Rhys Grinter
@rhyswg.bsky.social
Lab head at the University of Melbourne. Studying the structure and biochemistry of microbial membrane proteins and metalloenzymes.
Reposted by Rhys Grinter
Long-read on [NiFe]-hydrogenase Huc in @laborjournal.bsky.social (German language, RP with a proper image 🤗) www.laborjournal.de/rubric/journ...
November 12, 2025 at 10:14 AM
Long-read on [NiFe]-hydrogenase Huc in @laborjournal.bsky.social (German language, RP with a proper image 🤗) www.laborjournal.de/rubric/journ...
Reposted by Rhys Grinter
I'm deeply honoured & grateful to have been awarded the #CSLCentenaryFellowship at the #AAHMS dinner last week
Many thanks to my mentors & colleagues for their support
Congratulations to my Fellow winner @rhyswg.bsky.social
#MedicalResearch
#CSLCentenaryFellowships
#WomenInSTEMM
@mcri.bsky.social
Many thanks to my mentors & colleagues for their support
Congratulations to my Fellow winner @rhyswg.bsky.social
#MedicalResearch
#CSLCentenaryFellowships
#WomenInSTEMM
@mcri.bsky.social
November 7, 2025 at 7:50 AM
I'm deeply honoured & grateful to have been awarded the #CSLCentenaryFellowship at the #AAHMS dinner last week
Many thanks to my mentors & colleagues for their support
Congratulations to my Fellow winner @rhyswg.bsky.social
#MedicalResearch
#CSLCentenaryFellowships
#WomenInSTEMM
@mcri.bsky.social
Many thanks to my mentors & colleagues for their support
Congratulations to my Fellow winner @rhyswg.bsky.social
#MedicalResearch
#CSLCentenaryFellowships
#WomenInSTEMM
@mcri.bsky.social
Reposted by Rhys Grinter
Translation for last year PhD students: You want to watch the ARC webpage tomorrow to see who will be looking for postdocs in 2026
ARC says Discovery Projects outcomes will be tomorrow (Tuesday). Linkage Projects (2025, round 1) on Wed. Over past ~year, it's often been at about 11am (Canberra).
My bot will pick up the change to RMS & post immediately.
ARC should email outcomes to lead CIs, but might take an 1hr or so for DPs
My bot will pick up the change to RMS & post immediately.
ARC should email outcomes to lead CIs, but might take an 1hr or so for DPs
October 27, 2025 at 12:08 AM
Translation for last year PhD students: You want to watch the ARC webpage tomorrow to see who will be looking for postdocs in 2026
Reposted by Rhys Grinter
Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structural and mechanistic insights into translation initiation on the enterovirus Type 1 IRES
Enteroviruses are a widespread and diverse set of pathogens responsible for over ~1 billion human infections annually. Upon cell entry, translation of the virus genome is mediated by an internal ribos...
www.biorxiv.org
October 7, 2025 at 11:37 AM
Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rhys Grinter
Nature research paper: A new paradigm for outer membrane protein biogenesis in the Bacteroidota
go.nature.com/3KvfHiG
go.nature.com/3KvfHiG
A new paradigm for outer membrane protein biogenesis in the Bacteroidota - Nature
Structural and biochemical studies of the β-barrel-assembly machinery from Flavobacterium johnsoniae reveal a subunit composition and assembly that are distinct from those of the canonical Escherichia coli complex.
go.nature.com
October 7, 2025 at 7:51 AM
Nature research paper: A new paradigm for outer membrane protein biogenesis in the Bacteroidota
go.nature.com/3KvfHiG
go.nature.com/3KvfHiG
Reposted by Rhys Grinter
Check out our preprint in which we determine how a class of potent protein antibiotics specifically kill P. aeruginosa without a need to enter the cell.
doi.org/10.1101/2025...
This is work from my PhD in the lab of @rhyswg.bsky.social and many collaborators who contributed amazing data!
doi.org/10.1101/2025...
This is work from my PhD in the lab of @rhyswg.bsky.social and many collaborators who contributed amazing data!
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
doi.org
September 22, 2025 at 5:08 AM
Check out our preprint in which we determine how a class of potent protein antibiotics specifically kill P. aeruginosa without a need to enter the cell.
doi.org/10.1101/2025...
This is work from my PhD in the lab of @rhyswg.bsky.social and many collaborators who contributed amazing data!
doi.org/10.1101/2025...
This is work from my PhD in the lab of @rhyswg.bsky.social and many collaborators who contributed amazing data!
Reposted by Rhys Grinter
This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
September 20, 2025 at 8:46 AM
This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
September 20, 2025 at 9:29 AM
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
Reposted by Rhys Grinter
Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead !
www.cell.com/structure/fu...
www.cell.com/structure/fu...
Code to complex: AI-driven de novo binder design
In this review, Fox et al. discuss how artificial intelligence has transformed our
ability to design new-to-nature proteins that bind target proteins with high affinity
and specificity. The authors de...
www.cell.com
September 2, 2025 at 10:51 AM
Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead !
www.cell.com/structure/fu...
www.cell.com/structure/fu...
