Kuchroo Lab
@kuchroolab.bsky.social
Lab of Vijay Kuchroo at @GeneLayInstitute.bsky.social @MGBResearch.bsky.social @HarvardMed.bsky.social @BroadInstitute.org
🧪 #Immunosky
🔗 kuchroolab.bwh.harvard.edu
Posts by lab members unless signed by VKK. Views are our own.
🧪 #Immunosky
🔗 kuchroolab.bwh.harvard.edu
Posts by lab members unless signed by VKK. Views are our own.
Beautiful work!
Check out our new study in @ScienceMagazine! Using single-cell transcriptomics, we profile enteric nervous system responses to the microbiota and inflammation, identifying regulators of motor #neuron states and #gut transit time.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...
www.science.org
November 3, 2025 at 8:07 PM
Beautiful work!
Reposted by Kuchroo Lab
The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges.
Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...
www.science.org
November 3, 2025 at 8:03 PM
The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges.
Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social
| Science www.science.org/doi/10.1126/...
Reposted by Kuchroo Lab
Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com
"Neuropeptide signalling orchestrates T cell differentiation"
www.nature.com/articles/s41...
"Neuropeptide signalling orchestrates T cell differentiation"
www.nature.com/articles/s41...
Neuropeptide signalling orchestrates T cell differentiation - Nature
RAMP3, a component of the receptor for the neuropeptide CGRP, has a cell-intrinsic role in T helper type 1 cell fate determination.
www.nature.com
October 13, 2025 at 12:27 AM
Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com
"Neuropeptide signalling orchestrates T cell differentiation"
www.nature.com/articles/s41...
"Neuropeptide signalling orchestrates T cell differentiation"
www.nature.com/articles/s41...
Reposted by Kuchroo Lab
Reposted by Kuchroo Lab
Reposted by Kuchroo Lab
Reposted by Kuchroo Lab
We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social!
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
October 10, 2025 at 12:39 PM
We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social!
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
We’re thrilled to welcome experts, ignite new ideas, & push the field forward.
Huge thanks to our incredible sponsors for making #RTN2025 possible!
🧵👇
#KuchrooLabReunion at #CSNeuroimmune25 in NYC with VKK & Manu Rangachari
September 10, 2025 at 11:37 PM
#KuchrooLabReunion at #CSNeuroimmune25 in NYC with VKK & Manu Rangachari
This conference is going to be great!
Looking forward to it.
Looking forward to it.
#ReThinkNeuroimmunology!
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
August 25, 2025 at 10:22 PM
This conference is going to be great!
Looking forward to it.
Looking forward to it.
This conference is going to be great! Looking forward to it.
August 25, 2025 at 10:18 PM
This conference is going to be great! Looking forward to it.
Reposted by Kuchroo Lab
Blockade of STUB1 in T cells boosts anti-tumor immunity. Study from the #SharpeLab led by @martinlafleur.bsky.social & #LaurenMilling @natimmunol.nature.com.
@genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org
hms.harvard.edu/news/researc...
www.nature.com/articles/s41...
@genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org
hms.harvard.edu/news/researc...
www.nature.com/articles/s41...
Research Identifies New Ways To Supercharge Cancer Immunotherapy
Findings, based on mouse studies, could pave the way for more effective cancer treatments
hms.harvard.edu
August 18, 2025 at 11:46 PM
Blockade of STUB1 in T cells boosts anti-tumor immunity. Study from the #SharpeLab led by @martinlafleur.bsky.social & #LaurenMilling @natimmunol.nature.com.
@genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org
hms.harvard.edu/news/researc...
www.nature.com/articles/s41...
@genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org
hms.harvard.edu/news/researc...
www.nature.com/articles/s41...
Reposted by Kuchroo Lab
REV-ERBα & REV-ERBβ, which control clock gene expression, also maintain ILC3 in a state that facilitates the maintenance of a balanced and healthy intestine @natimmunol.nature.com #ColonnaLab
www.nature.com/articles/s41...
preview @theonlylabever.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
preview @theonlylabever.bsky.social
www.nature.com/articles/s41...
August 13, 2025 at 6:16 PM
REV-ERBα & REV-ERBβ, which control clock gene expression, also maintain ILC3 in a state that facilitates the maintenance of a balanced and healthy intestine @natimmunol.nature.com #ColonnaLab
www.nature.com/articles/s41...
preview @theonlylabever.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
preview @theonlylabever.bsky.social
www.nature.com/articles/s41...
