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Gabriele Corso @gcorso.bsky.social · 22d

Pretty surreal when out of the blue you see your model up on an ad on highway billboards and airport screens 🤯 (pictures from San Diego Airport and a highway in SF)

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Gabriele Corso @gcorso.bsky.social · Sep 9

You can find all the code and documentation at: github.com/jwohlwend/bo...
Join our community Slack: boltz.bio/join-slack

GitHub - jwohlwend/boltz: Official repository for the Boltz biomolecular interaction models

Official repository for the Boltz biomolecular interaction models - jwohlwend/boltz

github.com

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Gabriele Corso @gcorso.bsky.social · Sep 9

Boltz v2.2.1 out. A few improvements including support for .pdb templates, better treatment of stereochemistry in guidance potentials, and improved documentation. As always a great thank you to all those in the community who contributed via PR, raising issues or directly reporting issues to us.

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Gabriele Corso @gcorso.bsky.social · Sep 9

Sitting at the #AITHYRA symposium hearing about incredible new high-throughput datasets 🤯! If you have developed new data that you think could improve Boltz, e.g. protein small-molecule affinity, protein protein affinity, binding site (eg via proteomics), let's work together! 🤗

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Gabriele Corso @gcorso.bsky.social · Sep 9

Have you tried using the --use_potentials flag?

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Reposted by Gabriele Corso

ChimeraX @chimerax.ucsf.edu · Aug 20

Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX.
Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...

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Reposted by Gabriele Corso

Vojtech Spiwok @spiwokv.bsky.social · Aug 21

On #Boltz and #drugdesign by @gcorso.bsky.social #PragueBioML @elixircz.bsky.social

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Reposted by Gabriele Corso

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · Aug 15

If you use Boltz1/2, BioEmu, Chai1, or other MSA-dependent models, you’re likely using our ColabFold server. Please be considerate! Avoid large submissions across many IPs instead generate the MSA locally. Our server is an old-timer from 2014 and can’t handle that load.

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Reposted by Gabriele Corso

ChimeraX @chimerax.ucsf.edu · Jul 24

ChimeraX daily builds can predict binding affinity of small molecules using Boltz 2 on your Mac, Windows or Linux computer. www.rbvi.ucsf.edu/chimerax/dat...

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Reposted by Gabriele Corso

Alexander Ille @alexander-ille.bsky.social · Jul 4

Excited to share our work on modeling the human protein interactome in 3D. This currently includes 1,394 interaction structures predicted with Boltz-2. Grateful for the open-access resources making this possible!

Preprint: doi.org/10.1101/2025...

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Reposted by Gabriele Corso

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Jun 19

Boltz-2 : Towards accurate and efficient binding affinity prediction by @gcorso.bsky.social Saro Passaro and Jeremy Wohlwend

youtu.be/iHDauMATkr0?...

Boltz-2: Towards Accurate and Efficient Binding Affinity Prediction

YouTube video by Valence Labs

youtu.be

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Gabriele Corso @gcorso.bsky.social · Jun 17

Nice interview of Phil Sharp on the controversial birth of biotech and recombinant DNA with some great analogies to the current discourse on AI and gene editing!

- YouTube www.youtube.com/watch?v=LLij...
- Spotify spotifycreators-web.app.link/e/NNmzqnTjgUb
- Apple podcasts.apple.com/us/podcast/h...

The Nobel that Sparked Biotech - Prof Phil Sharp

YouTube video by Health Horizons

www.youtube.com

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Gabriele Corso @gcorso.bsky.social · Jun 14

We will be hosted by @hannes-stark.bsky.social in his renowned reading group!

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Gabriele Corso @gcorso.bsky.social · Jun 14

Thank you everyone for attending the Boltz-2 Boston, San Francisco and Paris events this week! Given the success of the in-person seminars and the many requests, we are organizing a virtual seminar on Tuesday at 12pm ET / 6pm CET! Sign up here: lu.ma/4bpuwbsr

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Reposted by Gabriele Corso

Science X / Phys.org @sciencex.bsky.social · Jun 10

A new AI model jointly predicts protein structure and binding affinity, enabling rapid, accurate screening of small molecules and accelerating early-stage drug discovery. Boltz-2 is now open source.

