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Reposted by Lucas Waltzer

The Francis Crick Institute @crick.ac.uk · 18h

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

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Ana Marija Jakšić @merianelion.bsky.social · 9d

🚨Preprint🚨
What started as an attempt to compare CT scans of diverse fly brains, ended up a new concept for analysis & segmentation of difficult tomographic data. No ground truths, no training, just maths. This is TopoTome, topological data analysis of 3D images

www.biorxiv.org/content/10.1...

Figure showing 3 panels. Panel A: workflow of a classical deep learning model vs TopoTome workflow, with marked differences between the methods, including manual segmentation of images, design and optimization of neural network and data post processing that is needed in deep learning workflow but not in TopoTome. Panel B: core concepts behind TopoTome shown connected by arrows. From left to right, there is a microCT scan of a fly brain (3D reconstruction), a persistence barcode of H2 homologies, an image of how persistent barcodes map to the original CT brain scan, and a segmentation of a CT scan. Panel C shows the concept of cubical complex filtration of 2D and 3D image data.

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FlyBase @flybase.bsky.social · 15h

Searches and tools are currently down for FlyBase.org. Our developers are working on getting us back up.

FlyBase Homepage

FlyBase: a database for drosophila genetics and molecular biology

FlyBase.org

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Dr. Sedona Murphy @sedonamurphy.bsky.social · 1d

If you’re interested in exploring the relationship between chromatin organization and epigenetic memory using chromatin tracing microscopy, my group is recruiting a talented PhD student 🥳

Max Planck Institute for Molecular Genetics @molgen.mpg.de · 1d

🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...

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fly paper broadcast @fly-broadcast.bsky.social · 1d

Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression
#Drosophila

Histone modification cross-talk and protein complex diversification confer plasticity to Polycomb repression #Drosophila

PubMed link

pubmed.ncbi.nlm.nih.gov

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Carlos Ribeiro @ribeirocarlitos.bsky.social · 1d

Interesting how companies and the financial world is racing to spend mindboggling amounts of money to build the infrastructure to train computers. But we are leaving the infrastructure to train and educate humans crumbling. The question is who will train who?

a man in a suit is holding a jacket and a cigarette .

ALT: a man in a suit is holding a jacket and a cigarette .

media.tenor.com

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Wellcome Sanger Institute @sangerinstitute.bsky.social · 1d

Read ‘Sperm sequencing reveals extensive positive selection in the male germline’ from @sangerinstitute.bsky.social and collaborators in @nature.com below:

nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

nature.com

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Nuria Lopez-Bigas @nlbigas.bsky.social · 1d

🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

www.nature.com

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Kirsty Wan @micromotility.bsky.social · 2d

Very sad to hear that Sir John Gurdon, former Master of Magdalene College, has passed away at the age of 92. www.cam.ac.uk/research/new...

Here is a powerful reminder that you should never give up on your dreams.

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Lucas Waltzer @lucaswaltzer.bsky.social · 2d

Congratulations, exciting reads!

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Bardin Lab @bardinlab.bsky.social · 3d

The PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social

www.cell.com/developmenta...

Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila

Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

www.cell.com

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James Briscoe @jamesbriscoe.bsky.social · 2d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Le Monde @lemonde.fr · 3d

Le Nobel de médecine 2025 récompense la découverte du processus de contrôle des maladies auto-immunes

Un Japonais, Shimon Sakaguchi, et deux Américains, Mary Brunkow et Fred Ramsdell, ont révélé l’existence d’une catégorie de lymphocytes T qui permettent à notre système immunitaire de combattre les infections tout en préservant nos tissus. Une découverte prometteuse pour traiter certaines maladies chroniques.

www.lemonde.fr

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Lucas Waltzer @lucaswaltzer.bsky.social · 3d

I must disagree: the Clermont-Ferrand/ Paris is and will remain the worst French train line, with delay regularly above 3 hours!! May be Marseille Bordeaux has a higher rate of delay, but we have long ones!! A free night in the train is always an option here!

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KOJAMF🤘🖤🤘 @kojamf.bsky.social · 4d

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

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Thiago Carvalho @cyrilpedia.bsky.social · 5d

,While these articles and blog posts have appeared in different media ...() they all share commonalities, such as similar introductions, trying to discredit the targeted scientists’ expertise, or question their neutrality or integrity, and seem to be generated by chatbots.'

Scientists targeted by dark PR tactics: Several academic scientists critical of de-extinction projects have become the targets of anonymous smear articles and weaponized copyright infringement claims:...

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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Fillip Port @crisprflydesign.bsky.social · 5d

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social

#CRISPR #Drosophila

www.biorxiv.org/content/10.1...

Figure from the preprint showing sensory neuron morphology with different levels of Cas9 expression.

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Lucas Waltzer @lucaswaltzer.bsky.social · 4d

www.science.org/content/arti...

