Brad Spellberg
@bradspellberg.bsky.social
Rock on my brother in ampho-hating!
@drboulware.bsky.social
@drboulware.bsky.social
February 1, 2026 at 8:22 PM
Rock on my brother in ampho-hating!
@drboulware.bsky.social
@drboulware.bsky.social
Reposted by Brad Spellberg
0 reason to think things would be difft in non HIV, children, xenomorphs, non carbon based life forms, or any other excuses stubborn deniers have. My suggestion? Do some yoga. Meditate. Light incense. Relax. And stop torturing your patients with 2 weeks of amphoterrible. Subtle as always, I know.
January 21, 2026 at 11:52 PM
0 reason to think things would be difft in non HIV, children, xenomorphs, non carbon based life forms, or any other excuses stubborn deniers have. My suggestion? Do some yoga. Meditate. Light incense. Relax. And stop torturing your patients with 2 weeks of amphoterrible. Subtle as always, I know.
And a congratulations to the humble @drboulware.bsky.social, who published a thoughtful editorial accompanying the study. Dr. Boulware is a true leader in ID, and it is an honor to have him evaluate our study. I encourage everyone to read his team's editorial!
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
January 21, 2026 at 11:31 PM
And a congratulations to the humble @drboulware.bsky.social, who published a thoughtful editorial accompanying the study. Dr. Boulware is a true leader in ID, and it is an honor to have him evaluate our study. I encourage everyone to read his team's editorial!
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Thank you my friend! Based on your original work!!!!
US docs gotta get on board & stop pretending things that work in other countries won't work in US. AMBITION protocol is MUCH safer and MUCH more patient centered, and just as effective as 2 weeks of old, sad, amphoterrible. @absteward.bsky.social
US docs gotta get on board & stop pretending things that work in other countries won't work in US. AMBITION protocol is MUCH safer and MUCH more patient centered, and just as effective as 2 weeks of old, sad, amphoterrible. @absteward.bsky.social
Patient-directed discharges (i.e. leaving against medical advice) dropped from 35% to 12%.
Major congratulations to the authors: Devin Clark,
Brad Spellberg @bradspellberg.bsky.social , and colleagues.
Major congratulations to the authors: Devin Clark,
Brad Spellberg @bradspellberg.bsky.social , and colleagues.
January 21, 2026 at 8:21 PM
Thank you my friend! Based on your original work!!!!
US docs gotta get on board & stop pretending things that work in other countries won't work in US. AMBITION protocol is MUCH safer and MUCH more patient centered, and just as effective as 2 weeks of old, sad, amphoterrible. @absteward.bsky.social
US docs gotta get on board & stop pretending things that work in other countries won't work in US. AMBITION protocol is MUCH safer and MUCH more patient centered, and just as effective as 2 weeks of old, sad, amphoterrible. @absteward.bsky.social
Reposted by Brad Spellberg
Patient-directed discharges (i.e. leaving against medical advice) dropped from 35% to 12%.
Major congratulations to the authors: Devin Clark,
Brad Spellberg @bradspellberg.bsky.social , and colleagues.
Major congratulations to the authors: Devin Clark,
Brad Spellberg @bradspellberg.bsky.social , and colleagues.
January 21, 2026 at 7:57 PM
Patient-directed discharges (i.e. leaving against medical advice) dropped from 35% to 12%.
Major congratulations to the authors: Devin Clark,
Brad Spellberg @bradspellberg.bsky.social , and colleagues.
Major congratulations to the authors: Devin Clark,
Brad Spellberg @bradspellberg.bsky.social , and colleagues.
Reposted by Brad Spellberg
In an excellent study of real world outcomes in LA General Medical Center, after implementing AMBITION single dose liposomal amphotericin protocol for crypto meningitis:
Similar survival without recurrence
Fewer severe adverse events
Shorter hospitalization (lower cost)
dx.doi.org/10.1001/jama...
Similar survival without recurrence
Fewer severe adverse events
Shorter hospitalization (lower cost)
dx.doi.org/10.1001/jama...
January 21, 2026 at 7:57 PM
In an excellent study of real world outcomes in LA General Medical Center, after implementing AMBITION single dose liposomal amphotericin protocol for crypto meningitis:
Similar survival without recurrence
Fewer severe adverse events
Shorter hospitalization (lower cost)
dx.doi.org/10.1001/jama...
Similar survival without recurrence
Fewer severe adverse events
Shorter hospitalization (lower cost)
dx.doi.org/10.1001/jama...
Reposted by Brad Spellberg
Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis in the USA?
The answer is yes!
doi.org/10.1001/jama...
The answer is yes!
doi.org/10.1001/jama...
Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis
Cryptococcal meningitis remains a life-threatening opportunistic infection among people with advanced HIV, even in high-resource settings. For decades, the standard induction regimen in the United Sta...
doi.org
January 21, 2026 at 7:57 PM
Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis in the USA?
The answer is yes!
doi.org/10.1001/jama...
The answer is yes!
doi.org/10.1001/jama...
Reposted by Brad Spellberg
Behind the scenes 🔥🔥 with all the laughs on the latest Febrile Podcast @febrilepodcast.com with @lageneral-id.bsky.social and @bradspellberg.bsky.social #IDSky
player.captivate.fm/episode/dd68...
player.captivate.fm/episode/dd68...
December 22, 2025 at 4:48 PM
Behind the scenes 🔥🔥 with all the laughs on the latest Febrile Podcast @febrilepodcast.com with @lageneral-id.bsky.social and @bradspellberg.bsky.social #IDSky
player.captivate.fm/episode/dd68...
player.captivate.fm/episode/dd68...
Reposted by Brad Spellberg
Highly recommend you check out @bradspellberg.bsky.social book "Broken, bankrupt and dying". Achieving universal coverage can be done in many different ways. The rest of the developed world has done it in all different ways (government coverage, private/public, state subsidized etc).
December 10, 2025 at 11:53 PM
Highly recommend you check out @bradspellberg.bsky.social book "Broken, bankrupt and dying". Achieving universal coverage can be done in many different ways. The rest of the developed world has done it in all different ways (government coverage, private/public, state subsidized etc).
Hasn't been much discussion of the 40% failure rate to fill ID programs this match year. Interesting. Wonder if anyone is ever going to do anything about that?
December 8, 2025 at 8:22 PM
Hasn't been much discussion of the 40% failure rate to fill ID programs this match year. Interesting. Wonder if anyone is ever going to do anything about that?
Reposted by Brad Spellberg
🆕🎙️🔥Febrile Podcast just dropped!
✅ID Jedi @bradspellberg.bsky.social
✅Mini-cases OM,IE,Bacteremia
✅IV vs PO debates
✅Duration of therapy
✅Shmidelines Vs WikiGuideline
✅A must-listen for every antibiotic steward! #IDsky #EMIMCC
febrilepodcast.com/episodes/
open.spotify.com/episode/6dkJ...
✅ID Jedi @bradspellberg.bsky.social
✅Mini-cases OM,IE,Bacteremia
✅IV vs PO debates
✅Duration of therapy
✅Shmidelines Vs WikiGuideline
✅A must-listen for every antibiotic steward! #IDsky #EMIMCC
febrilepodcast.com/episodes/
open.spotify.com/episode/6dkJ...
December 3, 2025 at 8:25 PM
🆕🎙️🔥Febrile Podcast just dropped!
✅ID Jedi @bradspellberg.bsky.social
✅Mini-cases OM,IE,Bacteremia
✅IV vs PO debates
✅Duration of therapy
✅Shmidelines Vs WikiGuideline
✅A must-listen for every antibiotic steward! #IDsky #EMIMCC
febrilepodcast.com/episodes/
open.spotify.com/episode/6dkJ...
✅ID Jedi @bradspellberg.bsky.social
✅Mini-cases OM,IE,Bacteremia
✅IV vs PO debates
✅Duration of therapy
✅Shmidelines Vs WikiGuideline
✅A must-listen for every antibiotic steward! #IDsky #EMIMCC
febrilepodcast.com/episodes/
open.spotify.com/episode/6dkJ...
Reposted by Brad Spellberg
New episode out today: Listen in to this team from LA as they walk through several mini-cases and chat IV vs PO antibiotics!
Feat: Fourth year medical student Hannah Chute, Dr. Paloma Reta-Impey, and @bradspellberg.bsky.social
Also check out: www.bradspellberg.com/oral-antibio...
#IDsky #MedSky
Feat: Fourth year medical student Hannah Chute, Dr. Paloma Reta-Impey, and @bradspellberg.bsky.social
Also check out: www.bradspellberg.com/oral-antibio...
#IDsky #MedSky
December 1, 2025 at 1:24 PM
New episode out today: Listen in to this team from LA as they walk through several mini-cases and chat IV vs PO antibiotics!
Feat: Fourth year medical student Hannah Chute, Dr. Paloma Reta-Impey, and @bradspellberg.bsky.social
Also check out: www.bradspellberg.com/oral-antibio...
#IDsky #MedSky
Feat: Fourth year medical student Hannah Chute, Dr. Paloma Reta-Impey, and @bradspellberg.bsky.social
Also check out: www.bradspellberg.com/oral-antibio...
#IDsky #MedSky
Reposted by Brad Spellberg
🆕🔥🦴 Our 2025 Update to @wiki-guidelines.bsky.social for the Management of Pyogenic Osteomyelitis in Adults 🌟 @bradspellberg.bsky.social
🔗 [link] #idsky
www.amjmed.com/article/S000...
