Hana Hanzlikova
@hanzlikovalab.bsky.social
We study how DNA breaks are detected and repaired, focusing on protein factors and pathways linking faulty DNA repair and altered RNA metabolism to neurological diseases and cancer.
Our latest study is out in Nucleic Acids Research. FEN1 is critical for rapid single-strand break repair in G1 phase url: academic.oup.com/nar/article/...
FEN1 is critical for rapid single-strand break repair in G1 phase
Abstract. Flap endonuclease 1 (FEN1)-dependent long-patch repair has been considered a minor sub-pathway of DNA single-strand break repair (SSBR), activate
academic.oup.com
July 28, 2025 at 7:35 AM
Our latest study is out in Nucleic Acids Research. FEN1 is critical for rapid single-strand break repair in G1 phase url: academic.oup.com/nar/article/...
Truly honoured to write about this brilliant work. Huge credit to Bea!
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Integrator complex collapse: A mechanistic route to integrated stress response and disease
June 20, 2025 at 9:18 PM
Truly honoured to write about this brilliant work. Huge credit to Bea!
Reposted by Hana Hanzlikova
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Integrator complex collapse: A mechanistic route to integrated stress response and disease
Integrator complex collapse: A mechanistic route to integrated stress response and disease
In a recent Cell article, Baluapuri et al. show that loss of the Integrator (INT) complex activates the integrated stress response via double-stranded RNA from incomplete pre-mRNAs, revealing a link to INT-related neurodevelopmental diseases and potential therapeutic targets.
dlvr.it
June 20, 2025 at 2:01 PM
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Reposted by Hana Hanzlikova
Exciting PhD project available in our lab (time sensitive)! 👇
May 7, 2025 at 12:10 PM
Exciting PhD project available in our lab (time sensitive)! 👇
Reposted by Hana Hanzlikova
Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
April 1, 2025 at 4:58 PM
Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres.
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
#theconferencetoendallconferences Register now:
woodstock.img.cas.cz
Reposted by Hana Hanzlikova
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
March 17, 2025 at 9:58 PM
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
Reposted by Hana Hanzlikova
Reposted by Hana Hanzlikova
❗WE ARE HIRING - POSTDOC WANTED in the Laboratory of Genome Dynamics @hanzlikovalab.bsky.social
👉https://www.img.cas.cz/group/hana-hanzlikova/
Join a dynamic, international, and multidisciplinary team with an open-door policy for idea exchange, experimental troubleshooting, and shared success.
👉https://www.img.cas.cz/group/hana-hanzlikova/
Join a dynamic, international, and multidisciplinary team with an open-door policy for idea exchange, experimental troubleshooting, and shared success.
February 10, 2025 at 9:40 AM
❗WE ARE HIRING - POSTDOC WANTED in the Laboratory of Genome Dynamics @hanzlikovalab.bsky.social
👉https://www.img.cas.cz/group/hana-hanzlikova/
Join a dynamic, international, and multidisciplinary team with an open-door policy for idea exchange, experimental troubleshooting, and shared success.
👉https://www.img.cas.cz/group/hana-hanzlikova/
Join a dynamic, international, and multidisciplinary team with an open-door policy for idea exchange, experimental troubleshooting, and shared success.
Reposted by Hana Hanzlikova
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
DNA replication and genome maintenance: from basic biology to disease
www.embl.org
February 26, 2025 at 3:22 PM
SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).
www.embl.org/about/info/c...
Great to have Bea as part of our team!
💜🔬Join Beatrice in the Laboratory of Genome Dynamics @hanzlikovalab.bsky.social.
Learn more about our PhD projects 👉http://img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
#phd #phdstudent #science #openpositions #phdcommunity #prague
Learn more about our PhD projects 👉http://img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
#phd #phdstudent #science #openpositions #phdcommunity #prague
February 13, 2025 at 9:49 PM
Great to have Bea as part of our team!
February 6, 2025 at 7:40 PM
Reposted by Hana Hanzlikova
✨Wondering how it looks at IMG? Come and find out!
Learn more about our PhD projects 👉http://img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
#phd #phdstudent #science #openpositions #phdcommunity
#prague
www.youtube.com/watch?v=FucH...
Learn more about our PhD projects 👉http://img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
#phd #phdstudent #science #openpositions #phdcommunity
#prague
www.youtube.com/watch?v=FucH...
Promotional video (short version) - Institute of Molecular Genetics of the Czech Academy of Sciences
YouTube video by Institute of Molecular Genetics
www.youtube.com
February 5, 2025 at 10:24 AM
✨Wondering how it looks at IMG? Come and find out!
Learn more about our PhD projects 👉http://img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
#phd #phdstudent #science #openpositions #phdcommunity
#prague
www.youtube.com/watch?v=FucH...
Learn more about our PhD projects 👉http://img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
#phd #phdstudent #science #openpositions #phdcommunity
#prague
www.youtube.com/watch?v=FucH...
Reposted by Hana Hanzlikova
Please RT. Join the sixth edition of our Training Unit @institut_curie
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
January 4, 2025 at 11:42 AM
Please RT. Join the sixth edition of our Training Unit @institut_curie
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
🧬🔊 We’re looking for a PhD student who’s ready to make discoveries!
🔬Join Laboratory of Genome Dynamics and study brain structures with @hanzlikovalab.bsky.social
Learn more about the project 👉img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
📸Kristýna Hrychová and Beatrice Valtorta
Learn more about the project 👉img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
📸Kristýna Hrychová and Beatrice Valtorta
February 4, 2025 at 4:34 PM
🧬🔊 We’re looking for a PhD student who’s ready to make discoveries!
Congratulations! Everything is possible..
1/n So, this is out in NAR, finally. The longest, the most expensive and the most challenging project in the lab. Sparked by controversy concerning mammalian antiviral RNAi and our identification of Dicer variant, which is sufficient to increase RNAi.
doi.org/10.1093/nar/...
doi.org/10.1093/nar/...
Enhanced RNAi does not provide efficient innate antiviral immunity in mice
Abstract. In RNA interference (RNAi), long double-stranded RNA is cleaved by the Dicer endonuclease into small interfering RNAs (siRNAs), which guide degra
doi.org
January 22, 2025 at 8:38 PM
Congratulations! Everything is possible..
An opening is also available in our group. We are looking forward to recruiting an enthusiastic scientist!
🚀Boost your scientific career with us!
See all open positions 👉 img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
See all open positions 👉 img.cas.cz/phd
Join us, we are waiting for you!
Your future starts now!
January 16, 2025 at 12:37 PM
An opening is also available in our group. We are looking forward to recruiting an enthusiastic scientist!
FEBS Registration open! Youth Travel Fund Grants deadline 16th February 2025 - An engaging gathering to connect with the PARP community parp2025.febsevents.org/speakers
FEBS Advanced Lecture Course 2025 – PARP2025: from molecular aspects to medical applications<br /> - Plenary Speakers
Plenary Speakers for the Proteases and biological course. Plenary Speakers for the Proteases and biological course.
parp2025.febsevents.org
January 14, 2025 at 1:17 PM
FEBS Registration open! Youth Travel Fund Grants deadline 16th February 2025 - An engaging gathering to connect with the PARP community parp2025.febsevents.org/speakers