Hartmut Vodermaier
@hvodermaier.bsky.social
Senior Scientific Editor for @embojournal.bsky.social @embopress.org
Ubiquitin & other PTMs, cell cycle & cell division, 3R stuff (replication, recombination, repair).
Opinions my own. He/his.
Ubiquitin & other PTMs, cell cycle & cell division, 3R stuff (replication, recombination, repair).
Opinions my own. He/his.
My seminar will only be on Nov 26th though - so still a chance to catch it 😀
#CIBseminars
Responsible Science Publishing & Open Science
Hartmut Vodermaier, @embojournal.org
📅November 19
⏰12pm
Responsible Science Publishing & Open Science
Hartmut Vodermaier, @embojournal.org
📅November 19
⏰12pm
November 21, 2025 at 2:48 PM
My seminar will only be on Nov 26th though - so still a chance to catch it 😀
Looking forward to my upcoming site visit in Madrid!
#CIBseminars
Responsible Science Publishing & Open Science
Hartmut Vodermaier, @embojournal.org
📅November 19
⏰12pm
Responsible Science Publishing & Open Science
Hartmut Vodermaier, @embojournal.org
📅November 19
⏰12pm
November 21, 2025 at 1:04 PM
Looking forward to my upcoming site visit in Madrid!
As my conference year draws to a close: still one last highlight coming up #EESNucleus on home turf @events.embl.org!
November 17, 2025 at 9:55 AM
As my conference year draws to a close: still one last highlight coming up #EESNucleus on home turf @events.embl.org!
It's been an amazing year for the new PTM field of #MARUbylation - happy that I could get involved first-hand!
Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
November 3, 2025 at 1:42 PM
It's been an amazing year for the new PTM field of #MARUbylation - happy that I could get involved first-hand!
On the train to Montpellier for the #EMBOsumoylation conference - looking forward to the 2nd recurrence of this #EMBOevents workshop and to the latest research in the SUMO field!
meetings.embo.org/event/25-sum...
meetings.embo.org/event/25-sum...
SUMOylation: From discovery to translation
Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …
meetings.embo.org
September 21, 2025 at 1:17 PM
On the train to Montpellier for the #EMBOsumoylation conference - looking forward to the 2nd recurrence of this #EMBOevents workshop and to the latest research in the SUMO field!
meetings.embo.org/event/25-sum...
meetings.embo.org/event/25-sum...
I continue to be astounded by the recent resurgence of intriguing studies revolving around #PARPs and the interplay of ADP-ribosylation with other PTMs! Latest example that we published in @embojournal.org:
A general rather than site- & function-specific role for protein modification by ADP-ribosylation?
@kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress
www.embopress.org/doi/full/10....
@kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress
www.embopress.org/doi/full/10....
September 4, 2025 at 4:10 PM
I continue to be astounded by the recent resurgence of intriguing studies revolving around #PARPs and the interplay of ADP-ribosylation with other PTMs! Latest example that we published in @embojournal.org:
Was fun to work on this manuscript - never would have thought that an E1 enzyme could be involved in selecting a particular #ubiquitin -like protein isoform over another!
What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
September 2, 2025 at 2:00 PM
Was fun to work on this manuscript - never would have thought that an E1 enzyme could be involved in selecting a particular #ubiquitin -like protein isoform over another!
Reposted by Hartmut Vodermaier
Our RNA & translation editor Cornelius Schneider is excited to be at #EMBLProtein starting tomorrow – make sure to say Hi to him and drag him to your posters 😀
@events.embl.org
@events.embl.org
September 2, 2025 at 12:39 PM
Our RNA & translation editor Cornelius Schneider is excited to be at #EMBLProtein starting tomorrow – make sure to say Hi to him and drag him to your posters 😀
@events.embl.org
@events.embl.org
Fascinating new insights into evolutionary conservation/diversification/repurposing in the chromosome segregation machinery!
Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 16, 2025 at 12:00 PM
Fascinating new insights into evolutionary conservation/diversification/repurposing in the chromosome segregation machinery!
