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Cells & Development
@cellsdev.bsky.social
1.2K followers 480 following 56 posts
'Cells & Development' journal (formerly 'Mechanisms of Development'). Official journal of the International Society of Developmental Biology isdb.bsky.social
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Cells & Development @cellsdev.bsky.social · Nov 15
From January 2021 MoD will become “CELLS & DEVELOPMENT”, subtitle: “CELL AND DEVELOPMENTAL BIOLOGY AND THEIR QUANTITATIVE APPROCHES”. We expect that C&D will become a forum for interdisciplinary research combining biology, physics and mathematics to study cell and dev biology.
Reposted by Cells & Development
isdb.bsky.social
Looks like a fantastic meeting. Register now.
bsdb.bsky.social British Society for Developmental Biology @bsdb.bsky.social · 3d
Don't forget to register for our upcoming Spring Meeting: 'Molecules to Morphogenesis'

Get your abstracts submitted by the 16th of January!

bsdb.org/meetings
January 12, 2026 at 1:12 PM
Reposted by Cells & Development
jcb.org
Ist2 is a #phospholipid scramblase that links #lipid transport at the ER to organelle homeostasis, say Heitor Gobbi Sebinelli, Camille Syska, Hafez Razmazma, Luca Monticelli, Guillaume Lenoir, Alenka Čopič @umontpellier.bsky.social et al: rupress.org/jcb/article/...

#Biophysics #ER_literature
January 12, 2026 at 3:45 PM
Reposted by Cells & Development
jrmarmor.bsky.social
We are looking for a Bioinformatician (both graduate and postdoctoral levels) to join our lab. Please help us spread the word about this opportunity!

Applicants should submit their motivation letter, full CV and academic record to Juan R. Martínez-Morales: [email protected]
January 12, 2026 at 10:35 AM
Reposted by Cells & Development
cellsdev.bsky.social
Organoid technology is one of the most significant advancements deriving from developmental biology. Yet, many aspects of the biology of organoid itself remain elusive, one of which is the role of mesenchymal stem cells.
This review:
doi.org/10.1016/j.cd...
by Wang et al discusses this in detail.
Fig. 1. Timeline of organoids development. The history of organoids was initiated by Ross Harrison's origin of nerve fiber experiments and continues to evolve to the present day. Fig. 2. Timeline of MSCs development. In 1970, Friedenstein first divided “fibroblast colonies” from guinea-pig bone marrow and spleen. In 1976, “clonogenic fibroblast precursor cells” were discovered in mouse bone marrow. In 1995, the first-in-human trial of MSCs was conducted. In 1999, it was first discovered that MSCs can differentiate in vitro into osteoblasts, adipocytes, and chondrocytes. During the period from 2000 to 2010, key functions of MSCs, including homing and migration, were discovered. In 2018, MSCs entered clinical trials for heart failure and Crohn's disease. From 2021 to 2025, clinical trials for MSCs expanded to include cirrhosis, osteoarthritis, and diabetic foot. Fig. 3. Schematic illustration of MSC-mediated optimization of organoids: from challenges to future perspectives. Current organoid systems face limitations such as lack of vasculature, central necrosis, and absence of functional immune components. MSCs address these challenges through two main strategies: acting as structural components in co-culture systems (direct relations) and serving as microenvironmental regulators via paracrine signaling and EVs (indirect relations). The integration of MSCs leads to improved organoid outcomes, including promoted angiogenesis, enhanced maturation, and immunomodulation. Future directions involve combining MSC-organoid systems with 3D bioprinting and organ-on-a-chip technologies to facilitate disease modeling, drug screening, and clinical translation.
January 10, 2026 at 5:33 PM
cellsdev.bsky.social
Organoid technology is one of the most significant advancements deriving from developmental biology. Yet, many aspects of the biology of organoid itself remain elusive, one of which is the role of mesenchymal stem cells.
This review:
doi.org/10.1016/j.cd...
by Wang et al discusses this in detail.
Fig. 1. Timeline of organoids development. The history of organoids was initiated by Ross Harrison's origin of nerve fiber experiments and continues to evolve to the present day. Fig. 2. Timeline of MSCs development. In 1970, Friedenstein first divided “fibroblast colonies” from guinea-pig bone marrow and spleen. In 1976, “clonogenic fibroblast precursor cells” were discovered in mouse bone marrow. In 1995, the first-in-human trial of MSCs was conducted. In 1999, it was first discovered that MSCs can differentiate in vitro into osteoblasts, adipocytes, and chondrocytes. During the period from 2000 to 2010, key functions of MSCs, including homing and migration, were discovered. In 2018, MSCs entered clinical trials for heart failure and Crohn's disease. From 2021 to 2025, clinical trials for MSCs expanded to include cirrhosis, osteoarthritis, and diabetic foot. Fig. 3. Schematic illustration of MSC-mediated optimization of organoids: from challenges to future perspectives. Current organoid systems face limitations such as lack of vasculature, central necrosis, and absence of functional immune components. MSCs address these challenges through two main strategies: acting as structural components in co-culture systems (direct relations) and serving as microenvironmental regulators via paracrine signaling and EVs (indirect relations). The integration of MSCs leads to improved organoid outcomes, including promoted angiogenesis, enhanced maturation, and immunomodulation. Future directions involve combining MSC-organoid systems with 3D bioprinting and organ-on-a-chip technologies to facilitate disease modeling, drug screening, and clinical translation.
January 10, 2026 at 5:33 PM
cellsdev.bsky.social
An amazing course!
You'll learn: genetic manipulation including CRISPR-Cas9, oragnoid generation, explant systems, biomechanics, high-resolution imaging and analysis, bioinformatics, and more!

