Crazy new pre-print from TSRI: fix whole mice, clear them transparent, click on fluorophores, & use light sheet microscopy to visualize where drugs bind throughout the body. Find ibrutinib-yne in low BTK heart & blood vessels, correlates with cardiac side effects.

www.biorxiv.org/content/10.1...

high quality conference stash 👌🧦 #ABPP2025 @li-corenv.bsky.social @selvita

To close the first session, Matt Child will discuss advances in high-throughout chemoproteogenomics 🧫 His group have previously used a chemoproteomic approach combined with CRISPR to identify reactive cysteines in Toxoplasma gondii www.nature.com/articles/s41...

Excited for @chrisgparker.bsky.social ‘s talk about Photoaffinity-based Chemical Proteomics! ⚡️
His group’s work to simplify the identification of the labelling site of diazirine-based probes using predictive models is very cool, amongst other recent PAL developments

www.nature.com/articles/s41...

Next up we’ll have a talk from @stephanhacker2.bsky.social about identifying electrophiles to target amino acids beyond cysteine, including the first probes to globally monitor tryptophans, histidines and arginines ✨

chemrxiv.org/engage/chemr...

First keynote speaker is Emily Balskus, whose lab focus on developing chemical modulators of the human microbiome, such as small molecule urease inhibitors to prevent liver injury.

pubs.acs.org/doi/10.1021/...

The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social

🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...

On this day in 1879, Maud Menten was born in Port Lambton, Ontario.
In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field.
Let's learn more about her life!

🧵1/10

This excellent commentary is a must-read for cancer biologists (and all biologists, really).
Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...

The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:

This week we hosted the inaugural Chemistry at the @crick.ac.uk symposium. Nearly 200 attendees enjoyed great talks from a range of group leaders across chemistry, biology, and translation. Huge thanks to our sponsors Cresset, IDT, Buchi, Merck, Dotmatics, WuXi, MedChem Express, and Enamine

www.nature.com/articles/d41... #RIPTACs

Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes

chemrxiv.org/engage/chemr...