Another week, another great conference - happy to be at #EESAgeing on home turf
📣 If you still want to join #EESAgeing you can do so by signing up for virtual participation 💻
⏰ You have until 3 June to register here: https://s.embl.org/ees25-05-bl
Don't miss this international event that will focus on the molecular mechanisms of ageing and age-related diseases 🧬⏳
⏰ You have until 3 June to register here: https://s.embl.org/ees25-05-bl
Don't miss this international event that will focus on the molecular mechanisms of ageing and age-related diseases 🧬⏳
June 10, 2025 at 1:00 PM
Another week, another great conference - happy to be at #EESAgeing on home turf
Reposted by Hartmut Vodermaier
Senate Democrats warn Trump plan to wipe out public broadcasting funding will shut down stations, eliminate essential services. But House GOP scheduled to vote to clawback $1.1 billion next week.
Partisan battle lines form over Trump's plan to defund NPR & PBS
Senate Democrats warn Trump plan to wipe out public broadcasting funding will shut down stations, eliminate essential services. But House GOP scheduled to vote to clawback $1.1 billion next week.
n.pr
June 5, 2025 at 1:00 PM
Senate Democrats warn Trump plan to wipe out public broadcasting funding will shut down stations, eliminate essential services. But House GOP scheduled to vote to clawback $1.1 billion next week.
Reposted by Hartmut Vodermaier
This vital resource @flybase.bsky.social is in acute peril: its funding blocked by the vindictiveness of Trump. Emergency funds needed *now*, pending longer term solutions. Personal donations from Europe can be made here (UK taxpayers can gift-aid); other routes also possible. US appeal to follow.
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 5, 2025 at 1:26 PM
This vital resource @flybase.bsky.social is in acute peril: its funding blocked by the vindictiveness of Trump. Emergency funds needed *now*, pending longer term solutions. Personal donations from Europe can be made here (UK taxpayers can gift-aid); other routes also possible. US appeal to follow.
Reposted by Hartmut Vodermaier
A scary situation!
#drosophila @flybase.bsky.social request emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!
www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 5, 2025 at 9:07 AM
A scary situation!
Reposted by Hartmut Vodermaier
‘Anyone can do this’: Sleuths publish a toolkit for post-publication review
@averyorrall.bsky.social reports on an initiative from @reeserichardson.bsky.social and colleagues
@averyorrall.bsky.social reports on an initiative from @reeserichardson.bsky.social and colleagues
‘Anyone can do this’: Sleuths publish a toolkit for post-publication review
For years, sleuths – whose names our readers are likely familiar with – have been diligently flagging issues with the scientific literature. More than a dozen of these specialists have teamed up to cr...
retractionwatch.com
June 4, 2025 at 1:57 PM
‘Anyone can do this’: Sleuths publish a toolkit for post-publication review
@averyorrall.bsky.social reports on an initiative from @reeserichardson.bsky.social and colleagues
@averyorrall.bsky.social reports on an initiative from @reeserichardson.bsky.social and colleagues
Reposted by Hartmut Vodermaier
If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!
June 4, 2025 at 9:01 PM
If you are interested in pursuing a postdoc combining proteomics a genomics with functional molecular biology to study ubiquitin (-like) signaling in genome biology we are looking for candidates for the next MSCA Fellowships call!!!!
Reposted by Hartmut Vodermaier
Today, these amazing NKI researchers are pushing their limits by climbing the Alpe d’Huez. Go for it lovely people! We are proud to see so many of you dedicate your time and effort to supporting cancer research.
With @oncodeinstitute.bsky.social
#AlpedHuZes #cancerresearch #ad6 #NKI
With @oncodeinstitute.bsky.social
#AlpedHuZes #cancerresearch #ad6 #NKI
June 5, 2025 at 6:57 AM
Today, these amazing NKI researchers are pushing their limits by climbing the Alpe d’Huez. Go for it lovely people! We are proud to see so many of you dedicate your time and effort to supporting cancer research.
With @oncodeinstitute.bsky.social
#AlpedHuZes #cancerresearch #ad6 #NKI
With @oncodeinstitute.bsky.social
#AlpedHuZes #cancerresearch #ad6 #NKI
Grateful for the opportunity to meet with so many enthusiastic early-career scientists and sharing behind-the-scenes insights with them #wUeBI2025
New day, new opportunities for connection! Conference participants meet with the EMBO Journal editor, Hartmut Vodermaier, for an engaging discussion on publishing, peer review, and the future of scientific communication. A valuable and inspiring exchange!
#wUeBI2025
#wUeBI2025
June 4, 2025 at 5:45 AM
Grateful for the opportunity to meet with so many enthusiastic early-career scientists and sharing behind-the-scenes insights with them #wUeBI2025
Excited that the symposium #wUeBI2025 @grk2243.bsky.social is now about to start - looking forward to exciting news from the #ubiquitin field, and to meeting this great community again!
