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Catherine Phelps @catmphelps.bsky.social · 9d

What a great opportunity to share our story! Thank you to all the organizers for putting this event together!

Pitt BGSA @pittbgsa.bsky.social · 9d

Our first talk is this year’s Stephen L Phillips Scientific Achievement Awardee, Catherine Phelps @catmphelps.bsky.social (PMI)

#symposium #GSR #bgsa

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Reposted by Catherine Phelps

Pitt Program in Microbiology & Immunology @pitt-pmi.bsky.social · 9d

Check out PMI talks tomorrow at the SOM Grad Student Symposium:
@catmphelps.bsky.social (in @meisellab.bsky.social ), Daria Jelic (Doug Reed lab), Kelsey Ertwine (Abby Overacre lab), @febrigunawan48.bsky.social (in Renfeng Li lab), and @dariavantyne.bsky.social !

Pitt BGSA @pittbgsa.bsky.social · 9d

Tomorrow from 8am-6pm, The Assembly transforms into a celebration of graduate research, innovation, and sustainability at the 30th School of Medicine Graduate Student Research Symposium.

See you tomorrow—bring your energy, your ideas, and join a scientific experience that is setting new standards!

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Reposted by Catherine Phelps

Pitt Program in Microbiology & Immunology @pitt-pmi.bsky.social · 15d

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

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Reposted by Catherine Phelps

Pitt Department of Immunology @pitt-immunology.bsky.social · 15d

Congrats, @catmphelps.bsky.social !

Pitt Program in Microbiology & Immunology @pitt-pmi.bsky.social · 15d

Congratulations to PMI student @catmphelps.bsky.social who is the recipient of the 23rd Stephen L. Phillips Scientific Achievement award for a Pitt School of Medicine graduate student who authored the best peer-review scientific journal author this year!

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Catherine Phelps @catmphelps.bsky.social · Aug 5

Awesome write-up! 🦠 🏃‍♀️ 💨

Nature Reviews Cancer @natrevcancer.nature.com · Aug 5

#ResearchHighlight

In a study published in #Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota & anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.

👇

No strain, no formate gains - Nature Reviews Cancer

In a study published in Cell, Phelps et al. find a mechanism connecting exercise, gut microbiota and anti-tumour immunity; exercise induces microbiota to produce formate, which in turn enhances CD8+ T cell functionality.

www.nature.com

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Catherine Phelps @catmphelps.bsky.social · Jul 24

Congrats! So excited to see this story in press !

Reposted by Catherine Phelps

Reinhard Hinterleitner @rh-lab.bsky.social · Jul 22

Excited to share our new publication in collaboration with Yi-Nan Gong: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity: Immunity www.cell.com/immunity/ful...

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestin...

www.cell.com

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Reposted by Catherine Phelps

Immunity @cp-immunity.bsky.social · Jul 22

Online now: Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

Pandey et al. identify Cathepsin S (CTSS) as the direct protease that cleaves Gasdermin C (GsdmC) in the intestine. Type 2 immune-promoting microbes trigger CTSS-dependent GsdmC activation in intestinal epithelial cells, targeting Rab7+ vesicles, altering lipid metabolism, and modulating anti-helminth immunity, revealing a non-pyroptotic function of GsdmC in mucosal immune regulation.

dlvr.it

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Catherine Phelps @catmphelps.bsky.social · Jul 11

I am BEYOND excited to share that my PhD thesis research is officially published in Cell @cellcellpress.bsky.social.

Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome to help fight #cancer 🏃‍♀️🦠

Cell - a Cell Press journal @cp-cell.bsky.social · Jul 9

Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

dlvr.it

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Catherine Phelps @catmphelps.bsky.social · Jul 11

Omg! Congratulations!!! 🎉🥳 🍾

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Reposted by Catherine Phelps

Waggoner Lab @labwaggoner.bsky.social · Jul 10

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression @cellcellpress.bsky.social @catmphelps.bsky.social @meisellab.bsky.social
www.cell.com/cell/fulltex...

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Reposted by Catherine Phelps

meisellab.bsky.social @meisellab.bsky.social · Jul 11

Thanks @nature.com for highlighting our recent study #exercise #microbiota #cancer

Nature @nature.com · Jul 10

Exercise helps the immune system to fight tumours by stimulating microbes in the gut to make a compound known as formate

go.nature.com/4lIZx2m

Workouts can help gut microbes to quell cancer

Mice that exercised produced higher levels of an immune-cell-stimulating molecule than sedentary rodents did.

go.nature.com

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Reposted by Catherine Phelps

Adriana Forero @adforu.bsky.social · Jul 10

📄🧫🔬🐭What are you reading this weekend? Check out @catmphelps.bsky.social, @meisellab.bsky.social, et al’s brand new work! #H2P

meisellab.bsky.social @meisellab.bsky.social · Jul 9

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

www.cell.com

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Reposted by Catherine Phelps

Cell - a Cell Press journal @cp-cell.bsky.social · Jul 9

Now online! Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

dlvr.it

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Reposted by Catherine Phelps

meisellab.bsky.social @meisellab.bsky.social · Jul 9

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...

Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy

Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

www.cell.com

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Catherine Phelps @catmphelps.bsky.social · Jul 9

I am BEYOND excited to share that my PhD thesis research is officially published in @cellpress.bsky.social today.

Read on for an exciting story about how #exercise promotes antitumor #immunity by modulating behavior of the #microbiome 🏃‍♀️🦠

authors.elsevier.com/c/1lPCrL7PXu...

authors.elsevier.com

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Reposted by Catherine Phelps

Eric Topol @erictopol.bsky.social · Jun 1

The remarkable benefit of exercise was just extended to improved survival after cancer in a randomized trial
@nejm.org
nejm.org/doi/full/10....

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Reposted by Catherine Phelps

The New York Times @nytimes.com · Jun 2

A first-of-its kind study adds powerful new evidence to research showing that exercise improves cancer survival. Here's what the trial, in people treated for colon cancer, showed.

Exercise Extends Life for People With Cancer, Study Shows

The trial, in people treated for colon cancer, showed clear evidence that an exercise program lowered the risk of disease recurrence and death.

trib.al

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Reposted by Catherine Phelps

meisellab.bsky.social @meisellab.bsky.social · May 5

not posting much these days…but this is just too positive not to share- 2 of my trainees (current) Catherine (@Catmphelps.bsky.social) and (former) Mackenzie received the AAI Trainee Achievement Award! Could not be prouder…#WomeninSTEM

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Catherine Phelps @catmphelps.bsky.social · Apr 27

Having a great time at #AACR25 in Chicago! Join me Sunday afternoon at the Overcoming Tumor Immune Suppression Minisymposium where I'll be discussing new @meisellab.bsky.social research on #exercise, #microbiome, and cancer immunity🏃 #WICR #WomenInSTEM

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Catherine Phelps @catmphelps.bsky.social · Feb 19

So excited to be in Banff for the @keystonesymposia.bsky.social with a focus on #microbiome! Loving the views on a beautiful trail #run today... RIP to my old cramp-ons though 😆

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