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Tom Scriba @tomscriba.bsky.social · 1d

We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad:

idm.uct.ac.za/media/739223

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Journal of Experimental Medicine @jem.org · 4d

Our October issue is here! rupress.org/jem/issue/22...
The cover image shows the lung of a mouse infected with M. #tuberculosis stained for #neutrophils (orange) normal lung parenchyma (blue), collagen (white) and CD4 T cells (green). See @bengern.bsky.social et al. rupress.org/jem/article/...

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Nicole M. Poole, MD, MPH @kiddocnic.bsky.social · 24d

Treat pediatric CAP with 5 days of amox monotherapy. Check out our QI project here in @annalsofem.bsky.social using pre-clicked durations in order sets and an EHR-integrated pathway! #Pedsky #PedsIDSky #AntimicrobialStewardship #EM #PEM #EmergencyMedicine

www.sciencedirect.com/science/arti...

Clinical Pathway Revision Increases Amoxicillin Monotherapy and 5-Day Durations of Therapy for Pediatric Community-Acquired Pneumonia in the Emergency Department and Urgent Care: A Quality Improvement...

The American Academy of Pediatrics recommends 5-day amoxicillin monotherapy as first-line treatment for pediatric uncomplicated community-acquired pne…

www.sciencedirect.com

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Science in Seattle @scienceinseattle.com · Sep 9

A recent study from the Gerner and Urdahl labs at UW and @seattlechildrens.org uncovers fundamental determinants of tuberculosis lung pathology. This has important implications for new strategies to prevent or treat tuberculosis.

🧐 See the abstract in @jem.org : https://bit.ly/41IdeHA

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Biomedical Picture of the Day BPoD @bpodaily.bsky.social · Sep 8

Conflict between the innate & adaptive immune system responses determines the kind of damage lungs suffer when infected with TB

Image made with @leicamicrosystems.bsky.social microscopy

📷 @bengern.bsky.social et al @seattlechildrens.org in @jem.org

➡️ bpod.org.uk/archive/2025...

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Alissa Rothchild @alissarothchild.bsky.social · Aug 18

Happy to share our new pre-print, led by PhD student Linh Pham! We examine inhibition of MHC II expression by NRF2 during Mtb infection and its impact on innate-adaptive crosstalk. Special thanks to the Behar lab who helped us set up a T cell co-culture system for the project! #TB #immunology

bioRxiv Immunology @biorxiv-immuno.bsky.social · Aug 18

NRF2 inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection https://www.biorxiv.org/content/10.1101/2025.08.16.670319v1

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Joanne Flynn @joanneflynn19.bsky.social · Aug 20

We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine

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Journal of Experimental Medicine @jem.org · Aug 15

#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · Aug 6

Early and opposing #neutrophil and CD4 T cell responses shape pulmonary #tuberculosis pathology, say Benjamin Gern @bengern.bsky.social, Michael Gerner, Kevin Urdahl et al. rupress.org/jem/article/...

#TB

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Ben Gern @bengern.bsky.social · Jul 30

Thanks, @alissarothchild.bsky.social!

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Rockefeller University Press @rupress.org · Jul 30

In @jem.org, @bengern.bsky.social et al. show that the early interplay between #neutrophils & CD4 T cells is pivotal in determining #TB pathology, and that depleting neutrophils can improve outcomes even at late timepoints, which has therapeutic relevance rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · Jul 30

@bengern.bsky.social et al. show that the early interplay between #neutrophils & CD4 T cells is pivotal in determining #TB pathology, and that depleting neutrophils can improve outcomes even at late timepoints, which has therapeutic relevance rupress.org/jem/article/...

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Ben Gern @bengern.bsky.social · Jul 30

I’m excited to announce that our paper, describing early and opposing roles for neutrophils and CD4 T cells in determining #TB lesion structure, is out at @jem.org ! Huge thanks to my lab, and the Urdahl, @michael-gerner.bsky.social, and Aitchison labs who made this possible

doi.org/10.1084/jem....

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Gabriele Pollara @gpollara.bsky.social · Jun 24

Tuberculosis continues to impair quality of life long after the antibiotics have finished...

Need to work out how to prevent and treat these post-TB sequelae.
#IDSky #TBSky

ATS Blue Journal @atsblueeditor.bsky.social · Jun 24

Contribution of Posttuberculosis Sequelae to Life-Years Lost from Tuberculosis Disease in the United States, 2015–2019

@atscommunity.bsky.social‬

www.atsjournals.org/doi/full/10....

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Erin McCaffrey, PhD @erin-mccaffrey.bsky.social · Feb 24

Happy to share a preprint from the Angelo lab many years in the making. Read on for a saga of multiplexed imaging, immunometabolism, and TB granulomas with some fun side quests into the realms of geographical information sciences and transcriptomics… (1/20) doi.org/10.1101/2025...

