Daniel Figeys
@dfigeys.bsky.social
Precision-function-based microbiome trials.
Ex vivo microbiome assays.
Microbiome–xenobiotic interactions.
Meta-omics analyses
Ex vivo microbiome assays.
Microbiome–xenobiotic interactions.
Meta-omics analyses
Reposted by Daniel Figeys
🆕 Anti-depressant drugs cause profound changes to the human gut microbiome, but these changes could be mitigated by prebiotics, according to a major new survey of how the microbial community in the gut responds to different therapeutic drugs 💊
@dfigeys.bsky.social
buff.ly/uKd5PDv
@dfigeys.bsky.social
buff.ly/uKd5PDv
Prebiotics reverse effects of anti-depressants on the gut microbiome - Quadram Institute
Scientists from the University of Ottawa and Beijing Institute of Lifeomics found that SSRIs, SNRIs and Tricyclic Antidepressants, commonly prescribed anti-depressants that target the…
buff.ly
November 20, 2025 at 12:15 PM
🆕 Anti-depressant drugs cause profound changes to the human gut microbiome, but these changes could be mitigated by prebiotics, according to a major new survey of how the microbial community in the gut responds to different therapeutic drugs 💊
@dfigeys.bsky.social
buff.ly/uKd5PDv
@dfigeys.bsky.social
buff.ly/uKd5PDv
Reposted by Daniel Figeys
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in
the scientific literature and popular press. Mitchell et al. critically examine influential
studies underpinning these...
www.cell.com
November 15, 2025 at 5:15 PM
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism www.cell.com/neuron/fullt...
Functional redundancy matters: the more overlapping microbial functions you have, the more resilient your #microbiome. We showed a strong negative correlation between redundancy loss and increase in #antimicrobial resistance protein upon #drug treatment of microbiomes.
@quadraminstitute.bsky.social
@quadraminstitute.bsky.social
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social
rdcu.be/eMmcT
@quadraminstitute.bsky.social
rdcu.be/eMmcT
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs
Nature Communications - Here, the authors systematically map metaproteomic responses of ex vivo human gut microbiota to common therapeutics, identifying several drug classes inducing strong...
rdcu.be
October 29, 2025 at 10:22 AM
Functional redundancy matters: the more overlapping microbial functions you have, the more resilient your #microbiome. We showed a strong negative correlation between redundancy loss and increase in #antimicrobial resistance protein upon #drug treatment of microbiomes.
@quadraminstitute.bsky.social
@quadraminstitute.bsky.social
Interestingly, #drugs for the nervous system (antidepressants/antipsychotics) stand out: #SSRI/ #SNRI/ #TCA push the gut #microbiome into alternate states, lowering functional redundancy(lower capacity to respond) and ramping up antimicrobial-resistance proteins.
@quadraminstitute.bsky.social
@quadraminstitute.bsky.social
From #drug cabinet → gut #microbiome: screening 312 therapeutic compounds, we mapped 4.6 million microbial protein-level responses to reveal how our drugs don’t just target us, they hit our gut microbes too.
rdcu.be/eMmcT
rdcu.be/eMmcT
October 27, 2025 at 7:32 AM
Interestingly, #drugs for the nervous system (antidepressants/antipsychotics) stand out: #SSRI/ #SNRI/ #TCA push the gut #microbiome into alternate states, lowering functional redundancy(lower capacity to respond) and ramping up antimicrobial-resistance proteins.
