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Lance Johnson @johnsonlab.bsky.social · Sep 7

new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Sep 6

Knockout of Perilipin 2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli https://www.biorxiv.org/content/10.1101/2025.09.02.673815v1

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · Aug 25

Thanks for putting together such a fantastic meeting, and for the opportunity to present! It was great to be part of the conversation with the rest of speakers.

International Society for Molecular Neurodegeneration @ismnd.bsky.social · Aug 25

👏 Great start to NextGen 2025!
S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease

Hosts: Kristine Freude & Marion Kadlecová

Speakers
🔹 Ghazaleh Eskandari-Sedighi
🔹 Lukas Busch
🔹 Johannes Schlachetzki
🔹 Zhiyuan Ning
🔹 Guoyan Zhao

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International Society for Molecular Neurodegeneration @ismnd.bsky.social · Aug 25

👏 Great start to NextGen 2025!
S1: Cellular Immune Responses in the Pathogenesis of #AlzheimersDisease

Hosts: Kristine Freude & Marion Kadlecová

Speakers
🔹 Ghazaleh Eskandari-Sedighi
🔹 Lukas Busch
🔹 Johannes Schlachetzki
🔹 Zhiyuan Ning
🔹 Guoyan Zhao

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Lance Johnson @johnsonlab.bsky.social · Aug 18

Are you an ATP!?!

We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).

Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.

Apply here! rb.gy/3zk4cm

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Canadian Association for Neuroscience @canacn.bsky.social · Aug 5

Identification of CD33m as a new protective factor in Alzheimer’s Disease development. Read about this research by Brain Star Award winner Ghazaleh Eskandari-Sedighi can-acn.org/brain-star-a... @ualberta.bsky.social @ghazeskandari.bsky.social

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Chris Parker @chrisgparker.bsky.social · Aug 3

Excited to share a new preprint from the lab. We show that PTMs like phosphorylation & glycosylation dynamically reshape proteome-wide ligandability in cells, including proteins like KRAS. Great collaboration with the Huang Lab, @forlilab.bsky.social and BMS. www.biorxiv.org/content/10.1...

Post-Translational Modifications Remodel Proteome-Wide Ligandability

Post-translational modifications (PTMs) vastly expand the diversity of human proteome, dynamically reshaping protein activity, interactions, and localization in response to environmental, pharmacologi...

www.biorxiv.org

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GlycoNet @glyconet.bsky.social · Jul 21

Join us for the next GTA webinar on Siglecs and their glycan ligands, featuring Dr. @siglecdude.bsky.social (U of A) and Dr. Edward Schmidt. Learn how their team is developing novel tools to uncover the biological roles of Siglecs across systems.

Register: canadianglycomics.ca/training/web...

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · Jun 28

Woohoo! Congrats to both of you guys! 🍾🎊

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Sarah Naguib, PhD @sarahnaguib.bsky.social · Jun 24

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

Gan Lab @liganlab.bsky.social · Jun 24

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

www.sciencedirect.com

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · Jun 15

Congrats! Nice job @zeinab-jc.bsky.social and the whole team👍

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Marco A. Maximo Prado @maximoprado.bsky.social · Jun 13

For #fluorescencefriday the Mesoscopic Integrated NeuroImaging Data (MIND) platform @westernu.bsky.social presents abeta plaques and blood vessels in the 🧠 of our ApoE4 mouse model of AD. 🧪 #clearing #lightsheet 🔬 Courtesy of Arash Salahinejad, Luke Smolders and @shahrzadbahrampour.bsky.social

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John Lukens @lukensjohnr.bsky.social · Jun 5

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

On-demand microglia deliver the therapeutic payload in Alzheimer’s disease

In this issue, Chadarevian et al. showed that engraftment of human iPSC-derived microglia (iMG) engineered to express secreted neprilysin (sNEP) under the plaque-responsive CD9 promoter reduces amyloi...

www.cell.com

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Jason Plemel @jrplemel.bsky.social · Jun 3

Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development.
journals.biologists.com/dev/article/...

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation

Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...

journals.biologists.com

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · Jun 3

Congrats @jrplemel.bsky.social and team! Really impressive work!

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · Jun 3

Congrats @johnsonlab.bsky.social really nice work 👍

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Lance Johnson @johnsonlab.bsky.social · Jun 3

What does the APOE 'lipid droplet-ome' look like???

Check out our new paper to find out!
www.sciencedirect.com/science/arti...

Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social

+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses

Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…

www.sciencedirect.com

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · May 19

The registration for the second round of 2025 Canadian Neuroscience Series are open now. This was a fantastic opportunity for me to learn about the impressive work of other #postdocs and share mine with them. Highly recommend it to anyone eligible in the field of #Neuroscience.

Canadian Neuroscience Seminars – Postdoctoral Series (CNS-PDS) @cns-pds.bsky.social · May 19

🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT.

Find more details here: tinyurl.com/56m946jh

Apply through this form: tinyurl.com/42cwhae3

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Canadian Neuroscience Seminars – Postdoctoral Series (CNS-PDS) @cns-pds.bsky.social · May 19

🇨🇦 🧠 Are you a #Postdoc in #Canada or #Canadian abroad? We are selecting #speakers for the (second round of the) 2025 Canadian #Neuroscience #Seminars: Postdoctoral Series. Apply by July 6th, 2025 @ 23:59PT.

Find more details here: tinyurl.com/56m946jh

Apply through this form: tinyurl.com/42cwhae3

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · May 8

Love it!

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John Lukens @lukensjohnr.bsky.social · May 3

Excited to share our new work demonstrating a role for astrocytic inflammasome signaling in modulating hippocampal plasticity. @cp-immunity.bsky.social
All credit to Kristine Zengeler, who was the brains🧠 and muscle💪 behind this project and is a wonderful collaborator. www.cell.com/immunity/ful...

Inflammasome signaling in astrocytes modulates hippocampal plasticity

The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in memory...

www.cell.com

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · May 1

Thanks to @canacn.bsky.social and #CIHR for choosing my work on human CD33 isoforms in Alzheimer’s disease for a #brainstar_award. I share the credit with Matt Macauley lab @siglecdude.bsky.social and all the amazing co-authors whose tremendous help was a huge contribution to this project.

Canadian Association for Neuroscience @canacn.bsky.social · May 1

Very proud to announce the winners of the 2024 Brain Star Awards! can-acn.org/congratulati...
Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...

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Canadian Association for Neuroscience @canacn.bsky.social · May 1

Very proud to announce the winners of the 2024 Brain Star Awards! can-acn.org/congratulati...
Très fiers d'annoncer les gagnants des prix Cerveau en tête 2024! can-acn.org/fr/bravo-aux...

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ghazeskandari.bsky.social @ghazeskandari.bsky.social · Apr 30

Thanks, Matt! Appreciate your kind words and support.

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Canadian Neuroscience Seminars – Postdoctoral Series (CNS-PDS) @cns-pds.bsky.social · Apr 29

Meet our first speaker 🗣️ Ghazaleh will be presenting at our webinar THIS Thursday! You can register here: zoom.us/webinar/regi...

And remember, you can stay up to date on webinars, events, and more by subscribing to our mailing list: t.co/Oa9dLowy1h

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Canadian Neuroscience Seminars – Postdoctoral Series (CNS-PDS) @cns-pds.bsky.social · Apr 28

Happening THIS week!

Register here: zoom.us/webinar/regi...

Stay up to date by subscribing to our mailing list: t.co/Oa9dLowy1h

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