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Max Planck Institute for Brain Research @mpibrain.bsky.social · 23d

A molecular atlas of the hippocampus: Scientist at the MPIs for Brain Research and Biophysics map RNAs and proteins at synaptic resolution 🔬 🔗 brain.mpg.de/molecular-at... @evakaulich.bsky.social @erin-schuman.bsky.social

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evakaulich.bsky.social @evakaulich.bsky.social · 25d

All data are openly available:
– Explore at syndive.org

– RNA-seq at NCBI SRA PRJNA1142450 + PRJNA1142761

– Proteomics at PRIDE PXD054879

We hope this atlas will be a lasting community resource for studies of hippocampal biology, plasticity, and disease.

syndive

Create beautiful synapses regardless of previous experience.

syndive.org

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evakaulich.bsky.social @evakaulich.bsky.social · 25d

We combined RNAseq & proteomics with synapse-level resolution to map the hippocampus. We find thousands of molecules with spatial enrichment, reveal how protein half-life and local translation shape compartment identity and show that distal dendrites rely more strongly on local protein synthesis.

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evakaulich.bsky.social @evakaulich.bsky.social · 25d

Excited to share our new paper in @natcomms.nature.com : An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution.

Press release: brain.mpg.de/molecular-at...
Paper: doi.org/10.1038/s414...

cc @mpibrain.bsky.social

A Molecular Atlas of the Hippocampus: Mapping RNAs and Proteins at Synaptic Resolution

New integrative study uncovers the spatial organization of transcripts and proteins in the mouse hippocampus, offering insights into brain function and plasticity.

brain.mpg.de

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 29

We hope this multi-omics atlas serves as a valuable resource for the neuroscience and multiomics community. Explore the data here: RNA-seq: PRJNA1142450 & PRJNA1142761 (NCBI SRA) and Proteomics: PRIDE PXD054879 @pride-ebi.bsky.social

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 29

Overall, this multi-omic study provides a comprehensive molecular map of hippocampus, revealing spatial gradients of transcripts and proteins, insights into mechanisms underlying synaptic diversity. The dataset is available for interactive exploration at syndive.org

syndive

Create beautiful synapses regardless of previous experience.

syndive.org

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 29

5/Our FASS-based synaptic profiling revealed distinct transcriptomic and proteomic signatures across hippocampal subregions and strata. Synapse diversity is shaped by both input origin and local molecular composition, defining layer-specific plasticity and organization.

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 29

4/ Local translation versus trafficking emerged as a key mechanism shaping protein distribution, particularly in distal dendrites within the SLM, which might indicate a hotspot for locally synthesized proteins.

mRNA and protein enrichment across sites, candidate genes with overlapping enrichment, and mRNA translation preference in somata or neuropil.

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 29

3/By integrating mRNA and protein data, we found that some proteins are tightly linked to local mRNA availability, while others are decoupled due to differences in protein half-lives.

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 29

2/ We dissected 3 subregions (CA1, CA3, DG) and 4 CA1 strata (SO, SP, SR, SLM) to profile >17,000 transcripts and ~10,000 proteins, capturing thousands of locally enriched molecules across receptors, channels, metabolism & adhesion families.

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 29

1/ Understanding brain molecular diversity requires mapping both mRNAs & proteins across regions & compartments. We combined microdissection, FASS-based synaptosome sorting, RNA-seq, and LC-MS/MS to do just that.

Experimental pipeline schematic: Crossing mouse lines, microdissections, FASS, transcriptomics and proteomics

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 29

Excited to share our latest collaborative work from Erin Schuman's lab @mpibrain.bsky.social : An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution, now published in @natcomms.nature.com. Here’s a thread summary 🧵
doi.org/10.1038/s414...

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 28

Absolutely, the omics world really is an exciting space to be in!

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evakaulich.bsky.social @evakaulich.bsky.social · Aug 27

Thank you so much! Excited for all of us to keep exploring multiomics research🧠

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Reposted

Cedric Boeckx @cedricboeckx.bsky.social · Aug 27

“An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution” 🧪🧠🧬

Great study (+resource) by @evakaulich.bsky.social Erin Schuman and colleagues
@natcomms.nature.com
www.nature.com/articles/s41...

