ISB
@isbscience.org
Institute for Systems Biology, 501(c)3, pioneers of systems biology. Affiliate of Providence. Stay up-to-date at http://isbscience.org.
What does a “healthy” bathroom routine actually look like? @isbscience.org microbiome researcher Dr. Sean Gibbons explains the science — from frequency to stool form — in a quick 11-minute podcast. Short, smart, and very listenable. @gibbological.bsky.social podcasts.apple.com/ca/podcast/d...
Dr. Sean Gibbons: Toilet Visits, How Often And How Long - November 6, 2025
Podcast Episode · The Last Show with David Cooper · 2025-11-07 · 11m
podcasts.apple.com
January 20, 2026 at 7:08 PM
What does a “healthy” bathroom routine actually look like? @isbscience.org microbiome researcher Dr. Sean Gibbons explains the science — from frequency to stool form — in a quick 11-minute podcast. Short, smart, and very listenable. @gibbological.bsky.social podcasts.apple.com/ca/podcast/d...
Reposted by ISB
Before we stop crossing out 2025 and remembering to write 2026 at the top of our lab notebooks, check out all that our Seattle institutes accomplished in 2025! 🎉
@isbscience.org: https://bit.ly/4su411j
BBI: https://bit.ly/49fJZ30
@fredhutch.org: https://bit.ly/4qJf5Wi
KPWHRI: https://bit.ly/4su5Fjv
@isbscience.org: https://bit.ly/4su411j
BBI: https://bit.ly/49fJZ30
@fredhutch.org: https://bit.ly/4qJf5Wi
KPWHRI: https://bit.ly/4su5Fjv
January 9, 2026 at 11:26 PM
Before we stop crossing out 2025 and remembering to write 2026 at the top of our lab notebooks, check out all that our Seattle institutes accomplished in 2025! 🎉
@isbscience.org: https://bit.ly/4su411j
BBI: https://bit.ly/49fJZ30
@fredhutch.org: https://bit.ly/4qJf5Wi
KPWHRI: https://bit.ly/4su5Fjv
@isbscience.org: https://bit.ly/4su411j
BBI: https://bit.ly/49fJZ30
@fredhutch.org: https://bit.ly/4qJf5Wi
KPWHRI: https://bit.ly/4su5Fjv
Reposted by ISB
Pooled CRISPR screens with transcriptomics readout arrived for bacteria. We introduce mapSPLiT, an approach to profiling transcriptional responses to CRISPR perturbations at scale. Collaborative work with Carothers, Zalatan, and Seelig groups at [email protected] www.biorxiv.org/content/10.6... 1/4
Pooled single-cell CRISPRa/i screens for functional genomics in bacteria at scale
Pooled CRISPR screens using single-cell RNA sequencing (scRNA-seq) have emerged as powerful tools to uncover gene function, map regulatory networks, and identify genetic interactions. However, the inh...
www.biorxiv.org
December 23, 2025 at 7:42 PM
Pooled CRISPR screens with transcriptomics readout arrived for bacteria. We introduce mapSPLiT, an approach to profiling transcriptional responses to CRISPR perturbations at scale. Collaborative work with Carothers, Zalatan, and Seelig groups at [email protected] www.biorxiv.org/content/10.6... 1/4
Reposted by ISB
🥉 Taking the #3 spot in our 2025 Post Countdown is the @isbscience.org Virtual Microbiome Symposium!
Don't worry if you missed out, the full recap is online: https://bit.ly/4qeNDQ4
https://bsky.app/profile/scienceinseattle.com/post/3m5wob373ce2k
Don't worry if you missed out, the full recap is online: https://bit.ly/4qeNDQ4
https://bsky.app/profile/scienceinseattle.com/post/3m5wob373ce2k
🦠 The @isbscience.org Virtual Microbiome Symposium is on December 12, 2025! This virtual symposium will dive into the influence of gut microbial metabolites on human #physiology.
This event is perfect for everyone in academia, industry, and the clinic. Register now: https://bit.ly/4oe67iw
This event is perfect for everyone in academia, industry, and the clinic. Register now: https://bit.ly/4oe67iw
December 29, 2025 at 5:49 PM
🥉 Taking the #3 spot in our 2025 Post Countdown is the @isbscience.org Virtual Microbiome Symposium!
