ChemRxiv
@chemrxiv.org
ChemRxiv is the open preprint server for the global chemistry community. Contact us at [email protected] for assistance.
Learn more: ChemRxiv.org
Learn more: ChemRxiv.org
Reposted by ChemRxiv
Docking results show that stability is driven by geometric convergence inside the pore, not just the number of interactions.
A geometric perspective on VGSC blockade.
@chemrxiv.org
How Tetrodotoxin Blocks Sodium Channels: A Docking and Geometric Perspective | ChemRxiv chemrxiv.org/doi/full/10....
A geometric perspective on VGSC blockade.
@chemrxiv.org
How Tetrodotoxin Blocks Sodium Channels: A Docking and Geometric Perspective | ChemRxiv chemrxiv.org/doi/full/10....
How Tetrodotoxin Blocks Sodium Channels: A Docking and Geometric Perspective | ChemRxiv
Voltage-gated sodium channels (VGSCs) are essential membrane proteins responsible for electrical signaling in excitable cells. Guanidinium toxins such as tetrodotoxin (TTX) and saxitoxin (STX) block these channels by binding to the extracellular pore ...
chemrxiv.org
February 17, 2026 at 11:04 AM
Docking results show that stability is driven by geometric convergence inside the pore, not just the number of interactions.
A geometric perspective on VGSC blockade.
@chemrxiv.org
How Tetrodotoxin Blocks Sodium Channels: A Docking and Geometric Perspective | ChemRxiv chemrxiv.org/doi/full/10....
A geometric perspective on VGSC blockade.
@chemrxiv.org
How Tetrodotoxin Blocks Sodium Channels: A Docking and Geometric Perspective | ChemRxiv chemrxiv.org/doi/full/10....
Reposted by ChemRxiv
This is the second installment of a review that reexamines drug discovery from the perspective of bioinformatics.
@chemrxiv.org
Review of a Withdrawn Drug Candidate: Indiplon | ChemRxiv chemrxiv.org/doi/full/10....
@chemrxiv.org
Review of a Withdrawn Drug Candidate: Indiplon | ChemRxiv chemrxiv.org/doi/full/10....
February 13, 2026 at 1:49 PM
This is the second installment of a review that reexamines drug discovery from the perspective of bioinformatics.
@chemrxiv.org
Review of a Withdrawn Drug Candidate: Indiplon | ChemRxiv chemrxiv.org/doi/full/10....
@chemrxiv.org
Review of a Withdrawn Drug Candidate: Indiplon | ChemRxiv chemrxiv.org/doi/full/10....
Reposted by ChemRxiv
This paper uses bioinformatics to reexamine the disappearance of drugs in drug discovery.
@chemrxiv.org
Review of a Withdrawn Drug Candidate: Adipiplon | ChemRxiv chemrxiv.org/doi/full/10....
@chemrxiv.org
Review of a Withdrawn Drug Candidate: Adipiplon | ChemRxiv chemrxiv.org/doi/full/10....
February 13, 2026 at 11:45 AM
This paper uses bioinformatics to reexamine the disappearance of drugs in drug discovery.
@chemrxiv.org
Review of a Withdrawn Drug Candidate: Adipiplon | ChemRxiv chemrxiv.org/doi/full/10....
@chemrxiv.org
Review of a Withdrawn Drug Candidate: Adipiplon | ChemRxiv chemrxiv.org/doi/full/10....
Reposted by ChemRxiv
Excited to share our @chemrxiv.org preprint on metabolically active living materials #MALMs with physciochemical biocontainment🧵
Why do we need #MALMs?
Because as @economist.com posits additive manufacturing is potentially a better way to make drinks and drugs
We argue #MALMs are the key for it
Why do we need #MALMs?
Because as @economist.com posits additive manufacturing is potentially a better way to make drinks and drugs
We argue #MALMs are the key for it
February 10, 2026 at 7:52 PM
Excited to share our @chemrxiv.org preprint on metabolically active living materials #MALMs with physciochemical biocontainment🧵
Why do we need #MALMs?
