Chloe Girard, PhD
@chloegirard.bsky.social
Personally done with meiosis I. Professionally in love with it.
Permanent researcher at I2BC 🇫🇷 Arabidopsis 🌱 Sordaria 🍄 Genetics/Genomics 🧬 Fixed and live imaging 🔬.
#meiosis4ever her/she
Permanent researcher at I2BC 🇫🇷 Arabidopsis 🌱 Sordaria 🍄 Genetics/Genomics 🧬 Fixed and live imaging 🔬.
#meiosis4ever her/she
Pinned
New faces = new intro !
We study how, where and when crossovers form during meiosis, using Arabidopsis 🌱 and Sordaria 🍄 as model organisms, with a combination of genomics 🧬 and imaging 🔬.
We are part of the I2BC in beautiful Gif-sur-Yvette, France.
www.i2bc.paris-saclay.fr/equipe-meiot...
We study how, where and when crossovers form during meiosis, using Arabidopsis 🌱 and Sordaria 🍄 as model organisms, with a combination of genomics 🧬 and imaging 🔬.
We are part of the I2BC in beautiful Gif-sur-Yvette, France.
www.i2bc.paris-saclay.fr/equipe-meiot...
Reposted by Chloe Girard, PhD
Team led by Tomoya Kitajima designed protein-based artificial #kinetochores to act as decoys to reduce bipolar microtubule pulling forces on chromosomes in aged mouse #oocytes, preventing premature #ChromosomeSegregation during meiosis I & II.
In @natcellbio.nature.com
👇
doi.org/10.1038/s415...
In @natcellbio.nature.com
👇
doi.org/10.1038/s415...
Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes - Nature Cell Biology
Zhou et al. design protein-based artificial kinetochore constructs as decoys to prevent premature chromosomal separation in aged oocytes. These constructs compete with chromosomal kinetochores, reduci...
doi.org
November 6, 2025 at 2:15 AM
Team led by Tomoya Kitajima designed protein-based artificial #kinetochores to act as decoys to reduce bipolar microtubule pulling forces on chromosomes in aged mouse #oocytes, preventing premature #ChromosomeSegregation during meiosis I & II.
In @natcellbio.nature.com
👇
doi.org/10.1038/s415...
In @natcellbio.nature.com
👇
doi.org/10.1038/s415...
Reposted by Chloe Girard, PhD
wikipedia's data shows that AI is siphoning traffic away from the site, which is a danger to its sustainability. ironically Wikipedia is more important than ever to users who want reliable information instead of slop, and to AI companies that need it for training data www.404media.co/wikipedia-sa...
Wikipedia Says AI Is Causing a Dangerous Decline in Human Visitors
“With fewer visits to Wikipedia, fewer volunteers may grow and enrich the content, and fewer individual donors may support this work.”
www.404media.co
October 17, 2025 at 1:15 AM
wikipedia's data shows that AI is siphoning traffic away from the site, which is a danger to its sustainability. ironically Wikipedia is more important than ever to users who want reliable information instead of slop, and to AI companies that need it for training data www.404media.co/wikipedia-sa...
Reposted by Chloe Girard, PhD
Want to understand how entire fungal chromosomes can be horizontally transferred?
Join us to unravel the mechanism/consequences of horizontal chromosome transfer in a fungal pathogen as part of an ERC-funded project. Postdoc/PhD positions available.
fungal-evolutionary-genetics.de/open-positio...
Join us to unravel the mechanism/consequences of horizontal chromosome transfer in a fungal pathogen as part of an ERC-funded project. Postdoc/PhD positions available.
fungal-evolutionary-genetics.de/open-positio...
Open Positions
ERC-funded project on the mechanism of horizontal transfer of entire fungal chromosomes PhD PostDoc
fungal-evolutionary-genetics.de
October 13, 2025 at 9:39 AM
Want to understand how entire fungal chromosomes can be horizontally transferred?
Join us to unravel the mechanism/consequences of horizontal chromosome transfer in a fungal pathogen as part of an ERC-funded project. Postdoc/PhD positions available.
fungal-evolutionary-genetics.de/open-positio...
Join us to unravel the mechanism/consequences of horizontal chromosome transfer in a fungal pathogen as part of an ERC-funded project. Postdoc/PhD positions available.
fungal-evolutionary-genetics.de/open-positio...
Reposted by Chloe Girard, PhD
Lost Science is a new NYT series of accounts from scientists who have lost their jobs or funding. You can send your story to the Times here www.nytimes.com/2025/10/08/c...
October 10, 2025 at 8:38 AM
Lost Science is a new NYT series of accounts from scientists who have lost their jobs or funding. You can send your story to the Times here www.nytimes.com/2025/10/08/c...