Don't worry if you missed out, the full recap is online: https://bit.ly/4qeNDQ4
https://bsky.app/profile/scienceinseattle.com/post/3m5wob373ce2k
Don't worry if you missed out, the full recap is online: https://bit.ly/4qeNDQ4
https://bsky.app/profile/scienceinseattle.com/post/3m5wob373ce2k
Celebrating the complex beauty of the season. ❄️🧬 From all of us at ISB, have a wonderful holiday and a Happy New Year!
December 24, 2025 at 5:47 PM
Celebrating the complex beauty of the season. ❄️🧬 From all of us at ISB, have a wonderful holiday and a Happy New Year!
2025 was a milestone year for ISB. We didn't just look back at our 25-year legacy; we used it to launch discoveries that will shape the future of health.
In our 2025 Year in Review, explore the science and the successes that made the past 12 months truly historic.
isbscience.org/news/our-peo...
In our 2025 Year in Review, explore the science and the successes that made the past 12 months truly historic.
isbscience.org/news/our-peo...
2025 Year in Review: Breakthroughs, Milestones & Moments That Defined ISB
In 2025, the Institute for Systems Biology marked a pivotal year — one that coincided with our 25th anniversary and underscored our enduring role in shaping the future of biomedical
isbscience.org
December 22, 2025 at 4:45 PM
2025 was a milestone year for ISB. We didn't just look back at our 25-year legacy; we used it to launch discoveries that will shape the future of health.
In our 2025 Year in Review, explore the science and the successes that made the past 12 months truly historic.
isbscience.org/news/our-peo...
In our 2025 Year in Review, explore the science and the successes that made the past 12 months truly historic.
isbscience.org/news/our-peo...
Another banner year for the Gibbons Lab. Great job, @gibbological.bsky.social!
It's time for the 2025 Gibbons Lab Research Roundup!
Yeehaw! 🤠 @isbscience.org
In these dark times, let the joy of scientific discovery and trainee success be your balm ❤️🩹
🧵...
Yeehaw! 🤠 @isbscience.org
In these dark times, let the joy of scientific discovery and trainee success be your balm ❤️🩹
🧵...
December 20, 2025 at 12:05 AM
Another banner year for the Gibbons Lab. Great job, @gibbological.bsky.social!
💡 Curious how your gut microbes talk to your brain, immune system, and hormones? @isbscience.org's 2025 Virtual Microbiome Symposium explored these questions with leaders in the field — over 1,000 attendees worldwide registered. Catch the highlights and full sessions: isbscience.org/news/health/...
Microbial Metabolites and Human Health Take Center Stage at ISB’s 2025 Virtual Microbiome Symposium
ISB's 2025 Virtual Microbiome Symposium focused on how microbial metabolites shape human physiology, development, and disease.
isbscience.org
December 18, 2025 at 1:46 AM
💡 Curious how your gut microbes talk to your brain, immune system, and hormones? @isbscience.org's 2025 Virtual Microbiome Symposium explored these questions with leaders in the field — over 1,000 attendees worldwide registered. Catch the highlights and full sessions: isbscience.org/news/health/...
@isbscience.org postdoc @n8ritz.bsky.social (Venkatesh Lab) was selected as a 2026 WRF Postdoc Fellow. The fellowship supports early-career researchers pursuing high-impact science. Congrats Nate! 🎉
@flash-point.bsky.social
More: tinyurl.com/y772pr2j
Venkatesh Lab: venkatesh.isbscience.org
@flash-point.bsky.social
More: tinyurl.com/y772pr2j
Venkatesh Lab: venkatesh.isbscience.org
December 17, 2025 at 7:55 PM
@isbscience.org postdoc @n8ritz.bsky.social (Venkatesh Lab) was selected as a 2026 WRF Postdoc Fellow. The fellowship supports early-career researchers pursuing high-impact science. Congrats Nate! 🎉
@flash-point.bsky.social
More: tinyurl.com/y772pr2j
Venkatesh Lab: venkatesh.isbscience.org
@flash-point.bsky.social
More: tinyurl.com/y772pr2j
Venkatesh Lab: venkatesh.isbscience.org
Reposted by ISB
If you missed the 2025 @isbscience.org Virtual Microbiome Symposium (theme: how microbial metabolites influence the brain, the immune system, & metabolism), the videos of the talks and the panel discussion are now available here:
youtube.com/playlist?lis...