Because as @economist.com posits additive manufacturing is potentially a better way to make drinks and drugs
We argue #MALMs are the key for it
Why do we need #MALMs?
Because as @economist.com posits additive manufacturing is potentially a better way to make drinks and drugs
We argue #MALMs are the key for it
Reposted by ChemRxiv
MOPEG, a new PEG-based polymer gel crossliked by MOP, shows macroscale deformation by coordinative guest recognition!! The idea from our former postdoc, Tomoki @tomokitateishi.bsky.social, finally appeared on @chemrxiv.org!!
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
Coordinative Guest Recognition Triggers Macroscale Deformation of Covalently Linked Metal-Organic Polyhedra Polymer Gels | ChemRxiv
Molecular recognition plays a central role in supramolecular chemistry. The concept of molecular recognition initially emerged from discrete molecular systems and has nowadays been expanded to solid-state soft materials; however, there remains a lack of ...
chemrxiv.org
February 10, 2026 at 4:28 AM
MOPEG, a new PEG-based polymer gel crossliked by MOP, shows macroscale deformation by coordinative guest recognition!! The idea from our former postdoc, Tomoki @tomokitateishi.bsky.social, finally appeared on @chemrxiv.org!!
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
Reposted by ChemRxiv
Check out our latest in @chemrxiv.org (doi.org/10.26434/che...), where we highlight the use of BINAP motifs to modulate the photophysics of hashtag#mrtadf emitters. @st-andrewschem.bsky.social @standrewsosc.bsky.social
February 6, 2026 at 1:25 PM
Check out our latest in @chemrxiv.org (doi.org/10.26434/che...), where we highlight the use of BINAP motifs to modulate the photophysics of hashtag#mrtadf emitters. @st-andrewschem.bsky.social @standrewsosc.bsky.social
Reposted by ChemRxiv
Additive Manufacturing of Metabolically Active Living Materials with Physicochemical Biocontainment @chemrxiv.org
#ELMs #livingmaterials #MALM
chemrxiv.org/doi/full/10....
#ELMs #livingmaterials #MALM
chemrxiv.org/doi/full/10....
February 5, 2026 at 4:30 PM
Additive Manufacturing of Metabolically Active Living Materials with Physicochemical Biocontainment @chemrxiv.org
#ELMs #livingmaterials #MALM
chemrxiv.org/doi/full/10....
#ELMs #livingmaterials #MALM
chemrxiv.org/doi/full/10....
Reposted by ChemRxiv
New work from the group online on @chemrxiv.org! We describe how Lewis Acid-Coupled Electron Transfer enables CO₂ reductive disproportionation with a very mild reductant. The mechanism implies Cp* non-innocence towards CO₂, highly unusual. Bravo Léon for this nice study!
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
Reductive Disproportionation of CO2 Beyond Redox Limits Enabled by Lewis Acid-Coupled Electron Transfer | ChemRxiv
A frustrated redox triad comprising Al(C6F5)3 (AlCF), CO2, and decamethylferrocene (FeCp*2) promotes reductive disproportionation of CO2 to CO and carbonate under ambient conditions. Spectroscopic and computational data show that a Lewis acid-bound CO2 ...
chemrxiv.org
February 5, 2026 at 11:30 AM
New work from the group online on @chemrxiv.org! We describe how Lewis Acid-Coupled Electron Transfer enables CO₂ reductive disproportionation with a very mild reductant. The mechanism implies Cp* non-innocence towards CO₂, highly unusual. Bravo Léon for this nice study!
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
Reposted by ChemRxiv
Check out our latest in @chemrxiv.org
(doi.org/10.26434/che...), where we highlight VOC sensing using coumarin #tadf emitters.
@standrewschem.bsky.social @standrewsosc.bsky.social
(doi.org/10.26434/che...), where we highlight VOC sensing using coumarin #tadf emitters.
