Carolina Makowski
@cmakowski.bsky.social
Neuroscientist 🧠🧬, movement lover 💃🏻 & resolute runner 🏃🏻♀️ | Asst Prof Psychiatry UCSD 🌴 | #FirstGenAcademic 🇨🇦🇵🇱| bridgelab.ucsd.edu
Reposted by Carolina Makowski
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders
rdcu.be/ePmwD
rdcu.be/ePmwD
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Nature Neuroscience - Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations....
rdcu.be
November 12, 2025 at 12:12 PM
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders
rdcu.be/ePmwD
rdcu.be/ePmwD
Reposted by Carolina Makowski
Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉
📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025...
Funded by National Institute of Mental Health (NIMH)
Funded by National Institute of Mental Health (NIMH)
Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health
Major mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopat...
doi.org
September 22, 2025 at 9:51 PM
Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉
📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io
The BRIDGE Lab has officially been launched! 🔗 bridgelab.ucsd.edu 👉 we Bridge Research in Imaging, Development, Genetics and Emerging mental health 🧠 🧬 🚸 🌉 please don't be shy to reach out if you are interested in learning more about our lab's research!
BRIDGE Lab
Welcome to the BRIDGE Lab (Bridging Research across Imaging, Development, Genetics, and Emerging Mental Health) within the Department of Psychiatry at the University of California San Diego! Our resea...
bridgelab.ucsd.edu
September 10, 2025 at 4:09 PM
The BRIDGE Lab has officially been launched! 🔗 bridgelab.ucsd.edu 👉 we Bridge Research in Imaging, Development, Genetics and Emerging mental health 🧠 🧬 🚸 🌉 please don't be shy to reach out if you are interested in learning more about our lab's research!
My fave part of attending #flux2025- connecting with talented trainees! 😊
It’s my third time at @fluxsociety.bsky.social and I’m thankful not just for the science, but also the intentional community-building and professional development of trainees. Glad to hear from @cmakowski.bsky.social that not all who wander are lost!
September 7, 2025 at 7:36 AM
My fave part of attending #flux2025- connecting with talented trainees! 😊
Super happy to see our latest research on multivariate brain-behavior patterns in adolescent eating disorders out in Molecular Psychiatry!
🔗Link to paper: rdcu.be/ewxpg
🗣️Lay summary thread of our work: tinyurl.com/dscnhduf
🔗Link to paper: rdcu.be/ewxpg
🗣️Lay summary thread of our work: tinyurl.com/dscnhduf
Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders
Molecular Psychiatry - Multivariate patterns linking brain microstructure to temperament and behavior in adolescent eating disorders
rdcu.be
August 7, 2025 at 10:00 PM
Super happy to see our latest research on multivariate brain-behavior patterns in adolescent eating disorders out in Molecular Psychiatry!
🔗Link to paper: rdcu.be/ewxpg
🗣️Lay summary thread of our work: tinyurl.com/dscnhduf
🔗Link to paper: rdcu.be/ewxpg
🗣️Lay summary thread of our work: tinyurl.com/dscnhduf
Reposted by Carolina Makowski
The ABCD Study 6.0 release is finally here! 🧠 Apply for data access here @theabcdstudy.bsky.social www.nbdc-datahub.org
NBDC Data Hub
NIH Brain Development Cohorts (NBDC) Data Sharing Platform: Unifying ABCD and HBCD data management in one powerful platform.
www.nbdc-datahub.org
June 26, 2025 at 11:16 PM
The ABCD Study 6.0 release is finally here! 🧠 Apply for data access here @theabcdstudy.bsky.social www.nbdc-datahub.org
Do you use ABCD study data and/or are interested in shaping the next phase of the study? Please join our roundtable in mezzanine 3! @ohbmofficial.bsky.social #OHBM2025
June 25, 2025 at 11:19 PM
Do you use ABCD study data and/or are interested in shaping the next phase of the study? Please join our roundtable in mezzanine 3! @ohbmofficial.bsky.social #OHBM2025
Super excited to be in Brisbane! Come check out new work from our group using ABCD study data and clinical data with the ABCD imaging protocol!
Posters:
📅 W/Th June 25th/26th
@cmakowski.bsky.social
🧠 “Multivariate patterns linking brain microstructure to behavior in adolescent eating disorders”
@parekhpravesh.bsky.social
🧠 “Modeling time-varying covariance with FEMA for large-scale longitudinal imaging and omics data”
📅 W/Th June 25th/26th
@cmakowski.bsky.social
🧠 “Multivariate patterns linking brain microstructure to behavior in adolescent eating disorders”
@parekhpravesh.bsky.social
🧠 “Modeling time-varying covariance with FEMA for large-scale longitudinal imaging and omics data”
June 25, 2025 at 12:45 AM
Super excited to be in Brisbane! Come check out new work from our group using ABCD study data and clinical data with the ABCD imaging protocol!
