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@thexavierlab.bsky.social
160 followers 27 following 52 posts
Genes to functions. Microbiome in health & disease. Computational biology. Chemical biology. Innate & adaptive immunity.

http://broadinstitute.org/xavier-lab
https://molbio.massgeneral.org/faculty/343
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Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis!

www.cell.com/cell-genomic...

#fibrosis #lung #ILD
Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases
Using single-nucleus RNA sequencing and spatial transcriptomics, Jaiswal et al. identify disease-associated cell communities that include aberrant transitional alveolar epithelium and pro-fibrotic fib...
www.cell.com
January 22, 2026 at 8:26 PM
(🧵1/7) New work, now online in @CellCellPress! Using a phased, binder-first strategy, we identified a ligandable pocket on CARD9 and discovered a small-molecule inhibitor of CARD9 inflammatory signaling.
www.sciencedirect.com/science/arti...
Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity
Human genetic association studies highlight key genes involved in disease pathology, yet targets identified by these analyses often fall outside the t…
www.sciencedirect.com
January 16, 2026 at 8:06 PM
Reposted
laurakiessling.bsky.social
Fun collaboration with @thexavierlab.bsky.social and Ribbeck groups to figure out how this human lectin plays multiple roles in controlling the #microbiome: stabilizing the mucus barrier and reducing bacteria that breach it. news.mit.edu/2026/protein... #glycotime
January 15, 2026 at 3:26 PM
Amazing work–with potential therapeutic implications–by the @laurakiessling.bsky.social group reveals dual actions of interlectin-2 in stabilizing mucosal barriers and targeting bacteria that escape a compromised barrier
www.nature.com/articles/s41...
Intelectin-2 is a broad-spectrum antimicrobial lectin - Nature Communications
Intelectin-2 defends mucosal interfaces by crosslinking mucus and blocking microbial growth. This study reveals that mouse and human intelectin-2 recognizes galactose-rich glycans to bind and target d...
www.nature.com
January 15, 2026 at 2:34 PM
Very excited to share our latest work in @Nature integrating single-cell & spatial transcriptomics with bidirectional CRISPR screens to unravel an immune–stromal cell circuit dependent on the transcription factor GLIS3 that regulates intestinal fibrosis during chronic inflammation. Congrats, Vlad!
January 7, 2026 at 8:58 PM
New in @NatureComms — collaborative work with the Knip & Orešič labs uncovers microbially conjugated bile acids in early life linked to immune development and type 1 diabetes risk.

pubmed.ncbi.nlm.nih.gov/41339624/

@broadinstitute.org @mgbresearch.bsky.social
Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity - PubMed
Emerging studies reveal that gut microbes can conjugate diverse amino acids to bile acids, known as microbially conjugated bile acids. However, their regulation and health effects remain unclear. Here, we analyzed early-life microbially conjugated bile acid patterns and their link to islet autoimmun …
pubmed.ncbi.nlm.nih.gov
December 12, 2025 at 4:14 PM
Register now for the International Human Microbiome Consortium (#IHMC) 2026, June 3–5 in Seoul, Korea!

Join this global gathering of researchers for an exciting program highlighting the latest discoveries in human #microbiome science:

www.ihmc2026seoul.com/html/
IHMC 2026 SEOUL
IHMC 2026 SEOUL 사이트입니다.
www.ihmc2026seoul.com
December 11, 2025 at 6:34 PM
Reposted
masakanai.bsky.social
Excited to share our new FinnGen single-nucleus multiome preprint! 🧬

We profiled ~10M PBMCs (snRNA-seq + snATAC-seq) from 1,108 Finnish donors to map how genetic variants drive complex disease through chromatin and gene regulation 🧵👇
🔗 Link: www.medrxiv.org/content/10.1...
December 1, 2025 at 3:36 PM
Registration now open for the International Congress of Mucosal Immunology (ICMI) 2026, Jul 13–17 in Montreal, Canada.

www.socmucimm.org/meetings-eve...

Looking forward to being part of this lineup of talks highlighting research at the interface of the immune system and mucosal surfaces!
ICMI 2026
ICMI provides an ideal opportunity to showcase your organization’s products and services and have direct interface with mucosal immunologists from around the globe.
www.socmucimm.org
December 4, 2025 at 3:04 PM
Kumar Thurimella & co-authors addressed the challenge of functionally annotating uncharacterized microbial enzymes with CAZyLingua, a deep learning model for classifying CAZymes from metagenomics. (1/2)
Protein language models uncover carbohydrate-active enzyme function in metagenomics
rdcu.be
December 1, 2025 at 7:15 PM
Solute carrier (SLC) transporters are implicated in many human diseases. In @jclinicalinvest, we show that efavirenz potentiates metal transporter SLC39A8 via a cryptic allosteric pocket—revealing new potential for therapeutic targeting.

www.jci.org/articles/vie...
JCI - Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake
www.jci.org
November 4, 2025 at 8:52 PM
Reposted
jem.org
In Nov issue: rupress.org/jem/issue/22...
@thexavierlab.bsky.social describe the biological function of Ankrd55 in mice, working as a functional modulator of T cell metabolism impacting Th17 responses. Cover shows a colon section of a mouse that received Ankrd55−/− T cells doi.org/10.1084/jem....
November 3, 2025 at 3:04 PM
Congrats to Jinjin Xu & co-authors – an image from their recent @jem.org article that describes Ankrd55 as a modulator of T cell metabolism impacting Th17 responses was selected for the cover!

