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brianmsweis.bsky.social
Brian Sweis
@brianmsweis.bsky.social
360 followers 220 following 35 posts
MD, PhD | psychiatry | neuroscience | neuroeconomics | neuromodulation | assistant professor | residency program training director @MountSinaiPsych @SinaiBrain 🧠
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Dec 7
Hi #ACNP2024 6th conference for me! I’m a physician-scientist Asst Prof in Psychiatry & Neuroscience studying decision-making across species. Come to our poster T185 on REGRET in humans. Huge collaboration across multiple labs - we want your help as a field to define this construct!🧠 #neuroeconomics
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Reposted by Brian Sweis
zachtpennington.bsky.social
Zach Pennington @zachtpennington.bsky.social · 10d
Excited to share that I landed my dream job!🎉🎉🎉 The Pennington Lab will be opening at the University of British Columbia in January 2026!
@ubcpsych.bsky.social @dmcbrainhealth.bsky.social
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Reposted by Brian Sweis
sinaibrain.bsky.social
The Friedman Brain Institute @sinaibrain.bsky.social · 17d
We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
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Reposted by Brian Sweis
denisejcai.bsky.social
Denise J. Cai, Ph.D. @denisejcai.bsky.social · 15d
So excited for this! Can't wait to see everyone there!
sinaibrain.bsky.social
The Friedman Brain Institute @sinaibrain.bsky.social · 17d
We're looking forward to the first annual New York Memory Hub conference later this week! Can't wait for all the talks and discussion about all things learning and memory 🧠
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Reposted by Brian Sweis
sinaibrain.bsky.social
The Friedman Brain Institute @sinaibrain.bsky.social · 17d
The amygdala helps mobilize #Stress hormones cortisol & adrenaline w/in about 15 minutes. A recent study by Icahn Mount Sinai's Dr. Sarah Stanley suggests a 2nd role for the #Amygdala in response to #Fear & #Anxiety. Dr. Stanley discusses her research @pnas.org 👉 www.pnas.org/post/journal...
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Reposted by Brian Sweis
marisosa.bsky.social
Mari Sosa @marisosa.bsky.social · 16d
The Sosa Lab website is now live!
www.sosaneurolab.com

We will be seeking a postdoctoral researcher to join the growing team! If you are a rodent neuroscientist and interested in doing systems neuro work in the mountains 🏔️, please check out the "Join" page.
Sosa Lab
www.sosaneurolab.com
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · 26d
#FluorescentFriday The lab’s 1st slice physiology recordings! Timelapse recording of striatal neurons ex vivo using a Thy1-GCaMP mouse 🐭 🧠 + glutamate in the bath. Thanks @neuromanonyc.bsky.social! Shout out to @keyenceusa.bsky.social who has been great to work with customizing the BZ-X800🔬
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Reposted by Brian Sweis
susieyufeng.bsky.social
Susie Yu Feng, PhD @susieyufeng.bsky.social · 28d
Couldn’t be more excited to see this work out!! Not just manipulating PV+ cell theta phase, but also shifting seizure susceptibility! how much cooler can it get?!!!
zoechristensonwick.bsky.social
Zoé Christenson Wick @zoechristensonwick.bsky.social · 28d
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
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Reposted by Brian Sweis
tristanshuman.bsky.social
Tristan Shuman @tristanshuman.bsky.social · 28d
Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.
zoechristensonwick.bsky.social
Zoé Christenson Wick @zoechristensonwick.bsky.social · 28d
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
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Reposted by Brian Sweis
zoechristensonwick.bsky.social
Zoé Christenson Wick @zoechristensonwick.bsky.social · 28d
🚨New preprint alert🚨
We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)
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Reposted by Brian Sweis
sfnjournals.bsky.social
SfN Journals @sfnjournals.bsky.social · Sep 6
Neuro Current Ep. 38 features #JNeurosci authors discussing their paper on disrupted choice behaviors in a rat model of FASD. Listen to learn more about their methods.
🎧Listen: vist.ly/45w9g
📺 Watch on demand: vist.ly/45w99
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Sep 4
Congrats Herbert and team!
herbertwu.bsky.social
Herbert Wu @herbertwu.bsky.social · Sep 4
Super excited to share the first cooperative foraging paradigm in freely interacting mouse pairs! Stable leader and follower roles emerge spontaneously and predict learning. Well-trained mice show stereotyped, role-specific “behavioral motifs” absent in naive animals (1/5)
doi.org/10.1101/2025...
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Reposted by Brian Sweis
animalsocaging.bsky.social
Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · Aug 7
Research Network 2023 Pilot & Feasibility awardee @brianmsweis.bsky.social published two papers in Science Advances in July of this year that feature his research on the neuroeconomics of decision making. Join us in congratulating Dr. Sweis!

