Marija Dramicanin
@dramarija.bsky.social
240 followers
450 following
19 posts
Head of Protein Production Facility at Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
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Reposted by Marija Dramicanin
Reposted by Marija Dramicanin
Cyntia Taveneau
@cyntiat.bsky.social
· Sep 2
Code to complex: AI-driven de novo binder design
In this review, Fox et al. discuss how artificial intelligence has transformed our
ability to design new-to-nature proteins that bind target proteins with high affinity
and specificity. The authors de...
www.cell.com
Reposted by Marija Dramicanin
Reposted by Marija Dramicanin
Marija Dramicanin
@dramarija.bsky.social
· Jul 10
Marija Dramicanin
@dramarija.bsky.social
· Jul 10
Rhys Grinter
@rhyswg.bsky.social
· Jul 9
Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins - Nature Communications
Many pathogens encode transporters that extract heme directly from host proteins. In this study, the authors demonstrate the utility of de novo-designed proteins in understanding the mechanism behind ...
www.nature.com
Marija Dramicanin
@dramarija.bsky.social
· Apr 11
Atom level enzyme active site scaffolding using RFdiffusion2
De novo enzyme design starts from ideal active site descriptions consisting of constellations of catalytic residue functional groups around reaction transition state(s), and seeks to generate protein ...
www.biorxiv.org
Marija Dramicanin
@dramarija.bsky.social
· Mar 24
De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development, yet the design of protein agonists and antagonists has been challenging as ...
www.biorxiv.org
Marija Dramicanin
@dramarija.bsky.social
· Mar 21
Reposted by Marija Dramicanin
Marija Dramicanin
@dramarija.bsky.social
· Feb 18
BindCraft: one-shot design of functional protein binders
Protein–protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present B...
www.biorxiv.org
Marija Dramicanin
@dramarija.bsky.social
· Feb 13
Reposted by Marija Dramicanin
Chris Greening
@greening.bsky.social
· Jan 29
Quinone extraction drives atmospheric carbon monoxide oxidation in bacteria - Nature Chemical Biology
Here, Kropp et al. use cryo-electron microscopy and structural modeling to show that the enzyme [MoCu]-CO dehydrogenase interacts with its partner, the membrane-bound quinone-binding protein CoxG, to ...
www.nature.com
Marija Dramicanin
@dramarija.bsky.social
· Jan 16
Marija Dramicanin
@dramarija.bsky.social
· Jan 16
De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
www.nature.com
Reposted by Marija Dramicanin
Marija Dramicanin
@dramarija.bsky.social
· Dec 13
Development of a De Novo Protein Binder that Inhibits the Alpha Kinase eEF2K
Elongation factor 2 kinase (eEF2K) is calmodulin activated and phosphorylates eEF2, a GTPase, that regulates global translation. When eEF2K phosphorylates eEF2, protein translation is halted. This pro...
www.biorxiv.org