Johannes Bohacek
@bohaceklab.bsky.social
Dad. Associate Professor @ ETH Zurich. We study stress, behavior, hippocampus, noradrenaline and the mighty locus coeruleus. We work with mice and focus a lot on 3Rs.
Here to learn, share, laugh and rant.
Here to learn, share, laugh and rant.
Pinned
How does your favorite gene respond to stress? Check out our updated “Stressome-app”!
In a new @natcomms.nature.com paper we vastly extend our interactive app with loads of bulk and single-cell transcriptomics after acute and chronic stress. www.nature.com/articles/s41...
I'll walk you through👇
In a new @natcomms.nature.com paper we vastly extend our interactive app with loads of bulk and single-cell transcriptomics after acute and chronic stress. www.nature.com/articles/s41...
I'll walk you through👇
Reposted by Johannes Bohacek
Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5
January 19, 2026 at 1:36 PM
Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5
January 19, 2026 at 1:44 PM
I just registered for - exciting!!!
The "stress meetings" (alternating between North America and Europe) are my favorites in the conference cycle.
#stress2026
The "stress meetings" (alternating between North America and Europe) are my favorites in the conference cycle.
#stress2026
January 15, 2026 at 2:38 PM
I just registered for - exciting!!!
The "stress meetings" (alternating between North America and Europe) are my favorites in the conference cycle.
#stress2026
The "stress meetings" (alternating between North America and Europe) are my favorites in the conference cycle.
#stress2026
Weltschmerz
From my collection of powerful (and timely) German words.
Literally: World pain.
It refers to the suffering and pain one feels because of the state of the world and its inadequacy in relation to one's own desires and expectations.
From my collection of powerful (and timely) German words.
Literally: World pain.
It refers to the suffering and pain one feels because of the state of the world and its inadequacy in relation to one's own desires and expectations.
January 14, 2026 at 7:21 PM
Weltschmerz
From my collection of powerful (and timely) German words.
Literally: World pain.
It refers to the suffering and pain one feels because of the state of the world and its inadequacy in relation to one's own desires and expectations.
From my collection of powerful (and timely) German words.
Literally: World pain.
It refers to the suffering and pain one feels because of the state of the world and its inadequacy in relation to one's own desires and expectations.
American colleagues: who of you uses LinkedIn for posting papers and preprints, to chat about research findings and stir the occasional controversy? In Europe LinkedIn seems to gain popularity amongst researchers, I just find it really sterile and all the posts too polished. Opinions?
January 14, 2026 at 11:30 AM
American colleagues: who of you uses LinkedIn for posting papers and preprints, to chat about research findings and stir the occasional controversy? In Europe LinkedIn seems to gain popularity amongst researchers, I just find it really sterile and all the posts too polished. Opinions?
Reposted by Johannes Bohacek
Preprints of pandemic potential - new historical piece from me on the history of bioRxiv/medRxiv, their role in the pandemic, and the way forward. 1/n journals.asm.org/doi/10.1128/...
January 12, 2026 at 2:33 PM
Preprints of pandemic potential - new historical piece from me on the history of bioRxiv/medRxiv, their role in the pandemic, and the way forward. 1/n journals.asm.org/doi/10.1128/...
Day 7: A classic.
(the 3 people following this have now realized that there are long delays between my days...)
(the 3 people following this have now realized that there are long delays between my days...)
January 12, 2026 at 3:29 PM
Day 7: A classic.
(the 3 people following this have now realized that there are long delays between my days...)
(the 3 people following this have now realized that there are long delays between my days...)
Day 6 of sharing gems from my personal cartoon collection. Share yours and make my day.
I like this one since I did my undergrad in psychology. And I'm Austrian, Sigmund Freud and all that stuff.
I like this one since I did my undergrad in psychology. And I'm Austrian, Sigmund Freud and all that stuff.
January 8, 2026 at 9:28 AM
Day 6 of sharing gems from my personal cartoon collection. Share yours and make my day.
I like this one since I did my undergrad in psychology. And I'm Austrian, Sigmund Freud and all that stuff.
I like this one since I did my undergrad in psychology. And I'm Austrian, Sigmund Freud and all that stuff.
I can't use twitter/X anymore, it's become an awful and useless place.
On this site here, I don't feel like I'm reaching the same colleagues I used to reach on twitter.
