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Reposted by Gareth Ball

Alessandro Gozzi @gozziale.bsky.social · Sep 10

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n

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Reposted by Gareth Ball

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Sep 9

Multimodal imaging of human fetal brain development at the mesoscopic scale using 11.7 T ex vivo MRI https://www.biorxiv.org/content/10.1101/2025.09.08.669657v1

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Reposted by Gareth Ball

Alex Fornito @alexfornito.bsky.social · Sep 5

🔥ATTENTION!🔥

Registration for the 2026 Noosa Brain Workshop is now open!

Join us for some amazing science, sun, and surf in one of Australia's most beautiful beach towns.

Details:
tinyurl.com/arbc5pp6

Check out or incredible list of confirmed speakers. More to come...

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Reposted by Gareth Ball

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Aug 27

Expanding canonical cortical cell type markers in the era of single-cell transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.26.672469v1

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Reposted by Gareth Ball

Debby Silver @debbysilver.bsky.social · Aug 10

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

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Reposted by Gareth Ball

Kevin Mitchell @wiringthebrain.bsky.social · Aug 8

Spatial transcriptomics reveals human cortical layer and area specification www.nature.com/articles/s41... - early emergence of layers; graded differentiation along A/P axis, w/ early, sharp V1/V2 boundary

Spatial transcriptomics reveals human cortical layer and area specification - Nature

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially res...

www.nature.com

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Reposted by Gareth Ball

Gareth Ball @garedaba.bsky.social · Jul 29

JOB ALERT! We're seeking a postdoctoral scientist to join Developmental Imaging at @mcri.bsky.social in Melbourne.

Role will involve working with international partners on a new project charting brain growth in children with NF-1

Please reach out for more information

www.seek.com.au/job/86090834

Research Officer Job in Parkville, Melbourne VIC - SEEK

We are seeking a Postdoctoral Research Officer to drive international neuroimaging research into childhood NF1 brain development.

www.seek.com.au

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Gareth Ball @garedaba.bsky.social · Jul 29

JOB ALERT! We're seeking a postdoctoral scientist to join Developmental Imaging at @mcri.bsky.social in Melbourne.

Role will involve working with international partners on a new project charting brain growth in children with NF-1

Please reach out for more information

www.seek.com.au/job/86090834

Research Officer Job in Parkville, Melbourne VIC - SEEK

We are seeking a Postdoctoral Research Officer to drive international neuroimaging research into childhood NF1 brain development.

www.seek.com.au

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Gareth Ball @garedaba.bsky.social · Jul 26

Big fan of acronyms

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jul 25

TRAMFIX: TRavelling Across Melbourne for FIXel-based analysis (a reproducibility study) https://www.biorxiv.org/content/10.1101/2025.07.21.666058v1

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Reposted by Gareth Ball

Thomas Yeo @bttyeo.bsky.social · Jul 17

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social

AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements...

doi.org/10.1038/s415...

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Reposted by Gareth Ball

Nature Neuroscience @natneuro.nature.com · Jul 7

Human thalamocortical connectivity matures along the cortex’s sensorimotor–association axis

www.nature.com/articles/s41...

Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity - Nature Neuroscience

Sydnor et al. developed a new tractography atlas of thalamocortical structural connections and applied it to three youth samples. They uncovered coordinated development between thalamic connectivity a...

www.nature.com

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Reposted by Gareth Ball

Bertoglio lab (FMC/UFSC) @bertogliolab.bsky.social · Jul 2

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
www.nature.com/articles/s41...

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution - Nature

A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promise...

www.nature.com

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Reposted by Gareth Ball

Jeremiah Tsyporin @tsyporin.bsky.social · Jul 1

Thrilled to present MIND!

A model for how the sensorimotor–association axis of the neocortex develops.

Huge thanks to the incredible multidisciplinary team who made this happen.

www.biorxiv.org/content/10.1...

Competing Programs Shape Cortical Sensorimotor-Association Axis Development

The neocortex is organized along a dominant sensorimotor-to-association (S-A) axis, anchored by modality-specific primary sensorimotor areas at one end and transmodal association areas that form distr...

www.biorxiv.org

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Reposted by Gareth Ball

Zhiqiang Sha (X: @sha_zhiqiang) @zhiqiangsha.bsky.social · Jul 2

Addressing artifactual bias in large, automated MRI analyses of brain development | Nature Neuroscience
www.nature.com/articles/s41...