Reposted by Carolina Makowski
Don’t miss more exciting research and discussion from our team:
Roundtable Discussion:
@cmakowski.bsky.social & @parekhpravesh.bsky.social
📅 Thursday, June 26th | ⏰ 13:00 - 14:00
“Shaping the Future of the ABCD Study: A Roundtable Discussion”
Roundtable Discussion:
@cmakowski.bsky.social & @parekhpravesh.bsky.social
📅 Thursday, June 26th | ⏰ 13:00 - 14:00
“Shaping the Future of the ABCD Study: A Roundtable Discussion”
June 24, 2025 at 11:56 PM
Don’t miss more exciting research and discussion from our team:
Roundtable Discussion:
@cmakowski.bsky.social & @parekhpravesh.bsky.social
📅 Thursday, June 26th | ⏰ 13:00 - 14:00
“Shaping the Future of the ABCD Study: A Roundtable Discussion”
Roundtable Discussion:
@cmakowski.bsky.social & @parekhpravesh.bsky.social
📅 Thursday, June 26th | ⏰ 13:00 - 14:00
“Shaping the Future of the ABCD Study: A Roundtable Discussion”
Reposted by Carolina Makowski
Introducing FEMA-Long for high-dimensional large-scale mixed-effects modelling! Includes modelling unstructured covariance, non-linear effects using splines, time-dependent effects with spline interactions, and longitudinal GWAS with time-dependent genetic effects!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets
Linear mixed-effects (LME) models are commonly used for analyzing longitudinal data. However, most applications of LME models rely on random intercepts or simple, e.g., stationary, covariance. Here, w...
www.biorxiv.org
May 16, 2025 at 3:22 PM
Introducing FEMA-Long for high-dimensional large-scale mixed-effects modelling! Includes modelling unstructured covariance, non-linear effects using splines, time-dependent effects with spline interactions, and longitudinal GWAS with time-dependent genetic effects!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Carolina Makowski
🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis.
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
May 12, 2025 at 1:09 AM
🧠💊New preprint differentiating antipsychotic medication vs. illness effects on cortical thickness in people w/ psychosis.
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
Finding: People receiving placebo show prominent cortical thinning over 1st year of illness, whereas those receiving antipsychotics do not. 1/3
www.medrxiv.org/content/10.1...
an absolute tour de force! Congrats @goliashf.bsky.social & team!
(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025...
Funded by National Institute of Mental Health (NIMH)
Funded by National Institute of Mental Health (NIMH)
Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health
Major mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopat...
doi.org
February 28, 2025 at 6:25 AM
an absolute tour de force! Congrats @goliashf.bsky.social & team!
Reposted by Carolina Makowski
🔍 New must-see resource! 🧠
--> Reproducible Brain Charts – an open-data tool for mapping brain development & mental health
www.biorxiv.org/content/10.1...
👏 Kudos to @ted-satterthwaite.bsky.social and Michael Milham @childmindinstitute.bsky.social for leading this effort!
--> Reproducible Brain Charts – an open-data tool for mapping brain development & mental health
www.biorxiv.org/content/10.1...
👏 Kudos to @ted-satterthwaite.bsky.social and Michael Milham @childmindinstitute.bsky.social for leading this effort!
February 27, 2025 at 1:30 PM
🔍 New must-see resource! 🧠
--> Reproducible Brain Charts – an open-data tool for mapping brain development & mental health
www.biorxiv.org/content/10.1...
👏 Kudos to @ted-satterthwaite.bsky.social and Michael Milham @childmindinstitute.bsky.social for leading this effort!
--> Reproducible Brain Charts – an open-data tool for mapping brain development & mental health
www.biorxiv.org/content/10.1...
👏 Kudos to @ted-satterthwaite.bsky.social and Michael Milham @childmindinstitute.bsky.social for leading this effort!
Since good news feels rare these days, excited to share a win - My R00 was awarded! Will be looking for a postdoc soon to help uncover biological 🧠🧬 & behavioral prospective 📈factors for adolescent eating disorders 🍽️ @ucsdhealthsci.bsky.social @ucsdhealth.bsky.social
February 19, 2025 at 7:45 PM
Since good news feels rare these days, excited to share a win - My R00 was awarded! Will be looking for a postdoc soon to help uncover biological 🧠🧬 & behavioral prospective 📈factors for adolescent eating disorders 🍽️ @ucsdhealthsci.bsky.social @ucsdhealth.bsky.social
Reposted by Carolina Makowski
jamanetwork.com/journals/jam...
Thread below👇
Thread below👇
Mapping Lesions That Cause Psychosis
This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit
jamanetwork.com
February 12, 2025 at 9:47 PM
jamanetwork.com/journals/jam...
Thread below👇
Thread below👇
Reposted by Carolina Makowski
Synaptome architecture shapes regional dynamics in the mouse brain | www.biorxiv.org/content/10.1...
Led by Justine Hansen
Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️
Led by Justine Hansen
Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️
February 12, 2025 at 6:23 PM
Synaptome architecture shapes regional dynamics in the mouse brain | www.biorxiv.org/content/10.1...
Led by Justine Hansen
Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️
Led by Justine Hansen
Big news: there are all sorts of different synapse types in the brain 👀‼️⤵️
Reposted by Carolina Makowski
A Direct Hit, by @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"This is a moment to unite."
www.science.org/doi/full/10....
"This is a moment to unite."
February 11, 2025 at 3:18 PM
A Direct Hit, by @holdenthorp.bsky.social @science.org
www.science.org/doi/full/10....
"This is a moment to unite."
www.science.org/doi/full/10....
"This is a moment to unite."