Usagi
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endimi.bsky.social
Usagi
@endimi.bsky.social
810 followers 560 following 9.7K posts
Agile change facilitator (#LSP #M30 #LCM #innovgames), geek, mama van Munchkin en Frommeltje, folkie, metalhead, eindelijk mezelf.

Imzadi logo design by @hnnlrgvrts.bsky.social.
Profile pic / avatar by @saradebruycker.bsky.social.
Posts Replies Media Videos
endimi.bsky.social
Uitwaaien.
January 2, 2026 at 12:19 PM
endimi.bsky.social
*giggles* (from @beyondthebrick.bsky.social on fbook)
Lego Indigo Montoya minifig stating: "My name is Indigo Montoya. You stepped on my father. Prepare to cry."
January 2, 2026 at 10:04 AM
endimi.bsky.social
Hey @twordtbeter.bsky.social happy happy one!
January 2, 2026 at 9:56 AM
endimi.bsky.social
🖤
January 2, 2026 at 9:55 AM
Reposted by Usagi
darthputinkgb.bsky.social
Happy new year, serfs. I have good news & bad news. 2026 will be worse than 2025, but it will be better than 2027.
December 31, 2025 at 11:30 PM
endimi.bsky.social
E gelukkig joar é!
December 31, 2025 at 11:16 PM
endimi.bsky.social
En hop. Voorgerecht. Kok was ooit echt kok. En andere gasten brachten wijn mee. De gravad lax was perfect. Fijn oudejaar iedereen!
December 31, 2025 at 8:11 PM
endimi.bsky.social
Unpopular opinion. Black verdient de nr 1 ab-so-luut niet. #DeTijdloze2025
December 31, 2025 at 7:01 PM
endimi.bsky.social
"The misery that is now upon us is but the passing of greed, the bitterness of men who fear the way of human progress." #DeTijdloze2025
December 31, 2025 at 2:55 PM
endimi.bsky.social
Bon, nog eentje in mijn rijtje "vertrok op 31/12 van deze aardkloot door de grote K". Kut K.
December 31, 2025 at 2:37 PM
endimi.bsky.social
Ik ben zelf gravad lax aan het marineren en wat ga ik doen als ik het helemaal fout gedaan heb en mijn bijdrage aan de hapjes om zeep is? En nee, het is niet het volk waar ik met ovenhapjes mag aandraven behalve als ik het bladerdeeg zelf gekneed heb 😅
December 31, 2025 at 9:14 AM
Reposted by Usagi
thembo.bsky.social
I said chatgpt doesn't have a soul and got put on this list
@ai-rights.bsky.social has added you to the "AI Racists" moderation list
December 30, 2025 at 6:54 PM
Reposted by Usagi
nucleus.bsky.social
December 29, 2025 at 9:46 PM
Reposted by Usagi
scottsantens.com
Spoiler: They used the money just as wisely as anyone else would, and it's so frustrating that this still isn't a common sense assumption to make.
One man used some of the money to pay off debts and the remainder to furnish a new home, as he moved out of temporary accommodation. A parent bought a car to be able to drop their children off at school and one participant has used the money to fund driving lessons and hopes to buy a car. Another young man also paid off debts and began researching courses to enable him to find work as a plumber. One woman said that the money came just at the right time, as she was struggling with childcare costs. For a young person who wasn’t able to study at university because they couldn’t afford the fees, the money has given them hope to continue pursuing education. Several participants gave money or bought gifts for relatives or friends. Three months after receiving the windfall, some people had not spent all of the money and put left-over cash in a bank account as savings. So far, there have been no adverse outcomes for participants taking part in this trial. Michael Sanders, professor of public policy at King’s College London, which is evaluating the trial, said: “Evidence from Canada suggests that when people experiencing homelessness get a cash sum they invest in themselves and in their future.
December 30, 2025 at 4:52 PM
endimi.bsky.social
Wake up dead man gekeken gisterenavond. Heerlijk vermaak. Aanrader!
a man in a suit and tie adjusts his glasses in a dark room
ALT: a man in a suit and tie adjusts his glasses in a dark room
media.tenor.com
December 30, 2025 at 5:56 PM
endimi.bsky.social
't Es gank.
December 29, 2025 at 4:34 PM
endimi.bsky.social
Prachtig! Hier in het gezin zijn ook al 4 staarten naar Haarwensen gegaan!
ellenngng.bsky.social Ellen @ellenngng.bsky.social · 5d
Ruben (10) laat al lang zijn haar groeien zodat Haarwensen er een pruik voor een ander kind van kan maken.
Tegelijk zamelt hij geld in voor NGNG💙
Straks gaan @michielveenstra.nl en ik met hem mee naar de kapper want vandaag is de dag!

Geven jullie hem een laatste zetje?
weglow.world/o/ngng/f/BL1...
December 29, 2025 at 9:07 AM
Reposted by Usagi
kurtsegers.bsky.social
Dit is ronduit spectaculair:
sailorrooscout.bsky.social Chise @sailorrooscout.bsky.social · 6d
In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️
Highlights •Severity of Alzheimer's disease (AD) correlates with NAD+ homeostasis dysregulation •Preserving brain NAD+ homeostasis prevents AD in mice • Restoring brain NAD+ homeostasis reverses advanced AD in mice • Multiomics across human and mouse AD brain identifies nodes for human AD reversal Summary Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible. Abstract Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care. Graphical Abstract (CREDIT: Cell Reports Medicine)
December 28, 2025 at 5:20 PM
Reposted by Usagi
jefftrnka.bsky.social
December 28, 2025 at 10:37 AM
endimi.bsky.social
Moh. #RIP BB.
a woman is looking at her reflection in a mirror .
ALT: a woman is looking at her reflection in a mirror .
media.tenor.com
December 28, 2025 at 11:12 AM
endimi.bsky.social
Happy Birthday @petatteke.bsky.social
a birthday card with a penguin holding a cake with a candle
ALT: a birthday card with a penguin holding a cake with a candle
media.tenor.com
December 28, 2025 at 8:10 AM
endimi.bsky.social
Dus ik kreeg van @ardanwen78.bsky.social een waxine parfum brander dingetje. De geur iets dat ik denk dat @dogcrazypinup.bsky.social ook zal kunnen smaken...
Label of wax perfume named "Shadow Daddy"
December 27, 2025 at 7:24 PM
Reposted by Usagi
georgetakei.bsky.social
Our government’s priorities are entirely backward. And purposefully so.
Screenshot of a tweet by James Tate reading, “An educated populace is a threat to power.” The tweet includes a quoted graphic stating that ICE is offering a $45,000 signing bonus and $100,000 starting salary, compared to a teacher earning $55,000 in their eighth year with a master’s degree, arguing that education has been intentionally defunded.
December 27, 2025 at 3:11 PM
Reposted by Usagi
sari3.bsky.social
Voorbereidingen voor vanavond
(Niet iedereen heeft er 3 dagen voor nodig om het te maken en 5 sec onoplettendheid om het daarna in de vuilbak te kieperen.)
December 27, 2025 at 1:18 PM
Reposted by Usagi
elonmusk-parody.bsky.social
New York City Fights ICE With Snowballs

Footage from New York City shows a winter street incident where residents threw snowballs toward ICE agents. The situation briefly intensified as snowballs filled the air, with one agent appearing to momentarily lose balance before recovering.
December 27, 2025 at 4:35 PM