@quadraminstitute.bsky.social
@quadraminstitute.bsky.social
Reposted by Daniel Figeys
1 in 5 people in the UK are estimated to be deficient in #vitaminD during winter and spring 📉
Our ViTaL-D Study aims to understand whether tomatoes biofortified through gene-editing tomatoes to be high in vitamin D leads to higher levels of active vitamin D in the blood 🍅
➡️ buff.ly/SIsELo6
Our ViTaL-D Study aims to understand whether tomatoes biofortified through gene-editing tomatoes to be high in vitamin D leads to higher levels of active vitamin D in the blood 🍅
➡️ buff.ly/SIsELo6
October 26, 2025 at 4:03 PM
1 in 5 people in the UK are estimated to be deficient in #vitaminD during winter and spring 📉
Our ViTaL-D Study aims to understand whether tomatoes biofortified through gene-editing tomatoes to be high in vitamin D leads to higher levels of active vitamin D in the blood 🍅
➡️ buff.ly/SIsELo6
Our ViTaL-D Study aims to understand whether tomatoes biofortified through gene-editing tomatoes to be high in vitamin D leads to higher levels of active vitamin D in the blood 🍅
➡️ buff.ly/SIsELo6
From #drug cabinet → gut #microbiome: screening 312 therapeutic compounds, we mapped 4.6 million microbial protein-level responses to reveal how our drugs don’t just target us, they hit our gut microbes too.
rdcu.be/eMmcT
rdcu.be/eMmcT
October 26, 2025 at 7:09 AM
From #drug cabinet → gut #microbiome: screening 312 therapeutic compounds, we mapped 4.6 million microbial protein-level responses to reveal how our drugs don’t just target us, they hit our gut microbes too.
rdcu.be/eMmcT
rdcu.be/eMmcT
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social
rdcu.be/eMmcT
@quadraminstitute.bsky.social
rdcu.be/eMmcT
Systematic metaproteomics mapping reveals functional and ecological landscapes of Ex vivo human gut microbiota responses to therapeutic drugs
Nature Communications - Here, the authors systematically map metaproteomic responses of ex vivo human gut microbiota to common therapeutics, identifying several drug classes inducing strong...
rdcu.be
October 24, 2025 at 4:20 PM
Interested in #drugs, #microbiome and #antibiotic resistance, then check out our paper on the effects of over 300 drugs on the gut microbiome. Exciting results as well on the role of antibiotic resistance defining how microbiomes respond to drugs.
@quadraminstitute.bsky.social
rdcu.be/eMmcT
@quadraminstitute.bsky.social
rdcu.be/eMmcT
Reposted by Daniel Figeys
We were delighted to welcome Sir Ian Chapman the new CEO of @ukri.org , together with BBSRC representatives, to Norwich Research Park today hear about our world leading bioscience.
Discover more about our research at the Quadram Institute
➡️ buff.ly/NZYHB2r
Discover more about our research at the Quadram Institute
➡️ buff.ly/NZYHB2r
October 23, 2025 at 4:15 PM
We were delighted to welcome Sir Ian Chapman the new CEO of @ukri.org , together with BBSRC representatives, to Norwich Research Park today hear about our world leading bioscience.
Discover more about our research at the Quadram Institute
➡️ buff.ly/NZYHB2r
Discover more about our research at the Quadram Institute
➡️ buff.ly/NZYHB2r
Reposted by Daniel Figeys
Exposure to sugar early in life: a natural experiment among >63,000 @uk_biobank participants: rationing of sugar was associated with less cardiovascular risk in adulthood www.bmj.com/content/391/...
Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes: natural experiment study
Objective To examine whether exposure to sugar rationing during early life is associated with a reduction in the risk of cardiovascular outcomes in adulthood.
Design Natural experiment study.
Settin...
www.bmj.com
October 23, 2025 at 12:44 AM
Exposure to sugar early in life: a natural experiment among >63,000 @uk_biobank participants: rationing of sugar was associated with less cardiovascular risk in adulthood www.bmj.com/content/391/...
Reposted by Daniel Figeys
“This study is particularly important to me as it took place during my post doc years at the @uniofeastanglia.bsky.social and it has been a source of inspiration for my current research line, as a newly appointed Early Career Fellow at the Quadram Institute."
