Mike Inouye
@mikeinouye.bsky.social
Computational biologist. Geriatric Millennial. Professor, University of Cambridge. Director of Data Sciences, Baker Heart & Diabetes Institute. British | Australian | American.
www.inouyelab.org | Cambridge, UK
www.inouyelab.org | Cambridge, UK
It can feel a bit silly to be sentimental about specific papers but today I had a moment when this one reached 200 cites... as an isolated postdoc down under, I well remember the support of Finnish colleagues (esp Samuli Ripatti) and the singular @piwdb.bsky.social journals.plos.org/plosgenetics...
Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis
Author Summary In this study, we aim to identify novel genetic variants for metabolism, characterize their effects on nearby genes, and show that the nearby genes are associated with metabolism and at...
journals.plos.org
November 25, 2025 at 9:04 PM
It can feel a bit silly to be sentimental about specific papers but today I had a moment when this one reached 200 cites... as an isolated postdoc down under, I well remember the support of Finnish colleagues (esp Samuli Ripatti) and the singular @piwdb.bsky.social journals.plos.org/plosgenetics...
Reposted by Mike Inouye
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
November 22, 2025 at 11:42 AM
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
Reposted by Mike Inouye
Image screening is going to fail. We need audit trails for data provenance.
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
November 22, 2025 at 4:21 PM
Image screening is going to fail. We need audit trails for data provenance.
Reposted by Mike Inouye
Pleased to share the final published version of our previous medRXiv pre-print, "Integrating large scale genetic and clinical information to predict cases of heart failure"
pubmed.ncbi.nlm.nih.gov/41272270/
pubmed.ncbi.nlm.nih.gov/41272270/
Integrating large scale genetic and clinical information to predict cases of heart failure - PubMed
We demonstrate the additive power of integrating GWAS- and EHR-derived risk scores to predict HF cases prior to diagnosis. This standardizable and scalable risk predictor may enable physicians to provide earlier interventions to improve patient outcomes.
pubmed.ncbi.nlm.nih.gov
November 22, 2025 at 4:21 PM
Pleased to share the final published version of our previous medRXiv pre-print, "Integrating large scale genetic and clinical information to predict cases of heart failure"
pubmed.ncbi.nlm.nih.gov/41272270/
pubmed.ncbi.nlm.nih.gov/41272270/
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
November 22, 2025 at 11:42 AM
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
Reposted by Mike Inouye
The search now turns towards understanding how inflation impacts the estimates of other studies and, ultimately, what specifically explains the "missing environments". /x
November 21, 2025 at 10:34 PM
The search now turns towards understanding how inflation impacts the estimates of other studies and, ultimately, what specifically explains the "missing environments". /x
Reposted by Mike Inouye
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Mike Inouye
Did you know that there's a wide range of scholarships, grants and bursaries at Cambridge for postgraduate study? Here are just a few of them.
Tap for a complete guide: https://bit.ly/4oOClBT
🚨 The deadline for most courses is early December so apply now.
Tap for a complete guide: https://bit.ly/4oOClBT
🚨 The deadline for most courses is early December so apply now.
November 21, 2025 at 6:14 PM
Did you know that there's a wide range of scholarships, grants and bursaries at Cambridge for postgraduate study? Here are just a few of them.
Tap for a complete guide: https://bit.ly/4oOClBT
🚨 The deadline for most courses is early December so apply now.
Tap for a complete guide: https://bit.ly/4oOClBT
🚨 The deadline for most courses is early December so apply now.
Reposted by Mike Inouye
Breaking News: Robert F. Kennedy Jr. said he personally instructed the CDC to abandon its position that vaccines do not cause autism. The move underscores his determination to challenge scientific orthodoxy — in this case, that vaccines save lives — and bend the health department to his will.
RFK Jr. Says He Instructed CDC to Change Vaccines and Autism Language on Website
In an interview, Health Secretary Robert F. Kennedy Jr. cited gaps in vaccine safety research. His critics say he is ignoring a larger point: Vaccines save lives.
nyti.ms
November 21, 2025 at 6:56 PM
Breaking News: Robert F. Kennedy Jr. said he personally instructed the CDC to abandon its position that vaccines do not cause autism. The move underscores his determination to challenge scientific orthodoxy — in this case, that vaccines save lives — and bend the health department to his will.
