% of your effort to them. Your >300k damn salary is covered. Is it even ethical to ask for more $$? At what point this becomes just a greedy game?
November 8, 2025 at 1:19 PM
You have a dozen active grants, half of them the size of an R01. You have committed 100% of your effort to them. Your >300k damn salary is covered. Is it even ethical to ask for more $$? At what point this becomes just a greedy game?
Reposted by Carlo Barnaba 🇮🇹🇲🇽
This is something I have often wondered about - how DNA damage alters genome architecture and if it is heritable across the cell cycle even after repair?
Well here is a nice study addressing this fundamental question 👇👇👇😍
Well here is a nice study addressing this fundamental question 👇👇👇😍
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 7, 2025 at 12:33 PM
This is something I have often wondered about - how DNA damage alters genome architecture and if it is heritable across the cell cycle even after repair?
Well here is a nice study addressing this fundamental question 👇👇👇😍
Well here is a nice study addressing this fundamental question 👇👇👇😍
Reposted by Carlo Barnaba 🇮🇹🇲🇽
Lactate biosensor
A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics - Nature Communications
l-lactate is a key metabolite supporting neuronal activity, but methods to monitor l-lactate dynamics alongside neuronal activity in vivo have been limited. Here, authors report R-eLACCO2.1, a red flu...
www.nature.com
November 4, 2025 at 1:51 PM
Lactate biosensor
Thanks @freudlab.bsky.social for the kind invitation at @kumedcenter.bsky.social BMB. 😁
November 1, 2025 at 12:50 AM
Thanks @freudlab.bsky.social for the kind invitation at @kumedcenter.bsky.social BMB. 😁
As a reviewer, please don't overuse AI to write your grants. I understand the need for a quick editing/grammar check, but the structure of the paragraphs and the logic is absolutely awful. I can spot it in a nanosecond.
October 29, 2025 at 5:20 PM
As a reviewer, please don't overuse AI to write your grants. I understand the need for a quick editing/grammar check, but the structure of the paragraphs and the logic is absolutely awful. I can spot it in a nanosecond.
🖤
Remembering Lou Reed, who passed away this day in 2013.
October 28, 2025 at 12:52 AM
🖤
Reposted by Carlo Barnaba 🇮🇹🇲🇽
I still contend that >90% of the benefit of writing a review isn't the audience. It's for the author going through the literature, finding gaps in knowledge, learning how experiments are done, etc. It really isn't about writing a review. It's about doing the review yourself. AI can't do that for you
October 21, 2025 at 5:28 PM
I still contend that >90% of the benefit of writing a review isn't the audience. It's for the author going through the literature, finding gaps in knowledge, learning how experiments are done, etc. It really isn't about writing a review. It's about doing the review yourself. AI can't do that for you
This was a great meeting, with outstanding speakers.
The 4th Regional Chemical Biology Symposium was held on Oct. 10-11, 2025. The symposium seeks to provide a forum for Graduate Training in Chemical Biology trainees and Chemical Biology of Infectious Disease researchers to present their work in chemical biology. @KUMolBio
October 17, 2025 at 6:11 PM
This was a great meeting, with outstanding speakers.
On LinkedIn, everybody is “thrilled”.
October 7, 2025 at 7:54 PM
On LinkedIn, everybody is “thrilled”.
Oops...that happens when your inner rocker forgets you have an important and formal Zoom meeting...😶
September 26, 2025 at 2:31 PM
Oops...that happens when your inner rocker forgets you have an important and formal Zoom meeting...😶
Reposted by Carlo Barnaba 🇮🇹🇲🇽
@FehrLab has new research on the antiviral functions of PARP14 which shows PARP14 represses both coronavirus and herpes simplex virus 1 (HSV-1) replication.
Learn more at journals.asm.org/doi/10.1128/mbio.02299-25
Learn more at journals.asm.org/doi/10.1128/mbio.02299-25
PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses | mBio
The antiviral response is largely regulated by post-translational modifications (PTM),
including ADP-ribosylation. PARP14 is an ADP-ribosyltransferase that is upregulated
by interferon and is under po...
journals.asm.org
September 15, 2025 at 3:35 PM
@FehrLab has new research on the antiviral functions of PARP14 which shows PARP14 represses both coronavirus and herpes simplex virus 1 (HSV-1) replication.
Learn more at journals.asm.org/doi/10.1128/mbio.02299-25
Learn more at journals.asm.org/doi/10.1128/mbio.02299-25
CellPose 4.0 is a beast. Segmented human microglia, in brightfield. Credit to Sydney Houser.
September 11, 2025 at 1:34 PM
CellPose 4.0 is a beast. Segmented human microglia, in brightfield. Credit to Sydney Houser.
I love my trainees ❤️#littlejoyindarktimes
September 8, 2025 at 6:22 PM
I love my trainees ❤️#littlejoyindarktimes
Post a PERFECT album from the 90s that isn't Nirvana or Pearl Jam.
September 6, 2025 at 3:31 AM
Post a PERFECT album from the 90s that isn't Nirvana or Pearl Jam.
Indeed. It's ruining an entire generation of trainees in science. They've just stopped thinking. And reading.
I honestly feel like ChatGPT is going to yield a whole new level of dementia in future generations because folks have just stopped using their brains. It’s really quite harrowing.
September 3, 2025 at 8:20 PM
Indeed. It's ruining an entire generation of trainees in science. They've just stopped thinking. And reading.
This is very good news
Good news! KU's IRACDA program was reinstated! We are now taking applications for postdocs. Please spread the word.
sjobs.brassring.com/TGnewUI/Sear...
sjobs.brassring.com/TGnewUI/Sear...
Postdoctoral Researcher - University of Kansas - Job Details
Job Details: The IRACDA Program at the University of Kansas (KU) is accepting applications for postdoctoral scholarships. W
sjobs.brassring.com
August 31, 2025 at 2:56 AM
This is very good news
I’m fighting this AI nonsense every single day. Trainees who answer even simple emails using ChatGPT. Trainees looking for hypotheses using ChatGPT. Trainees who don’t read papers because ChatGPT summarizes literature (in a very shitty way).
Received two reviews on a paper I am a co-author on that was submitted the @natureportfolio.nature.com Scientific Reports. Both reviews were written by ChatGPT & clearly not edited with hallucinations. Shame on the editors for letting this unethical nonsense out the door.
August 29, 2025 at 4:32 PM
I’m fighting this AI nonsense every single day. Trainees who answer even simple emails using ChatGPT. Trainees looking for hypotheses using ChatGPT. Trainees who don’t read papers because ChatGPT summarizes literature (in a very shitty way).