💬 Dr Serena Monaco
💬 Dr Serena Monaco
New technique to speed up the design of drugs targeting proteins in the cell membrane - Quadram Institute
An team has developed a new technique that will speed up the design of drugs targeting ion channels, a type of cell membrane protein
buff.ly
October 2, 2025 at 8:37 AM
“This study is particularly important to me as it took place during my post doc years at the @uniofeastanglia.bsky.social and it has been a source of inspiration for my current research line, as a newly appointed Early Career Fellow at the Quadram Institute."
💬 Dr Serena Monaco
💬 Dr Serena Monaco
Reposted by Daniel Figeys
“Vitamin D deficiency represents a significant public health concern, especially during the winter months with significant deficiency across the UK population."
💬 Professor Martin Warren, our Chief Scientific Officer
💬 Professor Martin Warren, our Chief Scientific Officer
Vitamin D3 concentrations are lowered by common vitamin D supplement - Quadram Institute
Taking vitamin D2 might be lowering the body's levels of the more efficient form of vitamin D, vitamin D3, according to new research
buff.ly
September 22, 2025 at 8:11 AM
“Vitamin D deficiency represents a significant public health concern, especially during the winter months with significant deficiency across the UK population."
💬 Professor Martin Warren, our Chief Scientific Officer
💬 Professor Martin Warren, our Chief Scientific Officer
Reposted by Daniel Figeys
Maternal emulsifier consumption alters the offspring microbiota leading to long-lasting diseases susceptibility
www.nature.com/articles/s41...
Consumption of food additives during pregnancy alters offspring gut microbiota and increases inflammatory disease risk
medicalxpress.com/news/2025-09...
www.nature.com/articles/s41...
Consumption of food additives during pregnancy alters offspring gut microbiota and increases inflammatory disease risk
medicalxpress.com/news/2025-09...
Maternal emulsifier consumption alters the offspring early-life microbiota and goblet cell function leading to long-lasting diseases susceptibility - Nature Communications
Here, Delaroque et al. show that maternal intake of dietary emulsifiers alters offspring microbiota early in life, which, associated with perturbation of goblet cell function, promotes increased susce...
www.nature.com
September 22, 2025 at 1:54 AM
Maternal emulsifier consumption alters the offspring microbiota leading to long-lasting diseases susceptibility
www.nature.com/articles/s41...
Consumption of food additives during pregnancy alters offspring gut microbiota and increases inflammatory disease risk
medicalxpress.com/news/2025-09...
www.nature.com/articles/s41...
Consumption of food additives during pregnancy alters offspring gut microbiota and increases inflammatory disease risk
medicalxpress.com/news/2025-09...
This is an exciting position that will shape the direction of how we target the gut microbiome. Come join my lab at the Quadram Institute.
🆕 Vacancy! We're looking for a Senior Research Scientist to advance precision prebiotic microbiome intervention trials to study the interactions of prebiotics, drugs and other xenobiotics on the gut microbiome.
💷 £45,450 to £56,750
🗓️ Apply by 2 October 2025
➡️ buff.ly/BQKamDW
💷 £45,450 to £56,750
🗓️ Apply by 2 October 2025
➡️ buff.ly/BQKamDW
September 17, 2025 at 10:07 AM
This is an exciting position that will shape the direction of how we target the gut microbiome. Come join my lab at the Quadram Institute.
Interested in compound- microbiome interactions, and how they affect health? Join my lab at the Quadram Institute.
🆕 Vacancy! We're looking for a Research Scientist (Xenobiotics) to investigate xenobiotic–microbiome interactions and understand the variation in responses across different individual microbiomes.
💷 £37,500 to £45,350
🗓️ Apply by 2 October 2025
➡️ buff.ly/8abEye5
💷 £37,500 to £45,350
🗓️ Apply by 2 October 2025
➡️ buff.ly/8abEye5
September 16, 2025 at 9:57 AM
Interested in compound- microbiome interactions, and how they affect health? Join my lab at the Quadram Institute.
Interested in healthy aging and the microbiome? Join my lab to explore how ex vivo microbiome assays can guide personalized interventions that modulate specific microbiome-derived metabolites critical for health.