Beaucoup de mauvaises nouvelles, célébrons les bonnes !
Le programme EVARS en absolument génial ! Apprendre aux enfants le consentement ("est-ce que je peux te prendre dans mes bras pour te consoler?"), pour diminuer les risques d'abus d'enfants = impératif !!
www.education.gouv.fr/sites/defaul...
Le programme EVARS en absolument génial ! Apprendre aux enfants le consentement ("est-ce que je peux te prendre dans mes bras pour te consoler?"), pour diminuer les risques d'abus d'enfants = impératif !!
www.education.gouv.fr/sites/defaul...
www.education.gouv.fr
October 10, 2025 at 9:14 AM
Beaucoup de mauvaises nouvelles, célébrons les bonnes !
Le programme EVARS en absolument génial ! Apprendre aux enfants le consentement ("est-ce que je peux te prendre dans mes bras pour te consoler?"), pour diminuer les risques d'abus d'enfants = impératif !!
www.education.gouv.fr/sites/defaul...
Le programme EVARS en absolument génial ! Apprendre aux enfants le consentement ("est-ce que je peux te prendre dans mes bras pour te consoler?"), pour diminuer les risques d'abus d'enfants = impératif !!
www.education.gouv.fr/sites/defaul...
Reposted by Chloe Girard, PhD
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
nyti.ms
October 8, 2025 at 11:29 PM
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
1st desk rejection ! I am very proud of this paper and will persist nevertheless,
Wish me luck (and share the paper widely ! Yes, I am doing shameless self-promotion) !
💪
Wish me luck (and share the paper widely ! Yes, I am doing shameless self-promotion) !
💪
🚨 First pre-print from my team !!
TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
October 6, 2025 at 8:18 AM
1st desk rejection ! I am very proud of this paper and will persist nevertheless,
Wish me luck (and share the paper widely ! Yes, I am doing shameless self-promotion) !
💪
Wish me luck (and share the paper widely ! Yes, I am doing shameless self-promotion) !
💪
Reposted by Chloe Girard, PhD
Nature research paper: Holliday junction–ZMM protein feedback enables meiotic crossover assurance
go.nature.com/42JHXnV
go.nature.com/42JHXnV
Holliday junction–ZMM protein feedback enables meiotic crossover assurance - Nature
Holliday junctions maintain chromosome synapsis to enable crossover assurance in budding yeast.
go.nature.com
September 30, 2025 at 7:47 AM
Nature research paper: Holliday junction–ZMM protein feedback enables meiotic crossover assurance
go.nature.com/42JHXnV
go.nature.com/42JHXnV
Reposted by Chloe Girard, PhD
Wow this is quite amazing - I know almost nothing on recombination, but always assumed that the more similar the sequences were, the more likely they would recombine, turns out it's the opposite!
🚨 First pre-print from my team !!
TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
October 1, 2025 at 7:32 PM
Wow this is quite amazing - I know almost nothing on recombination, but always assumed that the more similar the sequences were, the more likely they would recombine, turns out it's the opposite!
This is the work of a tremendous PhD student, Benoit Madec, who did everything in this study (genetics, molecular biology, all the bioinformatics analyses)
He defended his PhD on Monday and is now Dr Madec!
I am very proud of him and all the work he has accomplished!
He defended his PhD on Monday and is now Dr Madec!
I am very proud of him and all the work he has accomplished!
October 1, 2025 at 9:05 AM
This is the work of a tremendous PhD student, Benoit Madec, who did everything in this study (genetics, molecular biology, all the bioinformatics analyses)
He defended his PhD on Monday and is now Dr Madec!
I am very proud of him and all the work he has accomplished!
He defended his PhD on Monday and is now Dr Madec!
I am very proud of him and all the work he has accomplished!
🚨 First pre-print from my team !!
TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
October 1, 2025 at 8:31 AM
🚨 First pre-print from my team !!
TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
TL;DR: presence of polymorphism (sequence differences between the homologous chromosomes) can *increase* the local rate of recombination in Arabidopsis thaliana, turning cold regions of the genome hot (purple v. grey) !
Paper submitted! Not rejected yet!! Celebration is required 🥳
Thread will come as soon as it appears on BioRxiv
🥂
Thread will come as soon as it appears on BioRxiv
🥂
September 19, 2025 at 3:57 PM
Paper submitted! Not rejected yet!! Celebration is required 🥳
Thread will come as soon as it appears on BioRxiv
🥂
Thread will come as soon as it appears on BioRxiv
🥂
Congratulations @heidiserra.bsky.social for your @cnrs.fr Bronze Medal !!!
www.insb.cnrs.fr/fr/personne/...