Reposted by Kuchroo Lab
🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org.
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪
@kepauken.bsky.social, Markson, Sharpe et al. @harvardmed.bsky.social show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...
July 31, 2025 at 1:07 AM
🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org.
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪
Reposted by Kuchroo Lab
Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved.
From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab.
Study led by #LingjiaKong @broadinstitute.org
From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab.
Study led by #LingjiaKong @broadinstitute.org
📢ONLINE @natgenet.nature.com
📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network.
By Lingjia Kong, @thexavierlab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network.
By Lingjia Kong, @thexavierlab.bsky.social and colleagues.
⬇️
www.nature.com/articles/s41...
Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network - Nature Genetics
Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of fibroblasts and immune cells contri...
www.nature.com
July 31, 2025 at 1:35 AM
Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved.
From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab.
Study led by #LingjiaKong @broadinstitute.org
From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab.
Study led by #LingjiaKong @broadinstitute.org
Reposted by Kuchroo Lab
New work from the lab - we found a surprising role for the glycolytic enzyme PGAM in Treg function. Whereas most glycolytic enzymes support inflammatory T cells, PGAM has the opposite effect by controlling serine synthesis to regulate the Treg-Th17 axis. #immunometabolism doi.org/10.7554/eLif...
Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism
The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanc...
doi.org
July 29, 2025 at 1:44 AM
New work from the lab - we found a surprising role for the glycolytic enzyme PGAM in Treg function. Whereas most glycolytic enzymes support inflammatory T cells, PGAM has the opposite effect by controlling serine synthesis to regulate the Treg-Th17 axis. #immunometabolism doi.org/10.7554/eLif...
Reposted by Kuchroo Lab
Gratifyingly, our findings complement and corroborate a very cool recent story from @kuchroolab.bsky.social showing that PGAM activity negatively regulates pathogenic Th17 cells www.sciencedirect.com/science/arti...
The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity
Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we inve…
www.sciencedirect.com
July 29, 2025 at 1:49 AM
Gratifyingly, our findings complement and corroborate a very cool recent story from @kuchroolab.bsky.social showing that PGAM activity negatively regulates pathogenic Th17 cells www.sciencedirect.com/science/arti...
Reposted by Kuchroo Lab
Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again on August 6th.
🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman.
Joseph B. Martin Conference Center, Boston MA
🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman.
Joseph B. Martin Conference Center, Boston MA
July 17, 2025 at 12:20 AM
Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again on August 6th.
🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman.
Joseph B. Martin Conference Center, Boston MA
🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman.
Joseph B. Martin Conference Center, Boston MA
Reposted by Kuchroo Lab
Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/
June 12, 2025 at 11:26 PM
Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
The glycolytic enzyme, phosphoglycerate mutase (PGAM), is a key metabolic regulator suppressing Th17 cell pathogenicity & autoimmunity.
Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...
Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...
The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity
Wang et al. identify phosphoglycerate mutase (PGAM) as a negative regulator of pathogenic
Th17 cell differentiation, contrary to other glycolytic enzymes. PGAM inhibition suppresses
a regulatory progr...
www.cell.com
June 6, 2025 at 2:19 AM
The glycolytic enzyme, phosphoglycerate mutase (PGAM), is a key metabolic regulator suppressing Th17 cell pathogenicity & autoimmunity.
Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...
Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...
Reposted by Kuchroo Lab
The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity @cp-cellreports.bsky.social @kuchroolab.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
June 6, 2025 at 1:24 AM
The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity @cp-cellreports.bsky.social @kuchroolab.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Grad student, #RockyBarilla was responsible for driving this huge effort. Well done!
🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...
www.science.org
June 3, 2025 at 12:10 PM
Grad student, #RockyBarilla was responsible for driving this huge effort. Well done!
Reposted by Kuchroo Lab
(1/6) Our latest paper in @cp-cellhostmicrobe.bsky.social shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway.
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00186-6
May 30, 2025 at 8:02 PM
(1/6) Our latest paper in @cp-cellhostmicrobe.bsky.social shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway.
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Kuchroo Lab
Come join us next week to hear @kuchroolab.bsky.social talk about exciting new work @lji.org
May 29, 2025 at 12:39 AM
Come join us next week to hear @kuchroolab.bsky.social talk about exciting new work @lji.org