🆕 Vacancy! We're looking for a Research Scientist (Clinical Microbiome) to advance precision prebiotic microbiome intervention trials aimed at promoting healthy ageing.
💷 £37,500 to £45,350
🗓️ Apply by 2 October 2025
➡️ buff.ly/KGl7eiG
💷 £37,500 to £45,350
🗓️ Apply by 2 October 2025
➡️ buff.ly/KGl7eiG
September 16, 2025 at 9:52 AM
Interested in healthy aging and the microbiome? Join my lab to explore how ex vivo microbiome assays can guide personalized interventions that modulate specific microbiome-derived metabolites critical for health.
Reposted by Daniel Figeys
If you are UK-based and working on any aspect of microbiomes (human, plant, insect, soil, animal, ...), please do sign up to Microbiome-Net for details of networking, funding and training opportunities.
forms.office.com/pages/respon...
forms.office.com/pages/respon...
September 13, 2025 at 6:31 AM
If you are UK-based and working on any aspect of microbiomes (human, plant, insect, soil, animal, ...), please do sign up to Microbiome-Net for details of networking, funding and training opportunities.
forms.office.com/pages/respon...
forms.office.com/pages/respon...
Reposted by Daniel Figeys
🆕 Vacancy! We’re looking for a Chief Scientific Officer to support the development of the institute’s scientific strategy and scientific leadership of the institute.
💷 Competitive
🗓️ Apply by 12 October 2025
➡️ buff.ly/mKUhD3K
💷 Competitive
🗓️ Apply by 12 October 2025
➡️ buff.ly/mKUhD3K
September 12, 2025 at 2:00 PM
🆕 Vacancy! We’re looking for a Chief Scientific Officer to support the development of the institute’s scientific strategy and scientific leadership of the institute.
💷 Competitive
🗓️ Apply by 12 October 2025
➡️ buff.ly/mKUhD3K
💷 Competitive
🗓️ Apply by 12 October 2025
➡️ buff.ly/mKUhD3K
Thank you @microbiomevif.bsky.social for inviting me. Very insightful questions. Looking forward to follow up.
September 10, 2025 at 4:56 AM
Thank you @microbiomevif.bsky.social for inviting me. Very insightful questions. Looking forward to follow up.
Reposted by Daniel Figeys
@dfigeys.bsky.social speaks on:
"Life gut microbiome cryopreservation and assays"
@microbiotavault.bsky.social
"Life gut microbiome cryopreservation and assays"
@microbiotavault.bsky.social
September 9, 2025 at 1:52 PM
@dfigeys.bsky.social speaks on:
"Life gut microbiome cryopreservation and assays"
@microbiotavault.bsky.social
"Life gut microbiome cryopreservation and assays"
@microbiotavault.bsky.social
Reposted by Daniel Figeys
We were pleased to welcome Dr Yogesh Shouche, Director of SKAN Research Trust, to the Quadram Institute this week to discuss ongoing and future research collaborations.
Read more about our collaboration with the Bengaluru-based not-for-profit medical research trust🌏
➡️ buff.ly/TTa3VJj
Read more about our collaboration with the Bengaluru-based not-for-profit medical research trust🌏
➡️ buff.ly/TTa3VJj
September 4, 2025 at 9:01 AM
We were pleased to welcome Dr Yogesh Shouche, Director of SKAN Research Trust, to the Quadram Institute this week to discuss ongoing and future research collaborations.
