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emeraldaperlas.bsky.social
Emerald Perlas 🇵🇭🇺🇸🇮🇹
@emeraldaperlas.bsky.social
63 followers 93 following 38 posts
Visual Chronicler of gene expression through Histology at EMBL Rome. Reproductive Biology and plant enthusiast. UC Davis alum. Views my own.
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emeraldaperlas.bsky.social
www.sciencedirect.com/science/arti...
Decoding the heterogeneity of human undifferentiated spermatogonia reveals RAS-dependent regulation of stem cell fate
Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and hold therapeutic potential for treating male infertility. While roden…
www.sciencedirect.com
January 27, 2026 at 11:47 AM
emeraldaperlas.bsky.social
topographical distribution of spermatogonial subpopulations during the cycle of seminiferous epithelium in Macaca Fascicularis† url: academic.oup.com/biolreprod/a...
The topographical distribution of spermatogonial subpopulations during the cycle of seminiferous epithelium in Macaca Fascicularis†
Summary sentence We reveal stage-dependent spatial patterns of spermatogonial subpopulations in Macaca fascicularis, uncovering dynamic niche interactions
academic.oup.com
January 27, 2026 at 11:46 AM
emeraldaperlas.bsky.social
Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis | PLOS Genetics share.google/WTSK6Pgocmn6...
Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis
Author summary Mitochondria are energy generators inside our cells, and they carry their own DNA (mtDNA). Due to inadequate DNA repair mechanisms in the mitochondria, mitochondrial genome contains mor...
share.google
January 26, 2026 at 10:46 AM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
dev-journal.bsky.social
MEIOC facilitates meiotic entry in the mammalian female germ line

This Research Highlight showcases work by Esther G. Ushuhuda, Maria M. Mikedis (@mariamikedis.bsky.social) and colleagues:

journals.biologists.com/dev/article/...
Figure 3: CCNA2 protein expression is downregulated during the transition from mitosis to meiosis by MEIOC and STRA8. (C) Labeling of CCNA2 in DDX4-positive oogenic cells from wild-type, Stra8 knockout, Meioc knockout and Meioc Stra8 double knockout (dKO) ovaries at E16.5. Arrows and arrowheads mark EdU-positive and -negative oogenic cells, respectively. Meioc Stra8 double knockout panel also appears in Fig. 1B. Scale bar: 20 µm. (D) Quantification of CCNA2 intensity in EdU-positive and -negative oogenic cells. Data for EdU-positive cells represents 190 cells from five wild-type embryos, 35 cells from five Stra8 knockout embryos, 144 cells from three Meioc knockout embryos and 124 cells from three Meioc Stra8 double knockout embryos. Data for EdU-negative cells represents 2492 cells from five wild-type embryos, 579 cells from five Stra8 knockout embryos, 909 cells from three Meioc knockout embryos and 296 cells from three Meioc Stra8 double knockout embryos. Dot represents the median; whiskers represent the interquartile range. *adj. P<0.05; **adj. P<0.01; ****adj. P<0.0001. See Table S4 for statistical details.
January 13, 2026 at 5:46 PM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
jef.works
The authors did such a great job making this spatial transcriptomics data of ovulating mouse ovaries available: www.pnas.org/doi/10.1073/...

So I vibe coded a web browser app to interactively explore its spatiotemporal gene expression trends: jef.works/CellCarto-Ov...

Hope it's useful!
January 6, 2026 at 2:05 PM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
npr.org
In matching, brilliant blue suits, David Byrne and his band squeeze behind the Desk to perform four songs, including Talking Heads' "Life During Wartime." n.pr/4pFYoun
David Byrne: Tiny Desk Concert
In matching, brilliant blue suits, David Byrne and his band squeeze behind the Desk to perform four songs, including Talking Heads' "Life During Wartime."
n.pr
December 1, 2025 at 11:52 AM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
johanduchene.bsky.social
Bad antibodies are a major roadblock in biomedical research, harming reproducibility and wasting resources.

The International Antibody Validation Meeting was created to fix it.

Watch the talks from the 5th Antibody Validation Meeting (2025)
tinyurl.com/AntibodyVali...
#Integrity #reproducibility
5th International Antibody Validation Meeting - YouTube
Listen to talks from the speakers at the 5th AbVal meeting, held in Bath on the 9-11th September 2025.
tinyurl.com
November 22, 2025 at 10:57 AM
emeraldaperlas.bsky.social
Vitamin C conveys geroprotection on primate ovaries: Cell Stem Cell www.cell.com/cell-stem-ce...
Vitamin C conveys geroprotection on primate ovaries
Jing et al. demonstrate that oral vitamin C supplementation delays ovarian aging in non-human primates, attenuating key aging hallmarks and rejuvenating the ovarian cellular and molecular profiles. Th...
www.cell.com
November 18, 2025 at 11:41 AM
emeraldaperlas.bsky.social
ICYMI

A spatiotemporal molecular atlas of the ovulating mouse ovary | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 12, 2025 at 12:05 PM
emeraldaperlas.bsky.social
Generation of germinal-vesicle oocytes from mouse embryonic stem cells under an ovarian soma-free condition: Developmental Cell www.cell.com/developmenta...
Generation of germinal-vesicle oocytes from mouse embryonic stem cells under an ovarian soma-free condition
Using mouse pluripotent stem cells, Nosaka et al. created an ovarian somatic cell (OSC)-free system to induce an abundant number of oocyte-like cells at diplotene arrest, followed by their growth into...
www.cell.com
November 5, 2025 at 7:05 PM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
events.embl.org
Don't miss the chance to join us in Heidelberg for the EMBL Course #EMBLSpatialOmics! Apply by 24 Nov: https://s.embl.org/spa26-01-bl

🧬🔬🧪 Our trainers and speakers will introduce participants to a new generation of spatially resolved transcriptomics assays from 10x Genomics.