Addressing artifactual bias in large, automated MRI analyses of brain development - Nature Neuroscience

As large-scale neurodevelopmental MRI studies gain prominence, the authors identify tradeoffs between sample size and quality control that can dramatically affect results, and they evaluate a range of...

www.nature.com

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Reposted by Gareth Ball

Stuart Oldham @stuartoldham.bsky.social · Jun 25

On Friday/Saturday I have a poster (1205) on our work using generative network models, where I explore how heterochronous spatial gradients constrain brain connectivty 🧠⌛🏳️‍🌈 Also Saturday (11:30am; Great Hall) I have a talk on this work, so make sure you have recovered from club night in time for it!

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Reposted by Gareth Ball

Stuart Oldham @stuartoldham.bsky.social · Jun 25

For those at OHBM, check out my posters and talk! Today and tomorrow I (and maybe @garedaba.bsky.social) will be presenting my poster (1012) on our work linking fetal gene expression to neonatal connectome organisation 🧬🧠👶🌐 1/2 #OHBM #OHBM2025 (preprint here www.biorxiv.org/content/10.1... )

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Reposted by Gareth Ball

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jun 4

Accurate spatial localization of Allen Human Brain Atlas gene expression data for human neuroimaging https://www.biorxiv.org/content/10.1101/2025.06.02.656812v1

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Reposted by Gareth Ball

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · May 29

Macroscale Connectivity in the Octopus brain https://www.biorxiv.org/content/10.1101/2025.05.28.656524v1

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Reposted by Gareth Ball

Stuart Oldham @stuartoldham.bsky.social · May 28

Do you like brain network hubs?🧠🌐✳️Do you like genes?🧬What about neurodevelopment?👶What if I told you the latest work by @garedaba.bsky.social and myself combined all of these?🤯🤯🤯

See Gareth's thread for a primer of our findings, then read the paper for the details!
www.biorxiv.org/content/10.1...

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Gareth Ball @garedaba.bsky.social · May 28

We also demonstrate some intriguing findings on the enrichment of hub genes in human-accelerated genomic regions, associations with adult brain phenotypes and links to neurodevelopmental disorders.

more details here: www.biorxiv.org/content/10.1...

Transcriptomic divergence of network hubs in the prenatal human brain

Connections in the human brain are not uniformly distributed; instead, a dense network of long-range projections converge on highly connected hub regions located in transmodal, paralimbic, and associa...

www.biorxiv.org

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Gareth Ball @garedaba.bsky.social · May 28

We think this shows that hub regions begin forming circuits earlier than non-hub regions, affording more time to form the structural foundations of the brain's network.

a woman is talking on a phone and the words i 'm networking are above her

ALT: a woman is talking on a phone and the words i 'm networking are above her

media.tenor.com

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Gareth Ball @garedaba.bsky.social · May 28

Hub genes were specifically enriched for subplate neurons, the earliest population of neurons to mature and cirtical for the correct targeting of neural connections, as well as deep layer cortical neurons that connect across cortical areas.

pseudotime plot showing that hub gene expression is increased in layer 5/6 intratelencephalic neurons and subplate neurons

Plot showing hub gene expression increases with maturation in subplate neurons

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Gareth Ball @garedaba.bsky.social · May 28

We found that, by 20 weeks gestation, future cortical hubs can be identified by increased expression of genes associated with the formation and assembly of neural circuits in the subplate

genes that are associated with network connectivity in the prenatal brain include: AMIGO2, CHST2, NMT2 and EFNA5

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Gareth Ball @garedaba.bsky.social · May 28

While core hub connections are formed prior to the time of birth, the mechanism by which they arise are unclear.

We used our recent digital atlas - microBrain - to compare gene expression in cortical areas of the prenatal brain that go on to form network hubs

www.nature.com/articles/s41...

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Gareth Ball @garedaba.bsky.social · May 28

Hub connections are critical for the transfer of information across networks, account for significant energy demand, are vulnerable across a range of brain disorders and are strongly constrained by genetics

www.nature.com/articles/s41...

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