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Reposted by Hasanga Manikpurage

Sam Lambert @iamslambert.bsky.social · 22d

Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...

Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction

Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…

www.medrxiv.org

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Mike Inouye @mikeinouye.bsky.social · Jul 25

📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...

You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁

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Mike Inouye @mikeinouye.bsky.social · Jul 22

Wish we could've cited this highly relevant (and consistent) study, published nearly the same time: Psychological & emotional impacts of communicating breast cancer risk using multifactorial assessment with polygenic risk score: Findings from PERSPECTIVE I&I www.sciencedirect.com/science/arti...

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PHG Foundation @phgfoundation.bsky.social · Jul 15

The concept of personalised health is at the centre of a renewed NHS and its 10 Year Health Plan says Prof Mike Inouye (thank you @mikeinouye.bsky.social)as we put 'Making personalised health work for population health' in the spotlight.

Read it here: lnkd.in/eRDY5q2j
#personalisedhealth

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Mike Inouye @mikeinouye.bsky.social · Jul 5

Variation and prognostic potential of the gut antibiotic resistome in a population-based cohort www.nature.com/articles/s41...

We look at the risks and sociodemographic aspects of antimicrobial resistance, and its association with recent global urbanization and middle-class growth.

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Pradeep Natarajan @pnatarajanmd.bsky.social · Jul 3

Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are:
1. Hypertension
2. CAD polygenic risk score
www.ahajournals.org/doi/10.1161/...

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Hasanga Manikpurage @hasanga.bsky.social · Jul 2

Thank you to all colleagues involved in this project, supervised by Dr. S. Thériault. Thank you also to all scientists and participants involved in @cartagene.bsky.social, @clsa-elcv.bsky.social and at the Biobanque de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec.

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Hasanga Manikpurage @hasanga.bsky.social · Jul 2

- CAD-PGS is associated with the extent of coronary artery damage observed (coronary angiography data).
- In this study, not all CV-PGS are associated with the severity of CAD; lipid-PGS are.

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Hasanga Manikpurage @hasanga.bsky.social · Jul 2

- Adding independent CV-PGS, in addition to a CAD-PGS, increases the performance of our models, with or without clinical risk factors (clinical interest +++)

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Hasanga Manikpurage @hasanga.bsky.social · Jul 2

Briefly:
- Studied PGSs are all associated with the prevalence of myocardial infarction, suitable for a direct application in Canadians (from European ancestry).
- CAD-PGS and CV-PGS are not/only weakly correlated. Using them in a multivariable model provides better predictive performance.

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Hasanga Manikpurage @hasanga.bsky.social · Jul 2

📣 Clap de fin for my PhD work 🎬! The fourth and final article is now available in @commsmed.nature.com. We benchmarked a set of PGS for cardiovascular traits available from the pgscatalog.org resource in different Canadian cohorts🍁.

See more 👇🏽 - Link (OA):
www.nature.com/articles/s43...

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Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions - Communications Medicine

Manikpurage et al. evaluate the association between existing polygenic risk scores (PRS) and myocardial infarction (MI) as well as the extent of coronary artery lesions at coronary angiography. The co...

www.nature.com

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Mike Inouye @mikeinouye.bsky.social · Jun 16

Super excited to see beginning integration of PredictDB into OmicsPred!

We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org

More on its way... a wonderful collab with @hakyim.bsky.social & co!

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Mike Inouye @mikeinouye.bsky.social · Jun 12

📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co!

Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...

The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!

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Mike Inouye @mikeinouye.bsky.social · Jun 3

Its been an absolute pleasure to have @gmeric.bsky.social in the lab for the last 7 years (omg has it been that long)

Guillaume published a bunch of awesome studies (personal fav www.nature.com/articles/s41...) and continues his research programme as an Assoc Prof of Microbiome at the Univ of Bath!

Guillaume Méric @gmeric.bsky.social · May 8

Looks like I’ve got another move across the world in me! 🌏✈️📦 I'll be starting at @uniofbath.bsky.social in a few weeks as senior lecturer/associate prof in human microbiome. Excited to be back in Europe + for new collabs (alongside ongoing 🇦🇺🇬🇧🇫🇮🇸🇪🇦🇹 ones). Thanks to everyone who helped; more soon!

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Sam Lambert @iamslambert.bsky.social · May 24

@hasanga.bsky.social from @mikeinouye.bsky.social / @cambridgebaker.bsky.social @cambridge-ceu.bsky.social sharing new results for local-ancestry effects on CAD risk loci. #ESHG2025

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Mike Inouye @mikeinouye.bsky.social · May 12

📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41...

Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms

tl;dr 👉 There's little/no evidence for this

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Loïc Lannelongue @loiclnlg.bsky.social · May 9

📣 Interested in the environmental (un)sustainability of AI (and how to support positive change)? Or know someone who is? I have an open position for a postdoctoral researcher to join my group in Cambridge, UK 🌱

🚨Closing June 5th

www.jobs.cam.ac.uk/job/51255/

Topics below 👇

#AcademicSky #GreenSky

Photo of Cambridge River and view over King's College with a group of people punting.

Photo of the Heart and Lungs Research Institute on Cambridge Biomedical Campus. The building is bronze-colour and in front of a pond.

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Pradeep Natarajan @pnatarajanmd.bsky.social · Apr 23

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations!
www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

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Pradeep Natarajan @pnatarajanmd.bsky.social · Apr 23

Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...

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Hasanga Manikpurage @hasanga.bsky.social · Apr 17

Excellent work led by Ursula Houessou from Dr. Sébastien Thériault Lab

Hasanga Manikpurage @hasanga.bsky.social · Apr 17

Important work led by Jérôme Bourgault from Prof. Benoit Arsenault Team.

Hasanga Manikpurage @hasanga.bsky.social · Apr 15

📣 Feeling extremely lucky to have modestly contributed to this masterpiece, investigating the impact of loss-of-function mutations in APOC3 gene on aortic valve disease risk reduction.

See more in JACC 👇🏽

www.jacc.org/doi/10.1016/...

Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease:

Discover why JACC is the ultimate publishing partner for your cardiovascular research.

www.jacc.org

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Hasanga Manikpurage @hasanga.bsky.social · Apr 10

📣 Thrilled to share this paper. We leveraged transcriptomic data from one of the largest existing aortic valve collection. We identified genes/pathways involved in disease progression/severity, with distinct transcriptomic signatures in TAV vs BAV. Perspectives for potential therapeutics?
See more👇🏽

Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves

There is currently no medical therapy for calcific aortic valve stenosis. We aimed to identify transcriptomic signatures of the disease severity. We p…

www.sciencedirect.com

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Mike Inouye @mikeinouye.bsky.social · Apr 9

This study is a big deal. Is it going to be the one that kicks down the PRS door? Maybe. And that’s saying something.

Assessment of a Polygenic Risk Score in Screening for Prostate Cancer www.nejm.org/doi/full/10....

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Hasanga Manikpurage @hasanga.bsky.social · Apr 9

Can testify to this -> awesome research environment, with access to great ressources, sharing space and time with incredible colleagues and renowned experts...

Mike Inouye @mikeinouye.bsky.social · Apr 8

📣📣 New postdoc in biomedical data science available in our lab!! www.jobs.cam.ac.uk/job/50966/

Flexible funding - many research areas in scope + ideas welcome

Check out our group www.inouyelab.org/home

And the awesome Cambridge research environment! @vpd-hlri.bsky.social @uniofcam.bsky.social

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