Reposted by Rhys Grinter
New engineered protein shows promise as antidote for carbon monoxide poisoning
www.medschool.umaryl...
www.medschool.umaryl...
August 31, 2025 at 1:05 PM
New engineered protein shows promise as antidote for carbon monoxide poisoning
www.medschool.umaryl...
www.medschool.umaryl...
Reposted by Rhys Grinter
Fun fact: #bindcraft evolved from a binder design tutorial originally developed for BPDMC!
Come see @martinpacesa.bsky.social tonight at 7pm EDT in Room 181, Building 68, @mit.edu
"BindCraft: one-shot design of functional protein binders"
bpdmc.org
Come see @martinpacesa.bsky.social tonight at 7pm EDT in Room 181, Building 68, @mit.edu
"BindCraft: one-shot design of functional protein binders"
bpdmc.org
schedule
introduction and membership
Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...
bpdmc.org
August 13, 2025 at 1:52 PM
Fun fact: #bindcraft evolved from a binder design tutorial originally developed for BPDMC!
Come see @martinpacesa.bsky.social tonight at 7pm EDT in Room 181, Building 68, @mit.edu
"BindCraft: one-shot design of functional protein binders"
bpdmc.org
Come see @martinpacesa.bsky.social tonight at 7pm EDT in Room 181, Building 68, @mit.edu
"BindCraft: one-shot design of functional protein binders"
bpdmc.org
Reposted by Rhys Grinter
Next-level hydrogenase fuel cell just dropped, congrats @rhyswg.bsky.social and @greening.bsky.social et al.!
1/3 Electricity from air! In the top journal Nano Energy today, we report the first fuel cell that makes power from air alone. We achieved this by using the enzyme Huc to oxidize ambient hydrogen. This results in a continuous low-level power from air and higher outputs with industrial waste gases.
Nanoengineered bioanode with oxygen-insensitive hydrogenase for sustainable energy harvesting from atmospheric hydrogen and waste gases
Enzymatic biofuel cells (EBFCs) utilizing hydrogenases to oxidize hydrogen offer a sustainable approach to energy conservation. However, the oxygen se…
www.sciencedirect.com
August 8, 2025 at 6:13 AM
Next-level hydrogenase fuel cell just dropped, congrats @rhyswg.bsky.social and @greening.bsky.social et al.!
Reposted by Rhys Grinter
1/3 Electricity from air! In the top journal Nano Energy today, we report the first fuel cell that makes power from air alone. We achieved this by using the enzyme Huc to oxidize ambient hydrogen. This results in a continuous low-level power from air and higher outputs with industrial waste gases.
Nanoengineered bioanode with oxygen-insensitive hydrogenase for sustainable energy harvesting from atmospheric hydrogen and waste gases
Enzymatic biofuel cells (EBFCs) utilizing hydrogenases to oxidize hydrogen offer a sustainable approach to energy conservation. However, the oxygen se…
www.sciencedirect.com
August 8, 2025 at 3:49 AM
1/3 Electricity from air! In the top journal Nano Energy today, we report the first fuel cell that makes power from air alone. We achieved this by using the enzyme Huc to oxidize ambient hydrogen. This results in a continuous low-level power from air and higher outputs with industrial waste gases.
Reposted by Rhys Grinter
PM Mark Carney 🇨🇦
A new airlift of Canadian aid landed in Gaza today, with thanks to His Majesty King Abdullah II & our Jordanian partners.
Canada is dedicating more than $340 million in aid to address the humanitarian crisis in Gaza & we will ensure it moves forward at the necessary scale. #cdnpoli
A new airlift of Canadian aid landed in Gaza today, with thanks to His Majesty King Abdullah II & our Jordanian partners.
Canada is dedicating more than $340 million in aid to address the humanitarian crisis in Gaza & we will ensure it moves forward at the necessary scale. #cdnpoli
August 2, 2025 at 10:04 AM
PM Mark Carney 🇨🇦
A new airlift of Canadian aid landed in Gaza today, with thanks to His Majesty King Abdullah II & our Jordanian partners.
Canada is dedicating more than $340 million in aid to address the humanitarian crisis in Gaza & we will ensure it moves forward at the necessary scale. #cdnpoli
A new airlift of Canadian aid landed in Gaza today, with thanks to His Majesty King Abdullah II & our Jordanian partners.
Canada is dedicating more than $340 million in aid to address the humanitarian crisis in Gaza & we will ensure it moves forward at the necessary scale. #cdnpoli
Reposted by Rhys Grinter
In this system, bacteria detect phage infection through a sensor protein (YjbH) and respond by severing the infected part of the cell via aberrant division. The rest of the cell survives and continues growing happily, essentially, bacterial autotomy!
August 2, 2025 at 3:01 PM
In this system, bacteria detect phage infection through a sensor protein (YjbH) and respond by severing the infected part of the cell via aberrant division. The rest of the cell survives and continues growing happily, essentially, bacterial autotomy!
