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Graham Erwin @grahamerwin.bsky.social · 1d

Just trying to follow in your footsteps, Kara!

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Graham Erwin @grahamerwin.bsky.social · 1d

Absolutely!! Thanks David :)

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Graham Erwin @grahamerwin.bsky.social · 2d

Proud to announce that we received the NIH Director's New Innovator Award to develop a new class of genome editing tools!

From the Labs at Baylor College of Medicine @bcmfromthelabs.bsky.social · 2d

Dr. Graham Erwin @grahamerwin.bsky.social receives NIH New Innovator Award! www.bcm.edu/news/dr-grah... @bcmhouston.bsky.social @bcmgenetics.bsky.social #BCMCancerCenter

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Reposted by Graham Erwin

Jeremy Berg @jeremymberg.bsky.social · Apr 15

A follow-up to my quote of the day this morning:

A short Bluetorial about Vannevar Bush and his legacy

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

media.tenor.com

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Graham Erwin @grahamerwin.bsky.social · May 21

Interested in modern grant writing in the age of AI? Join us this summer through Stanford Continuing Studies! continuingstudies.stanford.edu/courses/prof...

Modern Grant Writing with AI

AI is transforming grant writing—turning a time-intensive task into a more strategic, efficient process that elevates both research and storytelling. This hands-on course explores how to integrate AI ...

continuingstudies.stanford.edu

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Reposted by Graham Erwin

Ethan Mollick @emollick.bsky.social · May 20

Big: The final version of a randomized, controlled World Bank study finds using a GPT-4 tutor with teacher guidance in a six week afterschool program in Nigeria had "more than twice the effect of some of the most effective interventions in education" ("equating to 1.5 to 2 years" of standard school)

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Reposted by Graham Erwin

DisabledInSTEM @disabledinstem.bsky.social · May 19

I had such a powerful experience at BCM SKY Retreat this weekend led by @grahamerwin.bsky.social and met so many amazing people!

It was a thought-provoking and reflective weekend with lessons that I will carry with me!

What a privilege to partake in such a transformative experience! 🥰

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Reposted by Graham Erwin

PacBio @pacbio.bsky.social · Apr 24

A first in human genomics: a 4-generation pedigree reference, now in Nature.

Built with #PacBio HiFi, it maps de novo mutation rates, reveals paternal bias, and captures high mutation rates in tandem repeats—even in Y and repeat-rich regions.

Paper here: go.nature.com/4lGMPlP

#TheresHiFiForThat

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Graham Erwin @grahamerwin.bsky.social · Apr 16

Here is the output in case there are issues with the link.

Prompt: Do research. find peer-reviewed publications of pyrrole-imidazole polyamides used to activate gene expression (transcriptional activators). Expected output: an exhaustive list of references to the original publication.

Graham Erwin @grahamerwin.bsky.social · Apr 16

The only tool to capture both so far has been ChatGPT Deep Research and o3 (new model from OpenAI released today. It also captures 2 other important papers from Sugiyama and Kodadek. (3/3)

bit.ly/LLMtaste

ChatGPT

A conversational AI system that listens, learns, and challenges

bit.ly

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Graham Erwin @grahamerwin.bsky.social · Apr 16

The two more important papers on polyamide-based transcriptional activators would be Mapp et al PNAS 2000 (the OG on the topic) and our 2017 Science paper (one of the most convincing in a disease model). (2/3)

ChatGPT

A conversational AI system that listens, learns, and challenges

chatgpt.com

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Graham Erwin @grahamerwin.bsky.social · Apr 16

There are a number of tools (Elicit, Perplexity, Google's Deep Research, Consensus within ChatGPT) to find references. One of the complaints from academics is these tools don't find "the right papers".

So far, ChatGPT Deep Research and their o3 model have the best "taste" that I have found. (1/3)

ChatGPT

A conversational AI system that listens, learns, and challenges

chatgpt.com

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Graham Erwin @grahamerwin.bsky.social · Apr 11

Caveat: The authors didn't perform a statistical test comparing these groups, but the trend is the same on bot top-1 and top-10 accuracy.

