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Geert Carmeliet @geertlab.bsky.social · 24d

Congratulatioins Patricia and team!!

Reposted by Geert Carmeliet

ECTS society @ectssociety.bsky.social · Sep 10

The European Calcified Tissue Society is thrilled to announce the upcoming Clinical Training Course in Metabolic Bone Diseases, set to take place online from November 14 to 17, 2025, with on-demand access available until February 15, 2026.

buff.ly/GJ9eS1d

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Reposted by Geert Carmeliet

ASBMR @asbmr.bsky.social · Aug 6

"Being a scientist is not easy but it is an amazing job. With the new technology available there are so many questions you can answer, so much you can accomplish and contribute. Keep the dream."

Congratulations Sylvia Christakos, Ph.D.!

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Geert Carmeliet @geertlab.bsky.social · Aug 6

Congratulations Sylvia!!

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Geert Carmeliet @geertlab.bsky.social · Jul 24

Frank was a great and wonderful scientist, a real Renaissance man, passionate to advance science, very open-minded to other scientific domains, although critical, always providing novel ideas, but above all very amicable and honest. We will miss you Frank! My thoughts are with the family.

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Geert Carmeliet @geertlab.bsky.social · Jul 22

Interesting findings Nick!!

Nick van Gastel @nickvangastel.bsky.social · Jul 21

New preprint from our lab! Given the importance of nucleotide synthesis for AML cells, and the fact that aspartate is essential for nucleotide synthesis, we wondered if exogenous aspartate uptake through EAAT transporters plays a role in this cancer.

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Geert Carmeliet @geertlab.bsky.social · Jun 13

Congratulations Patricia and team!!

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Reposted by Geert Carmeliet

Agostinis Lab @agostinislab.bsky.social · Jun 13

🚨 Where does lipid peroxidation kick off in ferroptosis? 🔥Excited to reveal ER-mitochondria contacts as hotspots of the lipid peroxidation cascade! Kudos to our Maria Livia Sassano @mariamls.bsky.social 🙏 to our amazing collaborators #Ferroptosis#contactsites#ER#mitochondria# doi.org/10.1038/s415...

Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology

Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

doi.org

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Reposted by Geert Carmeliet

Christian Frezza @frezzalab.bsky.social · Jun 11

www.nature.com/articles/s41...

Metabolic adaptations direct cell fate during tissue regeneration - Nature

Metabolic enzymes of the tricarboxylic acid cycle, such as 2-oxoglutarate dehydrogenase, are differentially expressed in absorptive and secretory lineages, guiding cell fate establishment and offering...

www.nature.com

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Geert Carmeliet @geertlab.bsky.social · May 31

Congratulations!!!

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Reposted by Geert Carmeliet

Nick van Gastel @nickvangastel.bsky.social · May 19

New paper from our lab! In this study, we show that AML cells critically depend on LDHA to maintain their NAD+/NADH balance. Congrats to first author Ayşegül Erdem and all co-authors! cancerandmetabolism.biomedcentral.com/articles/10....

Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival - Cancer & Metabolism

Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent...

cancerandmetabolism.biomedcentral.com

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Reposted by Geert Carmeliet

Nick van Gastel @nickvangastel.bsky.social · May 5

We have re-openend this position for a post-doctoral fellow in our lab! Reach out if you have an interest in studying metabolism in cancer/stem cells and ideally have some mass spec experience. Please share!

Nick van Gastel @nickvangastel.bsky.social · Nov 29

We are hiring! There is still time to apply for an open postdoc position in stem cell metabolomics (mass spec experience required) in our lab, and we’ll soon open applications for a PhD student interested in studying metabolic crosstalk in the bone marrow (but feel free to already send me your CV)!

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Reposted by Geert Carmeliet

Ben Jackson @btjackson.bsky.social · Apr 28

I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

rdcu.be

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Reposted by Geert Carmeliet

Christian Frezza @frezzalab.bsky.social · Apr 11

www.nature.com/articles/s42...

Metabolites are not genes. repeat, please!

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

www.nature.com

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Reposted by Geert Carmeliet

ECTS society @ectssociety.bsky.social · Mar 20

Early Registration Deadline for the congress in Innsbruck!
REGISTER TO NOT MISS OUT
Register until the 23 March to get the early registration fee and seize the opportunity to share science with colleagues from all around the world.

www.ects2025.org/registration/

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Reposted by Geert Carmeliet

Tom Ambrosi @drambrosi.bsky.social · Mar 20

I feel extremely fortunate to have had the chance to learn from & work with Chuck Chan, building on some of his seminal discoveries and scientific vision. A truly 'chuckesque' manuscript by a wonderful collaborative & interdisciplinary team @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites

Ambrosi and colleagues profile human skeletal stem cells (hSSCs) across ten fetal skeletal sites and from patients throughout adulthood, identifying, mapping, and functionally testing four distinct hS...

www.cell.com

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Geert Carmeliet @geertlab.bsky.social · Mar 20

Congratulations Tom, beautiful work!!
Great memory of Chuck!

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Geert Carmeliet @geertlab.bsky.social · Feb 16

Thanks to all co-authors for excellent collaboration and thanks to @kuleuven.bsky.social and FWO for funding.

Nature Metabolism @natmetabolism.nature.com · Feb 16

RESEARCH | S Loopmans, @geertlab.bsky.social et al. (KU Leuven):

The pentose phosphate pathway in #chondrocytes provides reducing power to ensure proteostasis necessary for #bone lengthening 🦴 🐁

https://bit.ly/3X1RuDS

The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes - Nature Metabolism

Loopmans et al. show that the pentose phosphate pathway in chondrocytes provides reducing power to ensure proteostasis necessary for bone lengthening.

bit.ly

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Reposted by Geert Carmeliet

Lydia Finley @lydiafinley.bsky.social · Feb 4

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:

www.cell.com/cell/fulltex...

Rhodoquinone carries electrons in the mammalian electron transport chain

Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

www.cell.com

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Reposted by Geert Carmeliet

Christian Frezza @frezzalab.bsky.social · Feb 1

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis

Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

www.cell.com

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Geert Carmeliet @geertlab.bsky.social · Jan 30

Congratulations!!

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Geert Carmeliet @geertlab.bsky.social · Jan 29

very interesting research and great mentor!!

Nick van Gastel @nickvangastel.bsky.social · Jan 27

We are hiring at different levels!

- Lab technician for mouse experiments
- Postdoctoral fellow with experience in mass spectrometry-based metabolomics

For more information:
www.deduveinstitute.be/jobs
&
www.deduveinstitute.be/research-gro...

Come join our team and contribute to exciting science!

www.deduveinstitute.be

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Reposted by Geert Carmeliet

Christian Frezza @frezzalab.bsky.social · Jan 23

Hi all, our lab will soon recruit a PhD student working within a very exciting MSCA Horizon Doctoral network working on ageing, UNION, which gathers some fantastic scientists. Please apply if your profile fits our project (see attached advert).
Looking forward to working with you!

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Geert Carmeliet @geertlab.bsky.social · Jan 14

Many thanks Sarah!

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