So proud to have such a badass friend and colleague !
#meiosis4ever
www.insb.cnrs.fr/fr/personne/...
So proud to have such a badass friend and colleague !
#meiosis4ever
July 10, 2025 at 12:52 PM
Congratulations @heidiserra.bsky.social for your @cnrs.fr Bronze Medal !!!
www.insb.cnrs.fr/fr/personne/...
So proud to have such a badass friend and colleague !
#meiosis4ever
www.insb.cnrs.fr/fr/personne/...
So proud to have such a badass friend and colleague !
#meiosis4ever
Reposted by Chloe Girard, PhD
One thing to emphasize strongly is that funding to science is like oxygen to the brain. Temporarily restricting oxygen flow for ten minutes (while you figure your shit out) is going to have the same outcome as shutting oxygen off permanently.
We are close to the ten minute mark.
We are close to the ten minute mark.
The current administration has more successfully destroyed US science and the scientific enterprise than the hypothetical nuclear weapons program in Iran.
NEW: NSF will be kicked out of their building. Announcement will be made tomorrow by HUD Sec. and Governor of VA. HUD will take over the NSF building over the next two years.
NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
NSF staffer: "There is no planning for NSF, no identified future location, appropriation for a new building or a move."
June 25, 2025 at 3:46 PM
One thing to emphasize strongly is that funding to science is like oxygen to the brain. Temporarily restricting oxygen flow for ten minutes (while you figure your shit out) is going to have the same outcome as shutting oxygen off permanently.
We are close to the ten minute mark.
We are close to the ten minute mark.
Reposted by Chloe Girard, PhD
Je reprends la métaphore de Robin Jamet : mobilisons-nous pour le Palais de la découverte et faisons-en le panda de la CSTI, l'espèce emblématique qui attire l'attention sur l'état d'un écosystème et amène à le préserver. 🐼
#Podcast du jour > Né sous l’impulsion de Jean Perrin en 1937, le Palais de la découverte est fermé depuis 2020 pour rénovation, le doute plane désormais sur sa réouverture en 2026, et sur l'avenir de la culture scientifique en général tinyurl.com/27kd37vu à (ré)écouter sur @franceculture.fr !
Palais de la découverte : un musée en danger
Né sous l’impulsion de Jean Perrin en 1937, le Palais de la découverte est célèbre pour son planétarium ou encore sa salle consacrée à l'électricité. Fermé depuis 2020 pour rénovation, le doute plane ...
tinyurl.com
June 24, 2025 at 3:29 PM
Je reprends la métaphore de Robin Jamet : mobilisons-nous pour le Palais de la découverte et faisons-en le panda de la CSTI, l'espèce emblématique qui attire l'attention sur l'état d'un écosystème et amène à le préserver. 🐼
Reposted by Chloe Girard, PhD
Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes.
🔗: doi.org/10.1016/j.ce...
#Genomics #Evolution #CellBiology #LECA
🔗: doi.org/10.1016/j.ce...
#Genomics #Evolution #CellBiology #LECA
June 22, 2025 at 12:15 AM
Excited to share our new paper in @cellreports.bsky.social that reshapes our understanding of chromosome organization's deep evolutionary roots! Our work dives into the origins of the machinery that structures our very genomes.
🔗: doi.org/10.1016/j.ce...
#Genomics #Evolution #CellBiology #LECA
🔗: doi.org/10.1016/j.ce...
#Genomics #Evolution #CellBiology #LECA
We’re here for the EMBO meiosis 2025 in Engelberg!
Very nice venue, thank you Kirsten Bomblies and Marinela Dukic for organizing!
Very nice venue, thank you Kirsten Bomblies and Marinela Dukic for organizing!
June 22, 2025 at 3:26 PM
We’re here for the EMBO meiosis 2025 in Engelberg!
Very nice venue, thank you Kirsten Bomblies and Marinela Dukic for organizing!
Very nice venue, thank you Kirsten Bomblies and Marinela Dukic for organizing!
Reposted by Chloe Girard, PhD
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
June 16, 2025 at 3:14 PM
🧬🌽 Happy Transposon Day! 🌽🧬
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Today we celebrate the birthday of Barbara McClintock - scientist extraordinaire and discoverer of jumping genes. Still the only woman to have an unshared Nobel Prize in the biomedical sciences #TransposonDay2025
Reposted by Chloe Girard, PhD
Rappel parce qu’apparemment c’est pas intégré par tout le monde :
Les variétés issue de mutagenèse aléatoire sont bien des OGM (décision de la CJUE en 2018) mais elles sont exemptées de régulation. Ainsi elles sont exemptées de mesures de traçabilité et d’évaluation des risques !