Thanks to all who helped make it happen!
youtube.com/playlist?lis...
Thanks to all who helped make it happen!
2025 ISB Microbiome Symposium - YouTube
The 2025 ISB Microbiome Symposium was a virtual scientific event hosted by the Institute for Systems Biology (ISB) on December 12, 2025. The symposium brough...
youtube.com
December 17, 2025 at 4:34 PM
If you missed the 2025 @isbscience.org Virtual Microbiome Symposium (theme: how microbial metabolites influence the brain, the immune system, & metabolism), the videos of the talks and the panel discussion are now available here:
youtube.com/playlist?lis...
Thanks to all who helped make it happen!
youtube.com/playlist?lis...
Thanks to all who helped make it happen!
Nearly 1,000 people have registered so far! Don't miss out!
December 10, 2025 at 11:26 PM
Nearly 1,000 people have registered so far! Don't miss out!
Reposted by ISB
Top #Citations 2025: 9️⃣🧪
@cdiener.com @gibbological.bsky.social et al ( @isbscience.org @medunigraz.at ) present a new method to estimate dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
@cdiener.com @gibbological.bsky.social et al ( @isbscience.org @medunigraz.at ) present a new method to estimate dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
bit.ly
December 9, 2025 at 6:01 PM
Top #Citations 2025: 9️⃣🧪
@cdiener.com @gibbological.bsky.social et al ( @isbscience.org @medunigraz.at ) present a new method to estimate dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
@cdiener.com @gibbological.bsky.social et al ( @isbscience.org @medunigraz.at ) present a new method to estimate dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
Did you miss @isbscience.org's Mary Brunkow give her Nobel lecture bright and early on Sunday morning? You can watch Mary and her co-Nobel Prize recipients here: www.youtube.com/watch?v=n1tf...
December 9, 2025 at 1:15 AM
Did you miss @isbscience.org's Mary Brunkow give her Nobel lecture bright and early on Sunday morning? You can watch Mary and her co-Nobel Prize recipients here: www.youtube.com/watch?v=n1tf...
Reposted by ISB
Had fun presenting in London last month on our microbiome-aging work, and spoke with Olivia Haslam afterwards about how we're thinking about moving forward with microbiome-informed precision nutrition to support healthy aging. @isbscience.org
www.nutraingredients.com/Article/2025...
www.nutraingredients.com/Article/2025...
Anti-aging methods for the gut microbiome: Focus on optimization, not rejuvenation
Anti-aging strategies may not work for gut health because the microbiome requires a unique approach for healthy aging. Expert researcher Dr. Sean Gibbons highlighted that optimizing gut microbiota, ra...
www.nutraingredients.com
December 7, 2025 at 8:01 PM
Had fun presenting in London last month on our microbiome-aging work, and spoke with Olivia Haslam afterwards about how we're thinking about moving forward with microbiome-informed precision nutrition to support healthy aging. @isbscience.org
www.nutraingredients.com/Article/2025...
www.nutraingredients.com/Article/2025...
ISB received a 2025 AWS Imagine Grant! 🙌 It's full steam ahead for Tarpon — our AI platform turning T-cell receptors into digital immune fingerprints. This kind of tech + biology mash-up could reshape how we understand disease and design future immune therapies.
isbscience.org/news/press-r...
isbscience.org/news/press-r...
ISB Named Winner of 2025 Amazon Web Services Imagine Grant for Nonprofits
ISB wins AWS Imagine Grant to launch Tarpon, a generative AI platform that decodes and designs human immune responses for next-gen therapies.
isbscience.org
December 5, 2025 at 2:55 PM
ISB received a 2025 AWS Imagine Grant! 🙌 It's full steam ahead for Tarpon — our AI platform turning T-cell receptors into digital immune fingerprints. This kind of tech + biology mash-up could reshape how we understand disease and design future immune therapies.
isbscience.org/news/press-r...
isbscience.org/news/press-r...
