Graham Dellaire
@docdellaire.bsky.social
Cancer biologist, environment and cancer, guitarist, would-be evolutionary molecular biologist, bread baker, sometimes coder, amateur photographer, professional microscopist, & gardener. Lab site: https://blogs.dal.ca/dellairelab/
Pinned
Graham Dellaire
@docdellaire.bsky.social
· Jun 19
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy
Mis-splicing of autophagy genes contributes to diverse pathologies including cancer.
Mathavarajah et al. report that depletion of tumor suppressor and splicing kinase
PRP4K leads to impaired autophagy...
www.cell.com
🔥12 years in the making!🔥
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.
The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...
The age old mystery of what rhymes with purple has been solved… 😂
November 25, 2025 at 3:52 PM
The age old mystery of what rhymes with purple has been solved… 😂
Proud of this advance! Nice one! #GoCanadian-US-ScienceCollab
Canadian-U.S. study boosts survival in aggressive #glioblastona tumour treatment - using bubbles focused ultrasound and chemotherapy @ctvnews-mirror.bsky.social
@sunnybrookhsc.bsky.social
www.ctvnews.ca/health/artic...
@sunnybrookhsc.bsky.social
www.ctvnews.ca/health/artic...
Canadian-U.S. study makes breakthrough in aggressive brain tumour treatment
A new Canadian-U.S. study gives glioblastoma patients hope and doctors a new doorway to treat brain tumours.
www.ctvnews.ca
November 24, 2025 at 11:55 PM
Proud of this advance! Nice one! #GoCanadian-US-ScienceCollab
Reposted by Graham Dellaire
Now speaking #CBIAS2025 @albertdm.bsky.social from @maweigert.bsky.social introducing spotiflow www.nature.com/articles/s41...
November 24, 2025 at 11:15 AM
Now speaking #CBIAS2025 @albertdm.bsky.social from @maweigert.bsky.social introducing spotiflow www.nature.com/articles/s41...
Reposted by Graham Dellaire
Reposted by Graham Dellaire
It’s out! The evolutionary origins of yeast point centromeres uncovered!
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
Ancient co-option of LTR retrotransposons as yeast centromeres
The evolutionary origins of the genetic point centromere in the brewer's yeast Saccharomyces cerevisiae, a member of the order Saccharomycetales, are still unknown. Competing hypotheses suggest that t...
www.biorxiv.org
April 25, 2025 at 1:59 PM
It’s out! The evolutionary origins of yeast point centromeres uncovered!
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.biorxiv.org/content/10.1...
👀👇
Check out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineered chromatin readers track damaged chromatin dynamics in live cells and animals - Nature Communications
DNA damage threatens genome stability, but its dynamics in living systems remain difficult to track. Here, the authors engineer MCPH1-based protein probes that specifically recognize γH2AX, enabling r...
www.nature.com
November 23, 2025 at 12:35 PM
👀👇
As a science undergrad I went for a beer with a guy in my Aikido class and he told me about working a Summer job in a lab… I was like “no way you get paid to do lab work! Better than mowing lawns”. The rest they say is history.
November 23, 2025 at 12:27 PM
As a science undergrad I went for a beer with a guy in my Aikido class and he told me about working a Summer job in a lab… I was like “no way you get paid to do lab work! Better than mowing lawns”. The rest they say is history.
🥹❤️😍
It’s time to make marmalade again. My husband made this every fall just before the holidays, & I make it now in memory of him. It makes the house smell so fragrant.
November 23, 2025 at 12:06 PM
🥹❤️😍
Shocker... 🙃 www.embopress.org/doi/full/10....
Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro | EMBO reports
imageimageProtein and peptide tags can profoundly alter condensation in a tag- and protein-specific
manner, both in cells and in vitro, highlighting the need for careful validation in
condensate studi...
www.embopress.org
November 22, 2025 at 3:55 PM
Shocker... 🙃 www.embopress.org/doi/full/10....
Here is where we are headed … only watermarking this 💩 in ways the average idiot faking data can’t comprehend will keep this from proliferating widely.
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
November 22, 2025 at 3:45 PM
Here is where we are headed … only watermarking this 💩 in ways the average idiot faking data can’t comprehend will keep this from proliferating widely.
