Our latest work : Statins are used to lower plasma cholesterol but often come with muscle-related side effects. Using cryo-EM, we show how multiple statin molecules cooperate to bind RyR1, a calcium release channel mainly found in skeletal muscle.
nature.com/articles/s41...

PIP2-driven cytoplasmic domain motions are coupled to Kir2 channel gating, say Eva-Maria Zangerl-Plessl, Anna Stary-Weinzinger, Colin G. Nichols, and Sun-Joo Lee rupress.org/jgp/article/...

@colinnicholslab.bsky.social

#IonChannels #Phospholipids

Very interesting paper from Susan Hamilton's lab, showing that phosphorylation of RyR1 by SPEG kinase can suppress pathological consequences of disease mutations.
www.science.org/doi/10.1126/...

Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD

www.nature.com/articles/s41...

We have a preprint of a book chapter for you: Structural Analysis of Membrane Proteins in Cell-Derived Microvesicles.

We describe how to image membrane proteins in mid-sized vesicles using cryo-electron tomography

zenodo.org/records/1717...

www.science.org/doi/10.1126/...

A study in collaboration with Frank Bosmans. Reproducible protocol to measure the elusive NaV1.9 currents, and revealing a big role for the preIQ region in gating properties.

Still a few days left to apply for a faculty position focused on cardiac arrhythmias at Simon Fraser University. Come join the greater Vancouver network on arrhythmia research!
www.academicwork.ca/jobs/assista...

Is it just me or is Pubmed down...??

Well done Kookjoo Kim on a great poster presentation, here visited by an RyR VIP, @filipvanpetegem.bsky.social!

And thanks @biophysicalsoc.bsky.social, @popstarlab.bsky.social & team for a great #BPS2025 under challenging circumstances - see you next year in SF!

Stress in action: our crystal structure of PKA bound to its preferred substrate in CaV1.2 (Ser1981 for the aficionados). Quantitative experiments on previously proposed sites in CaV1.2 and its regulator Rad shows that there are two tiers of substrates.

jbc.org/article/S002...

Calcins are scorpion-derived peptides that can cross the plasma membrane and modulate the Ryanodine Receptor. Marvin presenting the latest cryoEM results from our lab at the 2024 Translational Arrhythmia Day (TADA) meeting.
(description also here: www.science.org/doi/10.1126/...)

Every day since the late 1920s (except during WWII), the notes of the Last Post sound through the Menin Gate in Ypres, Belgium. Unfortunately, "never again" hasn't stuck. #ArmisticeDay

Can you find out which ion binds your protein using cryo-EM? This new method from Bonnie Murphy's lab combines electron energy loss spectroscopy and single particle imaging, showing this can become posssible. Test case on our favorite protein, the Ryanodine Receptor.

www.nature.com/articles/s41...

Our latest cryo-EM study, elucidating the type 3 Ryanodine Receptor (RyR3) in different conformational states
nature.com/articles/s4146…

Unexpected binding sites for ATP and chloride in the N-terminal region, affected by mutations linked to epileptic encephalopathy.

A new faculty position in cardiac arrhythmia in the greater Vancouver area.

sfu.ca/content/dam/...

Come join our local arrhythmia community.

OK this is COOL i love it
www.biorxiv.org/content/10.1...

A very cool method by Bonnie Murphy's lab to map elements for cryo-EM. The method, named REEL-EM, makes use of electron-energy loss spectroscopy. Honored to have contributed to this: www.biorxiv.org/content/10.1...