Daniel Durocher
@durocher1.bsky.social
Scientist: durocherlab.org @ Lunenfeld-Tanenbaum Research Institute, Toronto.
Founder: Repare Therapeutics & Induxion Therapeutics
Founder: Repare Therapeutics & Induxion Therapeutics
That will be fun to explore!
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 13, 2025 at 12:01 PM
That will be fun to explore!
Reposted by Daniel Durocher
How can we scale subcellular spatial proteomics across many experiments and conditions?
Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.
Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.
October 23, 2025 at 1:40 PM
How can we scale subcellular spatial proteomics across many experiments and conditions?
Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.
Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.
9 days to go:
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
October 11, 2025 at 12:40 PM
9 days to go:
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
* 2 x open positions!
* Exceptional environment, competitive start-up package
* University of Toronto appointments
* Toronto has great (and peaceful) quality of life!
Reposted by Daniel Durocher
Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
A comprehensive genetic catalog of human double-strand break repair
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...
www.science.org
October 4, 2025 at 7:27 AM
Kickstarting our Bluesky🦋 account with great news!
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Our REPAIRome study finally out today in
@science.org
www.science.org/doi/10.1126/...
Reposted by Daniel Durocher
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
October 2, 2025 at 3:49 PM
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
I really wonder what a $2K set of peanut butter jars from the NATIONAL INSTITUTES OF STANDARDS & TECHNOLOGY could be for?
September 26, 2025 at 4:53 PM
I really wonder what a $2K set of peanut butter jars from the NATIONAL INSTITUTES OF STANDARDS & TECHNOLOGY could be for?
Reposted by Daniel Durocher
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
September 20, 2025 at 7:43 AM
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Reposted by Daniel Durocher
Happy to share our latest research on the BRCA1-BRCTs now online.
academic.oup.com/nar/article/...
Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.
academic.oup.com/nar/article/...
Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.
Validate User
academic.oup.com
September 18, 2025 at 8:40 AM
Happy to share our latest research on the BRCA1-BRCTs now online.
academic.oup.com/nar/article/...
Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.
academic.oup.com/nar/article/...
Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.
New work from the lab! 🔬
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...
Mitotic single-stranded DNA suppression by DDIAS
Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...
www.biorxiv.org
September 10, 2025 at 4:50 PM
New work from the lab! 🔬
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...
Reposted by Daniel Durocher
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis
DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...
www.biorxiv.org
September 10, 2025 at 3:18 PM
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
Reposted by Daniel Durocher
Job Alert 🚨
Are you an emerging leader in biomedical discovery or population health data science?
We are looking for outstanding candidates to join our institute!
Learn more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
Are you an emerging leader in biomedical discovery or population health data science?
We are looking for outstanding candidates to join our institute!
Learn more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
September 9, 2025 at 2:05 PM
Job Alert 🚨
Are you an emerging leader in biomedical discovery or population health data science?
We are looking for outstanding candidates to join our institute!
Learn more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
Are you an emerging leader in biomedical discovery or population health data science?
We are looking for outstanding candidates to join our institute!
Learn more & apply:
Biomedical Discovery ➡️ apply.interfolio.com/172703
Population Health Data Science ➡️ apply.interfolio.com/172529
Reposted by Daniel Durocher
New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force.
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations
Distinctively, pancreatic ductal adenocarcinoma (PDAC) consists of sparse tumour lesions intertwined with extensive desmoplastic stroma. The complexity of tumour–microenvironment interactions within t...
biorxiv.org
August 23, 2025 at 12:00 PM
New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force.
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
biorxiv.org/content/10.1...
@standardbiology.bsky.social #SpatialBio #IMC
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
August 28, 2025 at 6:34 AM
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
www.nature.com/naturecareer...
Please repost!
Welcome Alissa! We are very excited to have you with us!
I'm thrilled to share that I'll be starting my lab (www.greenwald-lab.org) at the Lunenfeld-Tanenbaum Research Institute @sinaihealth.bsky.social and joining @moleculargenetics.bsky.social at the University of Toronto as an assistant professor this fall. 1/
August 22, 2025 at 12:29 PM
Welcome Alissa! We are very excited to have you with us!
Reposted by Daniel Durocher
Teaching stream faculty position in molecular genetics!
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
Assistant Professor, Teaching Stream (CLTA) - Molecular Biology, Genetics, and Microbiology
Assistant Professor, Teaching Stream (CLTA) - Molecular Biology, Genetics, and Microbiology
jobs.utoronto.ca
August 21, 2025 at 1:20 PM
Teaching stream faculty position in molecular genetics!
