Marco A. Maximo Prado
@maximoprado.bsky.social
Canada Research Chair. Misfolding proteins, chaperones and cholinergic function in neurodegeneration. Interested in reproducibility, translational research and open science. ORCID: 0000-0002-3028-5778
I also post pics of sunsets and bikes.
I also post pics of sunsets and bikes.
Pinned
Stress-inducible phosphoprotein 1 (STIP1) is a critical stemness regulator in mouse embryonic stem cells and early mammalian development - Communications Biology
Combined in silico and in vitro approaches reveal that the co-chaperone STIP1 supports pluripotent stem cell identity, proliferation, and stress resilience, highlighting proteostasis as a key mechanis...
www.nature.com
Just out. Work by Marilene Lopes who did a sabbatical in the lab and her student Camila Fernandes We explored the mechanisms by which the co chaperone STIP1 affects embryogenesis and early development following the phenotypes of STIP1 KO mice 🐁 www.nature.com/articles/s42...
Reposted by Marco A. Maximo Prado
Nov 2025 @rikiwilchins.bsky.social -- Groundbreaking study in journal Pediatrics found that suicidality dropped for transgender youth receiving hormone therapy by nearly 70%, with only 7 patients of 432 (1.6%) discontinuing treatment only 4 of whom re-identified as cisgender.
Study In The Journal Of Pediatrics Finds Trans Youth Care Lowers Suicidality, Few Detransition
The groundbreaking study found that suicidality dropped for transgender youth receiving hormone therapy by nearly 70%, with only 7 patients of 432 discontinuing treatment.
www.erininthemorning.com
November 25, 2025 at 11:24 AM
Nov 2025 @rikiwilchins.bsky.social -- Groundbreaking study in journal Pediatrics found that suicidality dropped for transgender youth receiving hormone therapy by nearly 70%, with only 7 patients of 432 (1.6%) discontinuing treatment only 4 of whom re-identified as cisgender.
Reposted by Marco A. Maximo Prado
The destruction of one of the world’s great public health agencies is a travesty. RFK Jr. seems determined to replace evidence-based science with quackery and use the CDC as his mouthpiece, by @picardonhealth.bsky.social
www.theglobeandmail.com/gift/0fc7a92... via @theglobeandmail.com
www.theglobeandmail.com/gift/0fc7a92... via @theglobeandmail.com
The destruction of one of the world’s great public health agencies is a travesty
RFK Jr.’s latest attack on vaccines shows evidence-based science has been replaced by the ill-informed opinions of a quack
www.theglobeandmail.com
November 25, 2025 at 11:31 AM
The destruction of one of the world’s great public health agencies is a travesty. RFK Jr. seems determined to replace evidence-based science with quackery and use the CDC as his mouthpiece, by @picardonhealth.bsky.social
www.theglobeandmail.com/gift/0fc7a92... via @theglobeandmail.com
www.theglobeandmail.com/gift/0fc7a92... via @theglobeandmail.com
One side is developing micro robotics and the latest drug therapies including mRNA vaccines. The other side claims vaccines cause autism and all sort of wellness bs. Choose wisely!
November 23, 2025 at 7:04 PM
One side is developing micro robotics and the latest drug therapies including mRNA vaccines. The other side claims vaccines cause autism and all sort of wellness bs. Choose wisely!
Reposted by Marco A. Maximo Prado
Know the difference.
November 19, 2025 at 10:08 PM
Know the difference.
Reposted by Marco A. Maximo Prado
In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus.
We need to stop the anti-science attacks against mRNA vaccines!
We need to stop the anti-science attacks against mRNA vaccines!
November 20, 2025 at 1:03 AM
In a new phase 3 trial, people randomly assigned to receive a flu shot made with modified mRNA were 34.5% less likely to be diagnosed with an influenza-like illness than people given a standard flu shot made with inactivated virus.
We need to stop the anti-science attacks against mRNA vaccines!
We need to stop the anti-science attacks against mRNA vaccines!
a reply all email chain just started. Have not had one of those for a while. Amazing how many smart scientists don’t understand when not to reply all….
a baby is covering his face and saying here we go again .
ALT: a baby is covering his face and saying here we go again .
media.tenor.com
November 18, 2025 at 4:17 PM
a reply all email chain just started. Have not had one of those for a while. Amazing how many smart scientists don’t understand when not to reply all….