shorturl.at/d65WV
shorturl.at/DoU4p
Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner
Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.
shorturl.at
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Reposted by Brian Sweis
npp-journal.bsky.social
Neuropsychopharmacology @npp-journal.bsky.social · Jul 29
Welcome to one of our newest @acnporg.bsky.social Associate Members, Dr. Brian Sweis 🎉

#WelcomeToACNP👋
acnporg.bsky.social
ACNP @acnporg.bsky.social · Jul 29
Congrats to Brian Sweis, M.D., Ph.D. a new Associate Member of ACNP! Welcome!! 👋
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Reposted by Brian Sweis
acnporg.bsky.social
ACNP @acnporg.bsky.social · Jul 29
Congrats to Brian Sweis, M.D., Ph.D. a new Associate Member of ACNP! Welcome!! 👋
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Reposted by Brian Sweis
markdhumphries.bsky.social
Mark D Humphries @markdhumphries.bsky.social · Jul 25
Abstract submission open for The Mechanistic Basis of Foraging 2025 (U. Birmingham, 3-5 November)

uobevents.eventsair.com/the-mechanis...
Deadline: August 17

A meeting for all fascinated by the brain's role in foraging

Pls share!
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Jul 17
Congrats!
brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Jul 15
This speaks to the importance of cross-species research that is constantly forward- & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in psychiatry🧠 tinyurl.com/yur3j2n8
From the linked press release: “Neuroscientists discover that a non-coding RNA molecule in the prefrontal cortex, which promotes resilience to depression only in women, alters how the female brain ruminates on the past when making certain types of decisions in a mouse model. The single-stranded RNA molecule LINC00473 is depicted in the center. Image generated by OpenAI.”
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Jul 15
+ evidence that sensitivity to sunk costs & change-of-mind regret stem from a shared value function related to negative rumination & stress susceptibility. Congrats @neuromanonyc.bsky.social @ornaissler.bsky.social @ericjnestler.bsky.social @scottrussophd.bsky.social & team!🧠 @sinaibrain.bsky.social
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Jul 15
Here, we discovered LINC00473 in mPFC specifically altered change-of-mind decisions in female mice only. This was driven by enhanced sensitivity to sunk costs and how much re-evaluating recent mistakes influenced future choices. This is the 1st demo of non-coding RNA playing a role in cognition 5/6
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Jul 15
A recent study led by @ornaissler.bsky.social found levels of the non-coding RNA LINC00473 were reduced specifically in mPFC 🧠 of women but not men diagnosed with MDD, based on post-mortem human 🧠 tissue studies. Expressing LINC00473 in mPFC promotes resilience to stress in female mice only. 4/6 🐭
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Jul 15
Women are 2x as likely to develop depression than men. Major depressive disorder can manifest w different symptoms b/t sexes, including alterations in negative rumination on the past. Combining clinical questions, behavioral neuroscience, & translational #neuroeconomics, we dove into this deeper 3/6
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Jul 15
We found striking sex differences in only change-of-mind choices, and not initial value-based judgements, in mice 🐭 working for food rewards of varying costs (delays ⏰) & preferences (flavors 🧀🍌🍫🍇) on our #neuroeconomic foraging task, Restaurant Row, while on a limited daily time budget. 2/6
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brianmsweis.bsky.social
Brian Sweis @brianmsweis.bsky.social · Jul 15
New paper alert!🚨📝

Paper: tinyurl.com/2cycsy6d
Press release: tinyurl.com/yur3j2n8

How the brain 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however…🧵👇1/6 #ScienceAdvances
Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner
Long non-coding RNA LINC00473 in mPFC alters change-of-mind re-evaluative decision-making behavior related to negative rumination.
tinyurl.com
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Reposted by Brian Sweis
denisejcai.bsky.social
Denise J. Cai, Ph.D. @denisejcai.bsky.social · Jul 14
What’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope!

Our new Miniscope2C is a dual-channel, open-source Miniscope that lets you record 2 fluorescent signals simultaneously in freely moving animals.

Read the paper here: www.science.org/doi/10.1126/...

(1/10)
Screenshot of the top of the article, including the title, authors, and abstract.
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Reposted by Brian Sweis
animalsocaging.bsky.social
Animal Models for Social Dimensions of Health and Aging Network @animalsocaging.bsky.social · Jul 14
Last day for early-career scientists (advanced PhD, postdoc, and faculty) to apply for a McEwen Fellowship, an up-to-$6,000 individual award available for research related to animal models and the social determinants of health and aging.

Apply here: www.animalsocialaging-network.org/funding/fell...
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