Read more about our collaboration with the Bengaluru-based not-for-profit medical research trust🌏
➡️ buff.ly/TTa3VJj
Read more about our collaboration with the Bengaluru-based not-for-profit medical research trust🌏
➡️ buff.ly/TTa3VJj
Reposted by Daniel Figeys
“Obesity affects 30% of children by Year 6,” says Dr Emma Webb, a Consultant Pediatrician at @nnuh.bsky.social
Read how Emma is working with @narbadlab.bsky.social to gather data on the gut microbiome in childhood obesity
➡️ buff.ly/MgSiiLR
Read how Emma is working with @narbadlab.bsky.social to gather data on the gut microbiome in childhood obesity
➡️ buff.ly/MgSiiLR
September 3, 2025 at 7:02 PM
“Obesity affects 30% of children by Year 6,” says Dr Emma Webb, a Consultant Pediatrician at @nnuh.bsky.social
Read how Emma is working with @narbadlab.bsky.social to gather data on the gut microbiome in childhood obesity
➡️ buff.ly/MgSiiLR
Read how Emma is working with @narbadlab.bsky.social to gather data on the gut microbiome in childhood obesity
➡️ buff.ly/MgSiiLR
Peptides in sync.
Sun et al. analysed peptide abundance correlations across hundreds of #metaproteomic samples from drug‑treated human gut microbiomes. Correlation maps showed that peptides from the same microbial genome clustered together. Why is this interesting?
www.nature.com/articles/s41...
Sun et al. analysed peptide abundance correlations across hundreds of #metaproteomic samples from drug‑treated human gut microbiomes. Correlation maps showed that peptides from the same microbial genome clustered together. Why is this interesting?
www.nature.com/articles/s41...
Peptide abundance correlations in metaproteomics enhance taxonomic and functional analysis of the human gut microbiome - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Peptide abundance correlations in metaproteomics enhance taxonomic and functional analysis of the human gut microbiome
www.nature.com
August 22, 2025 at 6:14 AM
Peptides in sync.
Sun et al. analysed peptide abundance correlations across hundreds of #metaproteomic samples from drug‑treated human gut microbiomes. Correlation maps showed that peptides from the same microbial genome clustered together. Why is this interesting?
www.nature.com/articles/s41...
Sun et al. analysed peptide abundance correlations across hundreds of #metaproteomic samples from drug‑treated human gut microbiomes. Correlation maps showed that peptides from the same microbial genome clustered together. Why is this interesting?
www.nature.com/articles/s41...
Reposted by Daniel Figeys
"We welcome the new National Food Strategy’s focus on health. A stronger focus on the nutritional quality of food in the UK is badly needed to tackle pressing public health challenges.”
💬 Professor Martin Warren, our Chief Scientific Officer
Read more about our health research
➡️ buff.ly/6u65ztG
💬 Professor Martin Warren, our Chief Scientific Officer
Read more about our health research
➡️ buff.ly/6u65ztG
July 16, 2025 at 3:38 PM
"We welcome the new National Food Strategy’s focus on health. A stronger focus on the nutritional quality of food in the UK is badly needed to tackle pressing public health challenges.”
💬 Professor Martin Warren, our Chief Scientific Officer
Read more about our health research
➡️ buff.ly/6u65ztG
💬 Professor Martin Warren, our Chief Scientific Officer
Read more about our health research
➡️ buff.ly/6u65ztG
Reposted by Daniel Figeys
and here is the link to the paper > www.nature.com/articles/s41...
Non-antibiotics disrupt colonization resistance against enteropathogens - Nature
Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of such drugs.
www.nature.com
July 18, 2025 at 8:29 AM
and here is the link to the paper > www.nature.com/articles/s41...
Reposted by Daniel Figeys
We were pleased to welcome @ukri.org and BBSRC to the Norwich Research Park today, which included a tour of our Clinical Research Facility Kitchen to chat about our collaborative work with the @johninnescentre.bsky.social on vitamin D 🔬
Read more about our research
➡️ buff.ly/f8mEx9J
Read more about our research
➡️ buff.ly/f8mEx9J
July 14, 2025 at 3:50 PM
We were pleased to welcome @ukri.org and BBSRC to the Norwich Research Park today, which included a tour of our Clinical Research Facility Kitchen to chat about our collaborative work with the @johninnescentre.bsky.social on vitamin D 🔬
Read more about our research
➡️ buff.ly/f8mEx9J
Read more about our research
➡️ buff.ly/f8mEx9J