@standrewschem.bsky.social @standrewsosc.bsky.social
January 28, 2026 at 3:09 PM
Check out our latest in @chemrxiv.org
(doi.org/10.26434/che...), where we highlight VOC sensing using coumarin #tadf emitters.
@standrewschem.bsky.social @standrewsosc.bsky.social
(doi.org/10.26434/che...), where we highlight VOC sensing using coumarin #tadf emitters.
@standrewschem.bsky.social @standrewsosc.bsky.social
Reposted by ChemRxiv
This is a cool one! We realize that thermally-initiated solid-state reactions are driven by terahertz phonons. Love how straightforward and clean this story is - the paper basically wrote itself! Much more soon! @urochester.bsky.social @chemrxiv.org
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
Terahertz Lattice Dynamics Govern Topochemical Click Reactions in Molecular Solids | ChemRxiv
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.For more information or tips please see 'Downloading to a citation manager' in the Help menu.
chemrxiv.org
January 23, 2026 at 11:55 AM
This is a cool one! We realize that thermally-initiated solid-state reactions are driven by terahertz phonons. Love how straightforward and clean this story is - the paper basically wrote itself! Much more soon! @urochester.bsky.social @chemrxiv.org
chemrxiv.org/doi/full/10....
chemrxiv.org/doi/full/10....
Reposted by ChemRxiv
How to make the smallest house?
Have a look a the last preprint at @chemrxiv.org of Clement Tanguy @vladyslavsmyrnov.bsky.social and Matthew Wodrich on the diastereoselective synthesis of housanes via the carbocupration of cyclopropenes!
chemrxiv.org/doi/full/10....
Have a look a the last preprint at @chemrxiv.org of Clement Tanguy @vladyslavsmyrnov.bsky.social and Matthew Wodrich on the diastereoselective synthesis of housanes via the carbocupration of cyclopropenes!
chemrxiv.org/doi/full/10....
January 22, 2026 at 10:00 AM
How to make the smallest house?
Have a look a the last preprint at @chemrxiv.org of Clement Tanguy @vladyslavsmyrnov.bsky.social and Matthew Wodrich on the diastereoselective synthesis of housanes via the carbocupration of cyclopropenes!
chemrxiv.org/doi/full/10....
Have a look a the last preprint at @chemrxiv.org of Clement Tanguy @vladyslavsmyrnov.bsky.social and Matthew Wodrich on the diastereoselective synthesis of housanes via the carbocupration of cyclopropenes!
chemrxiv.org/doi/full/10....
Reposted by ChemRxiv
We have a new @chemrxiv.org preprint out describing the first silicon containing spiropentane and its rearrangement to a cyclobutane. chemrxiv.org/doi/full/10..... Congrats to @upwinder.bsky.social and @benedekstdlr.bsky.social
January 22, 2026 at 12:02 PM
We have a new @chemrxiv.org preprint out describing the first silicon containing spiropentane and its rearrangement to a cyclobutane. chemrxiv.org/doi/full/10..... Congrats to @upwinder.bsky.social and @benedekstdlr.bsky.social
Reposted by ChemRxiv
New technology platform for ChemRxiv!
About ChemRxiv: ChemRxiv is an open-access preprint archive for chemistry and is jointly operated by the ACS, the GDCh, the RSC, the CCS, and the CSJ. ChemRxiv enables the efficient and timely dissemination of chemical knowledge.
About ChemRxiv: ChemRxiv is an open-access preprint archive for chemistry and is jointly operated by the ACS, the GDCh, the RSC, the CCS, and the CSJ. ChemRxiv enables the efficient and timely dissemination of chemical knowledge.
The new ChemRxiv website is now live! Come and check out the new platform at chemrxiv.org
chemrxiv.org
January 22, 2026 at 7:27 AM
New technology platform for ChemRxiv!
About ChemRxiv: ChemRxiv is an open-access preprint archive for chemistry and is jointly operated by the ACS, the GDCh, the RSC, the CCS, and the CSJ. ChemRxiv enables the efficient and timely dissemination of chemical knowledge.