Graham Erwin @grahamerwin.bsky.social · Apr 11

The LLM (AMIE in this case) performs higher (59.1% top-10 accuracy) than the clinician with the LLM (51.7%).

Another study consistent with what @emollick.bsky.social has been sharing for a while now.

www.nature.com/articles/s41...

Table 1 Top-1 and top-10 accuracy of DDx lists produced with AMIE and Search assistance

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Graham Erwin @grahamerwin.bsky.social · Apr 7

Yes! Benchmarks aside, 3.7 Sonnet and Gemini 2.5 Pro have been performing well for me.

Reposted by Graham Erwin

Ethan Mollick @emollick.bsky.social · Apr 4

Updated this chart with the newest Gemini. It shows the rapid progress in AI over less than two years: costs for GPT-4 class models has dropped 99.7% and even the most advanced models (beating PhDs at the GPQA) are still 82% cheaper than GPT-4.

Probably not worth betting on this trend ending soon.

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Reposted by Graham Erwin

Laura Kiessling @laurakiessling.bsky.social · Mar 27

A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab, @thebrysonlab.bsky.social and the Bernhardt lab. #TB

tcwarner.bsky.social @tcwarner.bsky.social · Mar 27

First post here! To inaugurate this account, I'd like to share my recent work, now published in JACS.

Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

Intercepting a Mycobacterial Biosynthetic Pathway with Covalent Labeling

The mycobacterial cell envelope plays both infectious and protective roles. Understanding its structure is crucial for unlocking the molecular basis underlying these functions. Studying glycans, the p...

pubs.acs.org

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Graham Erwin @grahamerwin.bsky.social · Mar 26

Congratulations, Harriet. This will be a valuable resource for us!

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Reposted by Graham Erwin

Harriet Dashnow @hdashnow.bsky.social · Mar 26

The strchive.org paper is out!!
The paper describes STRchive as a resource to improve the diagnosis of tandem repeat disorders, then goes beyond it to consider what can be learned about childhood onset and population prevalence of these diseases.
🖥️ 🧬
link.springer.com/article/10.1...

STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci - Genome Medicine

Approximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp moti...

link.springer.com

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Reposted by Graham Erwin

Aaron Quinlan (he/him) @aaronquinlan.bsky.social · Mar 26

A new article from Laurel Hiatt and @hdashnow.bsky.social describing STRchive is now available at Genome Medicine. genomemedicine.biomedcentral.com/articles/10....
Check out the database resource, as STRchive "streamlines TR variant interpretation at disease-associated loci."
strchive.org

STRchive: a dynamic resource detailing population-level and locus-specific insights at tandem repeat disease loci - Genome Medicine

Approximately 8% of the human genome consists of repetitive elements called tandem repeats (TRs): short tandem repeats (STRs) of 1–6 bp motifs and variable number tandem repeats (VNTRs) of 7 + bp moti...

genomemedicine.biomedcentral.com

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Reposted by Graham Erwin

Ethan Mollick @emollick.bsky.social · Mar 21

Evidence that a well prompted LLM can help learning from a (small, single-subject) randomized controlled trial at Harvard: “here we show that students learn more than twice as much in less time with an AI tutor compared to an active learning classroom, while also being more engaged and motivated.”

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Reposted by Graham Erwin

Mark Cuban @mcuban.bsky.social · Mar 14

We don't spend a penny on marketing. It's all word of mouth for @costplusdrugs.com

That's how we keep prices so low. Please spread the word !

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Reposted by Graham Erwin

Derek Lowe @dereklowe.bsky.social · Mar 12

The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:

A Bifunctional Degrader Reads Out in Phase 3

www.science.org

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Reposted by Graham Erwin

Clement Chow @clementychow.bsky.social · Mar 12

5 yr anniversary of the day I started my COVID ICU visit

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Reposted by Graham Erwin

Fyodor Urnov @urnov.bsky.social · Mar 10

Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...

investors.beamtx.com

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