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Graham Dellaire

@docdellaire.bsky.social

1.5K followers 220 following 1.8K posts

Cancer biologist, environment and cancer, guitarist, would-be evolutionary molecular biologist, bread baker, sometimes coder, amateur photographer, professional microscopist, & gardener. Lab site: https://blogs.dal.ca/dellairelab/

blogs.dal.ca

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Graham Dellaire @docdellaire.bsky.social · Jun 19

🔥12 years in the making!🔥
So excited our paper is finally out in Cell Reports!
Great collaboration with Dr. Robert Huber @ Trent U, funded by NSERC and CIHR.

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy: www.cell.com/cell-reports...

The evolutionarily conserved PRP4K-CHMP4B/vps32 splicing circuit regulates autophagy

Mis-splicing of autophagy genes contributes to diverse pathologies including cancer. Mathavarajah et al. report that depletion of tumor suppressor and splicing kinase PRP4K leads to impaired autophagy...

www.cell.com

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Graham Dellaire @docdellaire.bsky.social · 23h

Useful skill, indeed. Wait until you interview for major grant/salary awards. The PTSD from comp and thesis defenses will flood back.

a cartoon character named stewie from family guy is sitting on the ground with his hands folded

ALT: a cartoon character named stewie from family guy is sitting on the ground with his hands folded

media.tenor.com

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Graham Dellaire @docdellaire.bsky.social · 1d

This is exactly how I wrote my thesis... but the piles were knee high.

⚡️🔩Felsenstein's Monster🔩⚡️ @josephwb.bsky.social · 2d

Researchin'

A hirsute and bewiskered dork sits at a messy desk overflowing with various books, notes, and tea. Arranged on the floor in organized (and labelled) piles are papers on various topics.

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Graham Dellaire @docdellaire.bsky.social · 1d

Zeiss Elyra 7 at work 👇

Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 1d

My first time sitting down with a real sample. Phase separated membrane in a yeast lysosomal vacuole. Green is the V-ATPase, in the liquid disordered domain, and magenta is Ivy1, a protein that associates with the liquid ordered domain. This vacuole is about 2 microns in diameter.

Graham Dellaire @docdellaire.bsky.social · 1d

Amazing!

Graham Dellaire @docdellaire.bsky.social · 2d

Fall feeling…

Graham Dellaire @docdellaire.bsky.social · 2d

Then I am perpetually a 17 year old sk8t boarder - only thing changed, I can buy a setup without working two Summers for the cash.

Graham Dellaire @docdellaire.bsky.social · 2d

“Early career” … oh that ship sailed 13 years ago.

a man in a black shirt is giving a thumbs up and says goodnight !!!

ALT: a man in a black shirt is giving a thumbs up and says goodnight !!!

media.tenor.com

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Reposted by Graham Dellaire

Carmen Sandi @carmensandi10.bsky.social · 3d

Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.

Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!

🔗 Paper: doi.org/10.1016/j.bi...

Redirecting

doi.org

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Graham Dellaire @docdellaire.bsky.social · 2d

B&W is just so timeless.

Graham Dellaire @docdellaire.bsky.social · 2d

I think you just called out at least two pillars of CIHR...

a man in a suit and tie is holding a bucket of popcorn with the words here for it all below him

ALT: a man in a suit and tie is holding a bucket of popcorn with the words here for it all below him

media.tenor.com

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Graham Dellaire @docdellaire.bsky.social · 2d

Oh that is a rad camera - great specs, www.axiomoptics.com/products/kin...

Kinetix & Kinetix 22 | High-Speed sCMOS Cameras

Kinetix & Kinetix22 high-speed sCMOS cameras, in a nutshell The Kinetix & Kinetix22 are back-illuminated scientific CMOS (sCMOS) that deliver the

www.axiomoptics.com

Graham Dellaire @docdellaire.bsky.social · 2d

How do you like the Orca Fusion cameras?

Reposted by Graham Dellaire

Sheila Teves @sheilateves.bsky.social · 2d

How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

www.biorxiv.org

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Graham Dellaire @docdellaire.bsky.social · 2d

Oh cool! 😎 on the reading list!

Graham Dellaire @docdellaire.bsky.social · 2d

Have had two of those “perfect storm” papers as well: a data paper and a review. 🦄

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Graham Dellaire @docdellaire.bsky.social · 2d

Time for a timeline cleanser?
Here is a colourful street mural in #Halifax Nova Scotia, Canada #StreetArt #StreetMurals

Follow for more murals and pics posted each week.

Reposted by Graham Dellaire

Mark Peifer (He, him) @peiferlabunc.bsky.social · 3d

Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...

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Reposted by Graham Dellaire

Reto Fiolka @retof.bsky.social · 3d

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

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Graham Dellaire @docdellaire.bsky.social · 2d

All and good as long as bond rating services accept the math, as pointed out by the Parliamentary Budget Officer. Otherwise... our borrowing costs for all the nation building spending is going to go way up. #Caveat #DevilintheDetails.

Reposted by Graham Dellaire

Jean-Yves Tinevez @jytinevez.bsky.social · 3d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

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Graham Dellaire @docdellaire.bsky.social · 2d

UK Law protects satire under Article 10 of the Charter of Human Rights but it is more nuanced to acknowledge Harm, Distress, Harassment and Defamation of living individuals - which means you are not automatically protected and weaponization of law (i.e. Lawfare) can be used to suppress free speech.

Graham Dellaire @docdellaire.bsky.social · 2d

Canadian Law on the subject www.justice.gc.ca/eng/csj-sjc/...

Graham Dellaire @docdellaire.bsky.social · 2d

USA law and "satire as protected free speech" www.loc.gov/exhibitions/...

Showcases the Library’s collections of original art by talented artists hired by newspapers and television to capture the personal dynamics of legal trials. These artists create drawings that provide ...

www.loc.gov

Graham Dellaire @docdellaire.bsky.social · 2d

example: www.sagaftra.org/contracts-in...

www.sagaftra.org

Graham Dellaire @docdellaire.bsky.social · 2d

Yup - the ability to rip off some one's likeness is scary. The SAGA strike had provisions for protecting actors likeness, voice and image from AI abuse in "union-made" materials but lawsuits may be needed to prevent abuse outside of satire of political figures, which is protected free speech.