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control

Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to Mycobacterium tuberculosis (Mtb) infection and support bacterial persistence. We prev...

doi.org

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Ben Gern @bengern.bsky.social · Feb 28

Congrats on a really cool story, Erin!

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Christina Stallings @stallingslab.bsky.social · Dec 5

Very excited for this story to be out!! Check out our dissection of how type I IFN promotes NET release, which contributes to Mtb pathogenesis and is associated with granuloma necrosis. Congratulations to all authors!! www.cell.com/cell-host-mi...

Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation

Sur Chowdhury et al. report that Mycobacterium tuberculosis (Mtb) infection results in the release of neutrophil extracellular traps (NETs) that promote Mtb replication and associate with tissue damage. Blocking NET release results in better control of Mtb replication, revealing a strategy for treating these deadly infections.

www.cell.com

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Kat Mayer-Barber,PhD @mayerbarber.bsky.social · Dec 6

Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9

Graphical summary of our paper. In mice, prior lower airway exposure to diverse inflammatory stimuli, including chronic bacterial infections such as M. tuberculosis, acute bacterial infections such as pulmonary S. aureus, viral infections such as Influenza A, type-II allergic responses such as the OVA-Alum model, activation of pulmonary TLR9 by CpG or pulmonary TLR1/2 by Pam3CSK4
leads to reduced viral burden upon subsequent infection with SARS-CoV-2 (SCV2). (2) This SCV2 restriction occurs prior to induction of SCV2-specific adaptive immune responses
and is mediated through innate immune responses, including the induction of IFN-I, TNFα and IL-1 and sustained changes to the TRM (Tissue resident macrophage) cellular
compartment and the pulmonary epithelium. (3) Innate cytokine and TLR signaling to both recruited immune cells and the pulmonary epithelium creates a microenvironment in the
lung that limits early replication of SCV2. IFN-I signaling to pulmonary ECs (epithelial cells) increases expression of interferon-stimulated genes, that likely cell-intrinsically limit viral
replication. TNF- or IL-1 suppress SCV2 independently of IFN-I signaling. TNF acts exclusively through radio-resistant cell types such as the lung epithelium, whereas IL-1 affords
control both direct and indirectly, through either stromal and hematopoietic cell types, to restrict overall early SCV2 burden.

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John Green @johngreensbluesky.bsky.social · Nov 22

My new book, Everything Is Tuberculosis, explores the history of our deadliest infectious disease. It's also about our horrifying present: TB still kills kills over a million people per year, even though it's been curable since the 1950s.

Signed copies can be ordered at everythingistb.com

yellow book cover reading Everything Is Tuberculosis: The History and Persistence of Our Deadliest Infection Signed Edition

170 460 4.1K

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Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · Nov 17

Ok, in time for the International Day of Pride in STEM, here's a starter pack of LGBTQ+ immunologists. Since not everyone is open (or able to be open) about their identities, we're only adding people by request, so let me know if you'd like to be added #Immunosky #PrideInSTEM 🏳️‍🌈🏳️‍⚧️ go.bsky.app/7WTavcd

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Ben Gern @bengern.bsky.social · Nov 10

Hi! Would you include me in the global health starter pack?

I’m a PI focusing on #tuberculosis immunology at the Seattle Children’s Center for Global Infectious Disease Research and a peds ID specialist.

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Ben Gern @bengern.bsky.social · Oct 14

We are hiring a technician! This position is a great fit for motivated individuals who plan on going to graduate/medical school and want to study host-pathogen interactions using advanced imaging and immunologic tools. Please spread the word!

seattlechildrens.wd5.myworkdayjobs.com/External/job...

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Alissa Rothchild @alissarothchild.bsky.social · May 28

So happy to share the latest preprint from our lab, led by grad student @PameliaLim9! Pamelia set out to study alveolar #macrophage innate sensing and found that lack of c-Maf and IL-10 enables Type I IFNs to enhance responses to low-dose LPS. www.biorxiv.org/content/10.1...

Absence of c-Maf and IL-10 enables Type I IFN enhancement of innate responses to low-dose LPS in alveolar macrophages

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org

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Ben Gern @bengern.bsky.social · Apr 16

I’m excited to share that this collaborative effort with Kevin Urdahl, Michael Gerner, and many others is out!

We show that preexisting immunity-driven CD4 T cells and neutrophils are opposing forces in determining tuberculosis lesion structure and pathogenesis.

#tuberculosis

CD4-mediated immunity shapes neutrophil-driven tuberculous pathology

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org

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Louis Ates @mycolates.bsky.social · Dec 16

This is an excellent article. Kudo's to Katherine Wu for capturing the complexity.
www.theatlantic.com/science/arch...

A Big Misconception About the World’s Greatest Infectious Killer

The dogma that tuberculosis is lying dormant in the bodies of 2 billion people might be wrong.

www.theatlantic.com

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