About ChemRxiv: ChemRxiv is an open-access preprint archive for chemistry and is jointly operated by the ACS, the GDCh, the RSC, the CCS, and the CSJ. ChemRxiv enables the efficient and timely dissemination of chemical knowledge.
The new ChemRxiv website is now live! Come and check out the new platform at chemrxiv.org
chemrxiv.org
January 21, 2026 at 3:52 PM
The new ChemRxiv website is now live! Come and check out the new platform at chemrxiv.org
Reposted by ChemRxiv
Today on @chemrxiv.org, we disclose a C-to-N replacement that actually works complex natural products - a pipe-dream when we started. The secret is to lean in to the triplet nitrene.
Congrats Dong Il, and thanks to the whole team, including collaborators from Sanofi!
chemrxiv.org/engage/chemr...
Congrats Dong Il, and thanks to the whole team, including collaborators from Sanofi!
chemrxiv.org/engage/chemr...
January 13, 2026 at 6:41 PM
Today on @chemrxiv.org, we disclose a C-to-N replacement that actually works complex natural products - a pipe-dream when we started. The secret is to lean in to the triplet nitrene.
Congrats Dong Il, and thanks to the whole team, including collaborators from Sanofi!
chemrxiv.org/engage/chemr...
Congrats Dong Il, and thanks to the whole team, including collaborators from Sanofi!
chemrxiv.org/engage/chemr...
We’re moving! ChemRxiv is closed for new submissions until January 21 while we transfer to a new platform. Find out more here: connect.acspubs.org/chemrxiv-mig...
ChemRxiv Migration FAQ
connect.acspubs.org
January 14, 2026 at 9:01 AM
We’re moving! ChemRxiv is closed for new submissions until January 21 while we transfer to a new platform. Find out more here: connect.acspubs.org/chemrxiv-mig...
Reposted by ChemRxiv
We combine ML + #DigitalTwins to autonomously design photoreactors with high light capture and uniform irradiation. A virtual photoreactor guides #BayesianOptimization, allowing numerous designs in silico and fabrication only of the best candidates.
🔗 @chemrxiv.org : chemrxiv.org/engage/chemr...
🔗 @chemrxiv.org : chemrxiv.org/engage/chemr...
January 5, 2026 at 9:29 AM
We combine ML + #DigitalTwins to autonomously design photoreactors with high light capture and uniform irradiation. A virtual photoreactor guides #BayesianOptimization, allowing numerous designs in silico and fabrication only of the best candidates.
🔗 @chemrxiv.org : chemrxiv.org/engage/chemr...
🔗 @chemrxiv.org : chemrxiv.org/engage/chemr...
Reposted by ChemRxiv
📄 We report a radical disconnection strategy that enables the direct, single-step conversion of α-amino acids into differentiated vicinal diamines via photocatalytic decarboxylation.
Broad scope, functional-group tolerant, and scalable in flow.
🔗 @chemrxiv.org: chemrxiv.org/engage/chemr...
Broad scope, functional-group tolerant, and scalable in flow.
🔗 @chemrxiv.org: chemrxiv.org/engage/chemr...
January 6, 2026 at 9:30 AM
📄 We report a radical disconnection strategy that enables the direct, single-step conversion of α-amino acids into differentiated vicinal diamines via photocatalytic decarboxylation.
Broad scope, functional-group tolerant, and scalable in flow.
🔗 @chemrxiv.org: chemrxiv.org/engage/chemr...
Broad scope, functional-group tolerant, and scalable in flow.
🔗 @chemrxiv.org: chemrxiv.org/engage/chemr...