An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution - Nature Communications

Understanding the brain’s diversity requires spatially resolved maps of transcripts and proteins. Here, the authors construct an integrated molecular atlas of the mouse hippocampus revealing loca...

www.nature.com

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Reposted

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 9

Foliar mRNA spray induces protein synthesis in monocot crop and dicot model plant species https://www.biorxiv.org/content/10.1101/2025.08.07.668951v1

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Reposted

Max Planck Institute for Brain Research @mpibrain.bsky.social · Aug 1

🚛 Ribosomes on the road! New research from the Schuman Lab @mpibrain.bsky.social shows neurons can locally assemble ribosomes - far from the nucleus and close to synapses. A big shift from textbook biology! 📚🧬🔗 bit.ly/3GUJKPv #Neuroscience #CellBiology #Ribosomes

Ribosomes On the Road: Neurons Assemble Protein Factories Far from the Nucleus

New study shows ribosome biogenesis can occur within neuronal branches, challenging traditional textbook biology.

bit.ly

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Reposted

Amy Courtney @amycourtneyyy.bsky.social · Apr 4

Very excited and proud to finally share this story! 🐙

We discovered surprising roles for dopamine and acetylcholine in the Octopus visual system…
doi.org/10.1101/2025...

Novel dopaminergic neurotransmission in the Octopus visual system

Coleoid cephalopods such as the common octopus have a complex visual system, with a camera-type eye and a large optic lobe, that evolved independently from its counterpart in vertebrates. However, the...

doi.org

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Reposted

Alice Ting @aliceyting.bsky.social · Feb 26

Today we report the directed evolution of HUH into rHUH, a sequence-specific covalent protein tag for RNA labeling. rHUH was hard to engineer: the initial HUH template had no RNA activity, so we started with RNA-DNA hybrids. 30 rounds of selection on the yeast surface were required, and 7 cycles of

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Reposted

Max Planck Institute for Brain Research @mpibrain.bsky.social · Jul 10

🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social ‬#neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40P

Erin M. Schuman Wins 2026 Nakasone Award

bit.ly

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Reposted

Evelina Tutucci @anilevetu.bsky.social · Jul 8

Optogenetic storage and release of protein and mRNA in live cells and animals | Nature Communications share.google/gz8nYXZ3hUVh...

#spatialbiology #imagingtools #fluorescencemicroscopy

Optogenetic storage and release of protein and mRNA in live cells and animals - Nature Communications

Spatiotemporal control of biomolecules is a key challenge in cell biology. Here, authors introduce RELISR, an optogenetic condensate system enabling reversible, light-dependent sequestration and relea...

share.google

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Reposted

Max Planck Institute for Brain Research @mpibrain.bsky.social · Jul 7

🚀 We’re thrilled to welcome 14 talented and enthusiastic high-school students to the 2025 Max Planck Junior Scholars Program, kicking off today with a Science Boot Camp Week @mpibrain.bsky.social ! 🔬🧬 @maxplanck.de

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Reposted

Waggoner Lab @labwaggoner.bsky.social · Jul 7

Optogenetic storage and release of protein and mRNA in live cells and animals @natcomms.nature.com
www.nature.com/articles/s41...

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Reposted

EMBO @embo.org · Jul 2

119 EMBO Fellows from 30+ countries attended the EMBO Fellows’ Meeting in Heidelberg, DE from 27 June–1 July. #Research was shared and connections formed – an incredible opportunity for #networking and #collaboration. Thank you to all who joined and were part of this vibrant community! 🧪

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Reposted

Hilliard Lab @hilliardlab.bsky.social · Jan 24

Out now! We found a new molecule, OSP-1, that protects neurons from damage caused by oxidative stress. We show that OSP-1 reduces cell death by regulating autophagy, and can be an exciting target for future treatments of acute insults such as stroke.

www.nature.com/articles/s41...

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