🔗 [link] #idsky
www.amjmed.com/article/S000...
November 19, 2025 at 4:25 PM
🆕🔥🦴 Our 2025 Update to @wiki-guidelines.bsky.social for the Management of Pyogenic Osteomyelitis in Adults 🌟 @bradspellberg.bsky.social
🔗 [link] #idsky
www.amjmed.com/article/S000...
🔗 [link] #idsky
www.amjmed.com/article/S000...
Thrilled that another regulatory innovation out of LA General is now out in @jamanetworkopen.com!
The first hospital in California authorized by CDPH to administer outpt hemodialysis for up to 2 weeks for inpatients newly started on HD who lack insurance.
jamanetwork.com/journals/jam...
The first hospital in California authorized by CDPH to administer outpt hemodialysis for up to 2 weeks for inpatients newly started on HD who lack insurance.
jamanetwork.com/journals/jam...
Hospital Hemodialysis Unit Flexibility and Hospital Length of Stay
This quality improvement study evaluates the association of hospital length of stay with a first-in-state model in which an inpatient hemodialysis unit received regulatory approval to provide temporar...
jamanetwork.com
November 18, 2025 at 10:06 PM
Thrilled that another regulatory innovation out of LA General is now out in @jamanetworkopen.com!
The first hospital in California authorized by CDPH to administer outpt hemodialysis for up to 2 weeks for inpatients newly started on HD who lack insurance.
jamanetwork.com/journals/jam...
The first hospital in California authorized by CDPH to administer outpt hemodialysis for up to 2 weeks for inpatients newly started on HD who lack insurance.
jamanetwork.com/journals/jam...
Reposted by Brad Spellberg
📢📢📢 We are delighted to announce that we are assembling team for our next project, Pharyngitis WikiGuideline
Join us to create guidelines with the humility of uncertainty.
Deadline to sign up is November 21, 2025.
Join us to create guidelines with the humility of uncertainty.
Deadline to sign up is November 21, 2025.
November 3, 2025 at 12:07 AM
📢📢📢 We are delighted to announce that we are assembling team for our next project, Pharyngitis WikiGuideline
Join us to create guidelines with the humility of uncertainty.
Deadline to sign up is November 21, 2025.
Join us to create guidelines with the humility of uncertainty.
Deadline to sign up is November 21, 2025.
Thanks to @abimfoundation.bsky.social ation for posting the video of my recent lecture on the LA General Policy to Override Policies. For those of you who know my lectures, this one is among the most entertaining. And it's only 10 min. Check it out & implement the policy!
youtu.be/RuKAKH8A604?...
youtu.be/RuKAKH8A604?...
Administrator/Clinician Collaboration: Policies to Put Patients First
YouTube video by ABIM Foundation
youtu.be
September 5, 2025 at 2:05 AM
Thanks to @abimfoundation.bsky.social ation for posting the video of my recent lecture on the LA General Policy to Override Policies. For those of you who know my lectures, this one is among the most entertaining. And it's only 10 min. Check it out & implement the policy!
youtu.be/RuKAKH8A604?...
youtu.be/RuKAKH8A604?...
Reposted by Brad Spellberg
Another plug for #wikiguidelines @bradspellberg.bsky.social
When guidelines don’t keep up with medicine
When guidelines don’t keep up with medicine
UNMC ID faculty Dr. Jenn Davis and 🌟 resident Dr. Gigi Green joined up to publish an interesting case in @cidjournal.bsky.social as part of the Clinical Delimmas in ID series:
"A Blurry Line: Navigating Treatment Decisions When the Guidelines Don't Fit"
#IDSky
academic.oup.com/cid/advance-...
"A Blurry Line: Navigating Treatment Decisions When the Guidelines Don't Fit"
#IDSky
academic.oup.com/cid/advance-...
A Blurry Line: Navigating Treatment Decisions When the Guidelines Don’t Fit
A 45-year-old female was referred to the infectious diseases (ID) clinic for interpretation of discordant human immunodeficiency virus (HIV) test results.
academic.oup.com
August 22, 2025 at 3:38 PM
Another plug for #wikiguidelines @bradspellberg.bsky.social
When guidelines don’t keep up with medicine
When guidelines don’t keep up with medicine
Reposted by Brad Spellberg
Reposted by Brad Spellberg
I love Dalba
I just don’t know why we should do a PhD in statistics to understand a trial now
Or maybe am just getting old and grumpy
I just don’t know why we should do a PhD in statistics to understand a trial now
Or maybe am just getting old and grumpy
a white monkey with a blue face is sitting on a blue blanket .