Hear, hear!
@isbscience.org's Dr. Mary Brunkow gave a "practice talk" for her Nobel Lecture, and it was riveting! Mapping the Foxp3 locus was an arduous task in the late 90s, and this recognition is a fitting tribute. Thrilled for you, Mary! Your humility and grace are a wonderful example for all of us.
December 3, 2025 at 2:23 PM
Hear, hear!
On #GivingTuesday, we’re spotlighting the bold, early-stage science that shapes future breakthroughs.
Your support helps @isbscience.org push new ideas forward — and expands access to STEM education for the next generation.
Give today: give.isbscience.org
Your support helps @isbscience.org push new ideas forward — and expands access to STEM education for the next generation.
Give today: give.isbscience.org
December 2, 2025 at 6:08 PM
On #GivingTuesday, we’re spotlighting the bold, early-stage science that shapes future breakthroughs.
Your support helps @isbscience.org push new ideas forward — and expands access to STEM education for the next generation.
Give today: give.isbscience.org
Your support helps @isbscience.org push new ideas forward — and expands access to STEM education for the next generation.
Give today: give.isbscience.org
Reposted by ISB
#Multidomain therapy for #AlzheimersDisease: a scoping review of #cognitive decline trials
Jared C. Roach, Gwênlyn Glusman, Molly K. Rapozo... Leroy Hood @isbscience.org
link.springer.com/article/10.1...
Jared C. Roach, Gwênlyn Glusman, Molly K. Rapozo... Leroy Hood @isbscience.org
link.springer.com/article/10.1...
Multidomain therapy for Alzheimer’s disease: a scoping review of cognitive decline trials - Molecular Neurodegeneration
Molecular Neurodegeneration - Alzheimer’s disease (AD) leading to cognitive decline and dementia results from the interplay of multiple interacting dysfunctional biological systems. These...
link.springer.com
December 1, 2025 at 7:57 PM
#Multidomain therapy for #AlzheimersDisease: a scoping review of #cognitive decline trials
Jared C. Roach, Gwênlyn Glusman, Molly K. Rapozo... Leroy Hood @isbscience.org
link.springer.com/article/10.1...
Jared C. Roach, Gwênlyn Glusman, Molly K. Rapozo... Leroy Hood @isbscience.org
link.springer.com/article/10.1...
Reposted by ISB
Please join us on Dec 12th for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems".
Co-organized by @gibbological.bsky.social
Registration is free & we have a fantastic line-up of experts!
isbscience.org/events/2025-...
Co-organized by @gibbological.bsky.social
Registration is free & we have a fantastic line-up of experts!
isbscience.org/events/2025-...
2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB)
The gut’s microbial ecosystem produces diverse metabolites that actively shape neural, immune, and endocrine function. Join leading researchers on December 12 as they share new discoveries into these ...
isbscience.org
December 2, 2025 at 5:05 PM
Please join us on Dec 12th for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems".
Co-organized by @gibbological.bsky.social
Registration is free & we have a fantastic line-up of experts!
isbscience.org/events/2025-...
Co-organized by @gibbological.bsky.social
Registration is free & we have a fantastic line-up of experts!
isbscience.org/events/2025-...
Reposted by ISB
Meet Lina Yang! Lina is a junior at Shorecrest HS in WA who participated in our System Thinkers in STEM Ambassadorship. Check out Lina’s STiSA project: see.isbscience.org/projects/lin... #STEMsystemsthinkers @isbscience.org
November 21, 2025 at 11:47 PM
Meet Lina Yang! Lina is a junior at Shorecrest HS in WA who participated in our System Thinkers in STEM Ambassadorship. Check out Lina’s STiSA project: see.isbscience.org/projects/lin... #STEMsystemsthinkers @isbscience.org
New: PNW RECOVER Long COVID Update — @isbscience.org's Jim Heath, @uwmedicine.bsky.social's Helen Chu & Swedish's Jason Goldman shared new insights on #longCOVID symptom trajectories, clinical trial findings, and upcoming treatment studies.