Someone just told me the action is on LinkedIn now. Really, LinkedIn!? Can I get some opinions on this? Are some of you there?
On this site here, I don't feel like I'm reaching the same colleagues I used to reach on twitter.
Someone just told me the action is on LinkedIn now. Really, LinkedIn!? Can I get some opinions on this? Are some of you there?
an ad for jolt shows a linkedin logo in the clouds
ALT: an ad for jolt shows a linkedin logo in the clouds
media.tenor.com
January 7, 2026 at 8:21 PM
I can't use twitter/X anymore, it's become an awful and useless place.
On this site here, I don't feel like I'm reaching the same colleagues I used to reach on twitter.
Someone just told me the action is on LinkedIn now. Really, LinkedIn!? Can I get some opinions on this? Are some of you there?
On this site here, I don't feel like I'm reaching the same colleagues I used to reach on twitter.
Someone just told me the action is on LinkedIn now. Really, LinkedIn!? Can I get some opinions on this? Are some of you there?
Reposted by Johannes Bohacek
Hot off the @nature.com press!!
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Mimicking opioid analgesia in cortical pain circuits - Nature
The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of mor...
www.nature.com
January 7, 2026 at 5:05 PM
Hot off the @nature.com press!!
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
How does your favorite gene respond to stress? Check out our updated “Stressome-app”!
In a new @natcomms.nature.com paper we vastly extend our interactive app with loads of bulk and single-cell transcriptomics after acute and chronic stress. www.nature.com/articles/s41...
I'll walk you through👇
In a new @natcomms.nature.com paper we vastly extend our interactive app with loads of bulk and single-cell transcriptomics after acute and chronic stress. www.nature.com/articles/s41...
I'll walk you through👇
January 5, 2026 at 4:55 PM
How does your favorite gene respond to stress? Check out our updated “Stressome-app”!
In a new @natcomms.nature.com paper we vastly extend our interactive app with loads of bulk and single-cell transcriptomics after acute and chronic stress. www.nature.com/articles/s41...
I'll walk you through👇
In a new @natcomms.nature.com paper we vastly extend our interactive app with loads of bulk and single-cell transcriptomics after acute and chronic stress. www.nature.com/articles/s41...
I'll walk you through👇
Reposted by Johannes Bohacek
Extremely excited & proud to share our new preprint - we provide for the first time a single cell map of the mouse brain across sex, the estrous cycle, and peripartum! Data are 🔥 👇
"Single-cell map of the female brain across reproductive transitions"
www.biorxiv.org/content/10.6...
"Single-cell map of the female brain across reproductive transitions"
www.biorxiv.org/content/10.6...
January 4, 2026 at 8:45 PM
Extremely excited & proud to share our new preprint - we provide for the first time a single cell map of the mouse brain across sex, the estrous cycle, and peripartum! Data are 🔥 👇
"Single-cell map of the female brain across reproductive transitions"
www.biorxiv.org/content/10.6...
"Single-cell map of the female brain across reproductive transitions"
www.biorxiv.org/content/10.6...
Day 4 of sharing my favorite cartoons. I forget who, but someone showed this at a talk on startle behavior in mice and for some weird reason I have to laugh every time I see it.
December 26, 2025 at 12:09 PM
Day 4 of sharing my favorite cartoons. I forget who, but someone showed this at a talk on startle behavior in mice and for some weird reason I have to laugh every time I see it.
uff...
Psychedelic research must be grounded in pharmacology
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Psychedelic research must be grounded in pharmacology - Nature Neuroscience
Psychedelic science is growing rapidly and offers great promise for exciting new therapies, but this rapid growth has brought growing pains. These include a lack of appreciation of the history of the ...
www.nature.com
December 25, 2025 at 10:43 PM
uff...
Day 3 - the best science cartoon. If you have a better one, please share.
December 25, 2025 at 10:32 PM
Day 3 - the best science cartoon. If you have a better one, please share.
Day 2 from my cartoon collection. I don't know what it says about me that I find this so funny.
December 24, 2025 at 7:50 AM
Day 2 from my cartoon collection. I don't know what it says about me that I find this so funny.
The world can feel heavy these days, and holidays aren’t easy for everyone.
I’ll share one cartoon from my personal collection every day to lighten things up (and to re-activate myself on this medium).
Join me, post a cartoon that makes you laugh!
I’ll share one cartoon from my personal collection every day to lighten things up (and to re-activate myself on this medium).
