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Eric Topol @erictopol.bsky.social · 1d

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

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The Francis Crick Institute @crick.ac.uk · 1d

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Ewan Birney @ewanbirney.bsky.social · 2d

A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...

Application – EMBL International PhD Programme

www.embl.org

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dfachinetti.bsky.social @dfachinetti.bsky.social · 6d

10-year celebration of the Fachinetti team!
Thank you to all my amazing current and former members for making these two days so special for me! I feel so lucky to have met you all!

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Daniel Jost - Physical Biology of Chromatin group @djost-physbiol.bsky.social · 11d

New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social
www.biorxiv.org/content/10.1...

Loop extrusion provides mechanical robustness to chromatin

Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop e...

www.biorxiv.org

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Francesca Mattiroli @fmattiroli.bsky.social · 12d

Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.

Hubrecht Institute @hubrechtinstitute.bsky.social · 14d

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

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EMBO @embo.org · 15d

One of the core missions of EMBO is to grow and connect talents. Karin Dumstrei, head of the EMBO Fellowship Programme, tells us about how EMBO has been supporting scientists’ international mobility for more than five decades: www.embo.org/features/sup... 🧪 #research #funding #LifeSciences

Supporting scientists’ international mobility for more than five decades – Features – EMBO

A conversation with the Head of the Fellowship Programme, Karin Dumstrei

www.embo.org

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Vijay Ramani @vram142.bsky.social · 20d

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up!
www.biorxiv.org/content/10.1...
A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

The eukaryotic replisome intrinsically generates asymmetric daughter chromatin fibers

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

www.biorxiv.org

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Smolka Lab @smolka-lab.bsky.social · 22d

A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social
and Michelle Wang

brookscrickard1.bsky.social @brookscrickard1.bsky.social · 23d

Just throwing this out there as a significant conceptual advance in the field

www.biorxiv.org/content/10.1...

The Eukaryotic homology search complex distorts donor DNA structure to probe for homology

Homologous recombination (HR) is a DNA double-strand break repair pathway that facilitates genetic exchange and protects damaged replication forks during DNA synthesis. As a template-based repair proc...

www.biorxiv.org

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CRC1678 @crc1678.bsky.social · 22d

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

David Meyer @meyerdh.bsky.social · 22d

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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Manuel Mendoza @longchrom.bsky.social · 22d

Our chromatin scaling paper is now out in its peer-reviewed form! 🎉
We added some controls, statistics, and a new introduction to better contextualise our findings. Overall a much-improved version we hope! (see my earlier thread for the preprint background)
www.sciencedirect.com/science/arti...

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CNRS Biologie @cnrsbiologie.bsky.social · 25d

📢 Lancement de la campagne ATIP-Avenir 2026

@cnrsbiologie.bsky.social et @inserm.fr ouvre la campagne ATIP-Avenir 2026, destinée à soutenir des projets de recherche innovants portés par de jeunes chercheuses et chercheurs.

📅 Toutes les informations : buff.ly/5DH6mpd

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EMBO @embo.org · 22d

Meet George Garinis, professor at the University of Crete #Greece, affiliated group leader at imbb-forth.bsky.social and EMBO Member. “For me EMBO is all about connection,” he says, grateful for the role EMBO plays in facilitating #networking to other parts of #Europe: www.embo.org/people/creat... 🧪

Creating connections in Crete – People – EMBO

Meet George Garinis, professor at the University of Crete, affiliated group leader at the Foundation for Research and Technology – Hellas and EMBO Member

www.embo.org

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Mathew Jones @jonesmjk.bsky.social · Sep 1

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

rdcu.be

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EMBO @embo.org · 25d

Supporting the #LifeSciences community through different programmes and schemes, scientific #publishing, #policy as well as #innovation, EMBO champions scientific excellence throughout #Europe and worldwide.

This week’s feature: #Greece

www.embo.org/the-embo-com...
🧪 #research #opportunities

Focus on Greece - EMBO communities in EMBC Member States

Facts and figures, life scientists in Greece, EMBO opportunities

www.embo.org

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Naama Aviram @naamaaviram.bsky.social · 29d

Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer.
bit.ly/3WUiuo1

Gerstner Sloan Kettering Graduate School of Biomedical Sciences

The Gerstner Sloan Kettering Graduate School of Biomedical Sciences offers the next generation of basic scientists a program to study the biological sciences through the lens of cancer

bit.ly

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Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · Sep 9

New Online! Learning about break-induced replication from bacteriophages

Learning about break-induced replication from bacteriophages

Nature Reviews Molecular Cell Biology, Published online: 09 September 2025; doi:10.1038/s41580-025-00898-1Break-induced replication (BIR), a DNA double-strand break repair mechanism, was first studied in the 1960s in bacteriophages, showing that DNA could recombine by a 'break–copy' mechanism.

bit.ly

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Lopes_Lab @lopeslab.bsky.social · 29d

New important opportunity for young PI recruitment at our Institute! Please spread the news. Interested candidates should carefully check their eligibility for the indicated SNSF funding schemes, before submitting their application 👍 👇

www.imcr.uzh.ch/dam/jcr:3d1f...

www.imcr.uzh.ch/en.html

www.imcr.uzh.ch

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Lopes_Lab @lopeslab.bsky.social · Sep 8

Tomorrow (Tue 9th) at 5 PM CET. Don't miss it!

Lopes_Lab @lopeslab.bsky.social · Aug 20

Mark your calendar (September 9th) for two more exciting virtual seminars of the Genome Integrity Italian Network (GiiN). Full schedule for the Fall season also provided just below. No registration required, just come and join us with a click! 👇

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Institut Curie @institutcurie.bsky.social · Sep 4

🔬 Division cellulaire : comment une modification épigénétique protège nos chromosomes. L’équipe du Dr Daniele Fachinetti ( @institutcurie.bsky.social / @cnrs.fr), en collaboration avec l'université Stanford, révèle le rôle clé de la méthylation de l’ADN dans l’organisation des centromères.

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Kara Bernstein @karabernstein.bsky.social · Sep 3

Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...

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Fusion Conferences @fusionconf.bsky.social · Sep 2

📢Deadline extended!
Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25
Final slots ➡️https://bit.ly/3JJzYR4

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Institut Curie @institutcurie.bsky.social · Sep 4

▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

www.nature.com

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janeskok.bsky.social @janeskok.bsky.social · Sep 3

We’re back! Registration is NOW OPEN for the 6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025 #chromatin2025

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Chowdhury Lab @chowdhurylab.bsky.social · Sep 2

Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...

Pharmacologic interrogation of USP28 cellular function in p53 signaling

Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28 probe, alongside a control compound and an inhibitor-resistant mutant. They show that USP28 inhibition mimics p53 path...

www.cell.com

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