Sam Lambert
@iamslambert.bsky.social
🇨🇦 in 🇬🇧. Assistant Prof. studying polygenic scores & multimorbidity at University of Cambridge; co-lead @pgscatalog.bsky.social. Otherwise, probably talking about good films, bad tv, or wine.
Reposted by Sam Lambert
Are you an emerging clinical academic leader in respiratory medicine?
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Assistant/Associate Professor in Respiratory Medicine (Honorary Consultant) (Fixed Term)
An exciting opportunity has arisen for a new University of Cambridge-Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Respiratory Medicine. We are seeking applications
www.cam.ac.uk
December 16, 2025 at 10:53 PM
Are you an emerging clinical academic leader in respiratory medicine?
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Come and join @vpd-hlri.bsky.social and @royalpapworth.bsky.social and build your career!
Get in touch if you’d like to discuss.
www.cam.ac.uk/jobs/assista...
Reposted by Sam Lambert
🚨Wanted…emerging clinical academic leader in cardiology to join @vpd-hlri.bsky.social and @royalpapworth.bsky.social.
Get in touch if you’d like to discuss the role. We’d love to hear from you!
www.cam.ac.uk/jobs/assista...
Get in touch if you’d like to discuss the role. We’d love to hear from you!
www.cam.ac.uk/jobs/assista...
Assistant/Associate Professor in Cardiology (Honorary Consultant) (Fixed Term)
An exciting opportunity has arisen for a new University of Cambridge - Royal Papworth Hospital NHS Foundation Trust Assistant/Associate Professor in Cardiology. We are seeking expressions of interest
www.cam.ac.uk
December 16, 2025 at 10:55 PM
🚨Wanted…emerging clinical academic leader in cardiology to join @vpd-hlri.bsky.social and @royalpapworth.bsky.social.
Get in touch if you’d like to discuss the role. We’d love to hear from you!
www.cam.ac.uk/jobs/assista...
Get in touch if you’d like to discuss the role. We’d love to hear from you!
www.cam.ac.uk/jobs/assista...
Reposted by Sam Lambert
We hope it's easy to use with tutorials for UKB (pgsc-calc.readthedocs.io/en/v3-alpha....) & All of Us (pgsc-calc.readthedocs.io/en/v3-alpha.... )! But feel free to contact us on Github: github.com/PGScatalog/p...!
With that, happy holidays from the PGS Catalog team! 🎁 🎄
With that, happy holidays from the PGS Catalog team! 🎁 🎄
UK Biobank Research Analysis Platform tutorial | PGS Catalog Calculator documentation.
How to calculate polygenic scores on the UK Biobank Research Analysis Platform
buff.ly
December 15, 2025 at 3:44 PM
We hope it's easy to use with tutorials for UKB (pgsc-calc.readthedocs.io/en/v3-alpha....) & All of Us (pgsc-calc.readthedocs.io/en/v3-alpha.... )! But feel free to contact us on Github: github.com/PGScatalog/p...!
With that, happy holidays from the PGS Catalog team! 🎁 🎄
With that, happy holidays from the PGS Catalog team! 🎁 🎄
Reposted by Sam Lambert
The new alpha only implements PGS scoring at the moment, but the roadmap will reimplement our existing genetic ancestry tools! Lot's of under-the-hood optimisation using python (zarr, dash), and it only takes VCF or BGEN input atm. github.com/PGScatalog/p...
buff.ly
December 15, 2025 at 3:44 PM
The new alpha only implements PGS scoring at the moment, but the roadmap will reimplement our existing genetic ancestry tools! Lot's of under-the-hood optimisation using python (zarr, dash), and it only takes VCF or BGEN input atm. github.com/PGScatalog/p...
Reposted by Sam Lambert
Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/v3-alpha.1/
pgsc_calc: a reproducible workflow to calculate polygenic scores | PGS Catalog Calculator documentation.
The `pgsc_calc` workflow makes it easy to calculate a polygenic score
buff.ly
December 15, 2025 at 3:44 PM
Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/v3-alpha.1/
Reposted by Sam Lambert
Just published @ Eur Heart J: Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction academic.oup.com/eurheartj/ad...
tl;dr these next-gen risk factors could boost the number of CVD events prevented by +80% while keeping treatment efficiency (NNT) the same.
tl;dr these next-gen risk factors could boost the number of CVD events prevented by +80% while keeping treatment efficiency (NNT) the same.
December 15, 2025 at 10:00 AM
Just published @ Eur Heart J: Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction academic.oup.com/eurheartj/ad...
tl;dr these next-gen risk factors could boost the number of CVD events prevented by +80% while keeping treatment efficiency (NNT) the same.
tl;dr these next-gen risk factors could boost the number of CVD events prevented by +80% while keeping treatment efficiency (NNT) the same.
Reposted by Sam Lambert
Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social
November 22, 2025 at 11:47 AM
Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social
Reposted by Sam Lambert
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
November 22, 2025 at 11:42 AM
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
Reposted by Sam Lambert
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
GitHub - PGScatalog/pgsc_calc: The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation
The Polygenic Score Catalog Calculator is a nextflow pipeline for polygenic score calculation - PGScatalog/pgsc_calc
github.com
November 11, 2025 at 5:43 PM
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
Reposted by Sam Lambert
Another month and lots of new & useful data added to www.PGSCatalog.org! Including new multi-ancestry insulin resistance scores, a score tailored for heart failure in East Asian individuals & more!
PGS Catalog - The Polygenic Score Catalog
The Polygenic Score (PGS) Catalog is an open database of
published PGS and the relevant metadata needed to apply and evaluate them correctly.
www.PGSCatalog.org
November 11, 2025 at 5:41 PM
Another month and lots of new & useful data added to www.PGSCatalog.org! Including new multi-ancestry insulin resistance scores, a score tailored for heart failure in East Asian individuals & more!