June 2, 2025 at 10:41 AM
Excited that the symposium #wUeBI2025 @grk2243.bsky.social is now about to start - looking forward to exciting news from the #ubiquitin field, and to meeting this great community again!
Ever wondered how it would be as an Editor?
Here's your chance to try as an absence cover with our wonderful colleagues from @emboreports.org!
Here's your chance to try as an absence cover with our wonderful colleagues from @emboreports.org!
May 19, 2025 at 1:32 PM
Ever wondered how it would be as an Editor?
Here's your chance to try as an absence cover with our wonderful colleagues from @emboreports.org!
Here's your chance to try as an absence cover with our wonderful colleagues from @emboreports.org!
Reposted by Hartmut Vodermaier
Reposted by Hartmut Vodermaier
Great to get to publish another one on the emerging connections between ADP-ribosylation, immune signaling, ubiquitin and protein aggregation/degradation
🥳 Out now @embojournal.org!
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....
Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications.
p62 is usually linked to #autophagy — but not here.
These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....
Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system | The EMBO Journal
imageimageInterferon induces the formation of ADP-ribosylation (ADPr)-enriched p62 bodies, requiring
PARP14 and p62. Unlike canonical p62 bodies, these ADPr-enriched structures are independent
of auto...
www.embopress.org
April 8, 2025 at 9:28 AM
Great to get to publish another one on the emerging connections between ADP-ribosylation, immune signaling, ubiquitin and protein aggregation/degradation
Reposted by Hartmut Vodermaier
💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) www.embopress.org/doi/full/10....
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses | The EMBO Journal
imageimageSubcutaneous infection by lymphocytic choriomeningitis virus (LCMV) is characterized
by skewed CD4+ T-cell polarization, as well as severely impaired differentiation of T follicular
helper (...
www.embopress.org
April 1, 2025 at 11:41 AM
💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) www.embopress.org/doi/full/10....
Reposted by Hartmut Vodermaier
Highlighted in Issue 7:
Lysosome-CDK4/6 co-targeting in cancer therapy
Algal spliceosome structure
Also:
Opposite synaptic plasticity effects of Ras isoforms
Novel biosensor for spatiotemporal dynamics of STING activation
Cover: @plenart.bsky.social and coworkers
www.embopress.org/toc/14602075...
Lysosome-CDK4/6 co-targeting in cancer therapy
Algal spliceosome structure
Also:
Opposite synaptic plasticity effects of Ras isoforms
Novel biosensor for spatiotemporal dynamics of STING activation
Cover: @plenart.bsky.social and coworkers
www.embopress.org/toc/14602075...
April 1, 2025 at 9:41 AM
Highlighted in Issue 7:
Lysosome-CDK4/6 co-targeting in cancer therapy
Algal spliceosome structure
Also:
Opposite synaptic plasticity effects of Ras isoforms
Novel biosensor for spatiotemporal dynamics of STING activation
Cover: @plenart.bsky.social and coworkers
www.embopress.org/toc/14602075...
Lysosome-CDK4/6 co-targeting in cancer therapy
Algal spliceosome structure
Also:
Opposite synaptic plasticity effects of Ras isoforms
Novel biosensor for spatiotemporal dynamics of STING activation
Cover: @plenart.bsky.social and coworkers
www.embopress.org/toc/14602075...
Reposted by Hartmut Vodermaier
From large language models (LLMs) to large reasoning models (LRMs) based on chain-of-thought. Are LRMs "“genuinely reasoning” or “merely mimicking” the kinds of human reasoning that is in the pretraining or post-training data"?
Interesting read ➡️ www.science.org/doi/10.1126/...
Interesting read ➡️ www.science.org/doi/10.1126/...
Artificial intelligence learns to reason
Julia has two sisters and one brother. How many sisters does her brother Martin have?Solving this tiny puzzle requires a bit of thinking. You might mentally picture the family of three girls and one b...
www.science.org
March 28, 2025 at 7:37 AM
From large language models (LLMs) to large reasoning models (LRMs) based on chain-of-thought. Are LRMs "“genuinely reasoning” or “merely mimicking” the kinds of human reasoning that is in the pretraining or post-training data"?
Interesting read ➡️ www.science.org/doi/10.1126/...
Interesting read ➡️ www.science.org/doi/10.1126/...