Register now!
Deadline: January 16, 2026
January 4, 2026 at 10:30 PM
Reposted by Cells & Development
isdb.bsky.social
Modern Xenopus research uses this system to study #devbio, genetic diseases, biomechanics, and cell biology. If you want hands-on experience, register now to the CSHL Cell & Developmental Biology of Xenopus:
Gene Discovery & Disease
meetings.cshl.edu/courses.aspx...
Deadline: January 16, 2026
Cell & Developmental Biology of Xenopus: Gene Discovery & Disease
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
January 4, 2026 at 10:28 PM
Reposted by Cells & Development
cellsdev.bsky.social
Thank you for all the engagements. Have a wonderful holiday. We will see you again next year 👋
isdb.bsky.social International Society of Developmental Biology @isdb.bsky.social · 21d
This is our last post of the year. Hope you have a wonderful holidays. Remember, good science only comes from a well-rested mind. We will see you again next year! #MicroscopyMonday #Christmas
Image: 3D Christmas spheroids
Staining: Phalloidin
Photo credit: Postdoc Hoang Anh Le, @ucl-cdb.bsky.social
December 22, 2025 at 11:44 AM
cellsdev.bsky.social
Thank you for all the engagements. Have a wonderful holiday. We will see you again next year 👋
isdb.bsky.social International Society of Developmental Biology @isdb.bsky.social · 21d
This is our last post of the year. Hope you have a wonderful holidays. Remember, good science only comes from a well-rested mind. We will see you again next year! #MicroscopyMonday #Christmas
Image: 3D Christmas spheroids
Staining: Phalloidin
Photo credit: Postdoc Hoang Anh Le, @ucl-cdb.bsky.social
December 22, 2025 at 11:44 AM
Reposted by Cells & Development
isdb.bsky.social
This is our last post of the year. Hope you have a wonderful holidays. Remember, good science only comes from a well-rested mind. We will see you again next year! #MicroscopyMonday #Christmas
Image: 3D Christmas spheroids
Staining: Phalloidin
Photo credit: Postdoc Hoang Anh Le, @ucl-cdb.bsky.social
December 22, 2025 at 11:39 AM
Reposted by Cells & Development
opazo.bsky.social
✨ Blinking #nanobodies that work for single-molecule localization 🔬
Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!
December 22, 2025 at 10:45 AM
Reposted by Cells & Development
cellsdev.bsky.social
Tissue-resident macrophages are doing more than just protecting from infection. In this interesting paper, René Fernando Abarca-Buis et al shows that they can promote reepithelialization and blastema formation and regulate the maturation of chondrocytes. Check it out here:
doi.org/10.1016/j.cd...
Fig. 1. Doble immunodetection of CD68 and F4/80 during ear hole regeneration in early postnatal mice. Fig. 6. Clodronate liposomes treated ears in re-differentiation show acceleration of cartilage maturation. Fig. 4. Modifications in the regenerative response by the treatment with clodronate liposomes during wound healing phase of early postnatal mice ear hole regeneration.
November 28, 2025 at 5:57 PM
Reposted by Cells & Development
cellsdev.bsky.social
Check out the summary written by our Editor in Chief, Professor Roberto Mayor:
www.sciencedirect.com/science/arti...