ALT: a white monkey with a blue face is sitting on a blue blanket .
media.tenor.com
August 13, 2025 at 11:41 PM
I love Dalba
I just don’t know why we should do a PhD in statistics to understand a trial now
Or maybe am just getting old and grumpy
I just don’t know why we should do a PhD in statistics to understand a trial now
Or maybe am just getting old and grumpy
Reposted by Brad Spellberg
As @bradspellberg.bsky.social would say CRP is missing a letter as a test "A" (CRAP) - www.sciencedirect.com/science/arti...
Revisiting diagnostics: erythrocyte sedimentation rate and C-reactive protein: it is time to stop the zombie tests
www.sciencedirect.com
August 12, 2025 at 5:07 AM
As @bradspellberg.bsky.social would say CRP is missing a letter as a test "A" (CRAP) - www.sciencedirect.com/science/arti...
Reposted by Brad Spellberg
International guidelines recommend 5 to 7 days of antibiotic prophylaxis for patients with cirrhosis & upper GI bleeding.
🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky
jamanetwork.com/journals/jam...
🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky
jamanetwork.com/journals/jam...
Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis
This systematic review and meta-analysis evaluates the evidence supporting the current guidelines antibiotic prophylaxis use in patients with cirrhosis and upper gastrointestinal bleeding.
jamanetwork.com
August 11, 2025 at 4:20 PM
International guidelines recommend 5 to 7 days of antibiotic prophylaxis for patients with cirrhosis & upper GI bleeding.
🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky
jamanetwork.com/journals/jam...
🆕🔥Systematic Review ( 14 RCTs, N=1322) & Bayesian Meta-Analysis challenged this universally held dogma #idsky
jamanetwork.com/journals/jam...
Reposted by Brad Spellberg
#IDsky The Infectious Disease Brad Boy himself, @bradspellberg.bsky.social , has an updated Oral vs IV table, now including the Plague (Y really) and Lyme!
Link here:
www.bradspellberg.com/oral-antibio...
Link here:
www.bradspellberg.com/oral-antibio...
Oral Antibiotic RCTs | mysite
www.bradspellberg.com
August 9, 2025 at 6:48 PM
#IDsky The Infectious Disease Brad Boy himself, @bradspellberg.bsky.social , has an updated Oral vs IV table, now including the Plague (Y really) and Lyme!
Link here:
www.bradspellberg.com/oral-antibio...
Link here:
www.bradspellberg.com/oral-antibio...
Reposted by Brad Spellberg
WikiGuidelines lapel pins are available for purchase on
WikiGuidelines website: www.wikiguidelines.org
Support us to incorporate humility of uncertainty into guidelines!
WikiGuidelines website: www.wikiguidelines.org
Support us to incorporate humility of uncertainty into guidelines!
August 3, 2025 at 5:02 PM
WikiGuidelines lapel pins are available for purchase on
WikiGuidelines website: www.wikiguidelines.org
Support us to incorporate humility of uncertainty into guidelines!
WikiGuidelines website: www.wikiguidelines.org
Support us to incorporate humility of uncertainty into guidelines!
Reposted by Brad Spellberg
“We’re asking the wrong question. Let’s use fundamental PK. Let’s get the drug to where the bug is, at a high enough concentration to kill the bug, and not worry about whether we label the drug static or cidal”.
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
Bactericidal vs Bacteriostatic Antibiotics. This controversial topic has important conceptual ramifications to treat severe infections. youtu.be/3z4BItBrzbk
Bactericidal vs Bacteriostatic Antibiotics - Editors in Conversation Podcast, Live from ASM Microbe
YouTube video by American Society for Microbiology
youtu.be
July 10, 2025 at 4:26 PM
“We’re asking the wrong question. Let’s use fundamental PK. Let’s get the drug to where the bug is, at a high enough concentration to kill the bug, and not worry about whether we label the drug static or cidal”.
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
As said by @bradspellberg.bsky.social 🤩😇
Fabulous conversation!
#IDSky #MedSky #AMSSky
Really compelling story by @corinnepurtill: "Strangers in the middle of a city: The John and Jane Does of L.A. General Medical Center". This short video tells the powerful story of the unidentified admissions to one of the busiest trauma centers in the US.
www.latimes.com/00000197-c35...
www.latimes.com/00000197-c35...
LA Times Today: Strangers in the middle of a city: The John and Jane Does of L.A. General Medical Center
Watch L.A.
www.latimes.com
July 3, 2025 at 12:19 AM
Really compelling story by @corinnepurtill: "Strangers in the middle of a city: The John and Jane Does of L.A. General Medical Center". This short video tells the powerful story of the unidentified admissions to one of the busiest trauma centers in the US.
www.latimes.com/00000197-c35...
www.latimes.com/00000197-c35...