Insects aren’t ‘little robots’—so scientists are rethinking their welfare

Science chats with an entomologist and an expert in animal ethics who are monitoring how researchers report on the ethical treatment of insects

www.science.org

Lucas Waltzer @lucaswaltzer.bsky.social · 5d

= telomeres elongate in hybrid embryos only when maternal telomeres are short and paternal telomeres are long. In the reciprocal cross, telomeres shorten !!!

Mia Levine @levine-lab.bsky.social · 5d

Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.

We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).

authors.elsevier.com/c/1loW-3QW8S...

authors.elsevier.com

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Thiago Carvalho @cyrilpedia.bsky.social · 7d

'Innovation does not occur in a vacuum. It requires raw materials: the findings of basic research. We are currently burning through a stockpile of knowledge accumulated during a more enlightened era of public investment, while allocating insufficient resources for replenishing it.'

For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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Doulfikar @doulfikar.bsky.social · 7d

THE GODFATHER

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FlyBase @flybase.bsky.social · 6d

There's an update on the state of FlyBase on the FlyBase.org front page. You can contribute to FlyBase at this link wiki.flybase.org/wiki/FlyBase...
We express enormous gratitude to the people, labs, groups, and foundations who have already helped us.
#FlyBase #Drosophila

FlyBase Update – October 2025
The termination of the NIH/NHGRI FlyBase grant has placed the long-term sustainability of FlyBase at risk. However, thanks to the generous support of several key individuals and institutions, we are pleased to announce that FlyBase will remain operational through the coming year. We extend our deepest gratitude to Yukiko Yamashita, Cassandra Extavour, Hugo Bellen, Thom Kaufman, the Genetics Society of America / Drosophila Board, the Bloomington Drosophila Stock Center, an anonymous donor and the Wellcome Trust. We are especially thankful for a generous gift from Seemay Chou, Jed McCaleb, and The Navigation Fund. We also greatly appreciate the continued support from the broader Drosophila community – your donations and service fees have been vital in helping us stay afloat. Special thanks also go to Jessica Manning for her tireless administrative work at Harvard, to Ruth Lehmann, Hugo Bellen, and Paul Sternberg for advice and efforts, and to the Board of the European Drosophila Society for all their efforts. Sadly, we must also share that several long-standing FlyBase team members have recently moved on. We are immensely grateful to Susan Russo-Gelbart, Lynn Crosby, Gil dos Santos, Kris Broll, Victoria Jenkins, and TyAnna Lovato for their many years of dedicated service and contributions to FlyBase. Looking ahead, ensuring FlyBase’s sustainability beyond the next year – and successfully integrating with the Alliance – will require new funding sources. We kindly ask for your continued support:
• European labs: Please consider contributing to the Cambridge, U.K. FlyBase group
• U.S. and other non-European labs: Please consider contributing to the U.S. FlyBase groups
• Both U.K. and U.S. FlyBase are working diligently to establish an invoicing system. We appreciate your continued patience.
For more information on how to support us, please visit: Contribute to FlyBase wiki page https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

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the Node @the-node.bsky.social · 8d

The Kahneman Chronicles: Lessons from a Fly Lab

Entertaining post from @sameerthukral.bsky.social kicking of a series imagining what would transpire if Daniel Kahneman—the “grandfather of behavioural economics”—took a sabbatical and worked in a fly lab. 🪰

thenode.biologists.com/the-kahneman...

The Kahneman Chronicles: Lessons from a Fly Lab - the Node

The Kahneman Chronicles #1: When a Nobel Laureate Fixed Our Lab's Scheduling Disasters Daniel Kahneman (1934-2024) was a legendary psychologist who

thenode.biologists.com

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Ming Tommy Tang @tommytang.bsky.social · 6d

Your data is lying to you. Here’s how technical artifacts distort biology—and how to see the truth. 👇
1/ Beautiful t-SNE? Shiny heatmap?
Look closer.
Technical artifacts can fake whole cell types.
Here’s where the ghosts hide.

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Lucas Waltzer @lucaswaltzer.bsky.social · 6d

Congratulations @oliviermathieu.bsky.social and colleagues @igred.fr !! #epigenetics #arabidopsis

CNRS Biologie @cnrsbiologie.bsky.social · 6d

#ResultatScientifique 🔎 L'équilibre entre activation et répression des gènes est crucial pour le développement et chez les plantes ils existent des protéines "gardiennes" de ce mécanisme !

✍️ O. Mathieu & G. Moissiard
👉 L'article dans @natplants.nature.com
buff.ly/v7R7mbj

Des protéines « gardiennes » préservent l’expression des gènes chez les plantes

Chez les organismes multicellulaires, l'équilibre entre l’activation et la répression des gènes est crucial pour le développement.

www.insb.cnrs.fr

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