And if you missed it, here is the link to Part I of the collection:
www.sciencedirect.com/special-issu...
December 17, 2025 at 3:45 PM
Reposted by Cells & Development
cellsdev.bsky.social
We're in love with this cover image! 🧡
Part II of our Special Collection celebrating the Centennial of the Discovery of The Organiser is here. This issue focuses on the work presented at the Centennial Symposium at the University of Freiburg in September 2024:
www.sciencedirect.com/journal/cell...
Many small photos taken from the symposium organised to reveal Spemann and Mangold in the background.
December 17, 2025 at 3:45 PM
Reposted by Cells & Development
isdb.bsky.social
Check out Part II of our special collection celebrating the centennial of the discovery of the organiser. From classical developmental biology, to tissue mechanics, and organoid and plant development, we've got it all!
cellsdev.bsky.social Cells & Development @cellsdev.bsky.social · 26d
We're in love with this cover image! 🧡
Part II of our Special Collection celebrating the Centennial of the Discovery of The Organiser is here. This issue focuses on the work presented at the Centennial Symposium at the University of Freiburg in September 2024:
www.sciencedirect.com/journal/cell...
Many small photos taken from the symposium organised to reveal Spemann and Mangold in the background.
December 17, 2025 at 3:48 PM
Reposted by Cells & Development
isdb.bsky.social
❗PREPRINT ALERT❗
doi.org/10.64898/202...
The lab of M. Lisa Manning at @syracuseu.bsky.social in collaboration with Ale Mongera at @ucl-cdb.bsky.social show that in the avian presomitic mesoderm, Contact Inhibition of Locomotion has a tissue-wide effect, making tissue act like a fluid under tension.
December 17, 2025 at 5:20 PM
cellsdev.bsky.social
We're in love with this cover image! 🧡
Part II of our Special Collection celebrating the Centennial of the Discovery of The Organiser is here. This issue focuses on the work presented at the Centennial Symposium at the University of Freiburg in September 2024:
www.sciencedirect.com/journal/cell...
Many small photos taken from the symposium organised to reveal Spemann and Mangold in the background.
December 17, 2025 at 3:45 PM
Reposted by Cells & Development
socdevbio.bsky.social
The next the Ethel Browne Harvey Postdoc Seminar will be (today) Friday, December 12 at 3 pm Eastern Time with Weiyi Qian @weiyiqian.bsky.social at NYU Grossman School of Medicine and Robyn Allen @universityofky.bsky.social. Register today and join us. bit.ly/46rb0NZ #SDBPostdocSeminar
Society for Developmental Biology Ethel Browne Harvey Postdoctoral Seminar Series Friday, December 12, 2025, 3:00pm - 4:00 pm Eastern Time Weiyi Qian (New York University Grossman School of Medicine) Tug of war — Tissue splitting driven by cell-cell and cell-matrix adhesions Robyn Allen (University of Kentucky) Fibroblasts from highly regenerative mammals resist mechanical cues to drive regeneration
December 12, 2025 at 3:21 PM
Reposted by Cells & Development
cellsdev.bsky.social
Vertebrates can use entirely different mechanisms to generate its anterior and posterior dorsal tissue. In this thorough review from the lab of Lance Davidson, different morphogenetic events are compared between the front and the back in a developing embryo. Check it out:
doi.org/10.1016/j.cd...
Fig. 1. Comparative stages of transition from primary-to-posterior dorsal axial tissue formation. A dorsal and sagittal comparison of simplified CNS morphology in at the stage(s) of PNP closure (presumed junctional neurulation) between model organisms commonly used to study neurulation processes. A dorsal view of the shared structural characteristics between vertebrates at the posterior end depicts the anterior portion of the posterior processes which have completed neural tube closure and are in the process of segmenting somites from pre-formed PSM. Dashes mark the regions where primary and secondary neurulation processes occur at the same time and are overlapping (transition zone). Posterior to established neural tube and PSM is the region containing the NMP cell population, which are proliferating and maturing to form PSM and neural tube structures in an anterior to posterior direction. Mammals have formed roughly between 28 and 30 somites at neuropore closure (E9.5–10 in mouse, day 27 in humans). Avian have formed 22 somites at HH13, whereas amphibians have formed only 6–7 somites by NF 20. Finally, zebrafish have 21 somites at 19.5 hpf, which corresponds to the stage of neural primordium elongation, without convergence. Fig. 2. Antero-posterior progression of neurulation and somitogenesis. A graphical representation of primary and posterior processes that generate identical, uninterrupted structures through a transition zone. All vertebrates begin primary processes with a predetermined superficial neural cell layer, that converges at the midline to form a single lumen and pre-somitic mesoderm that condenses and segregates into somites. Posterior processes are established from a multi-potent NMP cell population that diverge to form separate neural and mesodermal populations and eventually forms structures indistinguishable from primary structures. These processes are hypothesized to occur at the same time within the transition zone, where primary processes progressively transition into posterior processes. Fig. 3. A comparison of naïve/pluripotent/stem cell populations and organizer regions. An organizer is capable of modulating the cell identities of neighboring cell populations through expression of various BMP antagonists and additional growth factors. Naïve cells are undifferentiated cells that are capable of developing into various cell types, dependent on the externally applied conditions. The diagrams are representative of the transplantation experiments completed by Spemann and Mangold, which illustrates the organizer's ability to induce neural identity from host cells.
December 12, 2025 at 2:00 PM
cellsdev.bsky.social
One of our favourite activities each year too.
jcb.org Journal of Cell Biology @jcb.org · Dec 12
Help choose JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Don’t miss your chance to have your say in celebrating the beauty of science. Voting closes on December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...