Les variétés issue de mutagenèse aléatoire sont bien des OGM (décision de la CJUE en 2018) mais elles sont exemptées de régulation. Ainsi elles sont exemptées de mesures de traçabilité et d’évaluation des risques !
June 12, 2025 at 10:03 AM
Rappel parce qu’apparemment c’est pas intégré par tout le monde :
Les variétés issue de mutagenèse aléatoire sont bien des OGM (décision de la CJUE en 2018) mais elles sont exemptées de régulation. Ainsi elles sont exemptées de mesures de traçabilité et d’évaluation des risques !
Les variétés issue de mutagenèse aléatoire sont bien des OGM (décision de la CJUE en 2018) mais elles sont exemptées de régulation. Ainsi elles sont exemptées de mesures de traçabilité et d’évaluation des risques !
Look at that red nucleus stretching like CRAZY ! Who knew nuclei could do that ! DNA stretching, sure, but what about the nuclear membrane ?! (scale bar 10µm !)
The longest measured nucleus reached 71µm !!
The longest measured nucleus reached 71µm !!
June 10, 2025 at 9:02 AM
Look at that red nucleus stretching like CRAZY ! Who knew nuclei could do that ! DNA stretching, sure, but what about the nuclear membrane ?! (scale bar 10µm !)
The longest measured nucleus reached 71µm !!
The longest measured nucleus reached 71µm !!
Reposted by Chloe Girard, PhD
Man comes to the US from Lebanon. Starts out delivering pizzas, becomes a Nobel winning neuroscientist. Trump freezes his funding, he gets an email from China offering to move his lab “any city, any university I want" with guaranteed funding for 20 years.
What are we doing?
What are we doing?
June 3, 2025 at 7:49 PM
Man comes to the US from Lebanon. Starts out delivering pizzas, becomes a Nobel winning neuroscientist. Trump freezes his funding, he gets an email from China offering to move his lab “any city, any university I want" with guaranteed funding for 20 years.
What are we doing?
What are we doing?
Reposted by Chloe Girard, PhD
This is a rupture, there will be a before and an after. There is no reason to believe the after will resemble the before, at all. This is a demarcation in the lives of thousands of researchers and tens of thousands of educators.
June 3, 2025 at 9:16 PM
This is a rupture, there will be a before and an after. There is no reason to believe the after will resemble the before, at all. This is a demarcation in the lives of thousands of researchers and tens of thousands of educators.
Reposted by Chloe Girard, PhD
A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social
www.jobs.cam.ac.uk/job/51488/
www.jobs.cam.ac.uk/job/51488/
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Plant Sciences at the University of Cambridge.
www.jobs.cam.ac.uk
May 30, 2025 at 12:13 PM
A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social
www.jobs.cam.ac.uk/job/51488/
www.jobs.cam.ac.uk/job/51488/
Les gnocchi rôtis de @owiowifouettemoi.bsky.social c’est l’invention géniale
June 1, 2025 at 5:42 PM
Les gnocchi rôtis de @owiowifouettemoi.bsky.social c’est l’invention géniale
What a joy it was!
Thank you to @namekawasatoshi.bsky.social and @cohenlab.bsky.social for their HUGE help organizing this meeting !!
The French crew will organize next year's meeting as well, but will hand over the reins to another #Meiosis4ever community for 2027 !
Thank you to @namekawasatoshi.bsky.social and @cohenlab.bsky.social for their HUGE help organizing this meeting !!
The French crew will organize next year's meeting as well, but will hand over the reins to another #Meiosis4ever community for 2027 !
It's a wrap for #MAYosis25 !
Thank you to all speakers for sharing their latest data, it was a great meeting!
Thanks to all the attendees for all the questions, this is a truly vibrant community!
See you next year!
--> updated Meiosis4ever starter kits
go.bsky.app/P3BJYze
go.bsky.app/Tdxbm9b
Thank you to all speakers for sharing their latest data, it was a great meeting!
Thanks to all the attendees for all the questions, this is a truly vibrant community!
See you next year!
--> updated Meiosis4ever starter kits
go.bsky.app/P3BJYze
go.bsky.app/Tdxbm9b
May 28, 2025 at 5:21 PM
What a joy it was!
Thank you to @namekawasatoshi.bsky.social and @cohenlab.bsky.social for their HUGE help organizing this meeting !!
The French crew will organize next year's meeting as well, but will hand over the reins to another #Meiosis4ever community for 2027 !
Thank you to @namekawasatoshi.bsky.social and @cohenlab.bsky.social for their HUGE help organizing this meeting !!
The French crew will organize next year's meeting as well, but will hand over the reins to another #Meiosis4ever community for 2027 !