Cyntia Taveneau
@cyntiat.bsky.social
Group Leader | Structural Biologist
Monash University (Melbourne) 🇦🇺 🇨🇵
CryoEM & Protein Design
Monash University (Melbourne) 🇦🇺 🇨🇵
CryoEM & Protein Design
Pinned
Cyntia Taveneau
@cyntiat.bsky.social
· Dec 10
De novo design of potent CRISPR-Cas13 inhibitors
CRISPR-Cas systems are transformative tools for gene editing which can be tuned or controlled by anti-CRISPRs (Acrs) - phage derived inhibitors that regulate CRISPR-Cas activity. However, Acrs that ar...
www.biorxiv.org
Excited to share my first-author preprint from the Knott Lab! Using de novo protein design, we developed anti-CRISPRs to potently inhibit CRISPR-Cas13. Thanks to my amazing co-authors !
www.biorxiv.org/content/10.1...
#CRISPR
www.biorxiv.org/content/10.1...
#CRISPR
Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead !
www.cell.com/structure/fu...
www.cell.com/structure/fu...
Code to complex: AI-driven de novo binder design
In this review, Fox et al. discuss how artificial intelligence has transformed our
ability to design new-to-nature proteins that bind target proteins with high affinity
and specificity. The authors de...
www.cell.com
September 2, 2025 at 10:51 AM
Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead !
www.cell.com/structure/fu...
www.cell.com/structure/fu...
Thrilled to be part of this great @ausbiocommons.bsky.social initiative : a webinar serie on AI-based binder design :)
I’ll be sharing a case study on using deep learning to design programmable CRISPR inhibitors
12 August 12pm AEST, love to see you there ! www.biocommons.org.au/events/prote...
I’ll be sharing a case study on using deep learning to design programmable CRISPR inhibitors
12 August 12pm AEST, love to see you there ! www.biocommons.org.au/events/prote...
August 5, 2025 at 11:26 AM
Thrilled to be part of this great @ausbiocommons.bsky.social initiative : a webinar serie on AI-based binder design :)
I’ll be sharing a case study on using deep learning to design programmable CRISPR inhibitors
12 August 12pm AEST, love to see you there ! www.biocommons.org.au/events/prote...
I’ll be sharing a case study on using deep learning to design programmable CRISPR inhibitors
12 August 12pm AEST, love to see you there ! www.biocommons.org.au/events/prote...
Reposted by Cyntia Taveneau
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
www.science.org
July 24, 2025 at 6:23 PM
🦠🧍♀️From bacterial to human immunity.
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social
www.science.org/doi/10.1126/...
Reposted by Cyntia Taveneau
Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c...
#CryoEM
#Membranes
#CryoEM
#Membranes
July 15, 2025 at 6:55 AM
Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c...
#CryoEM
#Membranes
#CryoEM
#Membranes
Reposted by Cyntia Taveneau
ASBC and Biocommons are building opportunities for researchers to discuss and explore protein design tech. First up is @rhyswg.bsky.social. Excited for this!
WEBINAR SERIES: Leveraging deep learning to design custom protein-binding proteins — Australian BioCommons
Be inspired by case studies that show you how deep learning methods are speeding up the process of designing proteins with desirable biophysical properties. More information Register
www.biocommons.org.au
July 2, 2025 at 8:47 AM
ASBC and Biocommons are building opportunities for researchers to discuss and explore protein design tech. First up is @rhyswg.bsky.social. Excited for this!
Reposted by Cyntia Taveneau
Proud to share some of the work from my PhD is now out in Nature Communications! Very grateful to all coauthors who helped make this happen, especially my supervisors @rhyswg.bsky.social and @knottrna.bsky.social for their support. 🩸 🦠 🔬
Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the @knottrna.bsky.social lab, with experimental work led by the talented @danielrfox.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Inhibiting heme piracy by pathogenic Escherichia coli using de novo-designed proteins - Nature Communications
Many pathogens encode transporters that extract heme directly from host proteins. In this study, the authors demonstrate the utility of de novo-designed proteins in understanding the mechanism behind ...
www.nature.com
July 10, 2025 at 2:08 AM
Proud to share some of the work from my PhD is now out in Nature Communications! Very grateful to all coauthors who helped make this happen, especially my supervisors @rhyswg.bsky.social and @knottrna.bsky.social for their support. 🩸 🦠 🔬
Reposted by Cyntia Taveneau
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
July 7, 2025 at 8:21 AM
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
Reposted by Cyntia Taveneau
An epic sky, singing cicadas, and a solar explosion. See this and more in this month's best science shots
https://go.nature.com/3ZaM0rD
https://go.nature.com/3ZaM0rD
See the Milky Way dazzle during a lunar eclipse — May’s best science images
The month’s sharpest science shots, selected by Nature’s photo team.
go.nature.com
May 30, 2025 at 3:15 PM
An epic sky, singing cicadas, and a solar explosion. See this and more in this month's best science shots
https://go.nature.com/3ZaM0rD
https://go.nature.com/3ZaM0rD
Reposted by Cyntia Taveneau
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 20, 2025 at 10:37 PM
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾
Reposted by Cyntia Taveneau
"Nous devons attaquer honnêtement et agressivement les universités de ce pays." Ces mots sont ceux du vice-président américain J.D. Vance en 2025. Claire Mathieu, mathématicienne à l’ENS et membre de l’Académie des sciences, alerte : la science et la quête de vérité sont menacées aux États-Unis.
