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Chaitanya Dingare

@chaitanyadingare.bsky.social

74 followers 120 following 11 posts

Postdoctoral researcher at Cambridge University studying Developmental Metabolism | PhD at Freiburg University | 🇬🇧🇩🇪🇮🇳

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Chaitanya Dingare @chaitanyadingare.bsky.social · Jan 29

Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids: Developmental Cell www.cell.com/developmenta...

Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids

Dingare et al. identified a critical role for mannose-dependent glycosylation during early mesoderm specification both in mouse embryonic stem-cell-derived gastruloids and in gastrulating mouse embryo...

www.cell.com

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Chaitanya Dingare @chaitanyadingare.bsky.social · 23d

Congratulations!

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Reposted by Chaitanya Dingare

Mathieu Preußner @mathpreu.bsky.social · 23d

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Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...

#DevBio #Zebrafish

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Reposted by Chaitanya Dingare

vlecaudey.bsky.social @vlecaudey.bsky.social · 24d

New preprint from the Lecaudey lab by first authors Anna Mertens and Nicola Moratscheck, with the help of other former members including @chaitanyadingare.bsky.social uncovering the role of integrin-laminin interactions during epithelial collective cell migration!

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 25d

Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1

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Reposted by Chaitanya Dingare

José Silva & Lab @josesilvalab.bsky.social · 24d

(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!
🙌 Huge thanks to the entire team and our collaborators, special shout-out to @cc0447.bsky.social (led the work) and @jinjin-0101.bsky.social (comp. analysis).
www.cell.com/cell-stem-ce...

Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling

Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days i...

www.cell.com

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Chaitanya Dingare @chaitanyadingare.bsky.social · 24d

This is a rigorous piece of work, completed with help of current @vlecaudey.bsky.social lab members.

Chaitanya Dingare @chaitanyadingare.bsky.social · 24d

I combined the genetics with live imaging approaches to delineate how hippo pathway and its regulators control the cell number. I have generated a few essential tools including the zebrafish specific yap1 antibody (works really well).

Chaitanya Dingare @chaitanyadingare.bsky.social · 24d

I have used the zebrafish lateral line primordium as a model. Reason - it contains only 100-120 cells to begin with so much easier to follow the mechanisms that controls the cell number.

Chaitanya Dingare @chaitanyadingare.bsky.social · 24d

www.biorxiv.org/content/10.1... late post! Parts of my PhD thesis are now in a preprint. Just imagine if each cell of your organs decides to undergo some extra divisions while being formed, how would they look and what prevents that from happening? This is exactly what I have shown in my work.

Vgll4 Proteins limit Organ Size in Zebrafish through Yap1-Dependent and -Independent Mechanisms

Precise control of organ size is crucial during development and homeostasis. Dysregulation of the underlying mechanisms can result in organ malformation and tumorigenesis. Although the Hippo signaling...

www.biorxiv.org

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Reposted by Chaitanya Dingare

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 25d

Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1

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Chaitanya Dingare @chaitanyadingare.bsky.social · 24d

@vlecaudey.bsky.social !

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · 25d

Patterned integrin-laminin adhesion coordinates epithelial collective cell migration https://www.biorxiv.org/content/10.1101/2025.09.12.675859v1

Chaitanya Dingare @chaitanyadingare.bsky.social · Jul 24

Congratulations!

Reposted by Chaitanya Dingare

Vicki Metzis @vmetzis.bsky.social · Jun 27

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

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Reposted by Chaitanya Dingare

Christian Frezza @frezzalab.bsky.social · Jun 25

Nerve-to-cancer transfer of mitochondria during cancer metastasis
www.nature.com/articles/s41...

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature

A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

www.nature.com

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Reposted by Chaitanya Dingare

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Jun 25

GATA6 Mediates Endoderm and Mesoderm Progenitor Fate Driven by WNT and NODAL Signaling https://www.biorxiv.org/content/10.1101/2025.06.20.660704v1

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Reposted by Chaitanya Dingare

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Jun 22

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1

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Reposted by Chaitanya Dingare

David Mörsdorf @davidmoersdorf.bsky.social · Jun 13

It’s out! 🥳

www.science.org/doi/10.1126/...

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Reposted by Chaitanya Dingare

Bruna Martins Garcia @brunamgarcia.bsky.social · Jun 9

The weekly Metabolites-driven PTMs focusing on cancer Biomed News is out ☺️ biomed.news/bims-prolim/...

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Chaitanya Dingare @chaitanyadingare.bsky.social · Jun 5

Congratulations! The images look amazing!

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Reposted by Chaitanya Dingare

Mathieu Preußner @mathpreu.bsky.social · Jun 5

If you’ve ever wondered how those intricate gill structures emerge—and how gills develop throughout a zebrafish’s lifespan—check out my new preprint!
We dive into the development of gills and their vasculature in detail.
Huge thanks to @vlecaudey.bsky.social for the support🐟

#zebrafish #microscopy

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Reposted by Chaitanya Dingare

vlecaudey.bsky.social @vlecaudey.bsky.social · Jun 5

New preprint from the lab! Beautiful work by @mathpreu.bsky.social, who delved into the early development of gills and their intricate vasculature. Thanks to the Clusterproject ENABLE and @goetheuni.bsky.social for the funding! www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Chaitanya Dingare

Nature Metabolism @natmetabolism.nature.com · May 31

COMMENT | KS Li, X Su & T Huan (Rutgers U, UBC):

Metabolites are not genes — avoiding the misuse of pathway analysis in #metabolomics.

https://bit.ly/4kIGbtI ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab

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Reposted by Chaitanya Dingare

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · May 27

A lipid metabolism defect is an underlying contributor to Diamond Blackfan anemia syndrome https://www.biorxiv.org/content/10.1101/2025.05.22.654334v1

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Reposted by Chaitanya Dingare

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · May 20

Signaling and Mechanics influence the number and size of epithelial rosettes in the migrating zebrafish Posterior Lateral Line primordium https://www.biorxiv.org/content/10.1101/2025.05.17.650326v1

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Reposted by Chaitanya Dingare

Berta Verd @bertaverd.bsky.social · May 19

Experimental embryology postdoc available in my lab at the @biology.ox.ac.uk @ox.ac.uk working on the evolution of vertebral counts. Reach out if you’re passionate about EvoDevo, enjoy lab work and microscopy and are into or could get into cichlid fishes. Deadline on the 16th June. Please share!

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Reposted by Chaitanya Dingare

David Mörsdorf @davidmoersdorf.bsky.social · May 18

Interesting work on #morphogen (BMP4, Wnt8) mobility and HSPGs in Xenopus🐸

bioRxivpreprint @biorxivpreprint.bsky.social · Apr 20

Identification of N-acetyl-rich heparan sulfate binding motifs and their role in expanding BMP distribution and signaling by Cerberus https://www.biorxiv.org/content/10.1101/2025.04.16.649141v1

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