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Carolin Ector

@carolinector.bsky.social

43 followers 53 following 2 posts

Passionate about circadian rhythms in cancer therapy 💫 | PhD in cell biology from Humboldt University of Berlin, Germany.

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Carolin Ector @carolinector.bsky.social · Apr 4

Proud moment to see work from my PhD in the @granadalab.bsky.social featured on the cover of the April 2025 issue of @molsystbiol.org 🥹 special thanks to my talented husband who helped design this cover. Check out the full paper here: lnkd.in/eDVQuRfc.

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Reposted by Carolin Ector

Bharath Ananthasubramaniam @timelyscientist.bsky.social · May 30

ML uncovers 24h rhythms in cancer 🕒🧬
Using COFE ☕, we reconstruct #circadian rhythms from human tumor biopsies across 11 #cancer types!
Turns out, tumor #clocks tick in a different timezone 🕰️💊
Got data? Let’s connect! 🤝
#AIforHealth #CircadianMedicine #oncology

PLOS Biology @plosbiology.org · May 28

Study of #circadian rhythms requires repeated sampling, but @timelyscientist.bsky.social &co present COFE, a #MachineLearning algorithm that enables virtual sampling of internal human tissues over time, revealing insights into circadian rhythms of human #tumors @plosbiology.org 🧪 plos.io/3Zx1Lt6

Workflow of Cyclic Ordering with Feature Extraction (COFE). Data without time labels are first optionally pre-filtered and then standardized. A novel cross-validation approach finds a value for the unknown sparsity parameter that guarantees good temporal ordering. Finally, COFE both assigns time labels to the samples and produces a list of rhythmic features in the data.

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Reposted by Carolin Ector

koseskalab.bsky.social @koseskalab.bsky.social · May 5

@granadalab.bsky.social recently showed how circadian coupling regulates cell growth. In order to regulate the cell on the inside, we should look outside! Great pleasure to write News&Views together with Jae Kyoung Kim! @mpinb.mpg.de

www.nature.com/articles/s41...

Outside-in regulation of cellular clocks - Nature Physics

Circadian clocks and cell division cycles are coupled. Now a study shows how cell-to-cell synchronization of circadian rhythms regulates cell division and growth.

www.nature.com

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Carolin Ector @carolinector.bsky.social · Apr 7

Thank you, Neha. Greetings to Tübingen!

Carolin Ector @carolinector.bsky.social · Apr 4

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Reposted by Carolin Ector

Granada Lab @granadalab.bsky.social · Mar 31

New work out in @naturephysics.bsky.social
Led by @NicaGutu & Malthe Nordentoft + great collaborators.

We show that circadian synchrony shapes cell growth. When coordination is lost, clock–cell cycle coupling breaks down.

May help explain paradoxes in circadian cancer biology.
📖 rdcu.be/efNaY

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Reposted by Carolin Ector

Granada Lab @granadalab.bsky.social · Mar 25

Our latest work is out in @commsbio.bsky.social
Led by Nica Gutu & Hitoshi Ishikuma, we show how circadian rhythms shape time-of-day drug sensitivity in human cells 🕒💊. Supported by @Charité, @BMBF_Bund, @emed-sysmed.bsky.social Read: rdcu.be/ee3FQ
#chronotherapy #circadian

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Reposted by Carolin Ector

Molecular Systems Biology @molsystbiol.org · Mar 14

New research suggests the circadian clock influences breast cancer cell drug sensitivity ➡️ www.embopress.org/doi/full/10....

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Reposted by Carolin Ector

Granada Lab @granadalab.bsky.social · Feb 24

Happy to share a new very exciting work from my lab! Congrats to CarolinEctor and the team on their study of circadian clock dynamics in breast cancer cells, now published in @molsystbiol.org.
We identified novel circadian subtypes linked to drug sensitivity 💊
www.embopress.org/doi/full/10....

Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity | Molecular Systems Biology

imageimageDeep circadian phenotyping across breast cancer cell lines reveals distinct circadian subtypes and their impact on drug responses. Novel circadian-based subtypes are established among breast cancer cell models. Deep circadian ...

www.embopress.org

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Reposted by Carolin Ector

Granada Lab @granadalab.bsky.social · Feb 20

🚀 Together with Carolin Ector, we recently published a review in the German medical journal Deutsches Ärzteblatt! 🎉

Topic: Chronobiology in Oncology ⏰💊

📌 Currently only in German

🔗 www.aerzteblatt.de/archiv/chron...

#Oncology #Chronobiology #MedicalResearch #CancerTreatment #HealthInnovation

Chronobiologie in der Onkologie: Onkologische Therapien am besten zur individuell optimalen Tageszeit – Deutsches Ärzteblatt

www.aerzteblatt.de

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