Reposted by ChemRxiv
Our first preprint of 2026 is out in @chemrxiv.org (doi.org/10.26434/che...), and it highlights the rational design of a potent, strongly photoreducing, and high triplet energy Ir #photocatalyst that can be excited in the visible. @st-andrewschem.bsky.social @standrewsosc.bsky.social
January 12, 2026 at 10:56 AM
Our first preprint of 2026 is out in @chemrxiv.org (doi.org/10.26434/che...), and it highlights the rational design of a potent, strongly photoreducing, and high triplet energy Ir #photocatalyst that can be excited in the visible. @st-andrewschem.bsky.social @standrewsosc.bsky.social
Reposted by ChemRxiv
Identifying Phase Transitions in Zeolitic Imidazolate Frameworks: Microscopic Insight from Molecular Simulations, our latest #compchem work on ZIF polymorphism #chemsky @chemrxiv.org doi.org/10.26434/che...
January 12, 2026 at 11:51 AM
Identifying Phase Transitions in Zeolitic Imidazolate Frameworks: Microscopic Insight from Molecular Simulations, our latest #compchem work on ZIF polymorphism #chemsky @chemrxiv.org doi.org/10.26434/che...
ChemRxiv will be closed to new submissions from January 14-20 while we migrate to our new platform. Find out more here: connect.acspubs.org/chemrxiv-mig...
ChemRxiv Migration FAQ
connect.acspubs.org
January 13, 2026 at 8:09 AM
ChemRxiv will be closed to new submissions from January 14-20 while we migrate to our new platform. Find out more here: connect.acspubs.org/chemrxiv-mig...
We’re celebrating the 8th anniversary of ChemRxiv! Thanks to our international community of authors, we’ve grown to host over 33,000 preprints which have collectively been viewed almost 60m times. Find out more about ChemRxiv at chemrxiv.org
Homepage | ChemRxiv | Cambridge Open Engage
ChemRxiv is a free-to-access pre-publication platform dedicated to early research outputs in a broad range of chemistry fields.
chemrxiv.org
August 15, 2025 at 2:13 PM
We’re celebrating the 8th anniversary of ChemRxiv! Thanks to our international community of authors, we’ve grown to host over 33,000 preprints which have collectively been viewed almost 60m times. Find out more about ChemRxiv at chemrxiv.org
Reposted by ChemRxiv
Happy to show the true collaboration of the Furukawa-Inose group!! Our PI, Tomoko Inose, realized remote-controlled nitric oxide release at the single-cell level by coating plasmonic nanowires with photo-responsive MOFs. Just posted on
@chemrxiv.org.
shorturl.at/ev8gx
@chemrxiv.org.
shorturl.at/ev8gx
July 29, 2025 at 9:11 AM
Happy to show the true collaboration of the Furukawa-Inose group!! Our PI, Tomoko Inose, realized remote-controlled nitric oxide release at the single-cell level by coating plasmonic nanowires with photo-responsive MOFs. Just posted on
@chemrxiv.org.
shorturl.at/ev8gx
@chemrxiv.org.
shorturl.at/ev8gx
Reposted by ChemRxiv
🔥 An approach for light-driven, Ni-catalyzed C-heteroatom couplings that:
-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications
Now on @chemrxiv.org: tinyurl.com/3ss6x24j
-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications
Now on @chemrxiv.org: tinyurl.com/3ss6x24j
July 30, 2025 at 12:46 PM
🔥 An approach for light-driven, Ni-catalyzed C-heteroatom couplings that:
-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications
Now on @chemrxiv.org: tinyurl.com/3ss6x24j
-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications
Now on @chemrxiv.org: tinyurl.com/3ss6x24j
Reposted by ChemRxiv
New @chemrxiv.org: interested in an inexpensive way to take advantage of carbenoid reactivity without excluding humidity or oxygen? Take a look here: doi.org/10.26434/che... #nhc #organocatalysis #polymerization #chemsky
August 6, 2025 at 7:35 AM
New @chemrxiv.org: interested in an inexpensive way to take advantage of carbenoid reactivity without excluding humidity or oxygen? Take a look here: doi.org/10.26434/che... #nhc #organocatalysis #polymerization #chemsky