March 17, 2025 at 2:36 PM
"Nous devons attaquer honnêtement et agressivement les universités de ce pays." Ces mots sont ceux du vice-président américain J.D. Vance en 2025. Claire Mathieu, mathématicienne à l’ENS et membre de l’Académie des sciences, alerte : la science et la quête de vérité sont menacées aux États-Unis.
Reposted by Cyntia Taveneau
New isolates from eukaryote's closest archaeal relative: ‘Hodarchaeales’!! Syntrophic microaerotolerant peptide-degrading anaerobic archaea w/ simple cell structure & protrusions. Features conserved across the phylum provide new insight into our ancestor’s biology!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Eukaryotes' closest relatives are internally simple syntrophic archaea
Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...
www.biorxiv.org
February 27, 2025 at 4:25 AM
New isolates from eukaryote's closest archaeal relative: ‘Hodarchaeales’!! Syntrophic microaerotolerant peptide-degrading anaerobic archaea w/ simple cell structure & protrusions. Features conserved across the phylum provide new insight into our ancestor’s biology!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Cyntia Taveneau
Session 9 Cyntia Taveneau: De novo design of crispr-cas inhibitors. CRISPR system degrades DNA from phage; phage escape with antiCRISPR. Can we design them?? AIcrs designed to block active site of Cas13. #RFdiffusion Scoring top 96. Expr and purify. Biolayer interferometry. #LorneProteins2025
February 11, 2025 at 10:31 PM
Session 9 Cyntia Taveneau: De novo design of crispr-cas inhibitors. CRISPR system degrades DNA from phage; phage escape with antiCRISPR. Can we design them?? AIcrs designed to block active site of Cas13. #RFdiffusion Scoring top 96. Expr and purify. Biolayer interferometry. #LorneProteins2025
Reposted by Cyntia Taveneau
Petit reportage de France Inter sur notre utilisation de l'IA au labo:
- Combiner prédictions informatiques et validations expérimentales
- Un nouveau monde à explorer
- Des utilisateur.rice.s divers doivent s'approprier l'IA pour inventer des usages divers.
www.radiofrance.fr/franceinter/...
- Combiner prédictions informatiques et validations expérimentales
- Un nouveau monde à explorer
- Des utilisateur.rice.s divers doivent s'approprier l'IA pour inventer des usages divers.
www.radiofrance.fr/franceinter/...
"On est entré dans un nouveau monde" : comment l'IA révolutionne la microbiologie
En permettant de prédire la structure d'une protéine à partir d'une séquence d'ADN, Alphafold, le système mis au point par Google DeepMind, a ouvert en grand le champ des possibles pour les chercheurs...
www.radiofrance.fr
February 7, 2025 at 12:57 PM
Petit reportage de France Inter sur notre utilisation de l'IA au labo:
- Combiner prédictions informatiques et validations expérimentales
- Un nouveau monde à explorer
- Des utilisateur.rice.s divers doivent s'approprier l'IA pour inventer des usages divers.
www.radiofrance.fr/franceinter/...
- Combiner prédictions informatiques et validations expérimentales
- Un nouveau monde à explorer
- Des utilisateur.rice.s divers doivent s'approprier l'IA pour inventer des usages divers.
www.radiofrance.fr/franceinter/...
Reposted by Cyntia Taveneau
Scaling data analyses in cellular cryoET using comprehensive segmentation [new]
Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.
Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.
January 18, 2025 at 2:50 PM
Scaling data analyses in cellular cryoET using comprehensive segmentation [new]
Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.
Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.
Reposted by Cyntia Taveneau
We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates - Nature Structural & Molecular Biology
Here the authors show that a gene-inactivating protein complex packs inactive genes into a dynamic and accessible structure. The study challenges the traditional views that restricted accessibility an...
www.nature.com
January 16, 2025 at 9:24 PM
We used cryoET and biophysical approaches in vitro together with molecular biology in differentiated cells to show that chromatin compacted by PRC1-CBX8 is porous and accessible while PRC1 is dynamic in it. 🧪🧬 #cryoET #Epigenetics #Polycomb www.nature.com/articles/s41...
Reposted by Cyntia Taveneau
After a decade in the oven🧑🍳, we’re happy to finally share our preprint on the in situ architecture of the ciliary base.
📜 https://dir.lat/41qAY4
We used #CryoET to resolve transition zone structures and reveal the stepwise assembly of IFT...
📜 https://dir.lat/41qAY4
We used #CryoET to resolve transition zone structures and reveal the stepwise assembly of IFT...
November 23, 2024 at 7:40 AM
After a decade in the oven🧑🍳, we’re happy to finally share our preprint on the in situ architecture of the ciliary base.