Recap + full video: isbscience.org/news/isb-eve...
Recap + full video: isbscience.org/news/isb-eve...
What We’re Learning About Long COVID: Updates from the PNW RECOVER Town Hall
In a virtual town hall, PNW RECOVER leaders shared data on long COVID trajectories, early clinical trial findings, and upcoming studies.
isbscience.org
November 19, 2025 at 2:51 AM
New: PNW RECOVER Long COVID Update — @isbscience.org's Jim Heath, @uwmedicine.bsky.social's Helen Chu & Swedish's Jason Goldman shared new insights on #longCOVID symptom trajectories, clinical trial findings, and upcoming treatment studies.
Recap + full video: isbscience.org/news/isb-eve...
Recap + full video: isbscience.org/news/isb-eve...
Reposted by ISB
🦠 The @isbscience.org Virtual Microbiome Symposium is on December 12, 2025! This virtual symposium will dive into the influence of gut microbial metabolites on human #physiology.
This event is perfect for everyone in academia, industry, and the clinic. Register now: https://bit.ly/4oe67iw
This event is perfect for everyone in academia, industry, and the clinic. Register now: https://bit.ly/4oe67iw
November 18, 2025 at 9:22 PM
🦠 The @isbscience.org Virtual Microbiome Symposium is on December 12, 2025! This virtual symposium will dive into the influence of gut microbial metabolites on human #physiology.
This event is perfect for everyone in academia, industry, and the clinic. Register now: https://bit.ly/4oe67iw
This event is perfect for everyone in academia, industry, and the clinic. Register now: https://bit.ly/4oe67iw
Reposted by ISB
📸Check out photos from our most recent Dean’s Distinguished Lecture Series on Nov. 12 with Leroy Hood, MD, PhD, CEO of Phenome Health and professor at both the Buck Institute for Research on Aging and @isbscience.org. flic.kr/s/aHBqjCACug #UCIMedSchool #UCIrvine #UCI @ucirvine.bsky.social
Leroy Hood, MD, PhD - Dean's Distinguished Lecture Series - Nov. 12-13, 2025
Explore this photo album by UC Irvine School of Medicine on Flickr!
flic.kr
November 18, 2025 at 10:52 PM
📸Check out photos from our most recent Dean’s Distinguished Lecture Series on Nov. 12 with Leroy Hood, MD, PhD, CEO of Phenome Health and professor at both the Buck Institute for Research on Aging and @isbscience.org. flic.kr/s/aHBqjCACug #UCIMedSchool #UCIrvine #UCI @ucirvine.bsky.social
Congrats to @gibbological.bsky.social, named a 2025 @clarivate.com Highly Cited Researcher for the fourth consecutive year. A clear reflection of the reach and influence of his work in #microbiome science.
Full list: clarivate.com/highly-cited...
Full list: clarivate.com/highly-cited...
November 14, 2025 at 8:12 PM
Congrats to @gibbological.bsky.social, named a 2025 @clarivate.com Highly Cited Researcher for the fourth consecutive year. A clear reflection of the reach and influence of his work in #microbiome science.
Full list: clarivate.com/highly-cited...
Full list: clarivate.com/highly-cited...
Join @isbscience.org on December 12 for a Virtual Microbiome Symposium highlighting new discoveries about how gut-derived metabolites affect neural, immune, and endocrine systems. Open to microbiome-curious researchers and practitioners everywhere. isbscience.org/events/2025-...
2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB)
The gut’s microbial ecosystem produces diverse metabolites that actively shape neural, immune, and endocrine function. Join leading researchers on December 12 as they share new discoveries into these ...
isbscience.org
November 13, 2025 at 11:53 PM
Join @isbscience.org on December 12 for a Virtual Microbiome Symposium highlighting new discoveries about how gut-derived metabolites affect neural, immune, and endocrine systems. Open to microbiome-curious researchers and practitioners everywhere. isbscience.org/events/2025-...