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
Reposted by Daniel Durocher
I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress
Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of
the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone
mH2A1.2 ubiquitination in p...
www.cell.com
August 13, 2025 at 3:20 PM
I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Daniel Durocher
New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rewiring DNA repair with PARP-based chemical inducers of proximity
Chemical inducers of proximity (CIPs) can elicit durable, and often neomorphic, biological effects through the formation of a ternary complex, even at low equilibrium occupancy of their targets. This ...
www.biorxiv.org
July 31, 2025 at 3:07 PM
New work out today introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Daniel Durocher
Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social).
jobs.sciencecareers.org/job/673968/p...
jobs.sciencecareers.org/job/673968/p...
Program Head – Developmental, Stem Cell, and Cancer Biology - Toronto (Region), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 673968
Provide leadership and mentorship to members of the Developmental, Stem Cell & Cancer and influence the scientific direction of the Research Institute
jobs.sciencecareers.org
July 27, 2025 at 11:35 PM
Great opportunity to join the vibrant developmental biology in Toronto (and boss around me and @wbderry.bsky.social).
jobs.sciencecareers.org/job/673968/p...
jobs.sciencecareers.org/job/673968/p...
Reposted by Daniel Durocher
🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
July 25, 2025 at 7:21 PM
🇨🇦🚨Job alert🚨🇨🇦
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
We're looking for a senior scientist (program head) in the developmental, stem cell, and cancer biology program at the Hospital for Sick Children
Reposted by Daniel Durocher
July 21, 2025 at 12:59 PM
Thanks for the wonderful conference @agnelsfeir.bsky.social @chowdhurylab.bsky.social and Karlene!
What a night! 💃🏼🪩
A wonderful way to spend our final evening at #BGFP25 with our Gala dinner and Poster Prize awards!
A huge congratulations to our poster presenter winners and a big thank you to our sponsors
@emboreports.org and QIAGEN for their generosity in supporting our prizes!
A wonderful way to spend our final evening at #BGFP25 with our Gala dinner and Poster Prize awards!
A huge congratulations to our poster presenter winners and a big thank you to our sponsors
@emboreports.org and QIAGEN for their generosity in supporting our prizes!
July 10, 2025 at 2:08 PM
Thanks for the wonderful conference @agnelsfeir.bsky.social @chowdhurylab.bsky.social and Karlene!
Reposted by Daniel Durocher
FANCM is a promising cancer therapeutic target due to genetic interactions with BRCA1, SMARCAL1 & RAD52 & in ALT-positive cancers. Moving toward this goal, our work was an amazing collaboration with industry and academic partners across Australia, China and the UK!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Structural basis of Fanconi anemia pathway activation by FANCM | The EMBO Journal
imageimageFANCM employs a sophisticated dual recognition mechanism in genome maintenance, using distinct DNA-binding domains to identify and move around on branched DNA structures. This study reveals how FANCM evolved from an ancient repair motor ...
www.embopress.org
June 2, 2025 at 12:42 AM
FANCM is a promising cancer therapeutic target due to genetic interactions with BRCA1, SMARCAL1 & RAD52 & in ALT-positive cancers. Moving toward this goal, our work was an amazing collaboration with industry and academic partners across Australia, China and the UK!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Daniel Durocher
⏰🚨FINAL DEADLINE APPROACHING
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
May 28, 2025 at 9:47 AM
⏰🚨FINAL DEADLINE APPROACHING
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!
Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF
Reposted by Daniel Durocher
We are looking to recruit three posts at the @crick.ac.uk in structural biology, cell biology, and pharmacology to join a 20+ strong multidisciplinary team focused on delivering the first precision medicines for the treatment of ALT cancers. Interested? Please check out the advertised jobs below:
May 27, 2025 at 9:52 PM
We are looking to recruit three posts at the @crick.ac.uk in structural biology, cell biology, and pharmacology to join a 20+ strong multidisciplinary team focused on delivering the first precision medicines for the treatment of ALT cancers. Interested? Please check out the advertised jobs below:
Reposted by Daniel Durocher
Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!
CTC1-STN1-TEN1 controls DNA break repair pathway choice via DNA end resection blockade
Antagonistic activities of the 53BP1 axis and the tumor suppressor BRCA1-BARD1 determine whether DNA double-strand breaks (DSBs) are repaired by end joining or homologous recombination. We show that t...
www.science.org
May 22, 2025 at 9:30 PM
Excited to share our latest publication, out in @science.org! We define a key role for the CST complex in double-strand break repair pathway choice. This study was conducted in close collaboration with the Sung lab at UT Health San Antonio. Congrats to @michelleswift.bsky.social and all authors!