Reposted by Mike Inouye
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Mike Inouye
Scientists tell Americans not to trust the CDC.
Instead of a global leader in science, the CDC has devolved into “a propaganda machine for RFK Jr.'s fixed, immutable, science-resistant theories,” said @pauloffit.bsky.social.
www.cidrap.umn.edu/childhood-va...
Instead of a global leader in science, the CDC has devolved into “a propaganda machine for RFK Jr.'s fixed, immutable, science-resistant theories,” said @pauloffit.bsky.social.
www.cidrap.umn.edu/childhood-va...
After unprecedented autism-vaccine messaging change, scientists, advocates say CDC no longer trustworthy
www.cidrap.umn.edu
November 20, 2025 at 10:26 PM
Scientists tell Americans not to trust the CDC.
Instead of a global leader in science, the CDC has devolved into “a propaganda machine for RFK Jr.'s fixed, immutable, science-resistant theories,” said @pauloffit.bsky.social.
www.cidrap.umn.edu/childhood-va...
Instead of a global leader in science, the CDC has devolved into “a propaganda machine for RFK Jr.'s fixed, immutable, science-resistant theories,” said @pauloffit.bsky.social.
www.cidrap.umn.edu/childhood-va...
Reposted by Mike Inouye
Following our latest update, the @ukbiobank.bsky.social dataset now offers the world's biggest collection of metabolomic data.
These biomarkers from half a million participant blood samples, provide researchers with a detailed picture of how the body processes energy and nutrients.
These biomarkers from half a million participant blood samples, provide researchers with a detailed picture of how the body processes energy and nutrients.
November 20, 2025 at 1:52 PM
Following our latest update, the @ukbiobank.bsky.social dataset now offers the world's biggest collection of metabolomic data.
These biomarkers from half a million participant blood samples, provide researchers with a detailed picture of how the body processes energy and nutrients.
These biomarkers from half a million participant blood samples, provide researchers with a detailed picture of how the body processes energy and nutrients.
Reposted by Mike Inouye
The update includes metabolomic, genetic, and imaging data, plus much more, all alongside our existing comprehensive dataset
Explore what's new: www.ukbiobank.ac.uk/news/metabol...
Explore what's new: www.ukbiobank.ac.uk/news/metabol...
Metabolomic, genetic, imaging data and more: new and updated UK Biobank data now available
The latest update to UK Biobank’s comprehensive dataset is available to approved researchers around the world via the Research Analysis Platform (UKB-RAP).
www.ukbiobank.ac.uk
November 20, 2025 at 9:09 AM
The update includes metabolomic, genetic, and imaging data, plus much more, all alongside our existing comprehensive dataset
Explore what's new: www.ukbiobank.ac.uk/news/metabol...
Explore what's new: www.ukbiobank.ac.uk/news/metabol...
Reposted by Mike Inouye
We're pleased to announce that our latest release of new and updated UK Biobank data is now available to approved researchers around the world ✅
November 20, 2025 at 9:09 AM
We're pleased to announce that our latest release of new and updated UK Biobank data is now available to approved researchers around the world ✅
Reposted by Mike Inouye
#AMR #Klebsiella cause >100,000 neonatal deaths globally each year.
Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW
doi.org/10.1101/2025...
Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW
doi.org/10.1101/2025...
![figure showing estimated proportion of cases in clusters, for each site. range from 0.04 to 0.93, mean estimate in random effects model is 0.57 [0.46,0.68]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:q5nky4heg5sfix4get4zh2pw/bafkreibshmuvkuafxwd2uk3r42ss6ma2dhmaidbysgvufnbkbv5cn4guai@jpeg)
November 19, 2025 at 3:43 PM
#AMR #Klebsiella cause >100,000 neonatal deaths globally each year.
Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW
doi.org/10.1101/2025...
Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW
doi.org/10.1101/2025...
Very cool work this.
November 19, 2025 at 2:02 AM
Very cool work this.