Reposted by Marco A. Maximo Prado
Peanut allergies are plummeting in children, and you can thank science. Early exposure has turned out to be one of the best prevention methods, by @picardonhealth.bsky.social www.theglobeandmail.com/opinion/arti... via @theglobeandmail.com
Opinion: Peanut allergies are plummeting in children, and you can thank science
Early exposure has turned out to be one of the best prevention methods for allergies in kids
www.theglobeandmail.com
November 18, 2025 at 12:57 PM
Peanut allergies are plummeting in children, and you can thank science. Early exposure has turned out to be one of the best prevention methods, by @picardonhealth.bsky.social www.theglobeandmail.com/opinion/arti... via @theglobeandmail.com
Reposted by Marco A. Maximo Prado
Share your research at the next Canadian Neuroscience Meeting May 18-21, 2026 in Montreal!
Calls for Parallel Symposia, Satellite Meetings, Poster Abstract and Travel & Professional Awards are now open - Don't miss these opportunities!
can-acn.org/meeting-2026/
Calls for Parallel Symposia, Satellite Meetings, Poster Abstract and Travel & Professional Awards are now open - Don't miss these opportunities!
can-acn.org/meeting-2026/
November 14, 2025 at 7:34 PM
Share your research at the next Canadian Neuroscience Meeting May 18-21, 2026 in Montreal!
Calls for Parallel Symposia, Satellite Meetings, Poster Abstract and Travel & Professional Awards are now open - Don't miss these opportunities!
can-acn.org/meeting-2026/
Calls for Parallel Symposia, Satellite Meetings, Poster Abstract and Travel & Professional Awards are now open - Don't miss these opportunities!
can-acn.org/meeting-2026/
Reposted by Marco A. Maximo Prado
Hard to believe last week we were all together for the #TRIDENT 2025 Annual General Meeting...a yearly cross-site event uniting all members of the TRIDENT platform in 2 days of collaborative discussions and discovery! Part 1 recap just dropped below! #NFRF 👇🌎🎉🎤🤝tridentpreclinicaltrials.org
November 13, 2025 at 4:58 PM
Reposted by Marco A. Maximo Prado
14 months after submission, our article “Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI" is now out in @natmethods.nature.com . You can read it here rdcu.be/ePJo6
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N
Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI
Nature Methods - Stimulus-modulated approach to steady state (SASS) is an acquisition scheme for event-related fMRI that generates data with high temporal signal-to-noise ratios interspaced with...
rdcu.be
November 13, 2025 at 12:23 PM
14 months after submission, our article “Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI" is now out in @natmethods.nature.com . You can read it here rdcu.be/ePJo6
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N
Reposted by Marco A. Maximo Prado
Great that top Canadian universities are hiring top scholars (why wouldn't they?) but the Ontario Progressive Conservative government has starved the post-secondary sector and the province has the lowest per-student funding of any Canadian province. www.theglobeandmail.com/canada/educa...
U of T hires three top U.S. scholars, plans for 100 new postdocs
Canadian-born MIT astrophysicist Sara Seagar among those joining the university
www.theglobeandmail.com
November 12, 2025 at 3:54 PM
Great that top Canadian universities are hiring top scholars (why wouldn't they?) but the Ontario Progressive Conservative government has starved the post-secondary sector and the province has the lowest per-student funding of any Canadian province. www.theglobeandmail.com/canada/educa...
Reposted by Marco A. Maximo Prado
Get your Covid booster. SARS Cov-2 is relying on ignorance and misinformation to continue to infect and injure and kill. Don’t let it.
Want to make a tiny anti-vaxxer head explode and then madly say "big pharma"'or "fake news"? Just the facts. #cdnpoli
November 11, 2025 at 11:44 PM
Get your Covid booster. SARS Cov-2 is relying on ignorance and misinformation to continue to infect and injure and kill. Don’t let it.
Reposted by Marco A. Maximo Prado
Canada has a lot of work to do
Anti-vaccine disinformation from the US is a huge threat
www.reuters.com/business/hea...
Anti-vaccine disinformation from the US is a huge threat
www.reuters.com/business/hea...
November 11, 2025 at 3:50 AM
Canada has a lot of work to do
Anti-vaccine disinformation from the US is a huge threat
www.reuters.com/business/hea...
Anti-vaccine disinformation from the US is a huge threat
www.reuters.com/business/hea...
Reposted by Marco A. Maximo Prado
New opportunity at Queen's University: Tenured Tier 1 Canada Research Chair / Tenure-Track or Tenured Faculty Position supported by the Bruce Mitchell gift (Mitchell Chair). can-acn.org/tenured-tier... #neurojobs
Tenured Tier 1 Canada Research Chair / Tenure-Track or Tenured Faculty Position supported by the Bruce Mitchell gift (Mitchell Chair). – Canadian Association for Neuroscience
Canadian Association for Neuroscience
can-acn.org
November 11, 2025 at 2:09 PM
New opportunity at Queen's University: Tenured Tier 1 Canada Research Chair / Tenure-Track or Tenured Faculty Position supported by the Bruce Mitchell gift (Mitchell Chair). can-acn.org/tenured-tier... #neurojobs
Reposted by Marco A. Maximo Prado
If you know an anti-vaxxer, you can congratulate them on this hard-earned "win".