📜 https://dir.lat/41qAY4
We used #CryoET to resolve transition zone structures and reveal the stepwise assembly of IFT...
📜 https://dir.lat/41qAY4
We used #CryoET to resolve transition zone structures and reveal the stepwise assembly of IFT...
Reposted by Cyntia Taveneau
More than 1'800 tomograms available for the community. Towards visual proteomics using our favorite organism Chlamy!
Check out the preprint: www.biorxiv.org/content/10.1...
Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com
#TeamTomo
Check out the preprint: www.biorxiv.org/content/10.1...
Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com
#TeamTomo
Towards community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii
In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate structures of biomolecules in their native context. However, challenges remain in the efficient production...
www.biorxiv.org
December 29, 2024 at 11:47 AM
More than 1'800 tomograms available for the community. Towards visual proteomics using our favorite organism Chlamy!
Check out the preprint: www.biorxiv.org/content/10.1...
Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com
#TeamTomo
Check out the preprint: www.biorxiv.org/content/10.1...
Find it on EMPIAR (11830) and fully annotated on the CZI data portal: cryoetdataportal.czscience.com
#TeamTomo
Reposted by Cyntia Taveneau
Do you want to work at the interface of molecular simulations, structural biology experiments and #AI? Come to Paris for a PhD at @pasteur.fr 1 PhD position is available in our lab funded by ERC_Research. Please repost!! #compchem #compbio Info 👇 research.pasteur.fr/b/15Hr
One PhD thesis in integrative structural biology | Research - Institut Pasteur
research.pasteur.fr
December 6, 2024 at 8:31 AM
Do you want to work at the interface of molecular simulations, structural biology experiments and #AI? Come to Paris for a PhD at @pasteur.fr 1 PhD position is available in our lab funded by ERC_Research. Please repost!! #compchem #compbio Info 👇 research.pasteur.fr/b/15Hr
Reposted by Cyntia Taveneau
Interactive Program now live for the Lorne Protein Conference 2025! Merry Christmas and Happy New Year!
www.lorneproteins.org
www.lorneproteins.org
December 18, 2024 at 3:52 AM
Interactive Program now live for the Lorne Protein Conference 2025! Merry Christmas and Happy New Year!
www.lorneproteins.org
www.lorneproteins.org
Reposted by Cyntia Taveneau
A postdoctoral position is available in our team to study the type VI secretion system.
Biochemistry, X-ray cryst and some cryoEM with @fronzeslab.bsky.social team
Reposts appreciated 😊
Biochemistry, X-ray cryst and some cryoEM with @fronzeslab.bsky.social team
Reposts appreciated 😊
November 15, 2024 at 4:12 PM
A postdoctoral position is available in our team to study the type VI secretion system.
Biochemistry, X-ray cryst and some cryoEM with @fronzeslab.bsky.social team
Reposts appreciated 😊
Biochemistry, X-ray cryst and some cryoEM with @fronzeslab.bsky.social team
Reposts appreciated 😊
This is such a cool initiative! DL4Proteins is democratizing deep learning for protein design and prediction at a pivotal time in science—a fantastic step toward making advanced protein engineering accessible to all!
github.com/Graylab/DL4P...
GitHub - Graylab/DL4Proteins-notebooks: Colab Notebooks covering deep learning tools for biomolecular structure prediction and design
Colab Notebooks covering deep learning tools for biomolecular structure prediction and design - Graylab/DL4Proteins-notebooks
github.com
December 14, 2024 at 11:35 PM
This is such a cool initiative! DL4Proteins is democratizing deep learning for protein design and prediction at a pivotal time in science—a fantastic step toward making advanced protein engineering accessible to all!
github.com/Graylab/DL4P...
Reposted by Cyntia Taveneau
Reposted by Cyntia Taveneau
1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM.
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
2024 S2C2 Single-Particle Cryo-EM Image Processing Workshop - YouTube
This playlist contains six recordings covering single particle cryo-EM data processing in CryoSPARC from the 2024 Single-Particle Cryo-EM Image Processing Wo...
www.youtube.com
December 13, 2024 at 6:56 PM
1/ A new series of #CryoSPARC tutorial videos from this year’s S2C2 #cryoEM image processing workshop are now online! These videos will be interesting to all users and especially those newer to #cryoEM.
www.youtube.com/playlist?lis...
www.youtube.com/playlist?lis...
Reposted by Cyntia Taveneau
To get the things going on this platform, I decided to start sharing some interesting de novo protein design papers! Hope you find them useful!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Development of a De Novo Protein Binder that Inhibits the Alpha Kinase eEF2K
Elongation factor 2 kinase (eEF2K) is calmodulin activated and phosphorylates eEF2, a GTPase, that regulates global translation. When eEF2K phosphorylates eEF2, protein translation is halted. This pro...
www.biorxiv.org
December 13, 2024 at 3:31 AM
To get the things going on this platform, I decided to start sharing some interesting de novo protein design papers! Hope you find them useful!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...