Lightnews — Scholar-powered news

Reposted by Dr Pallavi Prasad, MD, DNB ( Nephrology)

Nephrology Journal Club @nephjc.bsky.social · 10d

⏰30 min before the #NephJC chat
Let's learn about the Gurus who paved the path to make kidney transplant “Mission Impossible to Mission Possible” with their research.

2 8

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

Yes that would be good.

Not after DSAs have formed though #NephJC

1

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

Yes! agree- i would be interested to see comparison of protocol biopsy chronic changes in the two groups- esp features of tac toxicity , IFTA and TG.

There is no information about that.. although they did protocol biopsies.
#nephjc

1 3

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

May have to consider that- its possible lupus and anca etc have low recurrence risk due to the IS we give as standard in all of them #NephJC

keep in mind a LOT of our patients come as kidney failure and don't get a biopsy -will be difficult to decide which of these were burnt out GNs- but may recur

1 3

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

G-CSF self injection for 5-6 days followed by apheresis - Each donor underwent 1-2 such cycles to harvest the cells #NephJC

2

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

Whts enigmatic is that Maintenance phase..
like accomodation in ABOi transplants...

Wish we had a way to test which patients are the ones who can maintain ... probably there might be some in the Hla mismatch population as well- as we see from historical cases
#NephJc

1

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

Actually if 25% of HLA matched siblings are to resume immunosuppression , then to me this therapy doesn't sound so promising- #NephJC

1 2

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

Yeah. Neither do we have the reference for 9% as historical controls
( 4% as per discussion section- no references here too ⚠️)

However, with this kind of study...i shall let them pass..m sure FDA would have grilled them ! #NephJC

1 1

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

10 patients were in current control groups managed as per individual centre protocol #NephJC

Historical controls from Scientific Registry of transplant recipients used for deciding endpoints and sample size calculation

3

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

Have some from 1990s only on azoran and steroid..and doing great! #NephJc

1 5

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

Its OUR team! #NephJC

thor says " greatest team ever " in a room with lots of windows

ALT: thor says " greatest team ever " in a room with lots of windows

media.tenor.com

3

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 10d

Hello everyone! Pallavi here from New Delhi. No COI.
#NephJC

1 4

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

Great work ! #NephJC

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

HT emergency,yes! Accelerated HT- i think it never existed!

High Bp >180/120 without target organ damage is Severe Hypertension now
#NephJC

1 3

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

Thanks! will go through this #NephJC

4

Reposted by Dr Pallavi Prasad, MD, DNB ( Nephrology)

Jordy Cohen @jordybc.bsky.social · 24d

www.nejm.org/doi/full/10....

There’s some trial data on prevention of albuminuria

#nephjc

Preventing Microalbuminuria in Type 2 Diabetes | NEJM

The multicenter double-blind, randomized Bergamo Nephrologic Diabetes Complications Trial (BENEDICT) was designed to assess whether angiotensin-converting–enzyme inhibitors and non-dihydropyridine ...

www.nejm.org

2 6 12

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

HT in MHD . The biggest unanswered question worldwide
@hswapnil.medsky.social do something ! #NephJC

a black and white drawing of a stick figure with the words `` c mon , do something ... ''

ALT: a black and white drawing of a stick figure with the words `` c mon , do something ... ''

media.tenor.com

4

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

I get jittery when escalating dose with combo pills #NephJC. Not so fond of combo in general (COI)

1

Reposted by Dr Pallavi Prasad, MD, DNB ( Nephrology)

Nephrology Journal Club @nephjc.bsky.social · 24d

T2l
Initiation of 2 first-line agents is still recommended for Stage 2 HTN but there is a new emphasis on using single-pill combinations. One pill goes down easier than two!
What’s your favorite combo pill? Not using combo pills – what’s holding you back? #NephJC
www.thelancet.com/jo...

2 8

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

Yeah seriously i was wondering about this..whats the evidence of ARB in <30 mg/g in DM ?Thought about this while editing summary then got lost in the sea of information the 100 pager gave! #NephJC
@hswapnil.medsky.social @jordybc.bsky.social

a man in a boat is being pulled out of the water

ALT: a man in a boat is being pulled out of the water

media.tenor.com

1 3

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

Yeah, salt production will need regulation.
For eg in India, by regulation salts are iodised. Is it the same in other countries ? #NephJC

1

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

Proposed mechanism in Nature #NephJC
www.nature.com/articles/s41...

2 3

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

Interesting study from 2019! #NephJC

8.9% of OSA have PA.
Almost 70% of PA have OSA!

www.ahajournals.org/doi/10.1161/...

1 3 10

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

www.nejm.org/doi/full/10....

#NephJC

Effect of Salt Substitution on Cardiovascular Events and Death | NEJM

Salt substitutes with reduced sodium levels and increased potassium levels have been shown to lower blood pressure, but their effects on cardiovascular and safety outcomes are uncertain. We conduct...

www.nejm.org

1 3

Dr Pallavi Prasad, MD, DNB ( Nephrology) @drpallaviprasad.bsky.social · 24d

Wonder if it beeps only if ur BP is high after 30 min of rest.
Although i like it that they say "possible" hypertension and don't just label the person HT .

#NephJC

2