(Cell Metabolism 23, 206–219; January 12, 2016)

In a combined analysis of two large patient cohorts, three peripheral consensus transcriptomic subtypes of sepsis are identified, which can be linked to an 18-gene classifier associated with different odds of mortality and may offer a way to tailor care for patients with sepsis.

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Picard and Murugan introduce the energy resistance principle (ERP), a testable framework outlining how resistance to energy flow sustains life and shapes health. Excess resistance (éR) promotes hallmarks of disease, whereas restorative states minimize éR, thus linking the biophysics of energy to human health, aging, and healing.

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

Aging, a universal and inevitable process, is characterized by a progressive accumulation of physiological alterations and functional decline over tim…

The connection between the respiratory capacity of skeletal muscle mitochondria and athletic performance is widely acknowledged in contemporary resear…

Gallium is used as a sacrificial agent and mixing medium for the isothermal solidification synthesis of high-entropy alloy nanomaterials with diverse crystallinities and morphologies.

Childhood obesity rates have surpassed those of undernutrition for the first time, suggesting efforts to combat malnutrition will have to shift gears.

Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD).

Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

From 2010 to 2019, NCD mortality declined in four of every five countries in the world. These improvements were not as large as the preceding decade for most countries, driven by smaller declines in m...

Brown adipose tissue (BAT) is key for metabolic balance. Here, the authors show that RAP250 deficiency enhances BAT activity. Under these conditions, BAT-derived neuritin-1 regulates thermogenesis and...

Abstract figure legend Sprint interval training (SIT) is a popular time-efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all-out cycling sprints) over 3...

Tissue-specific mRNA or gene editing machinery delivery is achieved with lipid nanoparticles containing peptides with specific sequences, which tune the protein corona of the particles by mechanical o...

Obesity-associated saturated long-chain fatty acids regulate lung macrophage phenotype and function at steady state and during lung inflammation.

This randomized controlled nutrition intervention conducted in males of reproductive age shows that, compared with an unprocessed diet, consumption of ultra-processed foods impairs metabolic and repro...

Chen et al. show that Mist1+ cells resist oxidative stress by upregulating Bnip3/Tmed6, with sustained ROS activating YAP to drive cell proliferationwhile synergizing with Kras mutation in a “double-h...

Loss of mitochondrial quality control is closely associated with the onset of neurodegeneration. Basak & Holzbaur demonstrate neuron-specific stress response mechanisms that eliminate damaged mito...