#ScienceArt
December 12, 2025 at 2:18 PM
Reposted by Cells & Development
jcb.org
Help choose JCB’s cover of the year! Explore 12 breathtaking images submitted by our talented authors and vote for your favorite. Don’t miss your chance to have your say in celebrating the beauty of science. Voting closes on December 31! 👉 www.surveymonkey.com/r/JCB2025Cov...

#ScienceArt
December 12, 2025 at 2:15 PM
Reposted by Cells & Development
isdb.bsky.social
Looks like a really useful tool!
haoyin.bsky.social Hao Yin @haoyin.bsky.social · Dec 12
#SpatialTranscriptomics

STcompare
github.com/JEFworks-Lab...

Test your gene of interest if it is differentially spatially patterned (r, p, s)🤠
Spatial correlation
Spatial fold change
Control for spatial autocorrelation

@jef.works bioRxiv 2025
www.biorxiv.org/content/10.1...
December 12, 2025 at 2:13 PM
cellsdev.bsky.social
Vertebrates can use entirely different mechanisms to generate its anterior and posterior dorsal tissue. In this thorough review from the lab of Lance Davidson, different morphogenetic events are compared between the front and the back in a developing embryo. Check it out:
doi.org/10.1016/j.cd...
Fig. 1. Comparative stages of transition from primary-to-posterior dorsal axial tissue formation. A dorsal and sagittal comparison of simplified CNS morphology in at the stage(s) of PNP closure (presumed junctional neurulation) between model organisms commonly used to study neurulation processes. A dorsal view of the shared structural characteristics between vertebrates at the posterior end depicts the anterior portion of the posterior processes which have completed neural tube closure and are in the process of segmenting somites from pre-formed PSM. Dashes mark the regions where primary and secondary neurulation processes occur at the same time and are overlapping (transition zone). Posterior to established neural tube and PSM is the region containing the NMP cell population, which are proliferating and maturing to form PSM and neural tube structures in an anterior to posterior direction. Mammals have formed roughly between 28 and 30 somites at neuropore closure (E9.5–10 in mouse, day 27 in humans). Avian have formed 22 somites at HH13, whereas amphibians have formed only 6–7 somites by NF 20. Finally, zebrafish have 21 somites at 19.5 hpf, which corresponds to the stage of neural primordium elongation, without convergence. Fig. 2. Antero-posterior progression of neurulation and somitogenesis. A graphical representation of primary and posterior processes that generate identical, uninterrupted structures through a transition zone. All vertebrates begin primary processes with a predetermined superficial neural cell layer, that converges at the midline to form a single lumen and pre-somitic mesoderm that condenses and segregates into somites. Posterior processes are established from a multi-potent NMP cell population that diverge to form separate neural and mesodermal populations and eventually forms structures indistinguishable from primary structures. These processes are hypothesized to occur at the same time within the transition zone, where primary processes progressively transition into posterior processes. Fig. 3. A comparison of naïve/pluripotent/stem cell populations and organizer regions. An organizer is capable of modulating the cell identities of neighboring cell populations through expression of various BMP antagonists and additional growth factors. Naïve cells are undifferentiated cells that are capable of developing into various cell types, dependent on the externally applied conditions. The diagrams are representative of the transplantation experiments completed by Spemann and Mangold, which illustrates the organizer's ability to induce neural identity from host cells.
December 12, 2025 at 2:00 PM
Reposted by Cells & Development
zimengwu33.bsky.social
Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking.

It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.

Preprint: www.biorxiv.org/content/10.6...

[1/6]
December 8, 2025 at 9:48 AM
Reposted by Cells & Development
zebrafishrock.bsky.social
Very useful tool, for those interested! 🧪
zimengwu33.bsky.social Zimeng Wu @zimengwu33.bsky.social · Dec 8
Pleased to say that Jonas Hartmann (bs-less) and I have finally released DySTrack (“diss track”) - Dynamic Sample Tracking.

It’s a Python-based, modular tool that brings smart microscopy to everyday imaging on commercial systems.

Preprint: www.biorxiv.org/content/10.6...

[1/6]
December 8, 2025 at 9:49 AM