NealeLab
@labneale.bsky.social
Recombination, Meiosis, Chromosomes, DNA Break Repair
https://twitter.com/LabNeale
https://twitter.com/LabNeale
Pinned
NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
Reposted by NealeLab
@science.org A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/... #RNA #ribozyme #evolution
February 14, 2026 at 8:35 PM
@science.org A small polymerase ribozyme that can synthesize itself and its complementary strand | Science www.science.org/doi/10.1126/... #RNA #ribozyme #evolution
Indeed! And this depiction is just of one... www.nature.com/articles/sre...
February 12, 2026 at 3:28 PM
Indeed! And this depiction is just of one... www.nature.com/articles/sre...
NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
February 12, 2026 at 3:23 PM
NOW LIVE!: PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
Get in touch and apply if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
www.sussex.ac.uk/study/fees-f...
Reposted by NealeLab
Super strong representation from our department in SussexRNA at the RNA UK meeting in Windermere this week.
Many congrats to Jake, Courtney and Hope from the Ben Towler group, and Leandro Castellano, Lidia Vasilieva, Ben and Nikos for having abstracts accepted for presentation. 👏
Many congrats to Jake, Courtney and Hope from the Ben Towler group, and Leandro Castellano, Lidia Vasilieva, Ben and Nikos for having abstracts accepted for presentation. 👏
February 6, 2026 at 2:45 PM
Super strong representation from our department in SussexRNA at the RNA UK meeting in Windermere this week.
Many congrats to Jake, Courtney and Hope from the Ben Towler group, and Leandro Castellano, Lidia Vasilieva, Ben and Nikos for having abstracts accepted for presentation. 👏
Many congrats to Jake, Courtney and Hope from the Ben Towler group, and Leandro Castellano, Lidia Vasilieva, Ben and Nikos for having abstracts accepted for presentation. 👏
Beautiful! Is this in real time (20 seconds?)
(Speed also seem to slow over time?)
(Speed also seem to slow over time?)
An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.
February 5, 2026 at 1:25 PM
Beautiful! Is this in real time (20 seconds?)
(Speed also seem to slow over time?)
(Speed also seem to slow over time?)
Changes in the UK R&I funding landscape - doing fewer things better. An open letter from Ian Chapman to research and innovation community:
www.ukri.org/news/open-le...
www.ukri.org/news/open-le...
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
February 4, 2026 at 10:23 PM
Changes in the UK R&I funding landscape - doing fewer things better. An open letter from Ian Chapman to research and innovation community:
www.ukri.org/news/open-le...
www.ukri.org/news/open-le...
Reposted by NealeLab
"Writing papers is rarely (probably never) the rate-limiting step in scientific research"
Important to remember this. However painful writing is, however much more efficient we can make it, for experimental work it's the research that takes the time.
www.linkedin.com/feed/update/...
Important to remember this. However painful writing is, however much more efficient we can make it, for experimental work it's the research that takes the time.
www.linkedin.com/feed/update/...
𝗢𝗽𝗲𝗻𝗔𝗜 𝗷𝘂𝘀𝘁 𝗹𝗮𝘂𝗻𝗰𝗵𝗲𝗱 𝗣𝗿𝗶𝘀𝗺—𝗮 𝗳𝗿𝗲𝗲 𝗟𝗮𝗧𝗲𝗫 𝗲𝗱𝗶𝘁𝗼𝗿 𝗳𝗼𝗿 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀.
But this isn't about LaTeX. And it's not about training data.
They could get… | Adam Hyde | 25 comments
𝗢𝗽𝗲𝗻𝗔𝗜 𝗷𝘂𝘀𝘁 𝗹𝗮𝘂𝗻𝗰𝗵𝗲𝗱 𝗣𝗿𝗶𝘀𝗺—𝗮 𝗳𝗿𝗲𝗲 𝗟𝗮𝗧𝗲𝗫 𝗲𝗱𝗶𝘁𝗼𝗿 𝗳𝗼𝗿 𝘀𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁𝘀.
But this isn't about LaTeX. And it's not about training data.
They could get papers from arXiv or partner with Overleaf for that.
So w...
www.linkedin.com
February 4, 2026 at 2:55 PM
"Writing papers is rarely (probably never) the rate-limiting step in scientific research"
Important to remember this. However painful writing is, however much more efficient we can make it, for experimental work it's the research that takes the time.
www.linkedin.com/feed/update/...
Important to remember this. However painful writing is, however much more efficient we can make it, for experimental work it's the research that takes the time.
www.linkedin.com/feed/update/...
Coming soon! PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
a computer generated image of a dna structure
ALT: a computer generated image of a dna structure
media.tenor.com
February 3, 2026 at 12:18 PM
Coming soon! PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social
Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.
Reposted by NealeLab
Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
International Symposium on Chromosome Dynamics from Structure to Cellular Function
www.fbs.osaka-u.ac.jp
January 28, 2026 at 1:10 PM
Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!