Honourable mentions to the universities & political leaders who have been so instrumental in making it easier for them to succeed.
This was truly a team effort.
www.reuters.com/business/hea...
Honourable mentions to the universities & political leaders who have been so instrumental in making it easier for them to succeed.
This was truly a team effort.
www.reuters.com/business/hea...
Canada loses measles elimination status after three decades, health agency says
Canada has lost its measles elimination status after nearly three decades due to its failure to curb a year-long outbreak, the country's public health agency said on Monday.
www.reuters.com
November 10, 2025 at 5:12 PM
If you know an anti-vaxxer, you can congratulate them on this hard-earned "win".
Honourable mentions to the universities & political leaders who have been so instrumental in making it easier for them to succeed.
This was truly a team effort.
www.reuters.com/business/hea...
Honourable mentions to the universities & political leaders who have been so instrumental in making it easier for them to succeed.
This was truly a team effort.
www.reuters.com/business/hea...
Reposted by Marco A. Maximo Prado
Great observation! Here’s an image from our dataset — the OB has a much higher vessel density than the rest of the brain, suggesting distinct vascular architecture. The video focus was set for brain contrast, causing overexposure in the highly vascular OBs.
November 10, 2025 at 3:09 PM
Great observation! Here’s an image from our dataset — the OB has a much higher vessel density than the rest of the brain, suggesting distinct vascular architecture. The video focus was set for brain contrast, causing overexposure in the highly vascular OBs.
Reposted by Marco A. Maximo Prado
Going for a rollercoaster ride on the spinal cord! 🤩
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
November 7, 2025 at 9:14 PM
Going for a rollercoaster ride on the spinal cord! 🤩
Reposted by Marco A. Maximo Prado
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
November 7, 2025 at 7:42 PM
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
Reposted by Marco A. Maximo Prado
One of my favorite jokes ever:
What did Watson and Crick discover?
Rosalind Franklin's notebooks
What did Watson and Crick discover?
Rosalind Franklin's notebooks
Hey folks, as news of Watson's demise spreads, please don't set aside his weighty legacy of misogyny and racism. He was truly among the worst of us. www.vox.com/2019/1/15/18...
DNA scientist James Watson has a remarkably long history of sexist, racist public comments
“People say it would be terrible if we made all girls pretty,” he said in 2003. “I think it would be great.”
www.vox.com
November 7, 2025 at 7:54 PM
One of my favorite jokes ever:
What did Watson and Crick discover?
Rosalind Franklin's notebooks
What did Watson and Crick discover?
Rosalind Franklin's notebooks
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
November 7, 2025 at 7:42 PM
Slick-H/M83 mice injected with alpha synuclein preformed fibrils. Magenta pS129 and yellow for eGFP driven by the Thy-1 promoter. blue nuclei #fluorescencefriday courtesy of Vlad Novikov. Shaz and Nadia from the @mind-western.bsky.social
Reposted by Marco A. Maximo Prado
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 7, 2025 at 1:25 PM
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marco A. Maximo Prado
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience
Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...
www.nature.com
November 7, 2025 at 10:16 AM
Just published in Nat. Neurosci.
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.
@erzimmer.bsky.social
@natureportfolio.nature.com
www.nature.com/articles/s41...
Reposted by Marco A. Maximo Prado
Great to be in Toronto for the Second AG meeting for @tridentpct.bsky.social where our 🐁 molecular and cognition core will show what we are up to in the last 2 years facilitated by @touchscreencog.bsky.social and we will continue to learn about our organoid and marmoset models.
November 3, 2025 at 1:00 PM
Great to be in Toronto for the Second AG meeting for @tridentpct.bsky.social where our 🐁 molecular and cognition core will show what we are up to in the last 2 years facilitated by @touchscreencog.bsky.social and we will continue to learn about our organoid and marmoset models.
Reposted by Marco A. Maximo Prado
Bottom line of systematic assessment of studies on Covid vaccinations/boosters:
~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised
Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents
www.nejm.org/doi/full/10....
~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised
Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents
www.nejm.org/doi/full/10....
October 31, 2025 at 8:17 PM
Bottom line of systematic assessment of studies on Covid vaccinations/boosters:
~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised
Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents
www.nejm.org/doi/full/10....
~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised
Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents
www.nejm.org/doi/full/10....