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Reposted by ISAR International Society for Antiviral Research

Bogunovic Lab @bogunoviclab.bsky.social · Aug 13

Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...

An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo

A human inborn error of immunity guided discovery and development of a prophylactic, mRNA-based antiviral.

www.science.org

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Jun 3

Antiviral research needs new models for assessing efficacy! A new exciting paper from ISAR members evaluates human liver spheroids for hemorrhagic viruses
www.sciencedirect.com/science/arti...

Assessing human liver spheroids as a model for antiviral drug evaluation against BSL-3 haemorrhagic fever viruses

Haemorrhagic fever viruses (HFVs) cause highly lethal syndromes with limited therapeutic options. Increasingly, 3D cell culture models are becoming an…

www.sciencedirect.com

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Reposted by ISAR International Society for Antiviral Research

Di Jiang @dijiang319.bsky.social · May 15

@science.org 🧫🧬❄️🔬 Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis | Science www.science.org/doi/10.1126/...
@yiweichang.bsky.social www.yiweichanglab.org @jiwasa.bsky.social #virology #Influenza #Cryo-EM #StructuralBiology #RNA #polymerase

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Reposted by ISAR International Society for Antiviral Research

Nature @nature.com · May 15

📢 Calling PhD students 📢 we want to hear from you!

Help shape the future of PhD education. Take our survey to tell us all about your experiences

https://go.nature.com/43iJAsi

PhD students in STEM: Nature wants to hear from you

Buried in lab work or drowning in data? Take a break and help shape the future of PhD education.

go.nature.com

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Reposted by ISAR International Society for Antiviral Research

Stuart Neil @tetherin.bsky.social · May 1

Islolation of a new merbecovirus from sick mink on a Chinese fur farm. Broad generalist species tropism including for human cells via using ACE2, not DPP4, as an entry receptor.

www.nature.com/articles/s41...

A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor - Nature

Nature - A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor

www.nature.com

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Apr 23

A new contribution from ISAR members:
Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis  
www.sciencedirect.com/science/arti...

Mechanisms of action of repurposed Ebola virus antivirals – the roles of phospholipidosis and cholesterol homeostasis

Cell-based drug repurposing screens have been a common approach to identifying compounds with antiviral properties. For Ebola virus (EBOV), such scree…

www.sciencedirect.com

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Apr 20

A review on the management of herpes infections www.sciencedirect.com/science/arti...

Overview on the management of herpes simplex virus infections: Current therapies and future directions

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent, infecting approximately 64 % and 13 % of the world's population, respecti…

www.sciencedirect.com

Reposted by ISAR International Society for Antiviral Research

Jesse Erasmus @jesseerasmus.bsky.social · Apr 15

Just published! Here we report immunogenicity and efficacy of our replicon RNA vaccine against Crimean-Congo hemorrhagic fever in a cynomolgus macaque model of #CCHFV infection. Stay tuned as we advance this candidate in clinical trials.

www.thelancet.com/journals/ebi...

A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques

Our data demonstrate that our repNP vaccine and NP-specific antibody can protect against CCHFV in non-human primates.

www.thelancet.com

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Reposted by ISAR International Society for Antiviral Research

NWO XL Consortium "Viruses like it Sweet" @viruseslikeitsweet.bsky.social · Apr 9

Join us! We are looking for a highly motivated PhD Student to join our teams and investigate glycan-virus interaction at @erasmusmc.bsky.social

🍬Glycans
🦠Viruses
🫁🧠Organoids
🧬 Genetic Engineering

Apply here 👇
www.werkenbijerasmusmc.nl/en/vacancy/1...

Vacature: PhD position Virology

The department of Viroscience at the Erasmus MC and the department of Chemical Biology & Drug discovery at Utrecht University have joined forces to identify functional glycan receptors for influenza A...

www.werkenbijerasmusmc.nl

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Reposted by ISAR International Society for Antiviral Research

Kai Kupferschmidt @kakape.bsky.social · Apr 8

Researchers have been trying for a long time to nail down where in nature mpox lurks.
Now they appear to have caught the virus that causes mpox in the act of spilling over from squirrels to monkeys.
“It is the best clue so far for what the reservoir might be”, says @kgandersen.bsky.social
#IDsky 🧪

How do mpox outbreaks start? Dead baby monkey provides important clue

“Landmark” study fingers fire-footed rope squirrel as a reservoir of fatal disease

www.science.org

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Reposted by ISAR International Society for Antiviral Research

Marion Koopmans @marionkoopmans.bsky.social · Apr 4

Please share with people interested in arbovirology. We are looking for an enthusiastic colleague to strengthen our team please share if you know of scientists interested in arbovirology, ready to make a move to Rotterdam! www.academictransfer.com/en/jobs/3508...

Assistant professor Arbovirology

We are looking for a passionate researcher interested in basic arbovirology to join our team!

www.academictransfer.com

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Reposted by ISAR International Society for Antiviral Research

Nature Microbiology @natmicrobiol.nature.com · Apr 4

Read the full adjoining paper here:
www.nature.com/articles/s41...

Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow’s milk - Nature Microbiology

The FDA-approved antiviral baloxavir improves disease outcomes in mice compared with oseltamivir after ocular and intranasal challenge with A(H5N1)-contaminated cow milk.

www.nature.com

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Reposted by ISAR International Society for Antiviral Research

Markus Eyting @meyting.bsky.social · Apr 2

Our paper on the effect of herpes zoster vaccination on dementia is now out in Nature! 🎉

Huge thanks to Felix Michalik, Seunghun Chung, @pascalge.bsky.social and especially Min Xie (@minxiesci.bsky.social) & Simon Heß (@hesss.org) making the analysis so much fun!

www.nature.com/articles/s41...

A natural experiment on the effect of herpes zoster vaccination on dementia - Nature

Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

www.nature.com

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Reposted by ISAR International Society for Antiviral Research

Eddie Holmes @eddieholmes.bsky.social · Apr 2

Another zoonotic (alpha) coronavirus. Closely related to the rodent virus AcCoV-JC34 that contains a putative furin cleavage site. www.tandfonline.com/doi/full/10....

Novel human coronavirus in an infant patient with pneumonia, Republic of Korea

Coronaviruses (CoVs) pose a significant threat to public health, causing a wide spectrum of clinical manifestations and outcomes. Beyond precipitating global outbreaks, Human CoVs (HCoVs) are frequ...

www.tandfonline.com

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 28

Save the date! #ICAR2026

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 26

We had the chance to have a preview of this work at ICAR!
A demonstration of how phenotypic screenings and an excellent team of scientists can identify promising antivirals with a completely new mechanism of action! www.nature.com/articles/s41...
#science @nature.com @neytsjohan.bsky.social

A coronavirus assembly inhibitor that targets the viral membrane protein - Nature

High-throughput screening and hit optimization have led to the development of a small molecule, CIM-834, that targets the SARS-CoV-2 membrane protein and blocks assembly of the virus.

www.nature.com

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Reposted by ISAR International Society for Antiviral Research

Nature @nature.com.web.brid.gy · Mar 26

MFSD6 is an entry receptor for enterovirus D68

Nature, Published online: 25 March 2025; doi:10.1038/s41586-025-08908-0 MFSD6 is an entry receptor for enterovirus D68

www.nature.com

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 23

The conference is over, but the good memories remain! @leendelang.bsky.social won the prusoff award and gave an amazing lecture on how to study arboviruses with different mosquito models and the influence of skin microbiota in mosquito bites and arbovirus transmission.

#ICAR2025 #science

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 20

Today we had a very interesting session about AI in antiviral research. Small molecule discovery, mutation prediction and phenotypic screening with bright field images. Thanks to the speakers and we are looking forward to the future advancements in the field!!!
#AI #antiviral #ICAR2025

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 20

Yesterday we had an amazing lecture from @vignuzzilab.bsky.social that is what the diversity award is made for!

Vignuzzi Lab @vignuzzilab.bsky.social · Mar 20

Thank you @isaricar.bsky.social for this special recognition for my career achievements and my contribution to helping others get ahead!

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 11

New paper out by an ISAR member lab

www.sciencedirect.com/science/arti...

Bemnifosbuvir and ruzavir are potent inhibitors of hepatitis C virus.

And act synergistically in vitro when combined.

Bemnifosbuvir and ruzasvir in combination exhibit potent synergistic antiviral activity in vitro while maintaining a favorable nonclinical safety profile in vivo

Bemnifosbuvir (BEM), the orally available hemisulfate salt of the double prodrug of a guanosine nucleotide analog, is a potent, selective, and pan-gen…

www.sciencedirect.com

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 10

New paper: GS-1 blocks entry of herpes viruses and more broadly inhibits enveloped viruses

www.sciencedirect.com/science/arti...

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 10

New review on antiviral approaches targeting lipids, written by one of our society members.

www.sciencedirect.com/science/arti...

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Mar 5

considering whether to attend the 38th annual conference on Antiviral Research (#ICAR25), the annual meeting of International Society for Antiviral Research (ISAR)?

check the outstanding program and then join us on March 17-21 in lasvegas!

Last minute registration still open:

lnkd.in/gK_iTn-u

This link will take you to a page that’s not on LinkedIn

lnkd.in

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ISAR International Society for Antiviral Research @isaricar.bsky.social · Feb 18

new review article out from the Univ of Parma and Univ of Lausanne

compounds targeting the lipid kinase phosphatidylinositol 4-kinase IIIβ (PI4KB) and the tyrosine kinase proteins Src and Abl

link here:

www.sciencedirect.com/science/arti...

Targeting PI4KB and Src/Abl host kinases as broad-spectrum antiviral strategy: Myth or real opportunity?

Viruses pose a continuous threat to human health. Limited treatment options exist for current viruses, and the risk of infections with newly emerging …

www.sciencedirect.com

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