Nice work from Iftikhar Kullo and co on incorporating polygenic, monogenic and family history risk into the Pooled Cohort Equations for coronary heart disease risk. Assessed across spectrums of age and ethnic diversity using All of Us and eMERGE IV. www.medrxiv.org/content/10.1...
November 18, 2025 at 12:33 PM
Nice work from Iftikhar Kullo and co on incorporating polygenic, monogenic and family history risk into the Pooled Cohort Equations for coronary heart disease risk. Assessed across spectrums of age and ethnic diversity using All of Us and eMERGE IV. www.medrxiv.org/content/10.1...
Feeling much better
November 17, 2025 at 9:12 PM
Feeling much better
Reposted by Mike Inouye
Super excited to launch @thisinstitute.cam.ac.uk's new online collaborative community to help shape ambient voice technology in healthcare. A new way to share insights and learning about using AVT in practice: join here ambientvoice.thiscovery.org/p/welcome
The online ambient voice technology community - Avid
ambientvoice.thiscovery.org
November 17, 2025 at 3:45 PM
Super excited to launch @thisinstitute.cam.ac.uk's new online collaborative community to help shape ambient voice technology in healthcare. A new way to share insights and learning about using AVT in practice: join here ambientvoice.thiscovery.org/p/welcome
Hard missing the old twitter days. It’s a bit icky that a lot of interactions amongst academics now happens on linkedin… eventhough bluesky could absolutely be the twitter of old, people just aren’t engaging like they used to. Hope it changes…
November 16, 2025 at 6:03 PM
Hard missing the old twitter days. It’s a bit icky that a lot of interactions amongst academics now happens on linkedin… eventhough bluesky could absolutely be the twitter of old, people just aren’t engaging like they used to. Hope it changes…
Reposted by Mike Inouye
Right. Hitler's DNA. Brace yourselves for a deluge of misinformation and bad science.
I'm in Australia, so do get in touch if you want some expert debunking.
I'm in Australia, so do get in touch if you want some expert debunking.
November 13, 2025 at 6:37 AM
Right. Hitler's DNA. Brace yourselves for a deluge of misinformation and bad science.
I'm in Australia, so do get in touch if you want some expert debunking.
I'm in Australia, so do get in touch if you want some expert debunking.
Reposted by Mike Inouye
MHRA-led study reveals major inconsistencies in global microbiome research www.gov.uk/government/n...
MHRA-led study reveals major inconsistencies in global microbiome research
International collaboration establishes new quality standards to improve reliability of gut health studies – improving accuracy to provide better diagnosis and treatment.
www.gov.uk
November 15, 2025 at 1:53 PM
MHRA-led study reveals major inconsistencies in global microbiome research www.gov.uk/government/n...
Reposted by Mike Inouye
So when the aurora borealis is faint enough, you can capture its glow with the Milky Way 😍
Berthoud Pass, CO last night
Berthoud Pass, CO last night
November 13, 2025 at 3:25 PM
So when the aurora borealis is faint enough, you can capture its glow with the Milky Way 😍
Berthoud Pass, CO last night
Berthoud Pass, CO last night
Reposted by Mike Inouye
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Estimation and mapping of the missing heritability of human phenotypes - Nature
WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...
www.nature.com
November 12, 2025 at 5:57 PM
First time on Bsky and first big announcement!
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature.
Our manuscript is here: www.nature.com/articles/s41....
Guillaume has just moved on from the lab to a super exciting Assoc Prof in Microbiome at the University of Bath... he's amazing and if you're keen on a PhD check this out!
New PhD position in my lab at @uniofbath.bsky.social (with both @tweethinking.bsky.social & Dr Bethan Littleford-Colquhoun)!
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
We're looking for someone keen on bioinformatics and microbiome evolution.
Important info below on eligibility & URSA competition funding👇
www.findaphd.com/phds/project...
The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath on FindAPhD.com
PhD Project - The overlapping microbiome: ecology, function and resilience beyond species boundaries at University of Bath, listed on FindAPhD.com
www.findaphd.com
November 12, 2025 at 1:49 PM
Guillaume has just moved on from the lab to a super exciting Assoc Prof in Microbiome at the University of Bath... he's amazing and if you're keen on a PhD check this out!