Read the study here: rupress.org/jem/article-...

@broadinstitute.org @mgbresearch.bsky.social
November 4, 2025 at 2:47 PM
Great summary from the @mgbresearch.bsky.social team on our new Science paper about ENS–immune system interactions! Check it out: www.massgeneralbrigham.org/en/about/new...
Research Spotlight: Mapping How Gut Neurons Respond to Bacteria, Parasites and Food Allergy | Mass General Brigham
The enteric nervous system is a vast network of nerves built into the walls of the intestine. A new study adds to accumulating evidence showing that the ENS works closely with the immune system to hel...
www.massgeneralbrigham.org
October 31, 2025 at 2:07 PM
Check out our new study in @ScienceMagazine! Using single-cell transcriptomics, we profile enteric nervous system responses to the microbiota and inflammation, identifying regulators of motor #neuron states and #gut transit time.

www.science.org/doi/10.1126/...
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
Enteric neurons are essential regulators of intestinal physiology, yet their responses to varying microbial and immune environments along the intestinal tract and or during challenges remain poorly un...
www.science.org
October 30, 2025 at 8:34 PM
Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis.

www.nature.com/articles/s41...
Human immunodeficiency virus and antiretroviral therapies exert distinct influences across diverse gut microbiomes - Nature Microbiology
Metagenomic analysis of the gut microbiome of people with human immunodeficiency virus (HIV), from three distinct cohorts, revealed infection- and antiretroviral drug-linked alterations, which may con...
www.nature.com
October 30, 2025 at 4:18 PM
🔦 Spotlight! The Korean Association of Immuologists International 2025 is convening Oct 30th-Nov 1st in Incheon, South Korea. KAI 2025 will address current topics in immunology, encompassing both fundamental research and its application to immunological diseases.

kai2025.kr
October 28, 2025 at 8:33 PM
In his “Harvard Medical School 2025 State of the School Address”, Dean George Daley highlighted our collaboration with the Clardy lab studying the connection between the gut microbiome and depression @harvardmed.bsky.social @broadinstitute.org

#vimeo #microbiome #depression #gut
Harvard Medical School 2025 State of the School Address
In the 2025 State of the School Address, Dean George Q. Daley described the challenges and opportunities ahead for Harvard Medical School and academic research.
vimeo.com
September 25, 2025 at 6:31 PM
The @genelayinstitute.bsky.social
is excited to host its third #ReThinkNeuroimmunology meeting from October 14-16th, 2025. This year will focus on discussing major discoveries & breakthroughs in neuroimmunology, single cell genomics, immunology, & neuroscience.

genelayinstitute.org/rtn/
September 23, 2025 at 2:37 PM
Our latest effort to translate genetic risk variants to disease mechanisms revealed that the R448G missense mutation in nuclear receptor coregulator NRIP1 promotes tissue inflammation via inefficient repression of a retinoic acid-mediated T cell gut-homing program. www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 18, 2025 at 6:21 PM
ANKRD55 is associated with risk for multiple autoimmune diseases, but without a clear mechanism. In a new @jem.org study, we show that ANKRD55 promotes differentiation of inflammatory T cells via mitochondrial regulation, suggesting a new target for autoimmunity: rupress.org/jem/article-...
Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
The ANKRD55 locus has been associated with multiple autoimmune diseases. Using murine models of inflammation, Xu et al. demonstrate an important role of th
rupress.org
September 11, 2025 at 9:11 PM
Reposted
jem.org
Xu, @thexavierlab.bsky.social et al @harvardmed.bsky.social @broadinstitute.org reveal an important role of the ANKRD55 protein in TH17 biology, where its deletion impairs T cell proliferation & effector cytokine production through metabolic dysregulation. rupress.org/jem/article/...

#Autoimmunity
September 11, 2025 at 5:15 PM
NEW in PNAS: Our collaboration w/ the Seyedsayamdost lab, from Princeton University's Dept of Chem, revealed that indole-derived compounds produced by IBD-associated Campylobacter concisus are key modulators of inflammation
www.pnas.org/doi/10.1073/...

@broadinstitute.org
@mgbresearch.bsky.social
Elucidating the role of Campylobacter concisus–derived indole metabolites in gut inflammation and immune modulation | PNAS
The gut microbiota plays a pivotal role in maintaining human health with dysbiosis linked to a variety of diseases. Metagenome sequencing and robus...
www.pnas.org
August 27, 2025 at 4:42 PM
For a great example of complex science presented clearly and compellingly, check out this Base by Base PaperCast episode! It covers a recent @finngen.bsky.social n study showing protective effects of CFHR5 loss-of-function against age-related macular degeneration.

Links below 👇
️ 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration
️ Episode 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration In this episode of PaperCast Base by Base, we explore a genome‑wide association and fine‑mapping study in...
basebybase.castos.com
August 14, 2025 at 2:05 PM
Online now a multicenter Crohn's Disease study of South Asian patients that explores environmental impacts on #CD, linking geography and immigrant status with disease presentation and serologic markers.

linkinghub.elsevier.com/retrieve/pii...

#crohnsdisease
Redirecting
linkinghub.elsevier.com
July 21, 2025 at 4:51 PM