Reposted by Rhys Grinter
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
August 2, 2025 at 3:01 PM
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Reposted by Rhys Grinter
A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/
CAPRI Docking
www.capri-docking.org
July 29, 2025 at 6:26 AM
A small reminder to all structural biologists around working on biomolecular complexes: please consider sharing your complexes as targets for CAPRI - AI has not solved all structure prediction problems and there are still challenges! See www.capri-docking.org/contribute/
Reposted by Rhys Grinter
ATP synthesis driven by atmospheric hydrogen concentrations www.pnas.org/doi/abs/10.1... #jcampubs
ATP synthesis driven by atmospheric hydrogen concentrations | PNAS
All cells require a continuous supply of the universal energy currency, adenosine
triphosphate (ATP), to drive countless cellular reactions. The un...
www.pnas.org
July 28, 2025 at 2:37 PM
ATP synthesis driven by atmospheric hydrogen concentrations www.pnas.org/doi/abs/10.1... #jcampubs
Reposted by Rhys Grinter
Excellent nanomolar peptide design success rates with BindCraft!
Generative Design of High-Affinity Peptides Using BindCraft [new]
De novo designs peptide ligands for proteins. It generated MDM2 binders (nM affinity) and WDR5 binders (sub-µM affinity), with potency improved via stapling.
De novo designs peptide ligands for proteins. It generated MDM2 binders (nM affinity) and WDR5 binders (sub-µM affinity), with potency improved via stapling.
July 26, 2025 at 7:14 AM
Excellent nanomolar peptide design success rates with BindCraft!
Reposted by Rhys Grinter
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
July 25, 2025 at 7:48 AM
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
Did you know that some bacteria can generate ATP, the energy currency of life, literally out of thin air? 🌬⚡️
In PNAS today, we show how bacteria can do this using just three enzymes. Honoured to contribute to this study with Christoph von Ballmoos, Chris Greening and Gregory Cook
lnkd.in/gxm8SXxF
In PNAS today, we show how bacteria can do this using just three enzymes. Honoured to contribute to this study with Christoph von Ballmoos, Chris Greening and Gregory Cook
lnkd.in/gxm8SXxF
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
July 25, 2025 at 5:59 AM
Did you know that some bacteria can generate ATP, the energy currency of life, literally out of thin air? 🌬⚡️
In PNAS today, we show how bacteria can do this using just three enzymes. Honoured to contribute to this study with Christoph von Ballmoos, Chris Greening and Gregory Cook
lnkd.in/gxm8SXxF
In PNAS today, we show how bacteria can do this using just three enzymes. Honoured to contribute to this study with Christoph von Ballmoos, Chris Greening and Gregory Cook
lnkd.in/gxm8SXxF
Reposted by Rhys Grinter
Our article showing energy production from air alone is in PNAS today. This paper provides an ultimate biochemical proof that microbes can survive simply by 'making' energy from air (making two ATP per molecule atmospheric H2 consumed) and has biotech applications. www.pnas.org/doi/10.1073/...
ATP synthesis driven by atmospheric hydrogen concentrations | PNAS
All cells require a continuous supply of the universal energy currency, adenosine
triphosphate (ATP), to drive countless cellular reactions. The un...
www.pnas.org
July 25, 2025 at 12:54 AM
Our article showing energy production from air alone is in PNAS today. This paper provides an ultimate biochemical proof that microbes can survive simply by 'making' energy from air (making two ATP per molecule atmospheric H2 consumed) and has biotech applications. www.pnas.org/doi/10.1073/...
Reposted by Rhys Grinter
DeepMind will fund CASP for a year. Very nice to hear.
(not paying Stat $30 a month, but you can read the first bit).
www.statnews.com/2025/07/21/c...
(not paying Stat $30 a month, but you can read the first bit).
www.statnews.com/2025/07/21/c...
AlphaFold developer Google DeepMind to fund CASP as NIH funding falls short
Protein structure prediction contest CASP gets temporary funding from Google DeepMind as NIH grant runs out.
www.statnews.com
July 22, 2025 at 5:13 AM
DeepMind will fund CASP for a year. Very nice to hear.
(not paying Stat $30 a month, but you can read the first bit).
www.statnews.com/2025/07/21/c...
(not paying Stat $30 a month, but you can read the first bit).
www.statnews.com/2025/07/21/c...
Reposted by Rhys Grinter
💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.
Preprint 📝: biorxiv.org/content/10.1...
🧵 1/n
Preprint 📝: biorxiv.org/content/10.1...
🧵 1/n
July 21, 2025 at 9:56 AM
💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.
Preprint 📝: biorxiv.org/content/10.1...
🧵 1/n
Preprint 📝: biorxiv.org/content/10.1...
🧵 1/n
Reposted by Rhys Grinter
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
www.biorxiv.org
July 19, 2025 at 3:10 PM
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...