Protein-binding affinity model expands role of AI in drug discovery

Understanding how molecules interact is central to biology: from decoding how living organisms function to uncovering disease mechanisms and developing life-saving drugs.

phys.org

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Reposted by Gabriele Corso

Recursion @recursionpharma.bsky.social · Jun 13

Open science, activated.

Since the release of Boltz-2 last Friday – the new open-source protein structure and protein binding affinity model from MIT & Recursion – we’ve been introducing the model to the broader community and the reception has been terrific. 🧵

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Reposted by Gabriele Corso

Recursion @recursionpharma.bsky.social · Jun 13

On June 18 at the Molecular Machine Learning Conference (MoML) at MILA, Gabriele Corso, one of the lead researchers behind Boltz-2, will present more on this latest breakthrough in AI drug discovery alongside researchers from Valence.

👉 Learn more: portal.ml4dd.com #MOML2025

Home | MoML 2025

portal.ml4dd.com

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Reposted by Gabriele Corso

Kyle Tretina @allthingsapx.bsky.social · Jun 13

Boltz-2 just dropped: open-source AI that predicts both protein complex folds ✚ binding affinities in one shot 🚀

This is a win for protein AI, but let's not forget MSAs, the bioinformatics backbone many structure models lean on.

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Reposted by Gabriele Corso

Nick Boyd @nboyd.bsky.social · Jun 12

We added Boltz-2 to our protein design package! Under the hood this relies on a JAX translation, which, thanks to @jeremywohlwend.bsky.social and @gcorso.bsky.social ’s clean code, was fairly easy to write. We’ve been getting great results -- and we have yet to explore the most exciting new features

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Reposted by Gabriele Corso

Open Free Energy @openfree.energy · Jun 13

It's exciting to see our software used as a benchmark for cutting-edge AI methods!

Gabriele Corso @gcorso.bsky.social · Jun 6

On the standard FEP+ affinity benchmark, whose targets were held out of training, Boltz-2 achieves an average Pearson of 0.62—comparable to OpenFE, a widely adopted open-source FEP pipeline, while being over 1000x faster!

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Reposted by Gabriele Corso

C&EN (Chemical & Engineering News) @cenmag.bsky.social · Jun 10

A team led by Regina Barzilay, a computer science professor at MIT, has launched Boltz-2, an algorithm that unites protein folding and prediction of small-molecule binding affinity in one package. cen.acs.org/pharmaceutic... #chemsky 🧪

MIT and Recursion partner for AI drug discovery tool

Freely available Boltz-2 algorithm can predict small-molecule binding affinities

cen.acs.org

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Reposted by Gabriele Corso

MIT Jameel Clinic @aihealthmit.bsky.social · Jun 10

What a turnout! 🤯 Thank you to the 400+ attendees who came to listen to the first-ever Boltz-2 presentation in-person and for asking great questions! We look forward to seeing how Boltz-2 will empower future research in biomolecular structure prediction! 🧬🔥 #AIsky

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Reposted by Gabriele Corso

The Mark Foundation for Cancer Research @themarkfdn.bsky.social · Jun 9

Boltz-2 is here—and it’s poised to transform preclinical drug development. We were lucky to get a preview from Regina Barzilay at our 2025 Scientific Symposium, and we’re proud to support her work on the @cancergrand.bsky.social Matchmakers team. www.cancergrandchallenges.org/news/boltz-2...

Boltz-2: democratising the future of drug design

Open source structure prediction with binding affinity

www.cancergrandchallenges.org

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Reposted by Gabriele Corso

MIT Jameel Clinic @aihealthmit.bsky.social · Jun 9

'93 Nobel Prize laureate and Jameel Clinic Advisory Board Chair Phil Sharp breaks down why Boltz-2 is so groundbreaking. Join @gcorso.bsky.social + @jeremywohlwend.bsky.social today @ 4pm in Stata Center for their talk on Boltz-2!
🗓️RSVP: jclinic.mit.edu/events/unvei...
🎬: youtu.be/YDrFggLBEQw?...

'93 Nobel Laureate Phillip Sharp on significance of Boltz-2 and affinity binding

YouTube video by MIT Jameel Clinic - AI & Health

youtu.be

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Reposted by Gabriele Corso

Jan Gebauer @gebauer.bsky.social · Jun 9

This sounds really interesting! Eager to test it with some structures we have lying around. 👍

Gabriele Corso @gcorso.bsky.social · Jun 6

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

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