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NealeLab

@labneale.bsky.social

1.7K followers 190 following 120 posts

Recombination, Meiosis, Chromosomes, DNA Break Repair https://twitter.com/LabNeale

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NealeLab @labneale.bsky.social · Dec 5

Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...

Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications

Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...

www.nature.com

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Reposted by NealeLab

Richard Sever @richardsever.bsky.social · 8d

I'm always reminded of Tim Hunt's description of going to the library: "flipping through tables of contents of all the latest issues, hoping there isn't something relevant to your work..." 3/n

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NealeLab @labneale.bsky.social · 10d

Reminds me of The Starry Night upload.wikimedia.org/wikipedia/co...

Reposted by NealeLab

Laurence Pearl 🔥 @laurencepearl.bsky.social · 13d

Excited to announce that our PearlAI DependANT tool for identifying targeted treatments for patients with Cancer of Unknown Primary is one of the 48 projects funded by the UKRI Proof of Concept programme !!

www.ukri.org/news/48-proj...

48 projects backed to turn cutting-edge research into businesses

UKRI backs cutting-edge projects, from home tests for endometriosis to AI for accessible travel, to grow into market-leading products and services.

www.ukri.org

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NealeLab @labneale.bsky.social · 15d

Not sure if this links you there:
discord.com/channels/556...

Discord - Group Chat That’s All Fun & Games

Discord is great for playing games and chilling with friends, or even building a worldwide community. Customize your own space to talk, play, and hang out.

discord.com

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NealeLab @labneale.bsky.social · 15d

Main ZX Next one

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NealeLab @labneale.bsky.social · 15d

By the way, I wrote a Copper program that can make the L2 display behave like a 256x192 pixel, but 256x96 byte 16 colour screen. i.e. two pixels per byte in 16 colours. This would double the fill rate (assuming 16 colours is enough...)

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NealeLab @labneale.bsky.social · 15d

Not sure you are on Discord, but that point about odd-length copies also just came up. 👍

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NealeLab @labneale.bsky.social · 15d

I've just been discussing...is it worth using the stack pointer trick here and inlining (and jumping into) push HL for rapid byte fill? That's only 6T per byte, nearly as fast as DMA.

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NealeLab @labneale.bsky.social · 23d

My concern is that the world of hate and misinformation not just still exists...but is likely amplified without the sensible souls in there to help moderate... 😔

NealeLab @labneale.bsky.social · 23d

Slowly recovering after just briefly visiting that "other" place we used to hang out in and Tweet. So much hate and misinformation...😔

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Reposted by NealeLab

Sussex Cancer Research Centre @sussexcancer.org · 26d

👩‍🔬 We’re hiring! Join a dynamic team driving innovation in blood cancer research at the University of Sussex. Collaborate with experts, grow your skills in protein biochemistry, and contribute to vital discoveries.

👉 Apply here: www.jobs.ac.uk/job/DOP599/r...

Research Technician – Protein Biochemistry at University of Sussex

Discover Research Technician – Protein Biochemistry jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

www.jobs.ac.uk

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Reposted by NealeLab

Uli Rass @u-rass.bsky.social · 27d

Looking forward to contributing to Social DNAing @columbiauniversity.bsky.social @columbiacancer.bsky.social later today!

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Reposted by NealeLab

Katy Stoddard @katy-bird.bsky.social · 27d

Yesterday’s #EasternArc session on HE in Palestine felt like a direct call to action - so much can be achieved if we put effort into working with/round clunky university processes - pooling open resources, giving Gaza students honorary fellowships to enable library access… 1/2

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NealeLab @labneale.bsky.social · 27d

I feel this could go down in history as one of his most powerful works. I’ll certainly not forget it. Planned? Or just imagined?

NealeLab @labneale.bsky.social · 27d

For everyone

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NealeLab @labneale.bsky.social · 27d

Banksy = Genius

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NealeLab @labneale.bsky.social · Sep 8

The irony

Jolyon Maugham KC @goodlawproject.org · Sep 8

Reporting a new Banksy mural which attacks the legal system for criminalizing protests against genocide, the BBC adds "the graffiti has been covered up and guarded". Thanks Dad.

Reposted by NealeLab

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Aug 27

#NEW_PAPER

In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR).

rdcu.be/eCGxF

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...

rdcu.be

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Reposted by NealeLab

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Aug 29

#NEW_PAPER
The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...

rdcu.be

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Reposted by NealeLab

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Sep 3

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer.

doi.org/10.1038/s415...

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

doi.org

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NealeLab @labneale.bsky.social · Sep 3

Interested in the nuclease–helicase DNA2?
Fantastic new recombination-replication-checkpoint mechanics uncovered by Jessica Hudson et al: @u-rass.bsky.social @gdsc-sussex.bsky.social
www.nature.com/articles/s41...

DNA2 enables growth by restricting recombination-restarted replication - Nature

www.nature.com

Reposted by NealeLab

Scott Keeney @spo11rulz.bsky.social · Aug 16

New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...

Insight into Meiotic DNA End Resection: Mechanisms and Regulation

Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic ch…

www.sciencedirect.com

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Reposted by NealeLab

Dr Matt Pope @mattpope.bsky.social · Aug 31

The floating museum Galeón Andalucía looking spectacular and formidable in harbour at Shoreham-by-Sea today.

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NealeLab @labneale.bsky.social · Aug 28

@gdsc-sussex.bsky.social

Reposted by NealeLab

Helfrid Hochegger @helfridh.bsky.social · Aug 28

Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels.
www.nature.com/articles/s41...

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications

The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers…

www.nature.com

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