Last week on the #LCSOSynthesisProblem, Philipp challenged us to the total synthesis of Bipolarolides A and B by Jia and co-workers. 💡 Want to challenge yourself or your team with this synthesis prob...

Functional polymeric materials have recently emerged as promising supports for organic photocatalysts (PCs), yet the effects of PC design and polymer architecture on catalytic performance remain underexplored. In this study, we present a versatile strategy for small-molecule activation using carbazolyl-dicyanobenzene-based PCs featuring an isophthalonitrile (IPN) core. These PCs feature thermally activated delayed fluorescence (TADF) properties and long-lived excited states, although they also suffer from an intrinsic chemical fragility that hampers their recyclability. A library of IPN derivatives was synthesized, characterized, and integrated into either soluble copolymers (by exploiting controlled radical polymerization) or grafted from inert silica nanoparticles (NPs) to yield PC-loaded spherical polymer brushes. Although soluble copolymers showed catalytic activity comparable to that of free PCs while testing model Povarov-type cycloadditions, PC recovery was only modest and relied on precipitation steps. In contrast, PC-loaded brushes on NPs achieved high yields and enabled efficient catalyst recovery and reuse (≥90%) over multiple cycles. This comparative approach highlights how the nature of the polymeric support, soluble vs. nanostructured, critically influences both catalytic performance and recyclability. More generally, the incorporation of IPN PCs into advanced polymer scaffolds is demonstrated to enhance their applicability, cost-efficiency, and sustainability.

Herein, we report a bioinspired strategy for the selective modification of tyrosine residues in short peptides based on a formal umpolung of the phenolic side chain. Mild oxidation with a hypervalent iodine(V) reagent enables the in situ generation of ...

#LCSOJournalClub 216.1 (highlighted in picture) An amide bond formation promoted by trimethoxysilane reported by Hisashi Yamamoto and co-workers from Chubu University in JOC https://lnkd.in/dYaSPzgn 2...

Congratulations to Alexandre Schoepfer on the successful defense of his thesis and the completion of his PhD!🎓 As the first jointly supervised PhD student between LCSO and LCMD, he set a strong exampl...

Great teaching is expensive, but back-office functions should be getting cheaper. Why aren’t they?

SmI₂ enjoyers will not want to miss this week's #LCSOSynthesisProblem, where Najung challenged us to the total synthesis of Aberrarone by Xia, Ding, and co-workers. Check it out here 👉 https://lnkd.in...

#LCSOJournalClub 215.1 (highlighted in picture) A photocatalytic three-component coupling of aldehydes, anilines and alkyl arenes reported in Chem Catal. by Ludovic Troian-Gautier, Uttam Tambar and co...

Concerted 1,3-alkyl shifts are often challenging due to antiaromatic transition states and geometric strain. Now, a formal 1,3-migration can be achieved through two consecutive 1,2-shifts—a Pd(II)-cat...

Electrophilic nitration is a fundamental transformation in organic synthesis; however, traditional mineral acid-based methods suffer from harsh conditions and limited substrate scope, motivating the d...

From redox numbers to red light: Donor oxidation and core reduction potentials predict E0-0 in cyanoarene dyes, guiding selection of an efficient red-light catalyst, 4MeODPATPN (PC13). Under 620 nm l...

Fluctuating environments can lead to phenotypic heterogeneity within a monoclonal bacterial population, especially in response to antibiotics or the human immune system. Methods are required to analyz...

#LCSOJournalClub 213.1 (highlighted in picture) Let's start with a preprint at ChemRxiv by Johannes Walker and co-workers from Göttingen University on the stereoselective synthesis of bicyclo[2.1.1]he...