Join me, post a cartoon that makes you laugh!
December 23, 2025 at 8:16 AM
The world can feel heavy these days, and holidays aren’t easy for everyone.
I’ll share one cartoon from my personal collection every day to lighten things up (and to re-activate myself on this medium).
Join me, post a cartoon that makes you laugh!
I’ll share one cartoon from my personal collection every day to lighten things up (and to re-activate myself on this medium).
Join me, post a cartoon that makes you laugh!
@bejalab.bsky.social I watched spinal tap 1+2 back-to-back the last two days. I was laughing so much. Thanks for having this image as your icon 😍
a man with long hair and a beard is saying it 's a morale builder isn 't it
ALT: a man with long hair and a beard is saying it 's a morale builder isn 't it
media.tenor.com
December 23, 2025 at 8:01 AM
@bejalab.bsky.social I watched spinal tap 1+2 back-to-back the last two days. I was laughing so much. Thanks for having this image as your icon 😍
After an intense journal-club class, I've decided that this is my favorite neuroscience paper of 2025: www.cell.com/cell/fulltex...
Although we have evidence that this mechanism doesn't exist in the hippocampus, it's an incredible tour-de-force. Overall, the habenula field was dominant this year.
Although we have evidence that this mechanism doesn't exist in the hippocampus, it's an incredible tour-de-force. Overall, the habenula field was dominant this year.
Neuron-astrocyte coupling in lateral habenula mediates depressive-like behaviors
Stress-induced depression-like behaviors are driven by a dynamic recurrent network
involving neurons and astrocytes in the lateral habenula and norepinephrine release
from neurons in the locus coerule...
www.cell.com
December 22, 2025 at 3:13 PM
After an intense journal-club class, I've decided that this is my favorite neuroscience paper of 2025: www.cell.com/cell/fulltex...
Although we have evidence that this mechanism doesn't exist in the hippocampus, it's an incredible tour-de-force. Overall, the habenula field was dominant this year.
Although we have evidence that this mechanism doesn't exist in the hippocampus, it's an incredible tour-de-force. Overall, the habenula field was dominant this year.
I'm back from social media DETOX.
5 months... what did I miss?
5 months... what did I miss?
a man wearing a gas mask and a leather jacket is standing in front of a wooden building
ALT: a man wearing a gas mask and a leather jacket is standing in front of a wooden building
media.tenor.com
December 15, 2025 at 3:13 PM
I'm back from social media DETOX.
5 months... what did I miss?
5 months... what did I miss?
🔵 I'm interrupting my social media hiatus to flag this important preprint from the Bruchas lab (is he not on Bluesky!?) together with @davidweinshenker.bsky.social. Very difficult experiments to show that dopamine release from LC terminals is independent of VTA 🔥
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
September 17, 2025 at 5:44 AM
🔵 I'm interrupting my social media hiatus to flag this important preprint from the Bruchas lab (is he not on Bluesky!?) together with @davidweinshenker.bsky.social. Very difficult experiments to show that dopamine release from LC terminals is independent of VTA 🔥
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This preprint has been under review >110 days... I think they can't find reviewers.
WOULD YOU BE WILLING TO SERVE AS A REVIEWER?
If you're keen, I'd propose your name to the editor...
Please re-post
WOULD YOU BE WILLING TO SERVE AS A REVIEWER?
If you're keen, I'd propose your name to the editor...
Please re-post
How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint): www.biorxiv.org/content/10.1...
GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice
Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and aut...
www.biorxiv.org
June 27, 2025 at 11:43 AM
This preprint has been under review >110 days... I think they can't find reviewers.
WOULD YOU BE WILLING TO SERVE AS A REVIEWER?
If you're keen, I'd propose your name to the editor...
Please re-post
WOULD YOU BE WILLING TO SERVE AS A REVIEWER?
If you're keen, I'd propose your name to the editor...
Please re-post
I'd have so much to complain about these days. But given the state of affairs in the world, it feels inappropriate to whine about daily hassles. So let me just say this on behalf of everyone who is struggling but otherwise safe: fucking hell.
June 18, 2025 at 4:35 PM
I'd have so much to complain about these days. But given the state of affairs in the world, it feels inappropriate to whine about daily hassles. So let me just say this on behalf of everyone who is struggling but otherwise safe: fucking hell.