It’s a massive problem across the sector, and I’m not sure what is the solution is…
And that is: asking a student to do a literature review isn’t really about the output, the final product. It’s about learning the process - assessing the quality of the evidence as you read it, learning how your question may evolve as you engage with the literature, learning how to spot SALIENCE 1/2
January 19, 2026 at 9:01 AM
It’s a massive problem across the sector, and I’m not sure what is the solution is…
Reposted by NealeLab
Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
January 12, 2026 at 11:23 AM
Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Skip to 1m 39s for my current coding hobby project 🙃
youtu.be/-qHwnO15YqA?... The Nextcade music is now available on streaming services. I also made a simple video to go with the music, featuring clips from all the Next games on the SD Card. #retrogame #zxspectrum #zxspectrumnext #indiedev #videogamemusic
Jamie Mallender - Nextcade
YouTube video by Jamie Mallender
youtu.be
January 7, 2026 at 11:07 PM
Skip to 1m 39s for my current coding hobby project 🙃
Reposted by NealeLab
30 years ago today, December 31st 1995, the last ever Calvin & Hobbes comic strip was published. Even now, I still find it so poignant & moving.
December 31, 2025 at 2:32 PM
30 years ago today, December 31st 1995, the last ever Calvin & Hobbes comic strip was published. Even now, I still find it so poignant & moving.
Reposted by NealeLab
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 6, 2026 at 6:58 AM
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by NealeLab
Do #hybrids handle heat, cold better? ❄️🔥 Over 140 generations at 5C and 31C, #yeast #F2 hybrids adapted fast, were ~4× fitter in cold, more resilient to sudden flips. #Hybridization could turbocharge #adaptation, impacting #conservation & #agriculture. #Evolution www.yeastgenome.org/reference/41...
January 6, 2026 at 3:41 PM
Do #hybrids handle heat, cold better? ❄️🔥 Over 140 generations at 5C and 31C, #yeast #F2 hybrids adapted fast, were ~4× fitter in cold, more resilient to sudden flips. #Hybridization could turbocharge #adaptation, impacting #conservation & #agriculture. #Evolution www.yeastgenome.org/reference/41...
Reposted by NealeLab
Large and intricate naturally occurring structures composed exclusively of RNA... ROOL!
More at Molecule of the Month: pdb101.rcsb.org/motm...
More at Molecule of the Month: pdb101.rcsb.org/motm...
January 5, 2026 at 6:05 PM
Large and intricate naturally occurring structures composed exclusively of RNA... ROOL!
More at Molecule of the Month: pdb101.rcsb.org/motm...
More at Molecule of the Month: pdb101.rcsb.org/motm...
Reposted by NealeLab
Leanna Owen, Margot Riggi , David Drubin, Janet Iwasa and Yidi Sun use molecular animation to depict the full progression of CME in budding yeast, with an accompanying Cell Science at a Glance article and poster.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
December 9, 2025 at 4:27 PM
Leanna Owen, Margot Riggi , David Drubin, Janet Iwasa and Yidi Sun use molecular animation to depict the full progression of CME in budding yeast, with an accompanying Cell Science at a Glance article and poster.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Reposted by NealeLab
While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!
November 25, 2025 at 8:22 PM
While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!
Bye bye Edinburgh - such a lovely trip! Thanks to @marstonlab.bsky.social @owendavi77.bsky.social !
November 25, 2025 at 5:29 PM
Bye bye Edinburgh - such a lovely trip! Thanks to @marstonlab.bsky.social @owendavi77.bsky.social !
Successful change at Euston. Train is standing room only though due to a prior cancellation 😱
Very glad I booked a seat and it is still reserved!
Very glad I booked a seat and it is still reserved!
November 23, 2025 at 3:28 PM
Successful change at Euston. Train is standing room only though due to a prior cancellation 😱
Very glad I booked a seat and it is still reserved!
Very glad I booked a seat and it is still reserved!
Departure: Brighton 13:40
(Due Edinburgh 20:24) 😁
(Due Edinburgh 20:24) 😁
November 23, 2025 at 1:38 PM
Departure: Brighton 13:40
(Due Edinburgh 20:24) 😁
(Due Edinburgh 20:24) 😁
New research from Valerie Garcia and colleagues:
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
November 22, 2025 at 5:03 PM
New research from Valerie Garcia and colleagues:
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference
journals.plos.org/plosgenetics...
Reposted by NealeLab
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
International Symposium on Chromosome Dynamics from Structure to Cellular Function
www.fbs.osaka-u.ac.jp
November 21, 2025 at 6:33 PM
Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you
Reposted by NealeLab
Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair
www.yeastgenome.org/reference/39...
www.yeastgenome.org/reference/39...
November 13, 2025 at 8:57 PM
Using #yeast, Yu et al show templated insertions at double-strand breaks in cancers arise from foldback mechanism involving microhomologies. Lack of RPA may drive this process, shedding light on cancer's genetic instability #CancerResearch #Genetics #DNARepair
www.yeastgenome.org/reference/39...
www.yeastgenome.org/reference/39...
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae
Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor
academic.oup.com
November 13, 2025 at 8:40 PM
Delighted to see our study finally out in "print". Thanks to all the (many) contributors, collaborators and reviewers!
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...
Mismatch repair disturbs meiotic crossover control in S. cerevisiae academic.oup.com/nar/article/...