🗓️ 2 – 6 Mar 2026
November 5, 2025 at 8:33 AM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
natneuro.nature.com
Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway

@julie.buron.bsky.social @inmed.bsky.social @insermpacacorse.bsky.social [email protected]

www.nature.com/articles/s41...
Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway - Nature Neuroscience
Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a hypothalamus–brainstem ...
www.nature.com
October 29, 2025 at 1:16 PM
emeraldaperlas.bsky.social
www.nature.com/articles/s41...
Enhanced hybridization-proximity labeling discovers protein interactomes of single RNA molecules - Nature Communications
Systematic discovery of proteins interacting with low-abundance RNAs is challenging. Here, the authors develop an enhanced HyPro technology to identify proteins associated with compact RNA compartment...
www.nature.com
October 21, 2025 at 8:28 AM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
gioelelamanno.bsky.social
🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...
October 16, 2025 at 6:23 AM
emeraldaperlas.bsky.social
Source: Nature
search.app/6H4pn
microRNAs blaze into the clinic - Nature Biotechnology
After decades-long struggles with microRNA-based therapeutics, Regulus hits paydirt in the clinic and in the marketplace. Is it the beginning of a trend or a one-off?
search.app
October 15, 2025 at 12:50 PM
emeraldaperlas.bsky.social
www.science.org/doi/10.1126/...
Comparative analysis of human and mouse ovaries across age
The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. We compar...
www.science.org
October 13, 2025 at 6:13 PM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
mgrillo.bsky.social
www.nature.com/articles/s41...
Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology
As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.
www.nature.com
October 12, 2025 at 6:56 PM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
kaurr.bsky.social
#Wolbachia has puzzled scientists with its power to rewire insect reproduction. What if I tell you that we found one of the keys Wolbachia use to rewire its host AND a small molecule inhibitor uses this key to mimic what this microbe has mastered for millions of years.

www.cell.com/cell-reports...
Beyond Wolbachia—Can a small molecule control insect reproduction?
Kaur et al. demonstrate reduced histone acetylation as a key mechanism underpinning Wolbachia’s paternal-effect embryonic lethality trait in Drosophila melanogaster. Recapitulation of this trait by in...
www.cell.com
October 3, 2025 at 12:58 PM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
cp-cell.bsky.social
Now online! Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution
RAEFISH delivers whole-transcriptome (>20,000 genes) imaging at single-molecule resolution in cells and tissues and enables direct gRNA detection for high-content, image-based CRISPR screens.
dlvr.it
October 1, 2025 at 2:59 PM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
pastelbio.bsky.social
Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context www.biorxiv.org/cont...

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#proteomics #prot-preprint
September 29, 2025 at 8:00 AM
emeraldaperlas.bsky.social
www.nature.com/articles/d41...
The mini placentas and ovaries revealing the basics of women’s health
Lab-made organoids that mimic reproductive tissues could point to treatments for common conditions such as pre-eclampsia and endometriosis.
www.nature.com
September 26, 2025 at 9:34 AM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
gvallortigara.bsky.social
en.ilsole24ore.com/art/by-vallo...
Marsilio Editori
From Vallortigara a metaphysical thriller on the capacity to consolidate memories
The neuroresearcher and well-known essayist makes his debut with his first novel, 'Desiderare'. In the background, studies on the nature of memory and consciousness
en.ilsole24ore.com
September 20, 2025 at 8:38 AM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
narjournal.bsky.social
🤰 New research in NARMME reveals that uterine glands, not just eggs, are sensitive to maternal aging. 🧬 FOXC1 marks early dysfunction, reshaping how we understand fertility decline.

📖 Read more: lnkd.in/eahrVbMt

#FertilityResearch #FOXC1 #ReproductiveScience #NARMME #OpenAccessPublication
September 19, 2025 at 5:04 PM
Reposted by Emerald Perlas 🇵🇭🇺🇸🇮🇹
vladbndk.bsky.social
📣 It is my pleasure to announce our recent review with Margherita on the current approaches, challenges, and perspectives in studying human maternal-fetal interface using in vitro models www.cell.com/cell-stem-ce... 🚀✨️
September 5, 2025 at 9:07 AM
emeraldaperlas.bsky.social
Many many THANKS to everyone who made the course run smoothly, to the engaging speakers, to our attentive trainers, and most importantly to all the participants for such a wonderful week. 👏👏👏
#EMBL Events Team
#EMBOFISHingRNAs

www.embl.org/about/info/c...
September 8, 2025 at 10:02 PM