Reposted by Sam Lambert
🚨 Countdown to #ASHG25: Predicted Effector Gene standard is coming! 🚨 Join us and be part of the conversation!
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
PEGs Workshop
Friday, October 17th | 11:45AM – 1:15PM | Convention Center room 259A The meeting will open with an introduction (Noel Burtt), include a recap of the landscape analysis (Laura Harris), presentation…
kpnashg2025.wordpress.com
October 14, 2025 at 8:24 AM
🚨 Countdown to #ASHG25: Predicted Effector Gene standard is coming! 🚨 Join us and be part of the conversation!
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
Reposted by Sam Lambert
ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1...
Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)
h\t @iamslambert.bsky.social @clairecoffey.bsky.social
Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)
h\t @iamslambert.bsky.social @clairecoffey.bsky.social
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critical...
www.medrxiv.org
October 5, 2025 at 2:46 PM
ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1...
Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)
h\t @iamslambert.bsky.social @clairecoffey.bsky.social
Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids)
h\t @iamslambert.bsky.social @clairecoffey.bsky.social
Reposted by Sam Lambert
Our new paper is out, in which we developed an approach to transform Polygenic Scores (PGSs) into disorder probabilities (i.e., the absolute lifetime disorder risk).
Below a thread 👇
open access link: rdcu.be/eIjvC
Below a thread 👇
open access link: rdcu.be/eIjvC
Estimating disorder probability based on polygenic prediction using the BPC approach
Nature Communications - Here the authors present a method to transform polygenic scores into disorder probabilities using only GWAS summary statistics, genotype data and a prior - no tuning sample...
rdcu.be
September 27, 2025 at 2:47 AM
Our new paper is out, in which we developed an approach to transform Polygenic Scores (PGSs) into disorder probabilities (i.e., the absolute lifetime disorder risk).
Below a thread 👇
open access link: rdcu.be/eIjvC
Below a thread 👇
open access link: rdcu.be/eIjvC
Reposted by Sam Lambert
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…
www.medrxiv.org
September 19, 2025 at 5:06 PM
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…
www.medrxiv.org
September 19, 2025 at 5:06 PM
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Reposted by Sam Lambert
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
September 19, 2025 at 3:31 PM
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
Reposted by Sam Lambert
PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critica...
www.medrxiv.org
September 19, 2025 at 3:29 PM
PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Reposted by Sam Lambert
🚨Exciting fully funded PhD opportunity!
Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social
Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...
Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social
Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...
September 19, 2025 at 12:16 PM
🚨Exciting fully funded PhD opportunity!
Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social
Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...
Applications are open for a DTP iCase interdisciplinary PhD studentship in Public Health and Primary Care supervised by @eliasallara.bsky.social
Apply by 2 Dec 2025 👉 www.cam.ac.uk/jobs/dtp-ica...
Reposted by Sam Lambert
Sept is approaching & I can already hear initial chats/enquiries for potential PhD studies happening!
If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...
We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc
If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...
We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc
Doctoral Training | Department of Public Health and Primary Care (PHPC)
Course Code – MDPU22 A doctorate from the University of Cambridge is primarily a research degree based on a research programme developed in conjunction with a supervisor.
www.phpc.cam.ac.uk
August 27, 2025 at 12:35 PM
Sept is approaching & I can already hear initial chats/enquiries for potential PhD studies happening!
If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...
We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc
If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an...
We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc
Reposted by Sam Lambert
⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI!
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
Research Associate*/Research Assistant in Sustainability of AI (Fixed Term)
An exciting opportunity has arisen for a talented researcher to join our team as part of the Green Algorithms Initiative, one of the leading academic teams in the field of sustainable computing. The
www.cam.ac.uk
September 15, 2025 at 8:50 AM
⏰ Last couple of days to apply to join my group @Cambridge as a postdoc and work on the environmental (un)sustainability of AI!
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
⏳ Closing September 16th.
✏️ Apply here: tinyurl.com/2ukkp8yx
Or learn more about what we do at www.lannelongue-group.org
Initial examples of research projects below 👇
Reposted by Sam Lambert
ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
August 3, 2025 at 6:18 PM
ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...
Reposted by Sam Lambert
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
July 25, 2025 at 7:24 AM
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
Reposted by Sam Lambert
Is anyone aware of PhD students having access to #allofus data? We are being told it's impossible. Which seems... impractical... given that students do so much of the research in many places. Please reskeet even if you don't know the answer? Would really like to resolve this barrier for my student.
July 2, 2025 at 3:48 PM
Is anyone aware of PhD students having access to #allofus data? We are being told it's impossible. Which seems... impractical... given that students do so much of the research in many places. Please reskeet even if you don't know the answer? Would really like to resolve this barrier for my student.
Interested in methods for updating risk prediction models (time-to-event) with new features? Check out this new paper with Will Underwood & co introducing the CARE method, and an application where we augment SCORE2 with PGS & IMD: arxiv.org/abs/2506.23870.
July 1, 2025 at 8:31 PM
Interested in methods for updating risk prediction models (time-to-event) with new features? Check out this new paper with Will Underwood & co introducing the CARE method, and an application where we augment SCORE2 with PGS & IMD: arxiv.org/abs/2506.23870.
Reposted by Sam Lambert
We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors
We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org
More info www.omicspred.org/publication/...
We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org
More info www.omicspred.org/publication/...
OmicsPred is an atlas of genetic scores for prediction of multi-omics data.
www.omicspred.org
June 16, 2025 at 12:24 PM
We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors
We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org
More info www.omicspred.org/publication/...
We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org
More info www.omicspred.org/publication/...