My Saturday plans - a cupa and some homemade #Sourdough made with cracked rye berries
November 22, 2025 at 2:34 PM
My Saturday plans - a cupa and some homemade #Sourdough made with cracked rye berries
Reposted by Graham Dellaire
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
BigVolumeBrowser: a new 3D multi volume/mesh/point clould (SMLM) data viewer
Hello everyone, I’d like to share with you another 3D viewer for FIJI, BigVolumeBrowser (full documentation link). It‘s a first initial public release, so there is still space for improvements. Le...
forum.image.sc
November 21, 2025 at 9:29 AM
Finally, the first public release of #BigVolumeBrowser, so after teasers, you can try it yourself. For details, please check the announcement post (1/2)
forum.image.sc/t/bigvolumeb...
forum.image.sc/t/bigvolumeb...
Not going to lie… this is pretty awesome! 👏 👇
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
www.science.org
November 21, 2025 at 12:18 PM
Not going to lie… this is pretty awesome! 👏 👇
Reposted by Graham Dellaire
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
The two industries that need to have the greatest open trade between provinces, and greater competition (which will increase affordability) is FOOD & the WINE/BEER industry. So WTF Liberal Government - trade barriers drop for all goods EXCEPT Food and Alcohol... AYFKM?!🤦 www.cbc.ca/news/canada/...
Provinces sign agreement to drop interprovincial trade barriers on goods except food, alcohol | CBC News
An agreement, signed today, between all Canadian provinces, territories, and the federal government, will drop interprovincial trade barriers on many goods except food and alcohol. It's part of an eff...
www.cbc.ca
November 20, 2025 at 1:34 PM
The two industries that need to have the greatest open trade between provinces, and greater competition (which will increase affordability) is FOOD & the WINE/BEER industry. So WTF Liberal Government - trade barriers drop for all goods EXCEPT Food and Alcohol... AYFKM?!🤦 www.cbc.ca/news/canada/...
Looking forward to the supplemental data... it has to be huge.
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 20, 2025 at 1:02 PM
Looking forward to the supplemental data... it has to be huge.
Reposted by Graham Dellaire
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
HAK-actin, U-ExM-compatible probe to image the actin cytoskeleton - preLights
HAK-actin is a new probe that may help researchers see the actin cytoskeleton in sharper detail using expansion microscopy.
prelights.biologists.com
November 19, 2025 at 11:58 AM
Reliable actin labelling in expansion #microscopy 🔬
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
Beautiful #preprint from Olivier Mercey, @lreymond.bsky.social & team @dudinlab.bsky.social @centriolelab.bsky.social
Read the latest #preLight from @kanishka03.bsky.social ⬇️👀
prelights.biologists.com/highlights/h...
😍
quick test with SAM3 - impressed with how well it seems to track long protrusions? prompted for "cell", does not find anything when looking for "fibroblast" or "nucleus"
November 19, 2025 at 8:51 PM
😍
Reposted by Graham Dellaire
Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!
Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research
Academic Job Category Faculty Bargaining Job Title Associate Professor (tenure) or Professor (tenure) Dr. Connie Eaves Chair in Cancer Stem Cell Research Department School of Biomedical Engineering | ...
ubc.wd10.myworkdayjobs.com
November 18, 2025 at 11:52 PM
Apply for the 'Dr. Connie Eaves Chair in Cancer Cell Research' at UBC. Come join the dynamic research community in Vancouver 🇨🇦!
Totally not on my evolution bingo card… 🤯
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 2:12 PM
Totally not on my evolution bingo card… 🤯
November 18, 2025 at 12:37 PM
I don’t think I have ever used the word “sesh” to describe a lab meeting… #StuffSeenOnThisApp
November 18, 2025 at 12:35 PM
I don’t think I have ever used the word “sesh” to describe a lab meeting… #StuffSeenOnThisApp
😂😂😂😂
Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.
November 18, 2025 at 12:07 PM
😂😂😂😂
Reposted by Graham Dellaire
Finally! We have a FANCM:RMI inhibitor that is cell active and specifically kills ALT+ cancer cells 🎯
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....
November 17, 2025 at 5:24 AM
Finally! We have a FANCM:RMI inhibitor that is cell active and specifically kills ALT+ cancer cells 🎯
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....
@yuhenglau.bsky.social + my labs just published the first cell-active peptide inhibitors of this critical target in 10-15% of cancers. doi.org/10.1021/acs....